YLR055C / SPT8

Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR055C / SPT8

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.28|P-value:6.53E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:5.93|P-value:2.75E-9 ID:SGTC_22|Compound:0964-0034|FD-Score:3.24|P-value:7.43E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.76|P-value:1.21E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:4.84|P-value:9.69E-7 ID:SGTC_87|Compound:0100-0052|FD-Score:8.27|P-value:1.83E-16 ID:SGTC_90|Compound:0870-0863|FD-Score:3.55|P-value:2.47E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.84|P-value:7.97E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:3.61|P-value:1.95E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.54|P-value:4.03E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:4.61|P-value:2.90E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:4.99|P-value:4.54E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:5.41|P-value:5.22E-8 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.17|P-value:9.48E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.38|P-value:8.43E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:6.53|P-value:6.36E-11 ID:SGTC_293|Compound:4049-0273|FD-Score:5.26|P-value:1.15E-7 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.78|P-value:1.06E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.27|P-value:5.92E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.66|P-value:2.10E-11 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.79|P-value:8.64E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.12|P-value:2.21E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.90|P-value:6.50E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:-4.46|P-value:4.88E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:3.33|P-value:5.47E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.99|P-value:3.72E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:5.14|P-value:2.11E-7 ID:SGTC_505|Compound:gw-5074|FD-Score:3.33|P-value:5.32E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.85|P-value:7.75E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.75|P-value:1.14E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.16|P-value:9.72E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.46|P-value:3.01E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:6.63|P-value:3.31E-11 ID:SGTC_683|Compound:panaxydol|FD-Score:4.63|P-value:2.70E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.40|P-value:3.66E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:4.26|P-value:1.42E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:3.23|P-value:7.55E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.18|P-value:9.06E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.65|P-value:1.68E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:10.90|P-value:2.51E-27 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.22|P-value:8.00E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.37|P-value:6.25E-8 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.89|P-value:7.46E-7 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.37|P-value:4.70E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.97|P-value:4.89E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:6.55|P-value:5.87E-11 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.32|P-value:5.53E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.85|P-value:7.95E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:14.70|P-value:1.05E-47 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.50|P-value:7.74E-11 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.19|P-value:8.67E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.82|P-value:7.68E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.58|P-value:1.92E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.59|P-value:4.32E-11 ID:SGTC_1694|Compound:st024011|FD-Score:3.87|P-value:7.23E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.47|P-value:3.30E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.85|P-value:6.71E-5 ID:SGTC_1723|Compound:st034307|FD-Score:3.64|P-value:1.75E-4 ID:SGTC_1726|Compound:st035556|FD-Score:5.09|P-value:2.74E-7 ID:SGTC_1754|Compound:st042065|FD-Score:4.71|P-value:1.84E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.34|P-value:5.16E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.33|P-value:6.37E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.56|P-value:2.41E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.81|P-value:1.15E-6 ID:SGTC_1941|Compound:st076221|FD-Score:9.71|P-value:5.76E-22 ID:SGTC_2050|Compound:5263056|FD-Score:-4.03|P-value:3.14E-5 ID:SGTC_2096|Compound:5468907|FD-Score:3.49|P-value:3.11E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.14|P-value:2.06E-5 ID:SGTC_2335|Compound:9018011|FD-Score:4.66|P-value:2.30E-6 ID:SGTC_2338|Compound:7999974|FD-Score:-3.58|P-value:1.94E-4 ID:SGTC_2348|Compound:9022543|FD-Score:9.49|P-value:4.34E-21 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.27|P-value:1.15E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.63|P-value:2.21E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.11|P-value:9.93E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.84|P-value:8.16E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:-6.24|P-value:3.20E-10 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.45|P-value:1.13E-13 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.33|P-value:1.07E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.52|P-value:4.38E-6 ID:SGTC_2858|Compound:9025781|FD-Score:17.00|P-value:3.62E-63 ID:SGTC_2896|Compound:9052656|FD-Score:-5.48|P-value:2.84E-8 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.59|P-value:2.15E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-4.03|P-value:3.26E-5 ID:SGTC_3223|Compound:9129970|FD-Score:4.39|P-value:8.17E-6 ID:SGTC_3247|Compound:9135149|FD-Score:3.16|P-value:9.58E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.28|P-value:1.10E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.84|P-value:8.18E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:3.28|P-value:6.53E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:5.93|P-value:2.75E-9 ID:SGTC_22|Compound:0964-0034|FD-Score:3.24|P-value:7.43E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.76|P-value:1.21E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:4.84|P-value:9.69E-7 ID:SGTC_87|Compound:0100-0052|FD-Score:8.27|P-value:1.83E-16 ID:SGTC_90|Compound:0870-0863|FD-Score:3.55|P-value:2.47E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.84|P-value:7.97E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:3.61|P-value:1.95E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.54|P-value:4.03E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:4.61|P-value:2.90E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:4.99|P-value:4.54E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:5.41|P-value:5.22E-8 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.17|P-value:9.48E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.38|P-value:8.43E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:6.53|P-value:6.36E-11 ID:SGTC_293|Compound:4049-0273|FD-Score:5.26|P-value:1.15E-7 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.78|P-value:1.06E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.27|P-value:5.92E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.66|P-value:2.10E-11 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.79|P-value:8.64E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.12|P-value:2.21E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.90|P-value:6.50E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:-4.46|P-value:4.88E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:3.33|P-value:5.47E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.99|P-value:3.72E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:5.14|P-value:2.11E-7 ID:SGTC_505|Compound:gw-5074|FD-Score:3.33|P-value:5.32E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.85|P-value:7.75E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.75|P-value:1.14E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.16|P-value:9.72E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.46|P-value:3.01E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:6.63|P-value:3.31E-11 ID:SGTC_683|Compound:panaxydol|FD-Score:4.63|P-value:2.70E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.40|P-value:3.66E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:4.26|P-value:1.42E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:3.23|P-value:7.55E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.18|P-value:9.06E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.65|P-value:1.68E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:10.90|P-value:2.51E-27 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.22|P-value:8.00E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.37|P-value:6.25E-8 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.89|P-value:7.46E-7 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.37|P-value:4.70E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.97|P-value:4.89E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:6.55|P-value:5.87E-11 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.32|P-value:5.53E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.85|P-value:7.95E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:14.70|P-value:1.05E-47 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.50|P-value:7.74E-11 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.19|P-value:8.67E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.82|P-value:7.68E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.58|P-value:1.92E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.59|P-value:4.32E-11 ID:SGTC_1694|Compound:st024011|FD-Score:3.87|P-value:7.23E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.47|P-value:3.30E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.85|P-value:6.71E-5 ID:SGTC_1723|Compound:st034307|FD-Score:3.64|P-value:1.75E-4 ID:SGTC_1726|Compound:st035556|FD-Score:5.09|P-value:2.74E-7 ID:SGTC_1754|Compound:st042065|FD-Score:4.71|P-value:1.84E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.34|P-value:5.16E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.33|P-value:6.37E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.56|P-value:2.41E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.81|P-value:1.15E-6 ID:SGTC_1941|Compound:st076221|FD-Score:9.71|P-value:5.76E-22 ID:SGTC_2050|Compound:5263056|FD-Score:-4.03|P-value:3.14E-5 ID:SGTC_2096|Compound:5468907|FD-Score:3.49|P-value:3.11E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.14|P-value:2.06E-5 ID:SGTC_2335|Compound:9018011|FD-Score:4.66|P-value:2.30E-6 ID:SGTC_2338|Compound:7999974|FD-Score:-3.58|P-value:1.94E-4 ID:SGTC_2348|Compound:9022543|FD-Score:9.49|P-value:4.34E-21 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.27|P-value:1.15E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.63|P-value:2.21E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.11|P-value:9.93E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.84|P-value:8.16E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:-6.24|P-value:3.20E-10 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.45|P-value:1.13E-13 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.33|P-value:1.07E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.52|P-value:4.38E-6 ID:SGTC_2858|Compound:9025781|FD-Score:17.00|P-value:3.62E-63 ID:SGTC_2896|Compound:9052656|FD-Score:-5.48|P-value:2.84E-8 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.59|P-value:2.15E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-4.03|P-value:3.26E-5 ID:SGTC_3223|Compound:9129970|FD-Score:4.39|P-value:8.17E-6 ID:SGTC_3247|Compound:9135149|FD-Score:3.16|P-value:9.58E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.28|P-value:1.10E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.84|P-value:8.18E-5

Top fitness defect scores for YLR055C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2858 9025781 17.00 9.0 µM 3.62E-63 sphingolipid biosynthesis & PDR1 9 6.53E-65
2 SGTC_1287 0971-0001 14.70 34.6 µM 1.05E-47 sphingolipid biosynthesis & PDR1 5 5.00E-49
3 SGTC_955 1216-0110 10.90 33.0 µM 2.51E-27 sphingolipid biosynthesis & PDR1 13 4.38E-28
4 SGTC_1941 st076221 9.71 61.8 µM 5.76E-22 sphingolipid biosynthesis & PDR1 13 1.42E-22
5 SGTC_2348 9022543 9.49 33.4 µM 4.34E-21 mitochondrial processes 1 1.13E-21
6 SGTC_87 0100-0052 8.27 35.5 µM 1.83E-16 13 6.45E-17
7 SGTC_2752 diclazuril 7.45 33.1 µM 1.13E-13 41 4.77E-14
8 SGTC_2651 1327-0036 6.84 5.0 µM 8.16E-12 49 3.89E-12
9 SGTC_664 1222-0054 6.63 14.9 µM 3.31E-11 sphingolipid biosynthesis & PDR1 12 1.64E-11
10 SGTC_1687 st020778 6.59 55.4 µM 4.32E-11 98 2.16E-11
11 SGTC_1226 3909-7979 6.55 35.4 µM 5.87E-11 12 2.96E-11
12 SGTC_266 formosanin C 6.53 406.0 nM 6.36E-11 sphingolipid biosynthesis & PDR1 21 3.21E-11
13 SGTC_1304 1165-0502 6.50 251.0 µM 7.74E-11 25 3.94E-11
14 SGTC_8 0354-0001 5.93 70.0 µM 2.75E-9 27 1.55E-9
15 SGTC_168 3970-0862 5.41 530.5 µM 5.22E-8 59 3.20E-8
16 SGTC_1072 oxiconazole 5.37 14.9 nM 6.25E-8 ergosterol depletion effects on membrane 28 3.85E-8
17 SGTC_293 4049-0273 5.26 38.5 µM 1.15E-7 9 7.23E-8
18 SGTC_439 amiodarone 5.14 34.4 µM 2.11E-7 NEO1-PIK1 62 1.35E-7
19 SGTC_1726 st035556 5.09 14.6 µM 2.74E-7 18 1.76E-7
20 SGTC_156 3474-0145 4.99 5.6 µM 4.54E-7 endomembrane recycling 33 2.96E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.532 1.62E-244 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.411 3.23E-137 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.400 4.88E-129 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.339 5.07E-91 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.335 7.12E-89 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.319 3.59E-80 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.314 9.78E-78 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.308 1.75E-74 YDR073W SNF11 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions
0.302 8.50E-72 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.287 1.85E-64 YGL253W HXK2 hom Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication
0.279 8.45E-61 YJR074W MOG1 hom Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.271 2.45E-57 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.267 6.16E-56 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.267 8.07E-56 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.251 2.63E-49 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin