YLR042C_p

Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR042C / YLR042C

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:-3.15|P-value:3.27E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.97|P-value:8.11E-6 ID:SGTC_385|Compound:1494-0393|FD-Score:3.54|P-value:6.19E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.04|P-value:4.78E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:2.98|P-value:6.08E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:2.94|P-value:7.05E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:4.46|P-value:6.42E-7 ID:SGTC_653|Compound:0203-0016|FD-Score:-3.26|P-value:2.10E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:-2.86|P-value:9.91E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:2.93|P-value:7.48E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:5.10|P-value:1.61E-8 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.42|P-value:1.06E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:5.59|P-value:6.76E-10 ID:SGTC_1006|Compound:4099-6547|FD-Score:-2.96|P-value:6.82E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.78|P-value:2.01E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.34|P-value:1.49E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.34|P-value:1.49E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.45|P-value:9.03E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:2.87|P-value:9.33E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.08|P-value:4.13E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:-3.20|P-value:2.64E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.15|P-value:3.21E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.17|P-value:2.91E-4 ID:SGTC_1826|Compound:st055655|FD-Score:-3.97|P-value:8.56E-6 ID:SGTC_1834|Compound:st055981|FD-Score:-4.41|P-value:9.00E-7 ID:SGTC_1835|Compound:st008666|FD-Score:3.39|P-value:1.17E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.18|P-value:2.86E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.29|P-value:1.80E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-2.86|P-value:9.66E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-4.19|P-value:2.86E-6 ID:SGTC_2424|Compound:5537928|FD-Score:-3.37|P-value:1.32E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-4.06|P-value:5.55E-6 ID:SGTC_2713|Compound:st079149|FD-Score:3.95|P-value:8.93E-6 ID:SGTC_2786|Compound:7743617|FD-Score:-3.26|P-value:2.08E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-4.38|P-value:1.03E-6 ID:SGTC_2925|Compound:9010536|FD-Score:-3.50|P-value:7.37E-5 ID:SGTC_2929|Compound:9013348|FD-Score:2.93|P-value:7.38E-4 ID:SGTC_2933|Compound:9026794|FD-Score:4.31|P-value:1.47E-6 ID:SGTC_2951|Compound:9072950|FD-Score:2.90|P-value:8.34E-4 ID:SGTC_2994|Compound:9053520|FD-Score:5.17|P-value:1.01E-8 ID:SGTC_3000|Compound:9075062|FD-Score:-3.05|P-value:4.67E-4 ID:SGTC_3030|Compound:9087619|FD-Score:2.95|P-value:6.93E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.08|P-value:4.18E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.08|P-value:4.18E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.25|P-value:2.11E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.15|P-value:3.27E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.97|P-value:8.11E-6 ID:SGTC_385|Compound:1494-0393|FD-Score:3.54|P-value:6.19E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.04|P-value:4.78E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:2.98|P-value:6.08E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:2.94|P-value:7.05E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:4.46|P-value:6.42E-7 ID:SGTC_653|Compound:0203-0016|FD-Score:-3.26|P-value:2.10E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:-2.86|P-value:9.91E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:2.93|P-value:7.48E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:5.10|P-value:1.61E-8 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.42|P-value:1.06E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:5.59|P-value:6.76E-10 ID:SGTC_1006|Compound:4099-6547|FD-Score:-2.96|P-value:6.82E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.78|P-value:2.01E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.34|P-value:1.49E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.34|P-value:1.49E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.45|P-value:9.03E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:2.87|P-value:9.33E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.08|P-value:4.13E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:-3.20|P-value:2.64E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.15|P-value:3.21E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.17|P-value:2.91E-4 ID:SGTC_1826|Compound:st055655|FD-Score:-3.97|P-value:8.56E-6 ID:SGTC_1834|Compound:st055981|FD-Score:-4.41|P-value:9.00E-7 ID:SGTC_1835|Compound:st008666|FD-Score:3.39|P-value:1.17E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.18|P-value:2.86E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.29|P-value:1.80E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-2.86|P-value:9.66E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-4.19|P-value:2.86E-6 ID:SGTC_2424|Compound:5537928|FD-Score:-3.37|P-value:1.32E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-4.06|P-value:5.55E-6 ID:SGTC_2713|Compound:st079149|FD-Score:3.95|P-value:8.93E-6 ID:SGTC_2786|Compound:7743617|FD-Score:-3.26|P-value:2.08E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-4.38|P-value:1.03E-6 ID:SGTC_2925|Compound:9010536|FD-Score:-3.50|P-value:7.37E-5 ID:SGTC_2929|Compound:9013348|FD-Score:2.93|P-value:7.38E-4 ID:SGTC_2933|Compound:9026794|FD-Score:4.31|P-value:1.47E-6 ID:SGTC_2951|Compound:9072950|FD-Score:2.90|P-value:8.34E-4 ID:SGTC_2994|Compound:9053520|FD-Score:5.17|P-value:1.01E-8 ID:SGTC_3000|Compound:9075062|FD-Score:-3.05|P-value:4.67E-4 ID:SGTC_3030|Compound:9087619|FD-Score:2.95|P-value:6.93E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.08|P-value:4.18E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.08|P-value:4.18E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.25|P-value:2.11E-4

Top fitness defect scores for YLR042C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_967 1306-0166 5.59 352.0 µM 6.76E-10 6 1.15E-8
2 SGTC_2994 9053520 5.17 71.4 µM 1.01E-8 RPP1 & pyrimidine depletion 6 1.16E-7
3 SGTC_958 1222-0007 5.10 33.0 µM 1.61E-8 13 1.72E-7
4 SGTC_650 1328-0195 4.46 38.0 µM 6.42E-7 10 4.03E-6
5 SGTC_2933 9026794 4.31 32.5 µM 1.47E-6 10 8.20E-6
6 SGTC_163 1327-0036 3.97 7.5 µM 8.11E-6 103 3.53E-5
7 SGTC_2713 st079149 3.95 53.4 µM 8.93E-6 19 3.84E-5
8 SGTC_1119 parthenolide 3.78 318.5 nM 2.01E-5 TSC3-RPN4 42 7.69E-5
9 SGTC_385 1494-0393 3.54 12.4 µM 6.19E-5 36 2.02E-4
10 SGTC_1270 0831-1170 3.45 17.3 µM 9.03E-5 21 2.79E-4
11 SGTC_1835 st008666 3.39 49.2 µM 1.17E-4 39 3.48E-4
12 SGTC_1989 st071868 3.29 50.2 µM 1.80E-4 27 5.03E-4
13 SGTC_3343 9148379 3.25 19.0 µM 2.11E-4 20 5.77E-4
14 SGTC_1723 st034307 3.17 2.5 µM 2.91E-4 mitochondrial processes 57 7.61E-4
15 SGTC_1430 4049-0248 3.08 69.1 µM 4.13E-4 53 0.00103
16 SGTC_3231 9132313 3.08 49.5 µM 4.18E-4 30 0.00104
17 SGTC_3137 9097352 3.08 49.5 µM 4.18E-4 83 0.00104
18 SGTC_427 1354-0053 3.04 47.3 µM 4.78E-4 59 0.00117
19 SGTC_517 1365-0151 2.98 113.0 µM 6.08E-4 76 0.00144
20 SGTC_3030 9087619 2.95 49.5 µM 6.93E-4 56 0.00161

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.42E-13 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.114 3.55E-11 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.113 4.63E-11 YPL030W TRM44 hom tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
0.105 1.17E-9 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.104 1.68E-9 YPL209C IPL1 het Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest
0.103 1.86E-9 YDR036C EHD3 hom 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
0.103 2.60E-9 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.099 8.71E-9 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.098 1.09E-8 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.097 2.13E-8 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
0.091 1.39E-7 YBR062C_p YBR062C_p hom Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.
0.088 3.62E-7 YOR127W RGA1 hom GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.086 5.38E-7 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.084 1.10E-6 YPR002W PDH1 hom Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
0.084 1.13E-6 YDR046C BAP3 hom Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication