YLR039C / RIC1

Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR039C / RIC1

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:-7.59|P-value:8.95E-9 ID:SGTC_22|Compound:0964-0034|FD-Score:6.44|P-value:2.27E-6 ID:SGTC_57|Compound:miconazole|FD-Score:-4.25|P-value:7.02E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:5.72|P-value:2.46E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:5.11|P-value:1.51E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-5.92|P-value:5.14E-6 ID:SGTC_278|Compound:4092-0821|FD-Score:-4.63|P-value:2.57E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.63|P-value:2.58E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.81|P-value:1.56E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:7.14|P-value:1.78E-7 ID:SGTC_370|Compound:0180-0345|FD-Score:7.99|P-value:5.50E-9 ID:SGTC_383|Compound:2324-0395|FD-Score:-4.51|P-value:3.57E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-5.14|P-value:6.05E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.48|P-value:7.06E-7 ID:SGTC_515|Compound:4092-1064|FD-Score:-6.11|P-value:2.72E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.22|P-value:7.49E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:4.88|P-value:2.82E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-4.26|P-value:6.84E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-5.44|P-value:2.46E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-4.56|P-value:3.10E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-4.89|P-value:1.25E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:-5.17|P-value:5.46E-5 ID:SGTC_989|Compound:1501-0895|FD-Score:-4.32|P-value:5.75E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-4.19|P-value:8.16E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-5.03|P-value:8.25E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:5.76|P-value:2.18E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:-8.07|P-value:1.13E-9 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.29|P-value:8.91E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:9.60|P-value:2.83E-12 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.96|P-value:2.28E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:5.24|P-value:1.04E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:7.78|P-value:1.35E-8 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.86|P-value:2.98E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-4.70|P-value:2.12E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-4.50|P-value:3.64E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-8.08|P-value:1.10E-9 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-6.62|P-value:4.28E-7 ID:SGTC_1752|Compound:st044819|FD-Score:-5.20|P-value:5.04E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-7.54|P-value:1.11E-8 ID:SGTC_1757|Compound:st041620|FD-Score:-5.66|P-value:1.20E-5 ID:SGTC_1758|Compound:st042942|FD-Score:-5.89|P-value:5.69E-6 ID:SGTC_1760|Compound:st045453|FD-Score:-9.97|P-value:9.13E-14 ID:SGTC_1766|Compound:st045414|FD-Score:4.88|P-value:2.79E-4 ID:SGTC_1792|Compound:st045773|FD-Score:4.83|P-value:3.20E-4 ID:SGTC_1794|Compound:st048918|FD-Score:5.22|P-value:1.10E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-5.55|P-value:1.71E-5 ID:SGTC_1826|Compound:st055655|FD-Score:-4.73|P-value:1.95E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.41|P-value:9.47E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-5.15|P-value:5.88E-5 ID:SGTC_1953|Compound:st076800|FD-Score:6.86|P-value:5.06E-7 ID:SGTC_1993|Compound:st073995|FD-Score:-4.83|P-value:1.49E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-6.01|P-value:3.79E-6 ID:SGTC_2006|Compound:4011487|FD-Score:-4.36|P-value:5.31E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-5.58|P-value:1.58E-5 ID:SGTC_2038|Compound:4100038|FD-Score:-5.84|P-value:6.59E-6 ID:SGTC_2147|Compound:5545932|FD-Score:-5.26|P-value:4.20E-5 ID:SGTC_2155|Compound:5570423|FD-Score:-4.88|P-value:1.30E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-4.36|P-value:5.22E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-5.07|P-value:7.49E-5 ID:SGTC_2333|Compound:9017922|FD-Score:-6.26|P-value:1.60E-6 ID:SGTC_2350|Compound:9023895|FD-Score:-4.57|P-value:3.06E-4 ID:SGTC_2455|Compound:5377712|FD-Score:8.29|P-value:1.47E-9 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.81|P-value:3.42E-4 ID:SGTC_2678|Compound:equilin|FD-Score:4.81|P-value:3.36E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.11|P-value:1.51E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-4.16|P-value:8.78E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-4.30|P-value:6.14E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-5.53|P-value:1.82E-5 ID:SGTC_2880|Compound:9042983|FD-Score:-4.56|P-value:3.15E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.72|P-value:4.27E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-5.00|P-value:9.22E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-5.73|P-value:9.48E-6 ID:SGTC_3038|Compound:9091290|FD-Score:4.89|P-value:2.75E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-6.43|P-value:8.53E-7 ID:SGTC_3187|Compound:9109394|FD-Score:4.45|P-value:8.52E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-4.11|P-value:9.79E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-4.81|P-value:1.59E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:-7.59|P-value:8.95E-9 ID:SGTC_22|Compound:0964-0034|FD-Score:6.44|P-value:2.27E-6 ID:SGTC_57|Compound:miconazole|FD-Score:-4.25|P-value:7.02E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:5.72|P-value:2.46E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:5.11|P-value:1.51E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-5.92|P-value:5.14E-6 ID:SGTC_278|Compound:4092-0821|FD-Score:-4.63|P-value:2.57E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.63|P-value:2.58E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.81|P-value:1.56E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:7.14|P-value:1.78E-7 ID:SGTC_370|Compound:0180-0345|FD-Score:7.99|P-value:5.50E-9 ID:SGTC_383|Compound:2324-0395|FD-Score:-4.51|P-value:3.57E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-5.14|P-value:6.05E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.48|P-value:7.06E-7 ID:SGTC_515|Compound:4092-1064|FD-Score:-6.11|P-value:2.72E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.22|P-value:7.49E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:4.88|P-value:2.82E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-4.26|P-value:6.84E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-5.44|P-value:2.46E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-4.56|P-value:3.10E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-4.89|P-value:1.25E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:-5.17|P-value:5.46E-5 ID:SGTC_989|Compound:1501-0895|FD-Score:-4.32|P-value:5.75E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-4.19|P-value:8.16E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-5.03|P-value:8.25E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:5.76|P-value:2.18E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:-8.07|P-value:1.13E-9 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.29|P-value:8.91E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:9.60|P-value:2.83E-12 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.96|P-value:2.28E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:5.24|P-value:1.04E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:7.78|P-value:1.35E-8 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.86|P-value:2.98E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-4.70|P-value:2.12E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-4.50|P-value:3.64E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-8.08|P-value:1.10E-9 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-6.62|P-value:4.28E-7 ID:SGTC_1752|Compound:st044819|FD-Score:-5.20|P-value:5.04E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-7.54|P-value:1.11E-8 ID:SGTC_1757|Compound:st041620|FD-Score:-5.66|P-value:1.20E-5 ID:SGTC_1758|Compound:st042942|FD-Score:-5.89|P-value:5.69E-6 ID:SGTC_1760|Compound:st045453|FD-Score:-9.97|P-value:9.13E-14 ID:SGTC_1766|Compound:st045414|FD-Score:4.88|P-value:2.79E-4 ID:SGTC_1792|Compound:st045773|FD-Score:4.83|P-value:3.20E-4 ID:SGTC_1794|Compound:st048918|FD-Score:5.22|P-value:1.10E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-5.55|P-value:1.71E-5 ID:SGTC_1826|Compound:st055655|FD-Score:-4.73|P-value:1.95E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.41|P-value:9.47E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-5.15|P-value:5.88E-5 ID:SGTC_1953|Compound:st076800|FD-Score:6.86|P-value:5.06E-7 ID:SGTC_1993|Compound:st073995|FD-Score:-4.83|P-value:1.49E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-6.01|P-value:3.79E-6 ID:SGTC_2006|Compound:4011487|FD-Score:-4.36|P-value:5.31E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-5.58|P-value:1.58E-5 ID:SGTC_2038|Compound:4100038|FD-Score:-5.84|P-value:6.59E-6 ID:SGTC_2147|Compound:5545932|FD-Score:-5.26|P-value:4.20E-5 ID:SGTC_2155|Compound:5570423|FD-Score:-4.88|P-value:1.30E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-4.36|P-value:5.22E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-5.07|P-value:7.49E-5 ID:SGTC_2333|Compound:9017922|FD-Score:-6.26|P-value:1.60E-6 ID:SGTC_2350|Compound:9023895|FD-Score:-4.57|P-value:3.06E-4 ID:SGTC_2455|Compound:5377712|FD-Score:8.29|P-value:1.47E-9 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.81|P-value:3.42E-4 ID:SGTC_2678|Compound:equilin|FD-Score:4.81|P-value:3.36E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.11|P-value:1.51E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-4.16|P-value:8.78E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-4.30|P-value:6.14E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-5.53|P-value:1.82E-5 ID:SGTC_2880|Compound:9042983|FD-Score:-4.56|P-value:3.15E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.72|P-value:4.27E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-5.00|P-value:9.22E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-5.73|P-value:9.48E-6 ID:SGTC_3038|Compound:9091290|FD-Score:4.89|P-value:2.75E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-6.43|P-value:8.53E-7 ID:SGTC_3187|Compound:9109394|FD-Score:4.45|P-value:8.52E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-4.11|P-value:9.79E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-4.81|P-value:1.59E-4

Top fitness defect scores for YLR039C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1134 3477-0009 9.60 42.5 µM 2.83E-12 1 3.86E-22
2 SGTC_2455 5377712 8.29 9.8 µM 1.47E-9 1 5.43E-17
3 SGTC_370 0180-0345 7.99 38.7 µM 5.50E-9 DNA intercalators 1 6.66E-16
4 SGTC_1374 2889-5571 7.78 141.0 µM 1.35E-8 RSC complex & mRNA processing 4 3.66E-15
5 SGTC_366 0181-0206 7.14 4.3 µM 1.78E-7 Golgi 4 4.83E-13
6 SGTC_1953 st076800 6.86 12.1 µM 5.06E-7 8 3.49E-12
7 SGTC_22 0964-0034 6.44 14.5 µM 2.27E-6 unfolded protein response 16 5.99E-11
8 SGTC_1060 3448-7350 5.76 82.0 µM 2.18E-5 Golgi 14 4.29E-9
9 SGTC_59 0330-0160 5.72 1.3 µM 2.46E-5 43 5.40E-9
10 SGTC_1131 3454-3128 5.29 32.3 µM 8.91E-5 12 6.11E-8
11 SGTC_1313 1220-0047 5.24 237.0 µM 1.04E-4 19 8.11E-8
12 SGTC_1794 st048918 5.22 76.9 µM 1.10E-4 2 9.11E-8
13 SGTC_91 0417-1751 5.11 58.4 µM 1.51E-4 Golgi 22 1.64E-7
14 SGTC_2737 bleomycin 5.11 30.5 nM 1.51E-4 Golgi 49 1.65E-7
15 SGTC_1165 k072-0275 4.96 30.3 µM 2.28E-4 21 3.59E-7
16 SGTC_3038 9091290 4.89 49.5 µM 2.75E-4 6 5.09E-7
17 SGTC_1766 st045414 4.88 44.8 µM 2.79E-4 RPP1 & pyrimidine depletion 12 5.25E-7
18 SGTC_657 3534-0529 4.88 86.7 µM 2.82E-4 3 5.34E-7
19 SGTC_1416 3966-0321 4.86 25.3 µM 2.98E-4 4 5.91E-7
20 SGTC_1792 st045773 4.83 43.6 µM 3.20E-4 13 6.79E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.445 2.10E-162 YDR136C_d VPS61_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
0.401 2.94E-129 YDR137W RGP1 hom Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
0.400 2.08E-128 YLR262C YPT6 hom Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.345 1.30E-94 YLR261C_d VPS63_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
0.294 7.74E-68 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.261 2.34E-53 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.245 3.57E-47 YDR320C SWA2 hom Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
0.244 1.28E-46 YML071C COG8 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.227 1.88E-40 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.222 1.53E-38 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.167 2.48E-22 YGL223C COG1 hom Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.159 1.93E-20 YGR167W CLC1 hom Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W
0.158 3.76E-20 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.151 1.50E-18 YKR020W VPS51 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p
0.142 1.51E-16 YHL031C GOS1 hom v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28