YLR047C / FRE8

Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR047C / FRE8

Click on Significant Values for Screen Details ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.40|P-value:5.94E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.43|P-value:3.05E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.47|P-value:4.63E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.41|P-value:5.64E-6 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.44|P-value:2.94E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.30|P-value:1.83E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.67|P-value:2.23E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:5.87|P-value:7.55E-9 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.73|P-value:1.84E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.59|P-value:3.04E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.67|P-value:2.21E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:5.11|P-value:4.37E-7 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.37|P-value:3.70E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.10|P-value:4.21E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.60|P-value:1.61E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.26|P-value:5.39E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.29|P-value:8.43E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.89|P-value:9.74E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.13|P-value:8.46E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.57|P-value:3.28E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.99|P-value:6.54E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.30|P-value:8.39E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.25|P-value:9.91E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.22|P-value:6.20E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.89|P-value:5.16E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.42|P-value:1.12E-5 ID:SGTC_2282|Compound:7944268|FD-Score:3.34|P-value:7.33E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.35|P-value:3.93E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.37|P-value:3.68E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.34|P-value:7.87E-6 ID:SGTC_2477|Compound:5967686|FD-Score:3.78|P-value:1.51E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.82|P-value:1.85E-6 ID:SGTC_2815|Compound:7968870|FD-Score:3.40|P-value:5.91E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.39|P-value:6.03E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.33|P-value:7.40E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.66|P-value:2.31E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.60|P-value:4.88E-6 ID:SGTC_3206|Compound:9114350|FD-Score:4.98|P-value:8.29E-7 ID:SGTC_3229|Compound:9132204|FD-Score:3.68|P-value:2.18E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.52|P-value:3.80E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.24|P-value:5.80E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.40|P-value:5.94E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.43|P-value:3.05E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.47|P-value:4.63E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.41|P-value:5.64E-6 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.44|P-value:2.94E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.30|P-value:1.83E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.67|P-value:2.23E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:5.87|P-value:7.55E-9 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.73|P-value:1.84E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.59|P-value:3.04E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.67|P-value:2.21E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:5.11|P-value:4.37E-7 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.37|P-value:3.70E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.10|P-value:4.21E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.60|P-value:1.61E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.26|P-value:5.39E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.29|P-value:8.43E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.89|P-value:9.74E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.13|P-value:8.46E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.57|P-value:3.28E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.99|P-value:6.54E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.30|P-value:8.39E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.25|P-value:9.91E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.22|P-value:6.20E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.89|P-value:5.16E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.42|P-value:1.12E-5 ID:SGTC_2282|Compound:7944268|FD-Score:3.34|P-value:7.33E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.35|P-value:3.93E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.37|P-value:3.68E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.34|P-value:7.87E-6 ID:SGTC_2477|Compound:5967686|FD-Score:3.78|P-value:1.51E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.82|P-value:1.85E-6 ID:SGTC_2815|Compound:7968870|FD-Score:3.40|P-value:5.91E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.39|P-value:6.03E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.33|P-value:7.40E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.66|P-value:2.31E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.60|P-value:4.88E-6 ID:SGTC_3206|Compound:9114350|FD-Score:4.98|P-value:8.29E-7 ID:SGTC_3229|Compound:9132204|FD-Score:3.68|P-value:2.18E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.52|P-value:3.80E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.24|P-value:5.80E-4

Top fitness defect scores for YLR047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1207 2099-0101 5.87 141.0 µM 7.55E-9 1 2.16E-9
2 SGTC_1237 0330-0133 5.11 46.1 µM 4.37E-7 ergosterol biosynthesis 9 1.59E-7
3 SGTC_3206 9114350 4.98 49.5 µM 8.29E-7 7 3.14E-7
4 SGTC_2697 mebhydrolin 4.82 72.4 µM 1.85E-6 NEO1 47 7.34E-7
5 SGTC_3202 9113761 4.60 49.5 µM 4.88E-6 26 2.06E-6
6 SGTC_2249 haloperidol 4.42 116.4 µM 1.12E-5 ergosterol depletion effects on membrane 86 5.00E-6
7 SGTC_1113 artemisinin 4.30 1.2 µM 1.83E-5 heme biosynthesis & mitochondrial translocase 9 8.41E-6
8 SGTC_1247 0448-0043 4.10 5.8 µM 4.21E-5 ERG2 35 2.04E-5
9 SGTC_1526 st051518 3.99 75.0 µM 6.54E-5 19 3.25E-5
10 SGTC_1323 1348-1351 3.89 11.2 µM 9.74E-5 9 4.96E-5
11 SGTC_2477 5967686 3.78 25.2 µM 1.51E-4 28 7.92E-5
12 SGTC_1208 2323-2347 3.73 50.3 µM 1.84E-4 9 9.75E-5
13 SGTC_3229 9132204 3.68 49.5 µM 2.18E-4 5 1.17E-4
14 SGTC_1228 0124-0032 3.67 52.5 µM 2.21E-4 26 1.19E-4
15 SGTC_1140 3229-1848 3.67 3.0 µM 2.23E-4 14 1.20E-4
16 SGTC_3137 9097352 3.66 49.5 µM 2.31E-4 53 1.25E-4
17 SGTC_1210 3013-0140 3.59 750.0 nM 3.04E-4 11 1.67E-4
18 SGTC_1509 1326-1131 3.57 80.0 µM 3.28E-4 19 1.81E-4
19 SGTC_3248 9135562 3.52 49.5 µM 3.80E-4 12 2.12E-4
20 SGTC_808 0711-0032 3.47 135.0 µM 4.63E-4 28 2.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 6.11E-9 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.098 1.33E-8 YBR217W ATG12 hom Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
0.097 1.93E-8 YOR160W MTR10 het Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.092 8.95E-8 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.092 9.18E-8 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.091 1.27E-7 YBR177C EHT1 hom Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication
0.091 1.41E-7 YNL044W YIP3 hom Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
0.090 1.81E-7 YJL015C_d YJL015C_d het Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W
0.087 4.96E-7 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.085 7.26E-7 YGR173W RBG2 hom Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein
0.085 7.27E-7 YBL050W SEC17 het Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP
0.081 2.49E-6 YBR080C SEC18 het ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF
0.081 2.73E-6 YKL128C PMU1 hom Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
0.080 3.50E-6 YOR370C MRS6 het Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress
0.079 5.00E-6 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol