YLR059C / REX2

3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR059C / REX2

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:-3.79|P-value:1.49E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.47|P-value:4.55E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.39|P-value:5.85E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.50|P-value:4.18E-4 ID:SGTC_397|Compound:arbidol|FD-Score:-4.53|P-value:7.65E-6 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.46|P-value:4.73E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-4.03|P-value:5.87E-5 ID:SGTC_508|Compound:roscovitine|FD-Score:-3.65|P-value:2.41E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:6.66|P-value:9.42E-11 ID:SGTC_622|Compound:1348-1566|FD-Score:5.44|P-value:9.98E-8 ID:SGTC_623|Compound:k072-0108|FD-Score:5.36|P-value:1.47E-7 ID:SGTC_931|Compound:2812-0076|FD-Score:3.46|P-value:4.71E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.86|P-value:1.14E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:5.59|P-value:4.52E-8 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.54|P-value:3.54E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.29|P-value:8.20E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:-3.48|P-value:4.44E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.36|P-value:1.53E-5 ID:SGTC_1716|Compound:st033144|FD-Score:3.69|P-value:2.06E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-3.47|P-value:4.59E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.82|P-value:2.03E-6 ID:SGTC_2140|Compound:5586273|FD-Score:3.92|P-value:8.90E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.24|P-value:9.91E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.05|P-value:5.38E-5 ID:SGTC_2534|Compound:helenine|FD-Score:-3.74|P-value:1.79E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.72|P-value:1.91E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.31|P-value:7.80E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.35|P-value:1.57E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.00|P-value:6.73E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.76|P-value:1.63E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.02|P-value:6.14E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-3.33|P-value:7.24E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.63|P-value:2.55E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.31|P-value:7.63E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-4.03|P-value:6.00E-5 ID:SGTC_3002|Compound:9075603|FD-Score:3.50|P-value:4.02E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.54|P-value:3.61E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.47|P-value:4.53E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-4.15|P-value:3.69E-5 ID:SGTC_3274|Compound:9138298|FD-Score:3.84|P-value:1.19E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-3.38|P-value:6.24E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.15|P-value:3.63E-5 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.79|P-value:1.49E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.47|P-value:4.55E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.39|P-value:5.85E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.50|P-value:4.18E-4 ID:SGTC_397|Compound:arbidol|FD-Score:-4.53|P-value:7.65E-6 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.46|P-value:4.73E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-4.03|P-value:5.87E-5 ID:SGTC_508|Compound:roscovitine|FD-Score:-3.65|P-value:2.41E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:6.66|P-value:9.42E-11 ID:SGTC_622|Compound:1348-1566|FD-Score:5.44|P-value:9.98E-8 ID:SGTC_623|Compound:k072-0108|FD-Score:5.36|P-value:1.47E-7 ID:SGTC_931|Compound:2812-0076|FD-Score:3.46|P-value:4.71E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.86|P-value:1.14E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:5.59|P-value:4.52E-8 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.54|P-value:3.54E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.29|P-value:8.20E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:-3.48|P-value:4.44E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.36|P-value:1.53E-5 ID:SGTC_1716|Compound:st033144|FD-Score:3.69|P-value:2.06E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-3.47|P-value:4.59E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.82|P-value:2.03E-6 ID:SGTC_2140|Compound:5586273|FD-Score:3.92|P-value:8.90E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.24|P-value:9.91E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.05|P-value:5.38E-5 ID:SGTC_2534|Compound:helenine|FD-Score:-3.74|P-value:1.79E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.72|P-value:1.91E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.31|P-value:7.80E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.35|P-value:1.57E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.00|P-value:6.73E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.76|P-value:1.63E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.02|P-value:6.14E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-3.33|P-value:7.24E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.63|P-value:2.55E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.31|P-value:7.63E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-4.03|P-value:6.00E-5 ID:SGTC_3002|Compound:9075603|FD-Score:3.50|P-value:4.02E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.54|P-value:3.61E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.47|P-value:4.53E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-4.15|P-value:3.69E-5 ID:SGTC_3274|Compound:9138298|FD-Score:3.84|P-value:1.19E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-3.38|P-value:6.24E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.15|P-value:3.63E-5

Top fitness defect scores for YLR059C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_619 1652-1634 6.66 108.0 µM 9.42E-11 PDR1 2 1.34E-11
2 SGTC_1030 k029-0042 5.59 36.7 µM 4.52E-8 TSC3-RPN4 7 1.13E-8
3 SGTC_622 1348-1566 5.44 26.3 µM 9.98E-8 3 2.68E-8
4 SGTC_623 k072-0108 5.36 16.9 µM 1.47E-7 heme biosynthesis & mitochondrial translocase 3 4.11E-8
5 SGTC_1934 st074720 4.82 32.6 µM 2.03E-6 33 7.20E-7
6 SGTC_1580 hydrocortisone 21-hemisuccinate 4.36 43.2 µM 1.53E-5 17 6.49E-6
7 SGTC_2600 tangeritin 4.35 88.0 µM 1.57E-5 24 6.69E-6
8 SGTC_3319 9138450 4.15 16.8 µM 3.63E-5 18 1.67E-5
9 SGTC_2420 aureobasidin a 4.05 50.0 nM 5.38E-5 39 2.56E-5
10 SGTC_2749 bexarotene 4.02 57.4 µM 6.14E-5 19 2.95E-5
11 SGTC_2140 5586273 3.92 200.0 µM 8.90E-5 RSC complex & mRNA processing 6 4.43E-5
12 SGTC_3274 9138298 3.84 49.5 µM 1.19E-4 23 6.10E-5
13 SGTC_1716 st033144 3.69 30.6 µM 2.06E-4 28 1.10E-4
14 SGTC_2868 9035608 3.63 32.5 µM 2.55E-4 24 1.39E-4
15 SGTC_3072 9116419 3.54 49.5 µM 3.61E-4 ERG2 31 2.03E-4
16 SGTC_3002 9075603 3.50 71.4 µM 4.02E-4 35 2.29E-4
17 SGTC_3078 9116413 3.47 49.5 µM 4.53E-4 unfolded protein response 52 2.60E-4
18 SGTC_931 2812-0076 3.46 566.0 µM 4.71E-4 40 2.71E-4
19 SGTC_287 k060-0039 3.39 29.6 µM 5.85E-4 19 3.43E-4
20 SGTC_2870 9038528 3.31 13.0 µM 7.63E-4 37 4.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 7.60E-12 YML022W APT1 hom Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication
0.108 3.29E-10 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.104 1.33E-9 YGL086W MAD1 hom Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
0.095 3.86E-8 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.091 1.20E-7 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.090 1.77E-7 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.085 9.08E-7 YPR138C MEP3 hom Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease
0.084 1.23E-6 YNL272C SEC2 het Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles
0.082 1.80E-6 YBR116C_d YBR116C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
0.082 2.02E-6 YKL088W CAB3 het Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC
0.080 3.29E-6 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.079 4.34E-6 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.078 5.39E-6 YHL047C ARN2 hom Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
0.075 1.44E-5 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.073 2.43E-5 YDR003W RCR2 hom Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication