YLR046C_p

Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR046C / YLR046C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.71|P-value:6.93E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:-4.26|P-value:8.76E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:3.87|P-value:3.59E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:3.30|P-value:3.45E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.38|P-value:3.38E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-5.11|P-value:1.26E-7 ID:SGTC_559|Compound:1550-0661|FD-Score:3.67|P-value:8.24E-5 ID:SGTC_618|Compound:k072-0232|FD-Score:3.59|P-value:1.13E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.19|P-value:5.14E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.11|P-value:8.92E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:4.65|P-value:9.51E-7 ID:SGTC_761|Compound:k216-0224|FD-Score:3.54|P-value:1.39E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.10|P-value:7.13E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.55|P-value:1.79E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:4.17|P-value:9.47E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:3.79|P-value:5.07E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.14|P-value:8.02E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.41|P-value:2.23E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.05|P-value:8.54E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.30|P-value:3.47E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.48|P-value:2.33E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.05|P-value:8.49E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.05|P-value:8.55E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.50|P-value:2.00E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.12|P-value:1.20E-5 ID:SGTC_1822|Compound:st052468|FD-Score:-3.38|P-value:3.40E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.06|P-value:8.26E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.18|P-value:8.83E-6 ID:SGTC_2412|Compound:st077135|FD-Score:3.48|P-value:1.73E-4 ID:SGTC_2444|Compound:5485484|FD-Score:-4.13|P-value:1.53E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-3.19|P-value:6.74E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.36|P-value:3.91E-6 ID:SGTC_2701|Compound:st077767|FD-Score:3.75|P-value:5.96E-5 ID:SGTC_2705|Compound:st078069|FD-Score:3.38|P-value:2.56E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.32|P-value:3.18E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.68|P-value:1.04E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.59|P-value:1.48E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.06|P-value:8.12E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.08|P-value:9.76E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.18|P-value:7.00E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.47|P-value:1.83E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.77|P-value:7.29E-5 ID:SGTC_3173|Compound:9105693|FD-Score:-4.53|P-value:2.41E-6 ID:SGTC_3203|Compound:9113543|FD-Score:3.83|P-value:4.21E-5 ID:SGTC_3291|Compound:9121177|FD-Score:-5.49|P-value:1.45E-8 ID:SGTC_3314|Compound:9135860|FD-Score:3.02|P-value:9.30E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.71|P-value:6.93E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:-4.26|P-value:8.76E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:3.87|P-value:3.59E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:3.30|P-value:3.45E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.38|P-value:3.38E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-5.11|P-value:1.26E-7 ID:SGTC_559|Compound:1550-0661|FD-Score:3.67|P-value:8.24E-5 ID:SGTC_618|Compound:k072-0232|FD-Score:3.59|P-value:1.13E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.19|P-value:5.14E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.11|P-value:8.92E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:4.65|P-value:9.51E-7 ID:SGTC_761|Compound:k216-0224|FD-Score:3.54|P-value:1.39E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.10|P-value:7.13E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.55|P-value:1.79E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:4.17|P-value:9.47E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:3.79|P-value:5.07E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.14|P-value:8.02E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.41|P-value:2.23E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.05|P-value:8.54E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.30|P-value:3.47E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.48|P-value:2.33E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.05|P-value:8.49E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.05|P-value:8.55E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.50|P-value:2.00E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.12|P-value:1.20E-5 ID:SGTC_1822|Compound:st052468|FD-Score:-3.38|P-value:3.40E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.06|P-value:8.26E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.18|P-value:8.83E-6 ID:SGTC_2412|Compound:st077135|FD-Score:3.48|P-value:1.73E-4 ID:SGTC_2444|Compound:5485484|FD-Score:-4.13|P-value:1.53E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-3.19|P-value:6.74E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.36|P-value:3.91E-6 ID:SGTC_2701|Compound:st077767|FD-Score:3.75|P-value:5.96E-5 ID:SGTC_2705|Compound:st078069|FD-Score:3.38|P-value:2.56E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.32|P-value:3.18E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.68|P-value:1.04E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.59|P-value:1.48E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.06|P-value:8.12E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.08|P-value:9.76E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.18|P-value:7.00E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.47|P-value:1.83E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.77|P-value:7.29E-5 ID:SGTC_3173|Compound:9105693|FD-Score:-4.53|P-value:2.41E-6 ID:SGTC_3203|Compound:9113543|FD-Score:3.83|P-value:4.21E-5 ID:SGTC_3291|Compound:9121177|FD-Score:-5.49|P-value:1.45E-8 ID:SGTC_3314|Compound:9135860|FD-Score:3.02|P-value:9.30E-4

Top fitness defect scores for YLR046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_757 1066-0008 4.65 322.0 µM 9.51E-7 Golgi 10 1.69E-6
2 SGTC_1456 k015-0012 4.50 13.0 µM 2.00E-6 23 3.45E-6
3 SGTC_2635 hydroquinidine 4.36 100.0 µM 3.91E-6 15 6.56E-6
4 SGTC_2397 5161689 4.18 200.0 µM 8.83E-6 26 1.44E-5
5 SGTC_876 0720-0963 4.17 56.8 µM 9.47E-6 9 1.53E-5
6 SGTC_1564 D-Arginine 4.12 115.0 µM 1.20E-5 23 1.93E-5
7 SGTC_50 0929-0078 3.87 56.4 µM 3.59E-5 49 5.52E-5
8 SGTC_3203 9113543 3.83 49.5 µM 4.21E-5 34 6.43E-5
9 SGTC_912 3474-0017 3.79 2.2 µM 5.07E-5 28 7.68E-5
10 SGTC_2701 st077767 3.75 14.7 µM 5.96E-5 48 8.97E-5
11 SGTC_6 0844-0013 3.71 19.8 µM 6.93E-5 116 1.04E-4
12 SGTC_559 1550-0661 3.67 158.0 µM 8.24E-5 11 1.22E-4
13 SGTC_618 k072-0232 3.59 33.2 µM 1.13E-4 60S ribosome export 12 1.65E-4
14 SGTC_761 k216-0224 3.54 480.0 µM 1.39E-4 34 2.02E-4
15 SGTC_2412 st077135 3.48 33.4 µM 1.73E-4 40 2.49E-4
16 SGTC_2998 9066762 3.47 71.4 µM 1.83E-4 RPP1 & pyrimidine depletion 38 2.63E-4
17 SGTC_967 1306-0166 3.41 352.0 µM 2.23E-4 59 3.19E-4
18 SGTC_2705 st078069 3.38 42.8 µM 2.56E-4 19 3.63E-4
19 SGTC_2759 disulfiram 3.32 3.4 µM 3.18E-4 63 4.47E-4
20 SGTC_348 k064-0012 3.30 10.7 µM 3.45E-4 60S ribosome export 36 4.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 2.63E-9 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.091 1.33E-7 YNL182C IPI3 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene
0.086 6.37E-7 YLR053C_p YLR053C_p hom Putative protein of unknown function
0.082 1.94E-6 YDR036C EHD3 hom 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
0.081 2.69E-6 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.078 5.88E-6 YNL327W EGT2 hom Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
0.077 7.08E-6 YPL171C OYE3 hom Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death
0.077 7.19E-6 YEL023C_p YEL023C_p hom Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
0.077 7.23E-6 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.077 8.58E-6 YMR310C_p YMR310C_p hom Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene
0.076 9.17E-6 YGR279C SCW4 hom Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
0.076 1.15E-5 YPL151C PRP46 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.075 1.36E-5 YAR020C PAU7 hom Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
0.075 1.52E-5 YPL199C_p YPL199C_p hom Putative protein of unknown function, predicted to be palmitoylated
0.074 1.58E-5 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene