YLR051C / FCF2

Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR051C / FCF2

Click on Significant Values for Screen Details ID:SGTC_145|Compound:3737-0113|FD-Score:4.17|P-value:5.01E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.64|P-value:3.59E-4 ID:SGTC_264|Compound:promethazine|FD-Score:5.65|P-value:5.95E-8 ID:SGTC_428|Compound:3448-4153|FD-Score:4.67|P-value:6.44E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:5.84|P-value:2.14E-8 ID:SGTC_685|Compound:1278-0033|FD-Score:3.64|P-value:3.56E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.79|P-value:3.73E-6 ID:SGTC_694|Compound:1315-0438|FD-Score:3.60|P-value:4.01E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.75|P-value:2.44E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.66|P-value:3.30E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:4.44|P-value:1.72E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:4.11|P-value:6.33E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.66|P-value:3.28E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-5.76|P-value:1.55E-8 ID:SGTC_930|Compound:2810-3379|FD-Score:-6.67|P-value:7.74E-11 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.89|P-value:8.29E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.60|P-value:4.12E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.47|P-value:6.25E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.73|P-value:2.58E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.42|P-value:1.86E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.54|P-value:5.04E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.55|P-value:4.73E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.91|P-value:1.32E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.69|P-value:3.00E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.03|P-value:8.71E-5 ID:SGTC_1720|Compound:st037298|FD-Score:5.94|P-value:1.27E-8 ID:SGTC_1752|Compound:st044819|FD-Score:4.78|P-value:3.94E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.26|P-value:4.26E-7 ID:SGTC_1845|Compound:st056753|FD-Score:3.55|P-value:4.76E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.21|P-value:9.09E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.31|P-value:6.58E-4 ID:SGTC_1917|Compound:st066507|FD-Score:6.25|P-value:2.22E-9 ID:SGTC_2002|Compound:4023503|FD-Score:-4.15|P-value:3.01E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.62|P-value:3.76E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.95|P-value:1.18E-4 ID:SGTC_2112|Compound:5488546|FD-Score:5.89|P-value:1.65E-8 ID:SGTC_2350|Compound:9023895|FD-Score:3.73|P-value:2.61E-4 ID:SGTC_2434|Compound:5670830|FD-Score:4.20|P-value:4.40E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.89|P-value:8.51E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.38|P-value:5.31E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:5.02|P-value:1.35E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.23|P-value:3.89E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.63|P-value:3.62E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.80|P-value:1.19E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.33|P-value:2.61E-5 ID:SGTC_2817|Compound:7995342|FD-Score:4.37|P-value:2.29E-5 ID:SGTC_2826|Compound:7992541|FD-Score:3.67|P-value:3.18E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.30|P-value:6.85E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.74|P-value:4.62E-6 ID:SGTC_2995|Compound:9067767|FD-Score:4.28|P-value:3.20E-5 ID:SGTC_3135|Compound:9127742|FD-Score:3.35|P-value:9.30E-4 ID:SGTC_3158|Compound:9100007|FD-Score:6.77|P-value:1.00E-10 ID:SGTC_3195|Compound:9113082|FD-Score:-3.21|P-value:9.09E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-4.64|P-value:3.87E-6 ID:SGTC_3223|Compound:9129970|FD-Score:3.68|P-value:3.12E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.45|P-value:6.81E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.17|P-value:5.01E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.64|P-value:3.59E-4 ID:SGTC_264|Compound:promethazine|FD-Score:5.65|P-value:5.95E-8 ID:SGTC_428|Compound:3448-4153|FD-Score:4.67|P-value:6.44E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:5.84|P-value:2.14E-8 ID:SGTC_685|Compound:1278-0033|FD-Score:3.64|P-value:3.56E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.79|P-value:3.73E-6 ID:SGTC_694|Compound:1315-0438|FD-Score:3.60|P-value:4.01E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.75|P-value:2.44E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.66|P-value:3.30E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:4.44|P-value:1.72E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:4.11|P-value:6.33E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.66|P-value:3.28E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-5.76|P-value:1.55E-8 ID:SGTC_930|Compound:2810-3379|FD-Score:-6.67|P-value:7.74E-11 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.89|P-value:8.29E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.60|P-value:4.12E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.47|P-value:6.25E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.73|P-value:2.58E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.42|P-value:1.86E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.54|P-value:5.04E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.55|P-value:4.73E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.91|P-value:1.32E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.69|P-value:3.00E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.03|P-value:8.71E-5 ID:SGTC_1720|Compound:st037298|FD-Score:5.94|P-value:1.27E-8 ID:SGTC_1752|Compound:st044819|FD-Score:4.78|P-value:3.94E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.26|P-value:4.26E-7 ID:SGTC_1845|Compound:st056753|FD-Score:3.55|P-value:4.76E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.21|P-value:9.09E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.31|P-value:6.58E-4 ID:SGTC_1917|Compound:st066507|FD-Score:6.25|P-value:2.22E-9 ID:SGTC_2002|Compound:4023503|FD-Score:-4.15|P-value:3.01E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.62|P-value:3.76E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.95|P-value:1.18E-4 ID:SGTC_2112|Compound:5488546|FD-Score:5.89|P-value:1.65E-8 ID:SGTC_2350|Compound:9023895|FD-Score:3.73|P-value:2.61E-4 ID:SGTC_2434|Compound:5670830|FD-Score:4.20|P-value:4.40E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.89|P-value:8.51E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.38|P-value:5.31E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:5.02|P-value:1.35E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.23|P-value:3.89E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.63|P-value:3.62E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.80|P-value:1.19E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.33|P-value:2.61E-5 ID:SGTC_2817|Compound:7995342|FD-Score:4.37|P-value:2.29E-5 ID:SGTC_2826|Compound:7992541|FD-Score:3.67|P-value:3.18E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.30|P-value:6.85E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.74|P-value:4.62E-6 ID:SGTC_2995|Compound:9067767|FD-Score:4.28|P-value:3.20E-5 ID:SGTC_3135|Compound:9127742|FD-Score:3.35|P-value:9.30E-4 ID:SGTC_3158|Compound:9100007|FD-Score:6.77|P-value:1.00E-10 ID:SGTC_3195|Compound:9113082|FD-Score:-3.21|P-value:9.09E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-4.64|P-value:3.87E-6 ID:SGTC_3223|Compound:9129970|FD-Score:3.68|P-value:3.12E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.45|P-value:6.81E-4

