YLR061W / RPL22A

Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR061W / RPL22A

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:4.07|P-value:1.24E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.51|P-value:7.45E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:5.97|P-value:4.52E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:3.92|P-value:2.02E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.67|P-value:4.65E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:9.82|P-value:1.07E-18 ID:SGTC_148|Compound:3253-0744|FD-Score:3.60|P-value:5.75E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-5.07|P-value:5.21E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:-3.98|P-value:2.81E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.67|P-value:4.52E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.46|P-value:8.76E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.98|P-value:1.66E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.62|P-value:5.37E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.53|P-value:2.31E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:5.17|P-value:1.75E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:-5.28|P-value:2.18E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.25|P-value:1.15E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:-3.91|P-value:3.58E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:5.62|P-value:2.30E-7 ID:SGTC_791|Compound:1348-1292|FD-Score:8.20|P-value:1.25E-13 ID:SGTC_800|Compound:3448-7362|FD-Score:5.10|P-value:2.39E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:4.32|P-value:4.96E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:4.67|P-value:1.36E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:6.80|P-value:5.90E-10 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.42|P-value:9.85E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.63|P-value:5.22E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.96|P-value:1.76E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.08|P-value:1.17E-4 ID:SGTC_1998|Compound:st075797|FD-Score:4.03|P-value:1.41E-4 ID:SGTC_2100|Compound:5377183|FD-Score:4.56|P-value:2.05E-5 ID:SGTC_2106|Compound:5357045|FD-Score:-4.38|P-value:7.09E-5 ID:SGTC_2111|Compound:5486399|FD-Score:-4.96|P-value:8.15E-6 ID:SGTC_2127|Compound:5253358|FD-Score:4.59|P-value:1.85E-5 ID:SGTC_2194|Compound:5927483|FD-Score:3.82|P-value:2.81E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.54|P-value:6.79E-4 ID:SGTC_2280|Compound:7785178|FD-Score:4.63|P-value:1.57E-5 ID:SGTC_2283|Compound:7944793|FD-Score:4.34|P-value:4.63E-5 ID:SGTC_2286|Compound:7945697|FD-Score:-3.89|P-value:3.80E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-4.12|P-value:1.79E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.78|P-value:3.18E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-4.31|P-value:9.35E-5 ID:SGTC_2306|Compound:7482397|FD-Score:3.73|P-value:3.83E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.06|P-value:1.25E-4 ID:SGTC_2352|Compound:9027995|FD-Score:6.50|P-value:2.96E-9 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.28|P-value:1.04E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.46|P-value:8.71E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.74|P-value:1.03E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-5.54|P-value:7.01E-7 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.86|P-value:4.19E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.48|P-value:8.21E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.07|P-value:2.98E-13 ID:SGTC_2752|Compound:diclazuril|FD-Score:-4.07|P-value:2.13E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.56|P-value:3.78E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:5.29|P-value:1.02E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-4.29|P-value:9.84E-5 ID:SGTC_2988|Compound:9073640|FD-Score:6.67|P-value:1.20E-9 ID:SGTC_2993|Compound:9054257|FD-Score:-5.75|P-value:2.64E-7 ID:SGTC_3050|Compound:9093513|FD-Score:4.58|P-value:1.89E-5 ID:SGTC_3052|Compound:9092717|FD-Score:5.12|P-value:2.13E-6 ID:SGTC_3062|Compound:9077494|FD-Score:-6.29|P-value:2.02E-8 ID:SGTC_3083|Compound:9117465|FD-Score:4.52|P-value:2.41E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.83|P-value:4.56E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.50|P-value:7.70E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:4.07|P-value:1.24E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.51|P-value:7.45E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:5.97|P-value:4.52E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:3.92|P-value:2.02E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.67|P-value:4.65E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:9.82|P-value:1.07E-18 ID:SGTC_148|Compound:3253-0744|FD-Score:3.60|P-value:5.75E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-5.07|P-value:5.21E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:-3.98|P-value:2.81E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.67|P-value:4.52E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.46|P-value:8.76E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.98|P-value:1.66E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.62|P-value:5.37E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.53|P-value:2.31E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:5.17|P-value:1.75E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:-5.28|P-value:2.18E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.25|P-value:1.15E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:-3.91|P-value:3.58E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:5.62|P-value:2.30E-7 ID:SGTC_791|Compound:1348-1292|FD-Score:8.20|P-value:1.25E-13 ID:SGTC_800|Compound:3448-7362|FD-Score:5.10|P-value:2.39E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:4.32|P-value:4.96E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:4.67|P-value:1.36E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:6.80|P-value:5.90E-10 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.42|P-value:9.85E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.63|P-value:5.22E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.96|P-value:1.76E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.08|P-value:1.17E-4 ID:SGTC_1998|Compound:st075797|FD-Score:4.03|P-value:1.41E-4 ID:SGTC_2100|Compound:5377183|FD-Score:4.56|P-value:2.05E-5 ID:SGTC_2106|Compound:5357045|FD-Score:-4.38|P-value:7.09E-5 ID:SGTC_2111|Compound:5486399|FD-Score:-4.96|P-value:8.15E-6 ID:SGTC_2127|Compound:5253358|FD-Score:4.59|P-value:1.85E-5 ID:SGTC_2194|Compound:5927483|FD-Score:3.82|P-value:2.81E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.54|P-value:6.79E-4 ID:SGTC_2280|Compound:7785178|FD-Score:4.63|P-value:1.57E-5 ID:SGTC_2283|Compound:7944793|FD-Score:4.34|P-value:4.63E-5 ID:SGTC_2286|Compound:7945697|FD-Score:-3.89|P-value:3.80E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-4.12|P-value:1.79E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.78|P-value:3.18E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-4.31|P-value:9.35E-5 ID:SGTC_2306|Compound:7482397|FD-Score:3.73|P-value:3.83E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.06|P-value:1.25E-4 ID:SGTC_2352|Compound:9027995|FD-Score:6.50|P-value:2.96E-9 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.28|P-value:1.04E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.46|P-value:8.71E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.74|P-value:1.03E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-5.54|P-value:7.01E-7 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.86|P-value:4.19E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.48|P-value:8.21E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.07|P-value:2.98E-13 ID:SGTC_2752|Compound:diclazuril|FD-Score:-4.07|P-value:2.13E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.56|P-value:3.78E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:5.29|P-value:1.02E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-4.29|P-value:9.84E-5 ID:SGTC_2988|Compound:9073640|FD-Score:6.67|P-value:1.20E-9 ID:SGTC_2993|Compound:9054257|FD-Score:-5.75|P-value:2.64E-7 ID:SGTC_3050|Compound:9093513|FD-Score:4.58|P-value:1.89E-5 ID:SGTC_3052|Compound:9092717|FD-Score:5.12|P-value:2.13E-6 ID:SGTC_3062|Compound:9077494|FD-Score:-6.29|P-value:2.02E-8 ID:SGTC_3083|Compound:9117465|FD-Score:4.52|P-value:2.41E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.83|P-value:4.56E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.50|P-value:7.70E-4

Top fitness defect scores for YLR061W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_118 0083-0097 9.82 135.3 µM 1.07E-18 translation 2 4.68E-23
2 SGTC_791 1348-1292 8.20 225.0 µM 1.25E-13 5 1.21E-16
3 SGTC_2688 kanamycin b 8.07 96.7 µM 2.98E-13 calcium & mitochondrial duress 62 3.62E-16
4 SGTC_1021 4476-0760 6.80 85.3 µM 5.90E-10 2 5.18E-12
5 SGTC_2988 9073640 6.67 71.4 µM 1.20E-9 3 1.26E-11
6 SGTC_2352 9027995 6.50 87.8 µM 2.96E-9 tubulin folding & SWR complex 10 3.93E-11
7 SGTC_62 0180-0423 5.97 3.2 µM 4.52E-8 60S ribosome export 6 1.21E-9
8 SGTC_782 0083-0095 5.62 30.5 µM 2.30E-7 6 9.30E-9
9 SGTC_2760 etidronate 5.29 98.0 µM 1.02E-6 7 6.01E-8
10 SGTC_691 1548-0686 5.17 185.0 µM 1.75E-6 11 1.18E-7
11 SGTC_3052 9092717 5.12 49.5 µM 2.13E-6 7 1.51E-7
12 SGTC_800 3448-7362 5.10 155.0 µM 2.39E-6 translation 85 1.74E-7
13 SGTC_2543 pimpinellin 4.74 60.7 µM 1.03E-5 Golgi 4 1.08E-6
14 SGTC_924 2046-0044 4.67 21.3 µM 1.36E-5 6 1.53E-6
15 SGTC_2280 7785178 4.63 200.0 µM 1.57E-5 4 1.83E-6
16 SGTC_2127 5253358 4.59 187.9 µM 1.85E-5 14 2.25E-6
17 SGTC_3050 9093513 4.58 49.5 µM 1.89E-5 11 2.31E-6
18 SGTC_2100 5377183 4.56 190.0 µM 2.05E-5 60S ribosome export 5 2.55E-6
19 SGTC_625 k213-0058 4.53 121.0 µM 2.31E-5 translation 71 2.96E-6
20 SGTC_3083 9117465 4.52 49.5 µM 2.41E-5 7 3.13E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.240 3.68E-45 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.217 4.33E-37 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.213 7.68E-36 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.207 1.27E-33 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.200 1.76E-31 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.179 1.68E-25 YBR267W REI1 hom Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
0.178 3.05E-25 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.177 6.38E-25 YLR264C-A_p YLR264C-A_p hom Putative protein of unknown function
0.172 8.75E-24 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.172 8.84E-24 YNL248C RPA49 hom RNA polymerase I subunit A49
0.167 2.31E-22 YLR062C_d BUD28_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.166 4.00E-22 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.164 1.57E-21 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.161 5.59E-21 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.158 2.87E-20 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication