YLR038C / COX12

Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR038C / COX12

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:3.49|P-value:3.88E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.62|P-value:8.32E-17 ID:SGTC_236|Compound:1509-0011|FD-Score:18.90|P-value:2.99E-73 ID:SGTC_259|Compound:usnic acid|FD-Score:3.44|P-value:4.56E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.36|P-value:5.84E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.72|P-value:1.72E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:-3.32|P-value:9.40E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:6.09|P-value:2.69E-9 ID:SGTC_559|Compound:1550-0661|FD-Score:3.42|P-value:4.83E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:5.26|P-value:2.27E-7 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.68|P-value:2.75E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.91|P-value:8.16E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:4.42|P-value:1.07E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.94|P-value:7.38E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:3.72|P-value:1.68E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.37|P-value:5.76E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.89|P-value:1.30E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.30|P-value:9.89E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.50|P-value:5.09E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:5.33|P-value:1.60E-7 ID:SGTC_1006|Compound:4099-6547|FD-Score:-3.32|P-value:9.43E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.79|P-value:2.11E-6 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.49|P-value:3.80E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.34|P-value:6.40E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.65|P-value:2.18E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.21|P-value:2.57E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:-3.66|P-value:2.96E-4 ID:SGTC_1594|Compound:piperine|FD-Score:3.21|P-value:9.72E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.24|P-value:8.94E-4 ID:SGTC_1626|Compound:st003712|FD-Score:-3.51|P-value:5.00E-4 ID:SGTC_1635|Compound:st007035|FD-Score:21.60|P-value:6.45E-95 ID:SGTC_1708|Compound:st033234|FD-Score:3.41|P-value:5.05E-4 ID:SGTC_1717|Compound:st033143|FD-Score:5.63|P-value:3.27E-8 ID:SGTC_1746|Compound:st038117|FD-Score:3.39|P-value:5.41E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.32|P-value:6.71E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.26|P-value:2.08E-5 ID:SGTC_1966|Compound:st070145|FD-Score:4.04|P-value:4.99E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.36|P-value:1.36E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.55|P-value:3.12E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.64|P-value:4.03E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-6.57|P-value:2.81E-10 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.62|P-value:3.44E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.51|P-value:3.52E-4 ID:SGTC_2780|Compound:5215298|FD-Score:9.06|P-value:2.31E-18 ID:SGTC_2784|Compound:7567673|FD-Score:7.27|P-value:1.72E-12 ID:SGTC_2951|Compound:9072950|FD-Score:3.62|P-value:2.39E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.27|P-value:7.88E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.74|P-value:2.25E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.71|P-value:2.48E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.25|P-value:8.61E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.49|P-value:3.88E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.62|P-value:8.32E-17 ID:SGTC_236|Compound:1509-0011|FD-Score:18.90|P-value:2.99E-73 ID:SGTC_259|Compound:usnic acid|FD-Score:3.44|P-value:4.56E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.36|P-value:5.84E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.72|P-value:1.72E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:-3.32|P-value:9.40E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:6.09|P-value:2.69E-9 ID:SGTC_559|Compound:1550-0661|FD-Score:3.42|P-value:4.83E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:5.26|P-value:2.27E-7 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.68|P-value:2.75E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.91|P-value:8.16E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:4.42|P-value:1.07E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.94|P-value:7.38E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:3.72|P-value:1.68E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.37|P-value:5.76E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.89|P-value:1.30E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.30|P-value:9.89E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.50|P-value:5.09E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:5.33|P-value:1.60E-7 ID:SGTC_1006|Compound:4099-6547|FD-Score:-3.32|P-value:9.43E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.79|P-value:2.11E-6 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.49|P-value:3.80E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.34|P-value:6.40E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.65|P-value:2.18E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.21|P-value:2.57E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:-3.66|P-value:2.96E-4 ID:SGTC_1594|Compound:piperine|FD-Score:3.21|P-value:9.72E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.24|P-value:8.94E-4 ID:SGTC_1626|Compound:st003712|FD-Score:-3.51|P-value:5.00E-4 ID:SGTC_1635|Compound:st007035|FD-Score:21.60|P-value:6.45E-95 ID:SGTC_1708|Compound:st033234|FD-Score:3.41|P-value:5.05E-4 ID:SGTC_1717|Compound:st033143|FD-Score:5.63|P-value:3.27E-8 ID:SGTC_1746|Compound:st038117|FD-Score:3.39|P-value:5.41E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.32|P-value:6.71E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.26|P-value:2.08E-5 ID:SGTC_1966|Compound:st070145|FD-Score:4.04|P-value:4.99E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.36|P-value:1.36E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.55|P-value:3.12E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.64|P-value:4.03E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-6.57|P-value:2.81E-10 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.62|P-value:3.44E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.51|P-value:3.52E-4 ID:SGTC_2780|Compound:5215298|FD-Score:9.06|P-value:2.31E-18 ID:SGTC_2784|Compound:7567673|FD-Score:7.27|P-value:1.72E-12 ID:SGTC_2951|Compound:9072950|FD-Score:3.62|P-value:2.39E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.27|P-value:7.88E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.74|P-value:2.25E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.71|P-value:2.48E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.25|P-value:8.61E-4

Top fitness defect scores for YLR038C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 21.60 42.4 µM 6.45E-95 18 3.19E-104
2 SGTC_236 1509-0011 18.90 5.3 µM 2.99E-73 62 2.45E-80
3 SGTC_2780 5215298 9.06 71.4 µM 2.31E-18 1 6.60E-20
4 SGTC_134 0269-0018 8.62 6.9 µM 8.32E-17 52 3.38E-18
5 SGTC_2784 7567673 7.27 72.7 µM 1.72E-12 iron homeostasis 4 1.84E-13
6 SGTC_386 1509-0011 6.09 3.1 µM 2.69E-9 92 5.80E-10
7 SGTC_1717 st033143 5.63 58.0 µM 3.27E-8 14 8.91E-9
8 SGTC_977 1348-1378 5.33 135.0 µM 1.60E-7 7 5.05E-8
9 SGTC_581 0958-0271 5.26 211.0 µM 2.27E-7 21 7.39E-8
10 SGTC_1036 k216-0215 4.79 33.5 µM 2.11E-6 mitochondrial response to ROS 29 8.43E-7
11 SGTC_2151 5563267 4.64 85.4 µM 4.03E-6 11 1.71E-6
12 SGTC_766 1391-0721 4.42 126.0 µM 1.07E-5 7 4.97E-6
13 SGTC_2008 4012253 4.36 172.0 µM 1.36E-5 16 6.42E-6
14 SGTC_1932 st074806 4.26 40.9 µM 2.08E-5 20 1.02E-5
15 SGTC_1429 4049-0205 4.21 9.5 µM 2.57E-5 5 1.28E-5
16 SGTC_1966 st070145 4.04 16.1 µM 4.99E-5 21 2.65E-5
17 SGTC_772 k072-0172 3.94 35.3 µM 7.38E-5 18 4.05E-5
18 SGTC_607 4491-0986 3.91 66.8 µM 8.16E-5 heme requiring 30 4.52E-5
19 SGTC_803 4488-1585 3.72 147.0 µM 1.68E-4 16 9.90E-5
20 SGTC_310 1273-0058 3.72 1.1 µM 1.72E-4 mitochondrial stress 260 1.01E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.621 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.619 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.603 0 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.600 0 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.599 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.596 6.03E-322 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.592 1.79E-316 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.574 3.37E-293 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.564 2.75E-281 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.564 9.62E-281 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.562 3.22E-278 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.553 5.09E-268 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.531 5.05E-244 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.530 7.28E-242 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.525 3.32E-237 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex