YLR050C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR050C / YLR050C

Click on Significant Values for Screen Details ID:SGTC_217|Compound:ketoconazole|FD-Score:3.21|P-value:6.55E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.52|P-value:2.15E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.28|P-value:6.09E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:6.97|P-value:1.90E-12 ID:SGTC_346|Compound:4513-0042|FD-Score:3.50|P-value:2.37E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.10|P-value:9.59E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.42|P-value:3.80E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:3.43|P-value:3.08E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.97|P-value:4.55E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:-3.38|P-value:4.37E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.65|P-value:1.33E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.26|P-value:1.04E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.35|P-value:3.99E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.86|P-value:5.72E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.41|P-value:3.25E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:5.93|P-value:1.74E-9 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.13|P-value:5.10E-10 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.61|P-value:1.57E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.33|P-value:4.41E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.65|P-value:1.33E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.40|P-value:5.62E-6 ID:SGTC_1910|Compound:st062352|FD-Score:4.19|P-value:1.44E-5 ID:SGTC_1913|Compound:st060213|FD-Score:-5.20|P-value:1.43E-7 ID:SGTC_1917|Compound:st066507|FD-Score:3.14|P-value:8.39E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.96|P-value:3.89E-5 ID:SGTC_2013|Compound:4024628|FD-Score:-4.39|P-value:7.44E-6 ID:SGTC_2019|Compound:4016004|FD-Score:4.36|P-value:6.65E-6 ID:SGTC_2021|Compound:4019055|FD-Score:3.68|P-value:1.18E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.20|P-value:6.75E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.17|P-value:7.52E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-3.19|P-value:8.39E-4 ID:SGTC_2152|Compound:5568786|FD-Score:-3.16|P-value:9.43E-4 ID:SGTC_2385|Compound:9074692|FD-Score:3.50|P-value:2.30E-4 ID:SGTC_2476|Compound:5806916|FD-Score:5.34|P-value:5.15E-8 ID:SGTC_2480|Compound:5767542|FD-Score:-5.46|P-value:3.49E-8 ID:SGTC_2484|Compound:5809818|FD-Score:3.79|P-value:7.76E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.07|P-value:2.40E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.23|P-value:7.33E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.71|P-value:1.33E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.41|P-value:3.22E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.69|P-value:1.43E-6 ID:SGTC_3008|Compound:9078912|FD-Score:3.55|P-value:1.93E-4 ID:SGTC_3193|Compound:9111931|FD-Score:4.59|P-value:2.29E-6 ID:SGTC_3213|Compound:9129884|FD-Score:-5.41|P-value:4.46E-8 ID:SGTC_3248|Compound:9135562|FD-Score:3.96|P-value:3.77E-5 ID:SGTC_3307|Compound:9126885|FD-Score:3.32|P-value:4.55E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.21|P-value:6.55E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.52|P-value:2.15E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.28|P-value:6.09E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:6.97|P-value:1.90E-12 ID:SGTC_346|Compound:4513-0042|FD-Score:3.50|P-value:2.37E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.10|P-value:9.59E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.42|P-value:3.80E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:3.43|P-value:3.08E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.97|P-value:4.55E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:-3.38|P-value:4.37E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.65|P-value:1.33E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.26|P-value:1.04E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.35|P-value:3.99E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.86|P-value:5.72E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.41|P-value:3.25E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:5.93|P-value:1.74E-9 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.13|P-value:5.10E-10 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.61|P-value:1.57E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.33|P-value:4.41E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.65|P-value:1.33E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.40|P-value:5.62E-6 ID:SGTC_1910|Compound:st062352|FD-Score:4.19|P-value:1.44E-5 ID:SGTC_1913|Compound:st060213|FD-Score:-5.20|P-value:1.43E-7 ID:SGTC_1917|Compound:st066507|FD-Score:3.14|P-value:8.39E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.96|P-value:3.89E-5 ID:SGTC_2013|Compound:4024628|FD-Score:-4.39|P-value:7.44E-6 ID:SGTC_2019|Compound:4016004|FD-Score:4.36|P-value:6.65E-6 ID:SGTC_2021|Compound:4019055|FD-Score:3.68|P-value:1.18E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.20|P-value:6.75E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.17|P-value:7.52E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-3.19|P-value:8.39E-4 ID:SGTC_2152|Compound:5568786|FD-Score:-3.16|P-value:9.43E-4 ID:SGTC_2385|Compound:9074692|FD-Score:3.50|P-value:2.30E-4 ID:SGTC_2476|Compound:5806916|FD-Score:5.34|P-value:5.15E-8 ID:SGTC_2480|Compound:5767542|FD-Score:-5.46|P-value:3.49E-8 ID:SGTC_2484|Compound:5809818|FD-Score:3.79|P-value:7.76E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.07|P-value:2.40E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.23|P-value:7.33E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.71|P-value:1.33E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.41|P-value:3.22E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.69|P-value:1.43E-6 ID:SGTC_3008|Compound:9078912|FD-Score:3.55|P-value:1.93E-4 ID:SGTC_3193|Compound:9111931|FD-Score:4.59|P-value:2.29E-6 ID:SGTC_3213|Compound:9129884|FD-Score:-5.41|P-value:4.46E-8 ID:SGTC_3248|Compound:9135562|FD-Score:3.96|P-value:3.77E-5 ID:SGTC_3307|Compound:9126885|FD-Score:3.32|P-value:4.55E-4

Top fitness defect scores for YLR050C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_343 4130-2827 6.97 29.8 µM 1.90E-12 3 1.55E-12
2 SGTC_1130 3454-2858 6.13 15.9 µM 5.10E-10 NEO1 40 4.45E-10
3 SGTC_1128 3448-9350 5.93 235.0 µM 1.74E-9 5 1.54E-9
4 SGTC_2476 5806916 5.34 10.5 µM 5.15E-8 2 4.72E-8
5 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.71 70.0 µM 1.33E-6 redox potentiating 53 1.26E-6
6 SGTC_2816 7982706 4.69 58.4 µM 1.43E-6 azole & statin 34 1.36E-6
7 SGTC_3193 9111931 4.59 49.5 µM 2.29E-6 9 2.18E-6
8 SGTC_1500 4488-1866 4.40 171.0 µM 5.62E-6 RPP1 & pyrimidine depletion 9 5.40E-6
9 SGTC_2019 4016004 4.36 108.0 µM 6.65E-6 16 6.40E-6
10 SGTC_934 2950-0684 4.26 338.0 µM 1.04E-5 16 1.00E-5
11 SGTC_1910 st062352 4.19 60.4 µM 1.44E-5 26 1.39E-5
12 SGTC_2485 5633444 4.07 17.8 µM 2.40E-5 redox potentiating 38 2.34E-5
13 SGTC_3248 9135562 3.96 49.5 µM 3.77E-5 7 3.69E-5
14 SGTC_2008 4012253 3.96 172.0 µM 3.89E-5 25 3.80E-5
15 SGTC_1106 tegaserod maleate 3.86 11.7 µM 5.72E-5 20 5.61E-5
16 SGTC_2484 5809818 3.79 12.0 µM 7.76E-5 20 7.63E-5
17 SGTC_2021 4019055 3.68 173.0 µM 1.18E-4 endomembrane recycling 141 1.16E-4
18 SGTC_1490 4089-0339 3.65 670.0 nM 1.33E-4 12 1.32E-4
19 SGTC_883 0850-0245 3.65 24.6 µM 1.33E-4 cell wall 40 1.32E-4
20 SGTC_1198 1612-1005 3.61 86.7 µM 1.57E-4 20 1.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 4.16E-8 YJL093C TOK1 hom Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
0.093 6.84E-8 YOR361C PRT1 het eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
0.088 3.05E-7 YIL071C PCI8 hom Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
0.088 3.42E-7 YLR231C BNA5 hom Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.085 7.36E-7 YOR057W SGT1 het Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
0.080 3.41E-6 YBL014C RRN6 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.079 4.80E-6 YKL040C NFU1 hom Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
0.078 5.79E-6 YKL027W YKL027W hom Protein of unknown function, localized to the mitochondrial outer membrane
0.078 6.67E-6 YER181C_d YER181C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies
0.077 8.47E-6 YOR266W PNT1 hom Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
0.077 8.62E-6 YNL120C_d YNL120C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
0.076 1.06E-5 YLR224W_p YLR224W_p hom F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene
0.075 1.26E-5 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.074 1.65E-5 YKR002W PAP1 het Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.073 2.20E-5 YKL129C MYO3 hom One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization