YLR044C / PDC1

Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR044C / PDC1

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:5.90|P-value:1.14E-8 ID:SGTC_79|Compound:0052-0007|FD-Score:4.51|P-value:9.65E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:5.06|P-value:8.23E-7 ID:SGTC_100|Compound:0086-0128|FD-Score:18.60|P-value:7.44E-70 ID:SGTC_113|Compound:0099-0221|FD-Score:3.51|P-value:4.39E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.24|P-value:2.92E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:11.90|P-value:8.66E-30 ID:SGTC_163|Compound:1327-0036|FD-Score:13.10|P-value:1.37E-35 ID:SGTC_235|Compound:0330-0087|FD-Score:4.66|P-value:5.03E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.94|P-value:9.55E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:6.84|P-value:4.56E-11 ID:SGTC_318|Compound:1488-0629|FD-Score:8.45|P-value:5.89E-16 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.41|P-value:6.32E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.56|P-value:3.57E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:4.55|P-value:8.32E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:5.47|P-value:1.08E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.76|P-value:2.97E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:4.49|P-value:1.05E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:3.56|P-value:3.78E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.35|P-value:7.18E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.30|P-value:2.30E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.50|P-value:9.31E-6 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.44|P-value:5.74E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.35|P-value:7.56E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.58|P-value:3.51E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-3.68|P-value:2.32E-4 ID:SGTC_1924|Compound:st058459|FD-Score:5.19|P-value:4.44E-7 ID:SGTC_1934|Compound:st074720|FD-Score:5.94|P-value:9.16E-9 ID:SGTC_2140|Compound:5586273|FD-Score:3.38|P-value:6.99E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.51|P-value:4.21E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.53|P-value:3.91E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.16|P-value:4.08E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:6.96|P-value:2.11E-11 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:5.47|P-value:1.08E-7 ID:SGTC_2413|Compound:inermin|FD-Score:3.94|P-value:9.69E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.68|P-value:2.45E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.42|P-value:6.01E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.71|P-value:1.01E-10 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.52|P-value:4.24E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.51|P-value:4.41E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.79|P-value:1.66E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.43|P-value:1.35E-5 ID:SGTC_2812|Compound:7970281|FD-Score:4.49|P-value:1.04E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.68|P-value:2.49E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.49|P-value:4.84E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.68|P-value:2.49E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-4.25|P-value:2.71E-5 ID:SGTC_3214|Compound:9129694|FD-Score:-5.45|P-value:1.09E-7 ID:SGTC_3223|Compound:9129970|FD-Score:4.65|P-value:5.38E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:5.90|P-value:1.14E-8 ID:SGTC_79|Compound:0052-0007|FD-Score:4.51|P-value:9.65E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:5.06|P-value:8.23E-7 ID:SGTC_100|Compound:0086-0128|FD-Score:18.60|P-value:7.44E-70 ID:SGTC_113|Compound:0099-0221|FD-Score:3.51|P-value:4.39E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.24|P-value:2.92E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:11.90|P-value:8.66E-30 ID:SGTC_163|Compound:1327-0036|FD-Score:13.10|P-value:1.37E-35 ID:SGTC_235|Compound:0330-0087|FD-Score:4.66|P-value:5.03E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.94|P-value:9.55E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:6.84|P-value:4.56E-11 ID:SGTC_318|Compound:1488-0629|FD-Score:8.45|P-value:5.89E-16 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.41|P-value:6.32E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.56|P-value:3.57E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:4.55|P-value:8.32E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:5.47|P-value:1.08E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.76|P-value:2.97E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:4.49|P-value:1.05E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:3.56|P-value:3.78E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.35|P-value:7.18E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.30|P-value:2.30E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.50|P-value:9.31E-6 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.44|P-value:5.74E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.35|P-value:7.56E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.58|P-value:3.51E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-3.68|P-value:2.32E-4 ID:SGTC_1924|Compound:st058459|FD-Score:5.19|P-value:4.44E-7 ID:SGTC_1934|Compound:st074720|FD-Score:5.94|P-value:9.16E-9 ID:SGTC_2140|Compound:5586273|FD-Score:3.38|P-value:6.99E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.51|P-value:4.21E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.53|P-value:3.91E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.16|P-value:4.08E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:6.96|P-value:2.11E-11 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:5.47|P-value:1.08E-7 ID:SGTC_2413|Compound:inermin|FD-Score:3.94|P-value:9.69E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.68|P-value:2.45E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.42|P-value:6.01E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.71|P-value:1.01E-10 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.52|P-value:4.24E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.51|P-value:4.41E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.79|P-value:1.66E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.43|P-value:1.35E-5 ID:SGTC_2812|Compound:7970281|FD-Score:4.49|P-value:1.04E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.68|P-value:2.49E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.49|P-value:4.84E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.68|P-value:2.49E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-4.25|P-value:2.71E-5 ID:SGTC_3214|Compound:9129694|FD-Score:-5.45|P-value:1.09E-7 ID:SGTC_3223|Compound:9129970|FD-Score:4.65|P-value:5.38E-6

Top fitness defect scores for YLR044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_100 0086-0128 18.60 49.6 µM 7.44E-70 copper-dependent oxidative stress 1 2.03E-77
2 SGTC_163 1327-0036 13.10 7.5 µM 1.37E-35 8 2.35E-39
3 SGTC_134 0269-0018 11.90 6.9 µM 8.66E-30 30 6.51E-33
4 SGTC_318 1488-0629 8.45 67.2 µM 5.89E-16 copper-dependent oxidative stress 4 1.50E-17
5 SGTC_2406 ethylparaben 6.96 405.7 µM 2.11E-11 5 1.70E-12
6 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 6.84 4.6 µM 4.56E-11 heat shock/prefoldin 11 4.00E-12
7 SGTC_2651 1327-0036 6.71 5.0 µM 1.01E-10 52 9.69E-12
8 SGTC_1934 st074720 5.94 32.6 µM 9.16E-9 16 1.43E-9
9 SGTC_66 0109-0187 5.90 42.4 µM 1.14E-8 12 1.82E-9
10 SGTC_567 1080-0542 5.47 68.4 µM 1.08E-7 1 2.20E-8
11 SGTC_2410 aloe-emodin-8-o-glycoside 5.47 46.3 µM 1.08E-7 mitochondrial processes 7 2.20E-8
12 SGTC_1924 st058459 5.19 75.1 µM 4.44E-7 1 1.06E-7
13 SGTC_87 0100-0052 5.06 35.5 µM 8.23E-7 49 2.10E-7
14 SGTC_235 0330-0087 4.66 5.0 mM 5.03E-6 TSC3-RPN4 10 1.56E-6
15 SGTC_3223 9129970 4.65 49.5 µM 5.38E-6 13 1.68E-6
16 SGTC_548 1436-0017 4.55 110.0 µM 8.32E-6 TSC3-RPN4 27 2.73E-6
17 SGTC_79 0052-0007 4.51 94.1 µM 9.65E-6 27 3.22E-6
18 SGTC_2812 7970281 4.49 58.4 µM 1.04E-5 13 3.50E-6
19 SGTC_571 k831-0106 4.49 44.2 µM 1.05E-5 8 3.54E-6
20 SGTC_2782 7736369 4.43 71.4 µM 1.35E-5 26 4.66E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.238 2.19E-44 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.231 4.83E-42 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.231 5.53E-42 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.218 2.87E-37 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.199 2.35E-31 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.190 1.36E-28 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.188 4.29E-28 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.187 7.41E-28 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.187 1.15E-27 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.176 8.29E-25 YHR008C SOD2 hom Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
0.173 7.68E-24 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.168 1.12E-22 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.167 2.74E-22 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.164 1.50E-21 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.163 2.66E-21 YPL237W SUI3 het Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding