YLR065C / ENV10

Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR065C / ENV10

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:4.28|P-value:2.00E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.92|P-value:5.93E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:4.14|P-value:3.07E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.12|P-value:3.27E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.91|P-value:7.99E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:19.40|P-value:1.73E-57 ID:SGTC_192|Compound:3455-0609|FD-Score:4.80|P-value:3.73E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:5.25|P-value:7.32E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:4.14|P-value:3.10E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.97|P-value:2.01E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:5.68|P-value:1.41E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:9.17|P-value:2.33E-14 ID:SGTC_384|Compound:k007-0144|FD-Score:5.22|P-value:8.33E-6 ID:SGTC_413|Compound:propylparaben|FD-Score:4.04|P-value:4.20E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:11.50|P-value:2.64E-21 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.13|P-value:3.22E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:6.67|P-value:2.00E-8 ID:SGTC_553|Compound:k007-0256|FD-Score:3.76|P-value:9.34E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.04|P-value:4.17E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.87|P-value:2.94E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:8.88|P-value:1.47E-13 ID:SGTC_733|Compound:4069-0007|FD-Score:6.28|P-value:1.12E-7 ID:SGTC_796|Compound:1234-0020|FD-Score:7.25|P-value:1.21E-9 ID:SGTC_805|Compound:3852-0218|FD-Score:8.42|P-value:2.14E-12 ID:SGTC_834|Compound:0312-0008|FD-Score:4.10|P-value:3.50E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.91|P-value:6.01E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:6.07|P-value:2.78E-7 ID:SGTC_878|Compound:0828-0289|FD-Score:3.82|P-value:7.74E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.78|P-value:8.82E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-4.66|P-value:8.10E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:7.37|P-value:6.65E-10 ID:SGTC_1082|Compound:camptothecin|FD-Score:-8.63|P-value:1.10E-12 ID:SGTC_1086|Compound:cerivastatin|FD-Score:4.77|P-value:4.12E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.87|P-value:6.86E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-4.62|P-value:9.37E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.97|P-value:5.02E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.18|P-value:2.72E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.78|P-value:9.35E-7 ID:SGTC_1170|Compound:0310-0127|FD-Score:5.05|P-value:1.54E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.86|P-value:6.96E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.83|P-value:7.67E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.52|P-value:1.29E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-7.75|P-value:1.51E-10 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.53|P-value:9.16E-5 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.37|P-value:1.53E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:8.15|P-value:9.94E-12 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.91|P-value:7.84E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.23|P-value:2.32E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.95|P-value:5.40E-4 ID:SGTC_1751|Compound:st044839|FD-Score:6.35|P-value:8.38E-8 ID:SGTC_1752|Compound:st044819|FD-Score:9.83|P-value:3.35E-16 ID:SGTC_1757|Compound:st041620|FD-Score:4.20|P-value:2.60E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.17|P-value:2.79E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.90|P-value:8.07E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.04|P-value:5.43E-4 ID:SGTC_1999|Compound:st074831|FD-Score:6.02|P-value:3.51E-7 ID:SGTC_2016|Compound:5121758|FD-Score:4.65|P-value:6.15E-5 ID:SGTC_2049|Compound:5262831|FD-Score:4.67|P-value:5.76E-5 ID:SGTC_2057|Compound:5236571|FD-Score:4.52|P-value:9.49E-5 ID:SGTC_2077|Compound:5212015|FD-Score:4.80|P-value:3.67E-5 ID:SGTC_2185|Compound:6113692|FD-Score:-4.11|P-value:4.52E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.93|P-value:5.76E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.04|P-value:3.41E-9 ID:SGTC_2346|Compound:9031566|FD-Score:4.84|P-value:3.24E-5 ID:SGTC_2440|Compound:5628896|FD-Score:8.03|P-value:1.93E-11 ID:SGTC_2443|Compound:5493264|FD-Score:6.62|P-value:2.52E-8 ID:SGTC_2444|Compound:5485484|FD-Score:4.60|P-value:7.10E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:4.77|P-value:4.06E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:5.98|P-value:4.18E-7 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.97|P-value:2.02E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.96|P-value:2.12E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:6.76|P-value:1.27E-8 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.16|P-value:2.92E-4 ID:SGTC_2918|Compound:7977171|FD-Score:13.30|P-value:4.48E-28 ID:SGTC_2981|Compound:9013952|FD-Score:-5.89|P-value:8.68E-7 ID:SGTC_2982|Compound:9019404|FD-Score:6.16|P-value:1.94E-7 ID:SGTC_3071|Compound:9117417|FD-Score:3.79|P-value:8.43E-4 ID:SGTC_3126|Compound:9127922|FD-Score:5.13|P-value:1.14E-5 ID:SGTC_3151|Compound:9099821|FD-Score:3.99|P-value:4.86E-4 ID:SGTC_3200|Compound:9114385|FD-Score:5.43|P-value:3.76E-6 ID:SGTC_3203|Compound:9113543|FD-Score:4.23|P-value:2.33E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.43|P-value:1.25E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:4.28|P-value:2.00E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.92|P-value:5.93E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:4.14|P-value:3.07E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.12|P-value:3.27E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.91|P-value:7.99E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:19.40|P-value:1.73E-57 ID:SGTC_192|Compound:3455-0609|FD-Score:4.80|P-value:3.73E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:5.25|P-value:7.32E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:4.14|P-value:3.10E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.97|P-value:2.01E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:5.68|P-value:1.41E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:9.17|P-value:2.33E-14 ID:SGTC_384|Compound:k007-0144|FD-Score:5.22|P-value:8.33E-6 ID:SGTC_413|Compound:propylparaben|FD-Score:4.04|P-value:4.20E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:11.50|P-value:2.64E-21 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.13|P-value:3.22E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:6.67|P-value:2.00E-8 ID:SGTC_553|Compound:k007-0256|FD-Score:3.76|P-value:9.34E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.04|P-value:4.17E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.87|P-value:2.94E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:8.88|P-value:1.47E-13 ID:SGTC_733|Compound:4069-0007|FD-Score:6.28|P-value:1.12E-7 ID:SGTC_796|Compound:1234-0020|FD-Score:7.25|P-value:1.21E-9 ID:SGTC_805|Compound:3852-0218|FD-Score:8.42|P-value:2.14E-12 ID:SGTC_834|Compound:0312-0008|FD-Score:4.10|P-value:3.50E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.91|P-value:6.01E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:6.07|P-value:2.78E-7 ID:SGTC_878|Compound:0828-0289|FD-Score:3.82|P-value:7.74E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.78|P-value:8.82E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-4.66|P-value:8.10E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:7.37|P-value:6.65E-10 ID:SGTC_1082|Compound:camptothecin|FD-Score:-8.63|P-value:1.10E-12 ID:SGTC_1086|Compound:cerivastatin|FD-Score:4.77|P-value:4.12E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.87|P-value:6.86E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-4.62|P-value:9.37E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.97|P-value:5.02E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.18|P-value:2.72E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.78|P-value:9.35E-7 ID:SGTC_1170|Compound:0310-0127|FD-Score:5.05|P-value:1.54E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.86|P-value:6.96E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.83|P-value:7.67E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.52|P-value:1.29E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-7.75|P-value:1.51E-10 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.53|P-value:9.16E-5 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.37|P-value:1.53E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:8.15|P-value:9.94E-12 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.91|P-value:7.84E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.23|P-value:2.32E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.95|P-value:5.40E-4 ID:SGTC_1751|Compound:st044839|FD-Score:6.35|P-value:8.38E-8 ID:SGTC_1752|Compound:st044819|FD-Score:9.83|P-value:3.35E-16 ID:SGTC_1757|Compound:st041620|FD-Score:4.20|P-value:2.60E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.17|P-value:2.79E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.90|P-value:8.07E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.04|P-value:5.43E-4 ID:SGTC_1999|Compound:st074831|FD-Score:6.02|P-value:3.51E-7 ID:SGTC_2016|Compound:5121758|FD-Score:4.65|P-value:6.15E-5 ID:SGTC_2049|Compound:5262831|FD-Score:4.67|P-value:5.76E-5 ID:SGTC_2057|Compound:5236571|FD-Score:4.52|P-value:9.49E-5 ID:SGTC_2077|Compound:5212015|FD-Score:4.80|P-value:3.67E-5 ID:SGTC_2185|Compound:6113692|FD-Score:-4.11|P-value:4.52E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.93|P-value:5.76E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.04|P-value:3.41E-9 ID:SGTC_2346|Compound:9031566|FD-Score:4.84|P-value:3.24E-5 ID:SGTC_2440|Compound:5628896|FD-Score:8.03|P-value:1.93E-11 ID:SGTC_2443|Compound:5493264|FD-Score:6.62|P-value:2.52E-8 ID:SGTC_2444|Compound:5485484|FD-Score:4.60|P-value:7.10E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:4.77|P-value:4.06E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:5.98|P-value:4.18E-7 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.97|P-value:2.02E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.96|P-value:2.12E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:6.76|P-value:1.27E-8 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.16|P-value:2.92E-4 ID:SGTC_2918|Compound:7977171|FD-Score:13.30|P-value:4.48E-28 ID:SGTC_2981|Compound:9013952|FD-Score:-5.89|P-value:8.68E-7 ID:SGTC_2982|Compound:9019404|FD-Score:6.16|P-value:1.94E-7 ID:SGTC_3071|Compound:9117417|FD-Score:3.79|P-value:8.43E-4 ID:SGTC_3126|Compound:9127922|FD-Score:5.13|P-value:1.14E-5 ID:SGTC_3151|Compound:9099821|FD-Score:3.99|P-value:4.86E-4 ID:SGTC_3200|Compound:9114385|FD-Score:5.43|P-value:3.76E-6 ID:SGTC_3203|Compound:9113543|FD-Score:4.23|P-value:2.33E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.43|P-value:1.25E-4

Top fitness defect scores for YLR065C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 19.40 51.8 µM 1.73E-57 ERAD & cell cycle 4 1.70E-84
2 SGTC_2918 7977171 13.30 22.1 µM 4.48E-28 2 1.02E-40
3 SGTC_426 0988-0037 11.50 14.6 µM 2.64E-21 ERAD & cell cycle 3 1.16E-30
4 SGTC_1752 st044819 9.83 83.0 µM 3.35E-16 2 4.27E-23
5 SGTC_373 0844-0104 9.17 25.9 µM 2.33E-14 ERAD & cell cycle 11 2.28E-20
6 SGTC_682 0kpi-0099 8.88 17.0 µM 1.47E-13 11 3.49E-19
7 SGTC_805 3852-0218 8.42 479.0 µM 2.14E-12 ERAD & cell cycle 9 1.82E-17
8 SGTC_1447 4239-0816 8.15 81.9 µM 9.94E-12 2 1.76E-16
9 SGTC_2440 5628896 8.03 157.8 µM 1.93E-11 4 4.71E-16
10 SGTC_1069 diphenylcyclopropenone 7.37 8.5 µM 6.65E-10 4 8.69E-14
11 SGTC_796 1234-0020 7.25 70.7 µM 1.21E-9 SWF1 & branched chain AA biosynthesis 4 2.10E-13
12 SGTC_2322 7413319 7.04 38.2 µM 3.41E-9 ERAD & cell cycle 49 9.66E-13
13 SGTC_2721 ifenprodil 6.76 61.4 µM 1.27E-8 plasma membrane duress 5 6.72E-12
14 SGTC_533 1222-0222 6.67 6.7 µM 2.00E-8 PDR1 3 1.31E-11
15 SGTC_2443 5493264 6.62 126.7 µM 2.52E-8 4 1.83E-11
16 SGTC_1751 st044839 6.35 27.2 µM 8.38E-8 Golgi 2 1.07E-10
17 SGTC_733 4069-0007 6.28 56.1 µM 1.12E-7 ERAD & cell cycle 36 1.64E-10
18 SGTC_2982 9019404 6.16 26.0 µM 1.94E-7 7 3.69E-10
19 SGTC_871 0574-0004 6.07 149.0 µM 2.78E-7 13 6.24E-10
20 SGTC_1999 st074831 6.02 12.5 µM 3.51E-7 plasma membrane duress 13 8.80E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.327 3.01E-84 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.322 1.62E-81 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.291 1.94E-66 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.283 1.40E-62 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.278 2.42E-60 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.277 5.56E-60 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.259 2.37E-52 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.253 3.12E-50 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.253 6.03E-50 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.249 1.37E-48 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.241 1.19E-45 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.238 2.71E-44 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.234 1.05E-42 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.225 1.08E-39 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.224 2.83E-39 YNL026W SAM50 het Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85