YLR053C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR053C / YLR053C

Click on Significant Values for Screen Details ID:SGTC_219|Compound:mitoxanthrone|FD-Score:2.89|P-value:6.97E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:4.38|P-value:6.79E-7 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.24|P-value:1.69E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.36|P-value:1.02E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.07|P-value:3.77E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.30|P-value:1.32E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:2.92|P-value:6.19E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:2.97|P-value:5.24E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.09|P-value:3.21E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:8.11|P-value:2.01E-19 ID:SGTC_809|Compound:3998-0021|FD-Score:2.92|P-value:6.35E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:2.82|P-value:9.25E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.49|P-value:6.35E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.27|P-value:1.50E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.81|P-value:1.32E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.11|P-value:2.95E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.14|P-value:2.47E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.20|P-value:2.20E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.24|P-value:1.89E-4 ID:SGTC_2057|Compound:5236571|FD-Score:2.96|P-value:5.40E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.14|P-value:2.47E-6 ID:SGTC_2182|Compound:6325192|FD-Score:2.99|P-value:4.81E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.94|P-value:6.29E-4 ID:SGTC_2438|Compound:5259590|FD-Score:2.99|P-value:4.76E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.52|P-value:5.63E-5 ID:SGTC_2483|Compound:5729050|FD-Score:3.43|P-value:7.51E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.15|P-value:2.48E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.92|P-value:6.26E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.12|P-value:2.84E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.64|P-value:3.28E-5 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-2.95|P-value:6.18E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.64|P-value:2.93E-5 ID:SGTC_2847|Compound:9005661|FD-Score:3.40|P-value:8.61E-5 ID:SGTC_2930|Compound:9013230|FD-Score:5.32|P-value:2.16E-9 ID:SGTC_2935|Compound:9038016|FD-Score:-3.90|P-value:9.46E-6 ID:SGTC_2938|Compound:9059746|FD-Score:3.04|P-value:3.97E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-3.30|P-value:1.48E-4 ID:SGTC_3211|Compound:9128781|FD-Score:4.13|P-value:2.52E-6 ID:SGTC_3229|Compound:9132204|FD-Score:3.81|P-value:1.28E-5 ID:SGTC_3291|Compound:9121177|FD-Score:-3.21|P-value:2.11E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.33|P-value:1.31E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-3.79|P-value:1.58E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:2.89|P-value:6.97E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:4.38|P-value:6.79E-7 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.24|P-value:1.69E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.36|P-value:1.02E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.07|P-value:3.77E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.30|P-value:1.32E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:2.92|P-value:6.19E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:2.97|P-value:5.24E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.09|P-value:3.21E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:8.11|P-value:2.01E-19 ID:SGTC_809|Compound:3998-0021|FD-Score:2.92|P-value:6.35E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:2.82|P-value:9.25E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.49|P-value:6.35E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.27|P-value:1.50E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.81|P-value:1.32E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.11|P-value:2.95E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.14|P-value:2.47E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.20|P-value:2.20E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.24|P-value:1.89E-4 ID:SGTC_2057|Compound:5236571|FD-Score:2.96|P-value:5.40E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.14|P-value:2.47E-6 ID:SGTC_2182|Compound:6325192|FD-Score:2.99|P-value:4.81E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.94|P-value:6.29E-4 ID:SGTC_2438|Compound:5259590|FD-Score:2.99|P-value:4.76E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.52|P-value:5.63E-5 ID:SGTC_2483|Compound:5729050|FD-Score:3.43|P-value:7.51E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.15|P-value:2.48E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.92|P-value:6.26E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.12|P-value:2.84E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.64|P-value:3.28E-5 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-2.95|P-value:6.18E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.64|P-value:2.93E-5 ID:SGTC_2847|Compound:9005661|FD-Score:3.40|P-value:8.61E-5 ID:SGTC_2930|Compound:9013230|FD-Score:5.32|P-value:2.16E-9 ID:SGTC_2935|Compound:9038016|FD-Score:-3.90|P-value:9.46E-6 ID:SGTC_2938|Compound:9059746|FD-Score:3.04|P-value:3.97E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-3.30|P-value:1.48E-4 ID:SGTC_3211|Compound:9128781|FD-Score:4.13|P-value:2.52E-6 ID:SGTC_3229|Compound:9132204|FD-Score:3.81|P-value:1.28E-5 ID:SGTC_3291|Compound:9121177|FD-Score:-3.21|P-value:2.11E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.33|P-value:1.31E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-3.79|P-value:1.58E-5

Top fitness defect scores for YLR053C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_773 4358-1457 8.11 44.6 µM 2.01E-19 5 2.64E-16
2 SGTC_2930 9013230 5.32 14.9 µM 2.16E-9 heme biosynthesis & mitochondrial translocase 14 5.15E-8
3 SGTC_220 paclitaxel 4.38 373.4 µM 6.79E-7 3 6.03E-6
4 SGTC_1347 1493-0251 4.14 600.0 nM 2.47E-6 mitochondrial response to ROS 15 1.76E-5
5 SGTC_2059 5238311 4.14 157.0 µM 2.47E-6 16 1.76E-5
6 SGTC_3211 9128781 4.13 49.5 µM 2.52E-6 50 1.79E-5
7 SGTC_3229 9132204 3.81 49.5 µM 1.28E-5 4 6.89E-5
8 SGTC_1178 0988-0033 3.81 191.0 µM 1.32E-5 30 7.06E-5
9 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.64 100.0 µM 2.93E-5 46 1.37E-4
10 SGTC_2483 5729050 3.43 27.2 µM 7.51E-5 42 3.00E-4
11 SGTC_2847 9005661 3.40 71.4 µM 8.61E-5 15 3.36E-4
12 SGTC_381 3461-2219 3.36 42.7 µM 1.02E-4 copper-dependent oxidative stress 37 3.88E-4
13 SGTC_1345 1488-0192 3.31 31.4 µM 1.26E-4 34 4.63E-4
14 SGTC_551 k048-0028 3.30 34.9 µM 1.32E-4 43 4.81E-4
15 SGTC_1113 artemisinin 3.27 1.2 µM 1.50E-4 heme biosynthesis & mitochondrial translocase 32 5.32E-4
16 SGTC_261 5-fluorouridine 3.24 15.4 µM 1.69E-4 exosome 40 5.88E-4
17 SGTC_2490 carminic acid 3.15 95.4 µM 2.48E-4 20 8.10E-4
18 SGTC_2492 derrusnin 3.12 100.0 µM 2.84E-4 20 9.06E-4
19 SGTC_1309 pyrazolanthrone 3.11 13.4 µM 2.95E-4 51 9.36E-4
20 SGTC_689 0833-0039 3.09 98.0 µM 3.21E-4 ergosterol depletion effects on membrane 59 0.00100

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.213 9.55E-36 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.179 2.10E-25 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.164 1.70E-21 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.145 3.31E-17 YLR271W_p YLR271W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.142 1.68E-16 YDR166C SEC5 het Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip
0.140 5.10E-16 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.137 1.78E-15 YDR055W PST1 hom Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
0.136 2.39E-15 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.131 3.11E-14 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.127 1.86E-13 YBR241C_p YBR241C_p hom Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
0.121 2.88E-12 YGL220W FRA2 hom Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel
0.119 4.68E-12 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.117 1.24E-11 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.112 9.36E-11 YJR001W AVT1 hom Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.112 8.97E-11 YKR054C DYN1 hom Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p