YLR054C / OSW2

Protein of unknown function proposed to be involved in the assembly of the spore wall

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR054C / OSW2

Click on Significant Values for Screen Details ID:SGTC_264|Compound:promethazine|FD-Score:-3.52|P-value:2.59E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.20|P-value:8.19E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.32|P-value:5.52E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.32|P-value:5.15E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.49|P-value:2.86E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:7.02|P-value:2.47E-12 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.14|P-value:9.75E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:5.01|P-value:4.16E-7 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.32|P-value:5.24E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.32|P-value:5.43E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.44|P-value:5.88E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:3.58|P-value:2.16E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.77|P-value:1.05E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.18|P-value:8.96E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.19|P-value:8.07E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.51|P-value:2.82E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.28|P-value:6.37E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.26|P-value:6.71E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.16|P-value:9.63E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.95|P-value:5.24E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.67|P-value:1.56E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.23|P-value:7.58E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.34|P-value:9.25E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.65|P-value:2.35E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.22|P-value:7.82E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.59|P-value:3.02E-6 ID:SGTC_2830|Compound:7992007|FD-Score:8.43|P-value:5.19E-17 ID:SGTC_2831|Compound:7999036|FD-Score:-9.88|P-value:1.04E-22 ID:SGTC_2956|Compound:9076196|FD-Score:3.29|P-value:6.13E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-6.48|P-value:8.24E-11 ID:SGTC_2967|Compound:9089538|FD-Score:-4.98|P-value:4.52E-7 ID:SGTC_3023|Compound:9089636|FD-Score:3.15|P-value:9.79E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.29|P-value:6.08E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.65|P-value:1.68E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.52|P-value:2.59E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.20|P-value:8.19E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.32|P-value:5.52E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.32|P-value:5.15E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.49|P-value:2.86E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:7.02|P-value:2.47E-12 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.14|P-value:9.75E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:5.01|P-value:4.16E-7 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.32|P-value:5.24E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.32|P-value:5.43E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.44|P-value:5.88E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:3.58|P-value:2.16E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.77|P-value:1.05E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.18|P-value:8.96E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.19|P-value:8.07E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.51|P-value:2.82E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.28|P-value:6.37E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.26|P-value:6.71E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.16|P-value:9.63E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.95|P-value:5.24E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.67|P-value:1.56E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.23|P-value:7.58E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.34|P-value:9.25E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.65|P-value:2.35E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.22|P-value:7.82E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.59|P-value:3.02E-6 ID:SGTC_2830|Compound:7992007|FD-Score:8.43|P-value:5.19E-17 ID:SGTC_2831|Compound:7999036|FD-Score:-9.88|P-value:1.04E-22 ID:SGTC_2956|Compound:9076196|FD-Score:3.29|P-value:6.13E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-6.48|P-value:8.24E-11 ID:SGTC_2967|Compound:9089538|FD-Score:-4.98|P-value:4.52E-7 ID:SGTC_3023|Compound:9089636|FD-Score:3.15|P-value:9.79E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.29|P-value:6.08E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.65|P-value:1.68E-4

Top fitness defect scores for YLR054C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2830 7992007 8.43 71.4 µM 5.19E-17 1 1.67E-17
2 SGTC_515 4092-1064 7.02 102.0 µM 2.47E-12 plasma membrane duress 22 1.11E-12
3 SGTC_768 0384-0033 5.01 77.3 µM 4.16E-7 fatty acid desaturase (OLE1) 53 2.72E-7
4 SGTC_2587 piperic acid 4.65 92.2 µM 2.35E-6 8 1.62E-6
5 SGTC_2393 9031399 3.95 185.9 µM 5.24E-5 RNA processing & uracil transport 25 3.98E-5
6 SGTC_977 1348-1378 3.77 135.0 µM 1.05E-4 27 8.11E-5
7 SGTC_2394 5221648 3.67 200.0 µM 1.56E-4 32 1.23E-4
8 SGTC_3206 9114350 3.65 49.5 µM 1.68E-4 25 1.32E-4
9 SGTC_952 1185-0122 3.58 232.0 µM 2.16E-4 29 1.71E-4
10 SGTC_1347 1493-0251 3.51 600.0 nM 2.82E-4 mitochondrial response to ROS 26 2.25E-4
11 SGTC_940 3232-1287 3.32 54.8 µM 5.43E-4 NEO1 62 4.43E-4
12 SGTC_278 4092-0821 3.32 23.9 µM 5.52E-4 plasma membrane duress 70 4.50E-4
13 SGTC_3057 9095946 3.29 49.5 µM 6.08E-4 Golgi 29 4.97E-4
14 SGTC_2956 9076196 3.29 2.5 µM 6.13E-4 51 5.01E-4
15 SGTC_1842 st055362 3.28 61.2 µM 6.37E-4 34 5.22E-4
16 SGTC_2100 5377183 3.26 190.0 µM 6.71E-4 60S ribosome export 34 5.51E-4
17 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.23 3.7 µM 7.58E-4 164 6.24E-4
18 SGTC_2689 tacrolimus 3.22 100.0 µM 7.82E-4 82 6.45E-4
19 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 3.20 44.4 nM 8.19E-4 DNA damage response 50 6.76E-4
20 SGTC_1247 0448-0043 3.18 5.8 µM 8.96E-4 ERG2 94 7.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.58E-16 YLL052C AQY2 hom Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
0.130 4.53E-14 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.129 5.96E-14 YKR062W TFA2 het TFIIE small subunit, involved in RNA polymerase II transcription initiation
0.125 4.42E-13 YGR205W TDA10 hom ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele
0.118 6.05E-12 YDR525W-A SNA2 hom Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.115 2.17E-11 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.114 3.95E-11 YDR279W RNH202 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome
0.111 1.19E-10 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.106 7.71E-10 YBL029W_p YBL029W_p hom Non-essential protein of unknown function
0.105 1.12E-9 YLR244C MAP1 hom Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p
0.101 4.25E-9 YER162C RAD4 hom Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins
0.101 4.91E-9 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.096 2.59E-8 YDR179C CSN9 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
0.096 2.56E-8 YHR086W-A_p YHR086W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.095 3.13E-8 YHR176W FMO1 hom Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins