YLR043C / TRX1

Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR043C / TRX1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.24|P-value:4.79E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.14|P-value:6.97E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.07|P-value:9.06E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:5.57|P-value:7.40E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:3.07|P-value:9.05E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.57|P-value:1.38E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.35|P-value:3.29E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.78|P-value:5.98E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.81|P-value:5.35E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.13|P-value:7.25E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.28|P-value:6.76E-6 ID:SGTC_653|Compound:0203-0016|FD-Score:3.75|P-value:6.89E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.85|P-value:4.43E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:3.15|P-value:6.80E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.15|P-value:6.80E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.19|P-value:5.88E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.13|P-value:7.20E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.60|P-value:1.25E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.08|P-value:8.52E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:4.29|P-value:6.49E-6 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.20|P-value:5.67E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-4.12|P-value:1.36E-5 ID:SGTC_2157|Compound:5649910|FD-Score:-3.87|P-value:4.00E-5 ID:SGTC_2173|Compound:5763948|FD-Score:3.61|P-value:1.22E-4 ID:SGTC_2175|Compound:5807670|FD-Score:4.24|P-value:8.04E-6 ID:SGTC_2177|Compound:5811945|FD-Score:6.93|P-value:8.72E-13 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.20|P-value:5.70E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.07|P-value:8.84E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.01|P-value:2.24E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.90|P-value:3.65E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.67|P-value:9.22E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-4.70|P-value:8.62E-7 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.74|P-value:6.96E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.50|P-value:1.82E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.06|P-value:9.19E-4 ID:SGTC_2964|Compound:9083345|FD-Score:5.50|P-value:1.10E-8 ID:SGTC_3002|Compound:9075603|FD-Score:5.04|P-value:1.43E-7 ID:SGTC_3147|Compound:9097027|FD-Score:-4.01|P-value:2.20E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.32|P-value:3.67E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.09|P-value:1.57E-5 ID:SGTC_3248|Compound:9135562|FD-Score:3.27|P-value:4.45E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.50|P-value:2.31E-6 ID:SGTC_3295|Compound:9122362|FD-Score:-5.02|P-value:1.62E-7 ID:SGTC_3297|Compound:9117502|FD-Score:3.57|P-value:1.40E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.27|P-value:4.39E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.24|P-value:4.79E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.14|P-value:6.97E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.07|P-value:9.06E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:5.57|P-value:7.40E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:3.07|P-value:9.05E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.57|P-value:1.38E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.35|P-value:3.29E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.78|P-value:5.98E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.81|P-value:5.35E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.13|P-value:7.25E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.28|P-value:6.76E-6 ID:SGTC_653|Compound:0203-0016|FD-Score:3.75|P-value:6.89E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.85|P-value:4.43E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:3.15|P-value:6.80E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.15|P-value:6.80E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.19|P-value:5.88E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.13|P-value:7.20E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.60|P-value:1.25E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.08|P-value:8.52E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:4.29|P-value:6.49E-6 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.20|P-value:5.67E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-4.12|P-value:1.36E-5 ID:SGTC_2157|Compound:5649910|FD-Score:-3.87|P-value:4.00E-5 ID:SGTC_2173|Compound:5763948|FD-Score:3.61|P-value:1.22E-4 ID:SGTC_2175|Compound:5807670|FD-Score:4.24|P-value:8.04E-6 ID:SGTC_2177|Compound:5811945|FD-Score:6.93|P-value:8.72E-13 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.20|P-value:5.70E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.07|P-value:8.84E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.01|P-value:2.24E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.90|P-value:3.65E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.67|P-value:9.22E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-4.70|P-value:8.62E-7 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.74|P-value:6.96E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.50|P-value:1.82E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.06|P-value:9.19E-4 ID:SGTC_2964|Compound:9083345|FD-Score:5.50|P-value:1.10E-8 ID:SGTC_3002|Compound:9075603|FD-Score:5.04|P-value:1.43E-7 ID:SGTC_3147|Compound:9097027|FD-Score:-4.01|P-value:2.20E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.32|P-value:3.67E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.09|P-value:1.57E-5 ID:SGTC_3248|Compound:9135562|FD-Score:3.27|P-value:4.45E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.50|P-value:2.31E-6 ID:SGTC_3295|Compound:9122362|FD-Score:-5.02|P-value:1.62E-7 ID:SGTC_3297|Compound:9117502|FD-Score:3.57|P-value:1.40E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.27|P-value:4.39E-4

Top fitness defect scores for YLR043C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2177 5811945 6.93 192.0 µM 8.72E-13 5 2.08E-12
2 SGTC_115 0527-0192 5.57 112.0 µM 7.40E-9 17 1.30E-8
3 SGTC_2964 9083345 5.50 53.4 µM 1.10E-8 6 1.90E-8
4 SGTC_3002 9075603 5.04 71.4 µM 1.43E-7 5 2.28E-7
5 SGTC_3283 9109332 4.50 35.8 µM 2.31E-6 DNA intercalators 8 3.35E-6
6 SGTC_1450 4112-4260 4.29 37.6 µM 6.49E-6 calcium & mitochondrial duress 20 9.12E-6
7 SGTC_577 r071-0003 4.28 38.6 µM 6.76E-6 fatty acid desaturase (OLE1) 45 9.48E-6
8 SGTC_2175 5807670 4.24 165.3 µM 8.04E-6 17 1.12E-5
9 SGTC_3234 9132280 4.09 49.5 µM 1.57E-5 15 2.14E-5
10 SGTC_2614 arthonioic acid 4.01 13.4 µM 2.24E-5 20 3.02E-5
11 SGTC_773 4358-1457 3.85 44.6 µM 4.43E-5 49 5.84E-5
12 SGTC_417 st075190 3.81 100.0 µM 5.35E-5 11 7.02E-5
13 SGTC_287 k060-0039 3.78 29.6 µM 5.98E-5 15 7.81E-5
14 SGTC_653 0203-0016 3.75 55.2 µM 6.89E-5 21 8.96E-5
15 SGTC_2661 dactinomycin 3.74 13.0 µM 6.96E-5 redox potentiating 26 9.04E-5
16 SGTC_2173 5763948 3.61 167.0 µM 1.22E-4 tubulin folding & SWR complex 20 1.56E-4
17 SGTC_1167 k781-0610 3.60 148.0 µM 1.25E-4 RNA processing & uracil transport 41 1.60E-4
18 SGTC_3297 9117502 3.57 71.4 µM 1.40E-4 16 1.77E-4
19 SGTC_2837 9008476 3.50 45.5 µM 1.82E-4 52 2.29E-4
20 SGTC_259 usnic acid 3.35 108.9 µM 3.29E-4 37 4.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.14E-11 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.097 1.96E-8 YML022W APT1 hom Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication
0.089 2.85E-7 YBR162C TOS1 hom Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
0.087 4.96E-7 YFR029W PTR3 het Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
0.084 1.15E-6 YKL047W_p ANR2_p hom Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.084 1.21E-6 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.083 1.41E-6 YAR047C_d YAR047C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.082 1.72E-6 YOL163W_p YOL163W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.082 1.73E-6 YOR019W YOR019W hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.082 2.24E-6 YER156C_p YER156C_p hom Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1
0.080 3.85E-6 YJL123C MTC1 hom Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1
0.077 7.81E-6 YPR178W PRP4 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.077 8.23E-6 YML010W SPT5 het Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair
0.075 1.31E-5 YLR124W_d YLR124W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.075 1.33E-5 YLR063W_p YLR063W_p hom Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene