YLR048W / RPS0B

Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR048W / RPS0B

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.48|P-value:1.05E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.61|P-value:6.12E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.60|P-value:1.06E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.08|P-value:4.93E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.20|P-value:3.17E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.42|P-value:1.32E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.58|P-value:6.77E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.54|P-value:1.36E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.64|P-value:4.29E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:3.20|P-value:3.21E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.52|P-value:1.57E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:3.16|P-value:3.76E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.72|P-value:3.70E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:3.63|P-value:5.46E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:3.80|P-value:2.65E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:5.79|P-value:4.52E-10 ID:SGTC_691|Compound:1548-0686|FD-Score:3.31|P-value:2.06E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.39|P-value:1.49E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.25|P-value:5.90E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:5.36|P-value:6.67E-9 ID:SGTC_795|Compound:0685-0265|FD-Score:3.33|P-value:1.91E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:10.40|P-value:2.87E-28 ID:SGTC_830|Compound:4076-0286|FD-Score:6.28|P-value:1.57E-11 ID:SGTC_831|Compound:k061-1017|FD-Score:4.16|P-value:4.87E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:10.20|P-value:2.43E-27 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.37|P-value:1.66E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.99|P-value:1.10E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.28|P-value:2.76E-6 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.20|P-value:3.16E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.70|P-value:4.18E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.46|P-value:1.13E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.05|P-value:5.66E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.40|P-value:1.46E-4 ID:SGTC_1651|Compound:st011928|FD-Score:2.95|P-value:8.17E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-3.12|P-value:6.76E-4 ID:SGTC_1781|Compound:st038725|FD-Score:7.94|P-value:2.77E-17 ID:SGTC_1784|Compound:st039334|FD-Score:3.10|P-value:4.66E-4 ID:SGTC_1797|Compound:st048695|FD-Score:4.57|P-value:6.22E-7 ID:SGTC_1881|Compound:5652484|FD-Score:-3.06|P-value:8.57E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.71|P-value:3.87E-5 ID:SGTC_2001|Compound:4023502|FD-Score:-3.18|P-value:5.48E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.42|P-value:1.32E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.36|P-value:1.67E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.44|P-value:1.23E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.66|P-value:4.88E-5 ID:SGTC_2059|Compound:5238311|FD-Score:3.41|P-value:1.41E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.97|P-value:6.79E-8 ID:SGTC_2229|Compound:7354935|FD-Score:-3.26|P-value:4.03E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.15|P-value:3.79E-4 ID:SGTC_2269|Compound:7935389|FD-Score:5.72|P-value:7.16E-10 ID:SGTC_2272|Compound:7805186|FD-Score:-3.07|P-value:8.13E-4 ID:SGTC_2278|Compound:7948257|FD-Score:6.88|P-value:1.81E-13 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.37|P-value:1.65E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.39|P-value:2.98E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.03|P-value:5.99E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.64|P-value:1.21E-9 ID:SGTC_2723|Compound:salbutamol|FD-Score:-3.05|P-value:8.95E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.34|P-value:2.97E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.66|P-value:8.37E-5 ID:SGTC_2780|Compound:5215298|FD-Score:4.77|P-value:2.08E-7 ID:SGTC_2862|Compound:9027634|FD-Score:3.78|P-value:2.86E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.78|P-value:5.07E-5 ID:SGTC_2909|Compound:7941780|FD-Score:4.66|P-value:3.89E-7 ID:SGTC_2912|Compound:7964298|FD-Score:3.00|P-value:6.77E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.74|P-value:3.40E-5 ID:SGTC_2915|Compound:7971052|FD-Score:3.21|P-value:3.08E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.58|P-value:6.88E-5 ID:SGTC_2967|Compound:9089538|FD-Score:4.84|P-value:1.43E-7 ID:SGTC_2985|Compound:9022375|FD-Score:2.92|P-value:9.11E-4 ID:SGTC_3032|Compound:9089427|FD-Score:-3.24|P-value:4.37E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.53|P-value:8.47E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-4.37|P-value:3.20E-6 ID:SGTC_3224|Compound:9130643|FD-Score:-3.37|P-value:2.65E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.36|P-value:1.69E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.56|P-value:4.48E-9 ID:SGTC_15|Compound:0266-0086|FD-Score:3.48|P-value:1.05E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.61|P-value:6.12E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.60|P-value:1.06E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.08|P-value:4.93E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.20|P-value:3.17E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.42|P-value:1.32E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.58|P-value:6.77E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.54|P-value:1.36E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.64|P-value:4.29E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:3.20|P-value:3.21E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.52|P-value:1.57E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:3.16|P-value:3.76E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.72|P-value:3.70E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:3.63|P-value:5.46E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:3.80|P-value:2.65E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:5.79|P-value:4.52E-10 ID:SGTC_691|Compound:1548-0686|FD-Score:3.31|P-value:2.06E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.39|P-value:1.49E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.25|P-value:5.90E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:5.36|P-value:6.67E-9 ID:SGTC_795|Compound:0685-0265|FD-Score:3.33|P-value:1.91E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:10.40|P-value:2.87E-28 ID:SGTC_830|Compound:4076-0286|FD-Score:6.28|P-value:1.57E-11 ID:SGTC_831|Compound:k061-1017|FD-Score:4.16|P-value:4.87E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:10.20|P-value:2.43E-27 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.37|P-value:1.66E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.99|P-value:1.10E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.28|P-value:2.76E-6 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.20|P-value:3.16E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.70|P-value:4.18E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.46|P-value:1.13E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.05|P-value:5.66E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.40|P-value:1.46E-4 ID:SGTC_1651|Compound:st011928|FD-Score:2.95|P-value:8.17E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-3.12|P-value:6.76E-4 ID:SGTC_1781|Compound:st038725|FD-Score:7.94|P-value:2.77E-17 ID:SGTC_1784|Compound:st039334|FD-Score:3.10|P-value:4.66E-4 ID:SGTC_1797|Compound:st048695|FD-Score:4.57|P-value:6.22E-7 ID:SGTC_1881|Compound:5652484|FD-Score:-3.06|P-value:8.57E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.71|P-value:3.87E-5 ID:SGTC_2001|Compound:4023502|FD-Score:-3.18|P-value:5.48E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.42|P-value:1.32E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.36|P-value:1.67E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.44|P-value:1.23E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.66|P-value:4.88E-5 ID:SGTC_2059|Compound:5238311|FD-Score:3.41|P-value:1.41E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.97|P-value:6.79E-8 ID:SGTC_2229|Compound:7354935|FD-Score:-3.26|P-value:4.03E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.15|P-value:3.79E-4 ID:SGTC_2269|Compound:7935389|FD-Score:5.72|P-value:7.16E-10 ID:SGTC_2272|Compound:7805186|FD-Score:-3.07|P-value:8.13E-4 ID:SGTC_2278|Compound:7948257|FD-Score:6.88|P-value:1.81E-13 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.37|P-value:1.65E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.39|P-value:2.98E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.03|P-value:5.99E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.64|P-value:1.21E-9 ID:SGTC_2723|Compound:salbutamol|FD-Score:-3.05|P-value:8.95E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.34|P-value:2.97E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.66|P-value:8.37E-5 ID:SGTC_2780|Compound:5215298|FD-Score:4.77|P-value:2.08E-7 ID:SGTC_2862|Compound:9027634|FD-Score:3.78|P-value:2.86E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.78|P-value:5.07E-5 ID:SGTC_2909|Compound:7941780|FD-Score:4.66|P-value:3.89E-7 ID:SGTC_2912|Compound:7964298|FD-Score:3.00|P-value:6.77E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.74|P-value:3.40E-5 ID:SGTC_2915|Compound:7971052|FD-Score:3.21|P-value:3.08E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.58|P-value:6.88E-5 ID:SGTC_2967|Compound:9089538|FD-Score:4.84|P-value:1.43E-7 ID:SGTC_2985|Compound:9022375|FD-Score:2.92|P-value:9.11E-4 ID:SGTC_3032|Compound:9089427|FD-Score:-3.24|P-value:4.37E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.53|P-value:8.47E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-4.37|P-value:3.20E-6 ID:SGTC_3224|Compound:9130643|FD-Score:-3.37|P-value:2.65E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.36|P-value:1.69E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.56|P-value:4.48E-9

Top fitness defect scores for YLR048W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_800 3448-7362 10.40 155.0 µM 2.87E-28 translation 5 1.11E-25
2 SGTC_832 4083-0019 10.20 164.0 µM 2.43E-27 translation 2 7.71E-25
3 SGTC_1781 st038725 7.94 66.3 µM 2.77E-17 NEO1 33 1.03E-15
4 SGTC_2278 7948257 6.88 134.3 µM 1.81E-13 2 2.96E-12
5 SGTC_830 4076-0286 6.28 57.8 µM 1.57E-11 translation 12 1.69E-10
6 SGTC_625 k213-0058 5.79 121.0 µM 4.52E-10 translation 38 3.54E-9
7 SGTC_2269 7935389 5.72 174.4 µM 7.16E-10 tubulin folding & SWR complex 9 5.37E-9
8 SGTC_2688 kanamycin b 5.64 96.7 µM 1.21E-9 calcium & mitochondrial duress 187 8.66E-9
9 SGTC_791 1348-1292 5.36 225.0 µM 6.67E-9 14 4.05E-8
10 SGTC_2060 5238662 4.97 140.0 µM 6.79E-8 12 3.31E-7
11 SGTC_2967 9089538 4.84 49.9 µM 1.43E-7 14 6.47E-7
12 SGTC_2780 5215298 4.77 71.4 µM 2.08E-7 19 9.09E-7
13 SGTC_2909 7941780 4.66 10.5 µM 3.89E-7 6 1.60E-6
14 SGTC_301 4119-0100 4.64 24.5 µM 4.29E-7 NEO1 66 1.75E-6
15 SGTC_1797 st048695 4.57 56.8 µM 6.22E-7 NEO1 61 2.45E-6
16 SGTC_1038 k292-0204 4.28 154.0 µM 2.76E-6 11 9.43E-6
17 SGTC_831 k061-1017 4.16 217.0 µM 4.87E-6 translation 54 1.58E-5
18 SGTC_1031 k035-0009 3.99 16.0 µM 1.10E-5 28 3.28E-5
19 SGTC_602 3130-1533 3.80 38.1 µM 2.65E-5 21 7.27E-5
20 SGTC_2862 9027634 3.78 71.4 µM 2.86E-5 ERG2 37 7.81E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.354 1.91E-99 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.341 7.25E-92 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.285 1.23E-63 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.284 3.85E-63 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.272 5.00E-58 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.272 9.27E-58 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.268 2.67E-56 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.251 1.80E-49 YOR295W UAF30 hom Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
0.246 2.75E-47 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.240 3.68E-45 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.232 2.07E-42 YPL239W YAR1 hom Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
0.227 2.59E-40 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.226 5.57E-40 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.222 1.37E-38 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.221 1.91E-38 YDR516C EMI2 hom Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress