YLR041W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR041W / YLR041W

Click on Significant Values for Screen Details ID:SGTC_146|Compound:3448-8650|FD-Score:-3.14|P-value:2.89E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:3.35|P-value:1.19E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.20|P-value:2.22E-4 ID:SGTC_389|Compound:tpck|FD-Score:-3.22|P-value:2.01E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.09|P-value:3.46E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:-3.22|P-value:2.05E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.15|P-value:2.74E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.47|P-value:7.01E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:3.77|P-value:1.72E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:4.19|P-value:2.12E-6 ID:SGTC_746|Compound:1095-0025|FD-Score:3.10|P-value:3.37E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.01|P-value:5.38E-6 ID:SGTC_866|Compound:0495-0101|FD-Score:3.82|P-value:1.38E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.56|P-value:4.59E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.95|P-value:7.05E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.89|P-value:4.84E-11 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.22|P-value:2.04E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.19|P-value:2.33E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.37|P-value:1.06E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.29|P-value:1.54E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:4.20|P-value:2.01E-6 ID:SGTC_1615|Compound:st002656|FD-Score:3.99|P-value:6.04E-6 ID:SGTC_1622|Compound:st003707|FD-Score:3.26|P-value:1.69E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.19|P-value:2.30E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.29|P-value:1.22E-6 ID:SGTC_2073|Compound:5212005|FD-Score:2.84|P-value:9.17E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.04|P-value:4.18E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.06|P-value:3.96E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-4.54|P-value:3.05E-7 ID:SGTC_2331|Compound:7980721|FD-Score:3.01|P-value:4.83E-4 ID:SGTC_2397|Compound:5161689|FD-Score:2.90|P-value:7.16E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.25|P-value:1.80E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.34|P-value:1.24E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.61|P-value:3.64E-5 ID:SGTC_2707|Compound:st078556|FD-Score:3.74|P-value:1.97E-5 ID:SGTC_2781|Compound:5567276|FD-Score:-3.03|P-value:4.37E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-4.77|P-value:8.30E-8 ID:SGTC_2929|Compound:9013348|FD-Score:-4.34|P-value:9.35E-7 ID:SGTC_2955|Compound:9076254|FD-Score:3.61|P-value:3.76E-5 ID:SGTC_2959|Compound:9079155|FD-Score:3.46|P-value:7.34E-5 ID:SGTC_2965|Compound:9082772|FD-Score:2.87|P-value:8.16E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.60|P-value:3.91E-5 ID:SGTC_2994|Compound:9053520|FD-Score:2.97|P-value:5.50E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.17|P-value:2.47E-4 ID:SGTC_3106|Compound:9121286|FD-Score:4.17|P-value:2.34E-6 ID:SGTC_3263|Compound:9137018|FD-Score:3.63|P-value:3.38E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.14|P-value:2.89E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:3.35|P-value:1.19E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.20|P-value:2.22E-4 ID:SGTC_389|Compound:tpck|FD-Score:-3.22|P-value:2.01E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.09|P-value:3.46E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:-3.22|P-value:2.05E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.15|P-value:2.74E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.47|P-value:7.01E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:3.77|P-value:1.72E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:4.19|P-value:2.12E-6 ID:SGTC_746|Compound:1095-0025|FD-Score:3.10|P-value:3.37E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.01|P-value:5.38E-6 ID:SGTC_866|Compound:0495-0101|FD-Score:3.82|P-value:1.38E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.56|P-value:4.59E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.95|P-value:7.05E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.89|P-value:4.84E-11 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.22|P-value:2.04E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.19|P-value:2.33E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.37|P-value:1.06E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.29|P-value:1.54E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:4.20|P-value:2.01E-6 ID:SGTC_1615|Compound:st002656|FD-Score:3.99|P-value:6.04E-6 ID:SGTC_1622|Compound:st003707|FD-Score:3.26|P-value:1.69E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.19|P-value:2.30E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.29|P-value:1.22E-6 ID:SGTC_2073|Compound:5212005|FD-Score:2.84|P-value:9.17E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.04|P-value:4.18E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.06|P-value:3.96E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-4.54|P-value:3.05E-7 ID:SGTC_2331|Compound:7980721|FD-Score:3.01|P-value:4.83E-4 ID:SGTC_2397|Compound:5161689|FD-Score:2.90|P-value:7.16E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.25|P-value:1.80E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.34|P-value:1.24E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.61|P-value:3.64E-5 ID:SGTC_2707|Compound:st078556|FD-Score:3.74|P-value:1.97E-5 ID:SGTC_2781|Compound:5567276|FD-Score:-3.03|P-value:4.37E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-4.77|P-value:8.30E-8 ID:SGTC_2929|Compound:9013348|FD-Score:-4.34|P-value:9.35E-7 ID:SGTC_2955|Compound:9076254|FD-Score:3.61|P-value:3.76E-5 ID:SGTC_2959|Compound:9079155|FD-Score:3.46|P-value:7.34E-5 ID:SGTC_2965|Compound:9082772|FD-Score:2.87|P-value:8.16E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.60|P-value:3.91E-5 ID:SGTC_2994|Compound:9053520|FD-Score:2.97|P-value:5.50E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.17|P-value:2.47E-4 ID:SGTC_3106|Compound:9121286|FD-Score:4.17|P-value:2.34E-6 ID:SGTC_3263|Compound:9137018|FD-Score:3.63|P-value:3.38E-5

Top fitness defect scores for YLR041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1279 0874-0590 5.89 65.2 µM 4.84E-11 5 1.88E-9
2 SGTC_2019 4016004 4.29 108.0 µM 1.22E-6 20 8.83E-6
3 SGTC_1450 4112-4260 4.20 37.6 µM 2.01E-6 calcium & mitochondrial duress 23 1.34E-5
4 SGTC_740 k014-0057 4.19 261.0 µM 2.12E-6 19 1.40E-5
5 SGTC_3106 9121286 4.17 49.5 µM 2.34E-6 7 1.52E-5
6 SGTC_1615 st002656 3.99 86.5 µM 6.04E-6 redox potentiating 15 3.36E-5
7 SGTC_1231 0242-0792 3.95 125.0 µM 7.05E-6 19 3.83E-5
8 SGTC_866 0495-0101 3.82 262.0 µM 1.38E-5 60S ribosome export 19 6.71E-5
9 SGTC_659 k018-0002 3.77 107.0 µM 1.72E-5 21 8.10E-5
10 SGTC_2707 st078556 3.74 66.6 µM 1.97E-5 15 9.04E-5
11 SGTC_3263 9137018 3.63 49.5 µM 3.38E-5 27 1.42E-4
12 SGTC_2626 ethyl orsellinate 3.61 100.0 µM 3.64E-5 44 1.51E-4
13 SGTC_2955 9076254 3.61 12.2 µM 3.76E-5 22 1.55E-4
14 SGTC_1082 camptothecin 3.56 424.9 nM 4.59E-5 DNA damage response 58 1.84E-4
15 SGTC_618 k072-0232 3.47 33.2 µM 7.01E-5 60S ribosome export 20 2.62E-4
16 SGTC_2959 9079155 3.46 11.0 µM 7.34E-5 45 2.72E-4
17 SGTC_1304 1165-0502 3.37 251.0 µM 1.06E-4 89 3.69E-4
18 SGTC_316 k060-0003 3.35 58.6 µM 1.19E-4 32 4.08E-4
19 SGTC_1370 2001-0092 3.29 44.6 µM 1.54E-4 68 5.07E-4
20 SGTC_1622 st003707 3.26 19.4 µM 1.69E-4 calcium & mitochondrial duress 69 5.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.08E-13 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.122 1.24E-12 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.112 7.44E-11 YLR259C HSP60 het Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
0.100 7.21E-9 YLR280C_d YLR280C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 9.62E-9 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.096 2.23E-8 YLL026W HSP104 hom Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.094 5.17E-8 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.093 6.22E-8 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.093 6.38E-8 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.093 7.19E-8 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.092 8.48E-8 YJR098C_p YJR098C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.092 9.42E-8 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.091 1.32E-7 YBL098W BNA4 hom Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
0.091 1.44E-7 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.089 2.31E-7 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele