YLR066W / SPC3

Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR066W / SPC3

Click on Significant Values for Screen Details ID:SGTC_75|Compound:0159-0059|FD-Score:3.33|P-value:3.64E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:2.69|P-value:6.64E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:2.93|P-value:2.44E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:2.64|P-value:8.11E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.04|P-value:1.43E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-2.89|P-value:3.38E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:2.59|P-value:9.89E-4 ID:SGTC_389|Compound:tpck|FD-Score:-3.13|P-value:1.17E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.74|P-value:4.34E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.18|P-value:7.69E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.87|P-value:3.11E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.48|P-value:5.06E-8 ID:SGTC_532|Compound:1548-0774|FD-Score:2.79|P-value:4.33E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-2.73|P-value:6.58E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.05|P-value:1.70E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.30|P-value:4.21E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:2.72|P-value:5.86E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.88|P-value:1.90E-6 ID:SGTC_820|Compound:1582-0060|FD-Score:-2.95|P-value:2.60E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:2.60|P-value:9.57E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.14|P-value:4.93E-10 ID:SGTC_1131|Compound:3454-3128|FD-Score:-2.84|P-value:4.28E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.09|P-value:5.77E-7 ID:SGTC_1182|Compound:1222-0449|FD-Score:-2.75|P-value:6.16E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-2.96|P-value:2.55E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.34|P-value:3.48E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:2.72|P-value:5.84E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.04|P-value:1.77E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.15|P-value:3.89E-7 ID:SGTC_1287|Compound:0971-0001|FD-Score:-2.69|P-value:7.86E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.43|P-value:7.02E-8 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.93|P-value:2.42E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:2.73|P-value:5.64E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.67|P-value:6.41E-6 ID:SGTC_1732|Compound:st034308|FD-Score:2.86|P-value:3.24E-4 ID:SGTC_1758|Compound:st042942|FD-Score:2.98|P-value:1.93E-4 ID:SGTC_1977|Compound:st070720|FD-Score:-2.69|P-value:7.90E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.65|P-value:7.83E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.87|P-value:3.44E-9 ID:SGTC_2044|Compound:5102272|FD-Score:3.46|P-value:1.87E-5 ID:SGTC_2050|Compound:5263056|FD-Score:-2.72|P-value:6.93E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.47|P-value:2.23E-5 ID:SGTC_2139|Compound:5578692|FD-Score:3.67|P-value:6.34E-6 ID:SGTC_2141|Compound:5621638|FD-Score:4.28|P-value:1.77E-7 ID:SGTC_2143|Compound:5623677|FD-Score:4.19|P-value:3.05E-7 ID:SGTC_2247|Compound:cerulenin|FD-Score:-4.21|P-value:3.58E-7 ID:SGTC_2252|Compound:omeprazole|FD-Score:2.75|P-value:5.12E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.98|P-value:1.95E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.47|P-value:2.20E-5 ID:SGTC_2426|Compound:5582046|FD-Score:4.33|P-value:1.34E-7 ID:SGTC_2433|Compound:5607874|FD-Score:-2.89|P-value:3.42E-4 ID:SGTC_2483|Compound:5729050|FD-Score:4.58|P-value:2.52E-8 ID:SGTC_2487|Compound:5918373|FD-Score:3.36|P-value:3.19E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:2.86|P-value:3.28E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.25|P-value:5.53E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:2.79|P-value:4.39E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-2.75|P-value:6.24E-4 ID:SGTC_2678|Compound:equilin|FD-Score:2.88|P-value:2.95E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:2.81|P-value:3.96E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:2.80|P-value:4.22E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-2.73|P-value:6.56E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.52|P-value:1.73E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-3.99|P-value:1.34E-6 ID:SGTC_2832|Compound:7992762|FD-Score:-5.82|P-value:3.20E-12 ID:SGTC_2833|Compound:9001315|FD-Score:-3.16|P-value:1.03E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-2.99|P-value:2.23E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.10|P-value:1.10E-4 ID:SGTC_3083|Compound:9117465|FD-Score:2.91|P-value:2.67E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-2.99|P-value:2.24E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.54|P-value:3.39E-8 ID:SGTC_3218|Compound:9131285|FD-Score:-2.88|P-value:3.52E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.33|P-value:3.64E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:2.69|P-value:6.64E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:2.93|P-value:2.44E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:2.64|P-value:8.11E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.04|P-value:1.43E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-2.89|P-value:3.38E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:2.59|P-value:9.89E-4 ID:SGTC_389|Compound:tpck|FD-Score:-3.13|P-value:1.17E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.74|P-value:4.34E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.18|P-value:7.69E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.87|P-value:3.11E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.48|P-value:5.06E-8 ID:SGTC_532|Compound:1548-0774|FD-Score:2.79|P-value:4.33E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-2.73|P-value:6.58E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.05|P-value:1.70E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.30|P-value:4.21E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:2.72|P-value:5.86E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.88|P-value:1.90E-6 ID:SGTC_820|Compound:1582-0060|FD-Score:-2.95|P-value:2.60E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:2.60|P-value:9.57E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.14|P-value:4.93E-10 ID:SGTC_1131|Compound:3454-3128|FD-Score:-2.84|P-value:4.28E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.09|P-value:5.77E-7 ID:SGTC_1182|Compound:1222-0449|FD-Score:-2.75|P-value:6.16E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-2.96|P-value:2.55E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.34|P-value:3.48E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:2.72|P-value:5.84E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.04|P-value:1.77E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.15|P-value:3.89E-7 ID:SGTC_1287|Compound:0971-0001|FD-Score:-2.69|P-value:7.86E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.43|P-value:7.02E-8 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.93|P-value:2.42E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:2.73|P-value:5.64E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.67|P-value:6.41E-6 ID:SGTC_1732|Compound:st034308|FD-Score:2.86|P-value:3.24E-4 ID:SGTC_1758|Compound:st042942|FD-Score:2.98|P-value:1.93E-4 ID:SGTC_1977|Compound:st070720|FD-Score:-2.69|P-value:7.90E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.65|P-value:7.83E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.87|P-value:3.44E-9 ID:SGTC_2044|Compound:5102272|FD-Score:3.46|P-value:1.87E-5 ID:SGTC_2050|Compound:5263056|FD-Score:-2.72|P-value:6.93E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.47|P-value:2.23E-5 ID:SGTC_2139|Compound:5578692|FD-Score:3.67|P-value:6.34E-6 ID:SGTC_2141|Compound:5621638|FD-Score:4.28|P-value:1.77E-7 ID:SGTC_2143|Compound:5623677|FD-Score:4.19|P-value:3.05E-7 ID:SGTC_2247|Compound:cerulenin|FD-Score:-4.21|P-value:3.58E-7 ID:SGTC_2252|Compound:omeprazole|FD-Score:2.75|P-value:5.12E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.98|P-value:1.95E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.47|P-value:2.20E-5 ID:SGTC_2426|Compound:5582046|FD-Score:4.33|P-value:1.34E-7 ID:SGTC_2433|Compound:5607874|FD-Score:-2.89|P-value:3.42E-4 ID:SGTC_2483|Compound:5729050|FD-Score:4.58|P-value:2.52E-8 ID:SGTC_2487|Compound:5918373|FD-Score:3.36|P-value:3.19E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:2.86|P-value:3.28E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.25|P-value:5.53E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:2.79|P-value:4.39E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-2.75|P-value:6.24E-4 ID:SGTC_2678|Compound:equilin|FD-Score:2.88|P-value:2.95E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:2.81|P-value:3.96E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:2.80|P-value:4.22E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-2.73|P-value:6.56E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.52|P-value:1.73E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-3.99|P-value:1.34E-6 ID:SGTC_2832|Compound:7992762|FD-Score:-5.82|P-value:3.20E-12 ID:SGTC_2833|Compound:9001315|FD-Score:-3.16|P-value:1.03E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-2.99|P-value:2.23E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.10|P-value:1.10E-4 ID:SGTC_3083|Compound:9117465|FD-Score:2.91|P-value:2.67E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-2.99|P-value:2.24E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.54|P-value:3.39E-8 ID:SGTC_3218|Compound:9131285|FD-Score:-2.88|P-value:3.52E-4

Top fitness defect scores for YLR066W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_829 1635-0120 5.14 117.0 µM 4.93E-10 DNA damage response 33 1.35E-7 0.04
2 SGTC_2035 5154463 4.87 94.6 µM 3.44E-9 4 5.46E-7 0.16
3 SGTC_2483 5729050 4.58 27.2 µM 2.52E-8 4 2.28E-6 0.23
4 SGTC_3210 9128157 4.54 49.5 µM 3.39E-8 7 2.83E-6 0.13
5 SGTC_455 paf C-16 4.48 10.0 µM 5.06E-8 5 3.77E-6 0.25
6 SGTC_1298 1079-1278 4.43 263.0 µM 7.02E-8 DNA damage response 2 4.77E-6 0.16
7 SGTC_2426 5582046 4.33 32.2 µM 1.34E-7 3 7.58E-6 0.06
8 SGTC_2141 5621638 4.28 7.7 µM 1.77E-7 tubulin folding & SWR complex 1 9.28E-6 0.54
9 SGTC_2143 5623677 4.19 140.5 µM 3.05E-7 2 1.37E-5 0.63
10 SGTC_1259 0671-0132 4.15 43.0 µM 3.89E-7 4 1.64E-5 0.39
11 SGTC_1134 3477-0009 4.09 42.5 µM 5.77E-7 10 2.17E-5 0.07
12 SGTC_736 0958-0254 3.88 92.6 µM 1.90E-6 Golgi 7 5.12E-5 0.18
13 SGTC_422 cantharidin 3.74 155.0 µM 4.34E-6 cell wall signaling 9 9.31E-5 0.03
14 SGTC_2139 5578692 3.67 56.5 µM 6.34E-6 superoxide 19 1.22E-4 0.03
15 SGTC_1702 st027038 3.67 51.0 µM 6.41E-6 2 1.23E-4 0.09
16 SGTC_2044 5102272 3.46 200.0 µM 1.87E-5 13 2.67E-4 0.02
17 SGTC_2487 5918373 3.36 44.0 µM 3.19E-5 8 3.93E-4 0.09
18 SGTC_1228 0124-0032 3.34 52.5 µM 3.48E-5 5 4.19E-4 0.02
19 SGTC_75 0159-0059 3.33 199.0 µM 3.64E-5 fatty acid desaturase (OLE1) 18 4.33E-4 0.11
20 SGTC_705 1124-0212 3.30 310.0 µM 4.21E-5 15 4.81E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 6.57E-17 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.133 8.68E-15 YML023C NSE5 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.129 5.69E-14 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.127 1.76E-13 YJR012C_p YJR012C_p het Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
0.106 7.45E-10 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.105 1.02E-9 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.101 4.29E-9 YDR128W MTC5 hom Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress
0.101 4.63E-9 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.100 5.50E-9 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.095 3.83E-8 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.094 4.28E-8 YAL048C GEM1 hom Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases
0.092 7.97E-8 YDR279W RNH202 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome
0.090 1.86E-7 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.089 2.25E-7 YGL091C NBP35 het Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
0.089 2.51E-7 YLR310C CDC25 het Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1