Top fitness defect scores for YLR051C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3158 9100007 6.77 49.5 µM 1.00E-10 1 6.34E-12 1.24
2 SGTC_1917 st066507 6.25 28.5 µM 2.22E-9 Golgi 2 2.02E-10 1.45
3 SGTC_1720 st037298 5.94 9.5 µM 1.27E-8 1 1.42E-9 0.77
4 SGTC_2112 5488546 5.89 200.0 µM 1.65E-8 TSC3-RPN4 2 1.91E-9 1.16
5 SGTC_617 3770-0098 5.84 35.0 µM 2.14E-8 exosome 16 2.55E-9 0.03
6 SGTC_264 promethazine 5.65 12.5 mM 5.95E-8 DNA intercalators 11 8.03E-9 0.12
7 SGTC_1789 tunicamycin 5.26 25.0 nM 4.26E-7 unfolded protein response 7 7.28E-8 0.35
8 SGTC_2587 piperic acid 5.02 92.2 µM 1.35E-6 2 2.65E-7 0.88
9 SGTC_686 1319-0111 4.79 510.0 µM 3.73E-6 60S ribosome export 5 8.29E-7 0.43
10 SGTC_1752 st044819 4.78 83.0 µM 3.94E-6 4 8.81E-7 0.38
11 SGTC_2993 9054257 4.74 71.4 µM 4.62E-6 fatty acid desaturase (OLE1) 22 1.05E-6 0.08
12 SGTC_428 3448-4153 4.67 16.5 µM 6.44E-6 TSC3-RPN4 5 1.53E-6 0.02
13 SGTC_814 3342-0569 4.44 96.0 µM 1.72E-5 1 4.58E-6 0.67
14 SGTC_1213 1315-0166 4.42 115.0 µM 1.86E-5 12 5.00E-6 0.30
15 SGTC_2817 7995342 4.37 71.4 µM 2.29E-5 4 6.34E-6 0.05
16 SGTC_2795 7780010 4.33 54.5 µM 2.61E-5 6 7.33E-6 0.43
17 SGTC_2995 9067767 4.28 71.4 µM 3.20E-5 1 9.23E-6 0.44
18 SGTC_2617 dihydrotanshinone i 4.23 20.8 µM 3.89E-5 copper-dependent oxidative stress 17 1.15E-5 0.01
19 SGTC_2434 5670830 4.20 169.9 µM 4.40E-5 3 1.32E-5 0.04
20 SGTC_145 3737-0113 4.17 38.4 µM 5.01E-5 DNA intercalators 45 1.52E-5 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 8.95E-24 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.155 1.87E-19 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.148 5.65E-18 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.146 1.98E-17 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.145 3.30E-17 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.135 4.10E-15 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.134 5.84E-15 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.131 2.26E-14 YBR173C UMP1 hom Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly
0.126 2.20E-13 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.115 2.25E-11 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.112 8.92E-11 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.109 2.24E-10 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.104 1.87E-9 YDR113C PDS1 het Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
0.102 2.68E-9 YLR133W CKI1 hom Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication
0.099 9.70E-9 YNL101W AVT4 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters