YLR045C / STU2

Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR045C / STU2

Click on Significant Values for Screen Details ID:SGTC_128|Compound:0906-2981|FD-Score:-2.94|P-value:5.19E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.82|P-value:3.85E-8 ID:SGTC_277|Compound:nystatin|FD-Score:3.79|P-value:1.14E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:2.86|P-value:7.09E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.24|P-value:1.52E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.04|P-value:3.49E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.73|P-value:1.52E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:2.82|P-value:8.03E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:-2.85|P-value:7.60E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.00|P-value:4.20E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:2.79|P-value:9.01E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-4.17|P-value:1.63E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.22|P-value:1.68E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.81|P-value:1.09E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:4.50|P-value:2.46E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.06|P-value:3.20E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:-3.43|P-value:6.48E-5 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.00|P-value:4.05E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-2.92|P-value:5.62E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.26|P-value:1.37E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:-2.95|P-value:5.09E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.14|P-value:2.27E-4 ID:SGTC_1548|Compound:st061468|FD-Score:-2.80|P-value:9.11E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:2.81|P-value:8.61E-4 ID:SGTC_1632|Compound:st005650|FD-Score:-3.69|P-value:1.98E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.58|P-value:3.22E-5 ID:SGTC_1638|Compound:st008370|FD-Score:3.32|P-value:1.05E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.13|P-value:2.32E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.79|P-value:9.16E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.35|P-value:8.96E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-4.27|P-value:9.86E-7 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.05|P-value:3.45E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-2.97|P-value:4.73E-4 ID:SGTC_1942|Compound:st076330|FD-Score:5.45|P-value:5.65E-10 ID:SGTC_1948|Compound:st076329|FD-Score:3.02|P-value:3.77E-4 ID:SGTC_1954|Compound:st077032|FD-Score:4.53|P-value:2.08E-7 ID:SGTC_2108|Compound:5365811|FD-Score:4.00|P-value:3.95E-6 ID:SGTC_2428|Compound:5615643|FD-Score:2.78|P-value:9.44E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:2.77|P-value:9.84E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-2.78|P-value:9.61E-4 ID:SGTC_2807|Compound:7945238|FD-Score:2.90|P-value:5.95E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.34|P-value:9.71E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-5.37|P-value:1.08E-9 ID:SGTC_2928|Compound:9011484|FD-Score:4.33|P-value:6.65E-7 ID:SGTC_2930|Compound:9013230|FD-Score:3.04|P-value:3.48E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-2.87|P-value:6.89E-4 ID:SGTC_2994|Compound:9053520|FD-Score:4.45|P-value:3.43E-7 ID:SGTC_3083|Compound:9117465|FD-Score:4.27|P-value:9.29E-7 ID:SGTC_3185|Compound:9108267|FD-Score:4.00|P-value:4.03E-6 ID:SGTC_3203|Compound:9113543|FD-Score:4.65|P-value:1.05E-7 ID:SGTC_3217|Compound:9129673|FD-Score:-3.04|P-value:3.50E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.62|P-value:2.68E-5 ID:SGTC_3246|Compound:9135460|FD-Score:3.03|P-value:3.54E-4 ID:SGTC_3288|Compound:9119690|FD-Score:-3.76|P-value:1.37E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-3.13|P-value:2.44E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.26|P-value:1.00E-6 ID:SGTC_128|Compound:0906-2981|FD-Score:-2.94|P-value:5.19E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.82|P-value:3.85E-8 ID:SGTC_277|Compound:nystatin|FD-Score:3.79|P-value:1.14E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:2.86|P-value:7.09E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.24|P-value:1.52E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.04|P-value:3.49E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.73|P-value:1.52E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:2.82|P-value:8.03E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:-2.85|P-value:7.60E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.00|P-value:4.20E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:2.79|P-value:9.01E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-4.17|P-value:1.63E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.22|P-value:1.68E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.81|P-value:1.09E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:4.50|P-value:2.46E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.06|P-value:3.20E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:-3.43|P-value:6.48E-5 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.00|P-value:4.05E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-2.92|P-value:5.62E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.26|P-value:1.37E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:-2.95|P-value:5.09E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.14|P-value:2.27E-4 ID:SGTC_1548|Compound:st061468|FD-Score:-2.80|P-value:9.11E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:2.81|P-value:8.61E-4 ID:SGTC_1632|Compound:st005650|FD-Score:-3.69|P-value:1.98E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.58|P-value:3.22E-5 ID:SGTC_1638|Compound:st008370|FD-Score:3.32|P-value:1.05E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.13|P-value:2.32E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.79|P-value:9.16E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.35|P-value:8.96E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-4.27|P-value:9.86E-7 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.05|P-value:3.45E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-2.97|P-value:4.73E-4 ID:SGTC_1942|Compound:st076330|FD-Score:5.45|P-value:5.65E-10 ID:SGTC_1948|Compound:st076329|FD-Score:3.02|P-value:3.77E-4 ID:SGTC_1954|Compound:st077032|FD-Score:4.53|P-value:2.08E-7 ID:SGTC_2108|Compound:5365811|FD-Score:4.00|P-value:3.95E-6 ID:SGTC_2428|Compound:5615643|FD-Score:2.78|P-value:9.44E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:2.77|P-value:9.84E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-2.78|P-value:9.61E-4 ID:SGTC_2807|Compound:7945238|FD-Score:2.90|P-value:5.95E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.34|P-value:9.71E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-5.37|P-value:1.08E-9 ID:SGTC_2928|Compound:9011484|FD-Score:4.33|P-value:6.65E-7 ID:SGTC_2930|Compound:9013230|FD-Score:3.04|P-value:3.48E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-2.87|P-value:6.89E-4 ID:SGTC_2994|Compound:9053520|FD-Score:4.45|P-value:3.43E-7 ID:SGTC_3083|Compound:9117465|FD-Score:4.27|P-value:9.29E-7 ID:SGTC_3185|Compound:9108267|FD-Score:4.00|P-value:4.03E-6 ID:SGTC_3203|Compound:9113543|FD-Score:4.65|P-value:1.05E-7 ID:SGTC_3217|Compound:9129673|FD-Score:-3.04|P-value:3.50E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.62|P-value:2.68E-5 ID:SGTC_3246|Compound:9135460|FD-Score:3.03|P-value:3.54E-4 ID:SGTC_3288|Compound:9119690|FD-Score:-3.76|P-value:1.37E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-3.13|P-value:2.44E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.26|P-value:1.00E-6

Top fitness defect scores for YLR045C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1942 st076330 5.45 65.2 µM 5.65E-10 2 2.46E-8 0.70
2 SGTC_3203 9113543 4.65 49.5 µM 1.05E-7 5 1.68E-6 0.21
3 SGTC_1954 st077032 4.53 68.9 µM 2.08E-7 3 2.91E-6 0.21
4 SGTC_995 3931-2021 4.50 34.6 µM 2.46E-7 RPP1 & pyrimidine depletion 4 3.34E-6 0.47
5 SGTC_2994 9053520 4.45 71.4 µM 3.43E-7 RPP1 & pyrimidine depletion 6 4.36E-6 0.25
6 SGTC_2928 9011484 4.33 9.8 µM 6.65E-7 heme biosynthesis & mitochondrial translocase 25 7.46E-6 0.05
7 SGTC_3083 9117465 4.27 49.5 µM 9.29E-7 4 9.78E-6 0.29
8 SGTC_3337 9144342 4.26 33.5 µM 1.00E-6 10 1.04E-5 0.25
9 SGTC_2108 5365811 4.00 200.0 µM 3.95E-6 4 3.16E-5 0.05
10 SGTC_3185 9108267 4.00 49.5 µM 4.03E-6 60S ribosome export 5 3.21E-5 0.32
11 SGTC_277 nystatin 3.79 15.5 µM 1.14E-5 5 7.46E-5 0.47
12 SGTC_425 3825-7017 3.73 13.1 µM 1.52E-5 11 9.42E-5 0.11
13 SGTC_3244 9134489 3.62 49.5 µM 2.68E-5 5 1.49E-4 0.09
14 SGTC_1635 st007035 3.58 42.4 µM 3.22E-5 25 1.73E-4 0.19
15 SGTC_1861 st057647 3.35 17.4 µM 8.96E-5 11 3.98E-4 0.31
16 SGTC_2908 7930301 3.34 100.0 µM 9.71E-5 10 4.25E-4 0.03
17 SGTC_1638 st008370 3.32 60.6 µM 1.05E-4 ergosterol biosynthesis 20 4.52E-4 0.01
18 SGTC_1284 0929-0043 3.26 16.0 µM 1.37E-4 10 5.61E-4 0.02
19 SGTC_1381 2324-0066 3.14 62.1 µM 2.27E-4 16 8.46E-4 0.04
20 SGTC_1741 st038134 3.13 10.2 µM 2.32E-4 13 8.64E-4 0.23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 9.69E-15 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.131 2.56E-14 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.119 5.04E-12 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.107 5.77E-10 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.106 7.07E-10 YDL233W_p MFG1_p hom Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.100 5.74E-9 YHR065C RRP3 het Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
0.100 6.73E-9 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.099 8.48E-9 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.099 8.85E-9 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.098 1.16E-8 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.098 1.31E-8 YMR163C INP2 hom Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene
0.097 1.67E-8 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.096 2.88E-8 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.095 3.94E-8 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.093 6.42E-8 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)