YLR052W / IES3

Subunit of the INO80 chromatin remodeling complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR052W / IES3

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:-5.81|P-value:4.99E-8 ID:SGTC_7|Compound:0192-1582|FD-Score:3.75|P-value:2.07E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:5.51|P-value:1.25E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:4.41|P-value:1.74E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:3.30|P-value:9.47E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.32|P-value:8.75E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:6.07|P-value:6.76E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:3.83|P-value:1.56E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.42|P-value:6.30E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.36|P-value:7.79E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.82|P-value:3.06E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:4.34|P-value:2.35E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:8.34|P-value:3.60E-15 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.83|P-value:4.85E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:3.55|P-value:4.18E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.90|P-value:1.86E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.40|P-value:6.73E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:5.66|P-value:5.90E-8 ID:SGTC_617|Compound:3770-0098|FD-Score:4.47|P-value:1.39E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:-4.48|P-value:2.09E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-6.13|P-value:9.42E-9 ID:SGTC_786|Compound:4544-0069|FD-Score:4.02|P-value:7.94E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:-4.28|P-value:4.67E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:4.14|P-value:5.10E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.60|P-value:3.53E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.40|P-value:9.97E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.33|P-value:8.61E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.06|P-value:6.71E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.07|P-value:1.02E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:5.00|P-value:1.38E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.43|P-value:8.83E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.41|P-value:1.74E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:5.58|P-value:8.86E-8 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.81|P-value:1.72E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.65|P-value:6.48E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.17|P-value:4.56E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:4.15|P-value:4.82E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-4.04|P-value:1.12E-4 ID:SGTC_1554|Compound:st069299|FD-Score:4.02|P-value:7.84E-5 ID:SGTC_1621|Compound:st003705|FD-Score:-3.52|P-value:6.61E-4 ID:SGTC_1641|Compound:st009299|FD-Score:4.01|P-value:8.21E-5 ID:SGTC_1676|Compound:st018489|FD-Score:3.60|P-value:3.51E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.40|P-value:2.86E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.70|P-value:3.75E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.63|P-value:7.10E-6 ID:SGTC_1769|Compound:st044406|FD-Score:4.37|P-value:2.07E-5 ID:SGTC_1905|Compound:st060207|FD-Score:-3.42|P-value:9.09E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.68|P-value:4.01E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.61|P-value:1.23E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.88|P-value:1.97E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.44|P-value:1.56E-5 ID:SGTC_2456|Compound:5770359|FD-Score:4.44|P-value:1.56E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.78|P-value:2.82E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.49|P-value:5.09E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.55|P-value:9.96E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-7.70|P-value:7.41E-13 ID:SGTC_2929|Compound:9013348|FD-Score:-5.61|P-value:1.33E-7 ID:SGTC_2932|Compound:9016711|FD-Score:3.29|P-value:9.74E-4 ID:SGTC_3183|Compound:9108214|FD-Score:3.30|P-value:9.28E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.27|P-value:3.10E-5 ID:SGTC_3288|Compound:9119690|FD-Score:-3.53|P-value:6.49E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.85|P-value:1.46E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.75|P-value:3.12E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:-5.81|P-value:4.99E-8 ID:SGTC_7|Compound:0192-1582|FD-Score:3.75|P-value:2.07E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:5.51|P-value:1.25E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:4.41|P-value:1.74E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:3.30|P-value:9.47E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.32|P-value:8.75E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:6.07|P-value:6.76E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:3.83|P-value:1.56E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.42|P-value:6.30E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.36|P-value:7.79E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.82|P-value:3.06E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:4.34|P-value:2.35E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:8.34|P-value:3.60E-15 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.83|P-value:4.85E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:3.55|P-value:4.18E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.90|P-value:1.86E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.40|P-value:6.73E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:5.66|P-value:5.90E-8 ID:SGTC_617|Compound:3770-0098|FD-Score:4.47|P-value:1.39E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:-4.48|P-value:2.09E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-6.13|P-value:9.42E-9 ID:SGTC_786|Compound:4544-0069|FD-Score:4.02|P-value:7.94E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:-4.28|P-value:4.67E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:4.14|P-value:5.10E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.60|P-value:3.53E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.40|P-value:9.97E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.33|P-value:8.61E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.06|P-value:6.71E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.07|P-value:1.02E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:5.00|P-value:1.38E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.43|P-value:8.83E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.41|P-value:1.74E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:5.58|P-value:8.86E-8 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.81|P-value:1.72E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.65|P-value:6.48E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.17|P-value:4.56E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:4.15|P-value:4.82E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-4.04|P-value:1.12E-4 ID:SGTC_1554|Compound:st069299|FD-Score:4.02|P-value:7.84E-5 ID:SGTC_1621|Compound:st003705|FD-Score:-3.52|P-value:6.61E-4 ID:SGTC_1641|Compound:st009299|FD-Score:4.01|P-value:8.21E-5 ID:SGTC_1676|Compound:st018489|FD-Score:3.60|P-value:3.51E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.40|P-value:2.86E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.70|P-value:3.75E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.63|P-value:7.10E-6 ID:SGTC_1769|Compound:st044406|FD-Score:4.37|P-value:2.07E-5 ID:SGTC_1905|Compound:st060207|FD-Score:-3.42|P-value:9.09E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.68|P-value:4.01E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.61|P-value:1.23E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.88|P-value:1.97E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.44|P-value:1.56E-5 ID:SGTC_2456|Compound:5770359|FD-Score:4.44|P-value:1.56E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.78|P-value:2.82E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.49|P-value:5.09E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.55|P-value:9.96E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-7.70|P-value:7.41E-13 ID:SGTC_2929|Compound:9013348|FD-Score:-5.61|P-value:1.33E-7 ID:SGTC_2932|Compound:9016711|FD-Score:3.29|P-value:9.74E-4 ID:SGTC_3183|Compound:9108214|FD-Score:3.30|P-value:9.28E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.27|P-value:3.10E-5 ID:SGTC_3288|Compound:9119690|FD-Score:-3.53|P-value:6.49E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.85|P-value:1.46E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.75|P-value:3.12E-4

Top fitness defect scores for YLR052W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_358 0075-0058 8.34 9.4 µM 3.60E-15 4 3.64E-17
2 SGTC_158 k038-0087 6.07 26.4 µM 6.76E-9 ubiquinone biosynthesis & proteasome 64 6.25E-10
3 SGTC_522 1273-0010 5.66 11.6 µM 5.90E-8 60S ribosome export 5 7.55E-9
4 SGTC_1228 0124-0032 5.58 52.5 µM 8.86E-8 5 1.21E-8
5 SGTC_86 0417-1630 5.51 471.9 µM 1.25E-7 ubiquinone biosynthesis & proteasome 98 1.79E-8
6 SGTC_1094 duloxetine 5.00 25.4 µM 1.38E-6 RPP1 & pyrimidine depletion 2 2.82E-7
7 SGTC_352 k048-0007 4.82 5.1 µM 3.06E-6 ERAD & cell cycle 53 7.03E-7
8 SGTC_1430 4049-0248 4.65 69.1 µM 6.48E-6 8 1.66E-6
9 SGTC_1750 st081859 4.63 2.4 µM 7.10E-6 endomembrane recycling 147 1.84E-6
10 SGTC_2651 1327-0036 4.55 5.0 µM 9.96E-6 135 2.72E-6
11 SGTC_617 3770-0098 4.47 35.0 µM 1.39E-5 exosome 10 3.99E-6
12 SGTC_2268 7933382 4.44 153.8 µM 1.56E-5 26 4.54E-6
13 SGTC_2456 5770359 4.44 74.5 µM 1.56E-5 12 4.55E-6
14 SGTC_90 0870-0863 4.41 4.6 µM 1.74E-5 36 5.14E-6
15 SGTC_1223 0764-0573 4.41 147.0 µM 1.74E-5 11 5.16E-6
16 SGTC_1769 st044406 4.37 64.4 µM 2.07E-5 6 6.26E-6
17 SGTC_354 2783-3500 4.34 4.9 µM 2.35E-5 cell wall 39 7.26E-6
18 SGTC_3201 9113999 4.27 49.5 µM 3.10E-5 26 9.97E-6
19 SGTC_1534 6-azauridine 4.17 81.6 µM 4.56E-5 RNA pol III & RNase P/MRP 18 1.55E-5
20 SGTC_1535 tetrahydropapaveroline hydrobromide 4.15 54.3 µM 4.82E-5 RPP1 & pyrimidine depletion 7 1.65E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 4.33E-24 YDL002C NHP10 hom Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
0.157 5.14E-20 YER092W IES5 hom Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
0.139 7.99E-16 YPL125W KAP120 hom Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.137 1.54E-15 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.133 1.31E-14 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.126 2.27E-13 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.125 4.66E-13 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.117 1.13E-11 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.117 1.16E-11 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.115 2.12E-11 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.115 2.39E-11 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.113 4.69E-11 YGL135W RPL1B hom Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.112 7.24E-11 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.112 7.33E-11 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.111 1.03E-10 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance