YLR069C / MEF1

Mitochondrial elongation factor involved in translational elongation

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR069C / MEF1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.21|P-value:4.40E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.79|P-value:2.00E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.82|P-value:3.16E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:5.25|P-value:5.07E-7 ID:SGTC_172|Compound:1112-0046|FD-Score:-4.11|P-value:8.47E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:11.90|P-value:2.01E-28 ID:SGTC_182|Compound:3448-4371|FD-Score:4.41|P-value:2.01E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:10.50|P-value:1.18E-22 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.03|P-value:3.41E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:13.70|P-value:2.77E-37 ID:SGTC_314|Compound:1671-0008|FD-Score:4.93|P-value:2.24E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.86|P-value:4.20E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.23|P-value:8.29E-7 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.81|P-value:1.87E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:4.42|P-value:1.94E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:4.22|P-value:4.20E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:3.68|P-value:2.99E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.58|P-value:4.22E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.69|P-value:2.88E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.33|P-value:9.36E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.58|P-value:4.09E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.77|P-value:2.90E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.79|P-value:2.06E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.96|P-value:1.46E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.37|P-value:8.33E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.57|P-value:4.24E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.09|P-value:6.86E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.59|P-value:3.99E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.47|P-value:5.94E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:6.11|P-value:6.77E-9 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.86|P-value:1.61E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.95|P-value:1.14E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.49|P-value:1.46E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.85|P-value:1.66E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.73|P-value:2.47E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.92|P-value:2.35E-6 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.85|P-value:2.14E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.67|P-value:3.02E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.48|P-value:1.49E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.50|P-value:5.36E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.71|P-value:2.68E-4 ID:SGTC_1627|Compound:st003713|FD-Score:7.37|P-value:3.92E-12 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.11|P-value:6.45E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-3.66|P-value:4.20E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.18|P-value:6.56E-5 ID:SGTC_1742|Compound:st038235|FD-Score:13.60|P-value:9.36E-37 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.31|P-value:5.70E-7 ID:SGTC_1882|Compound:5615643|FD-Score:4.07|P-value:7.30E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.89|P-value:2.66E-6 ID:SGTC_2010|Compound:4012422|FD-Score:3.35|P-value:8.67E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.06|P-value:7.67E-5 ID:SGTC_2077|Compound:5212015|FD-Score:4.59|P-value:9.56E-6 ID:SGTC_2136|Compound:5328288|FD-Score:-5.51|P-value:2.23E-7 ID:SGTC_2157|Compound:5649910|FD-Score:-3.46|P-value:7.83E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.61|P-value:4.89E-4 ID:SGTC_2167|Compound:5876490|FD-Score:4.04|P-value:8.20E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.62|P-value:3.61E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-5.11|P-value:1.41E-6 ID:SGTC_2242|Compound:6630449|FD-Score:-5.12|P-value:1.38E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.31|P-value:5.90E-12 ID:SGTC_2254|Compound:7938975|FD-Score:3.95|P-value:1.15E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.23|P-value:4.11E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-7.09|P-value:3.83E-11 ID:SGTC_2301|Compound:7769476|FD-Score:-3.75|P-value:3.07E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.50|P-value:1.39E-5 ID:SGTC_2367|Compound:9070478|FD-Score:-3.60|P-value:5.03E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.42|P-value:7.07E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-4.57|P-value:1.43E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.30|P-value:3.10E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.09|P-value:1.09E-6 ID:SGTC_2698|Compound:st077697|FD-Score:-4.01|P-value:1.24E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-7.34|P-value:7.92E-12 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.58|P-value:1.39E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.94|P-value:1.20E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.14|P-value:7.56E-5 ID:SGTC_2926|Compound:9010726|FD-Score:3.40|P-value:7.42E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.68|P-value:2.97E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-7.01|P-value:5.98E-11 ID:SGTC_2947|Compound:9072639|FD-Score:-7.06|P-value:4.57E-11 ID:SGTC_2954|Compound:9074818|FD-Score:7.32|P-value:5.36E-12 ID:SGTC_2960|Compound:9079389|FD-Score:4.26|P-value:3.63E-5 ID:SGTC_3194|Compound:9111903|FD-Score:4.19|P-value:4.63E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:4.21|P-value:4.40E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.79|P-value:2.00E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.82|P-value:3.16E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:5.25|P-value:5.07E-7 ID:SGTC_172|Compound:1112-0046|FD-Score:-4.11|P-value:8.47E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:11.90|P-value:2.01E-28 ID:SGTC_182|Compound:3448-4371|FD-Score:4.41|P-value:2.01E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:10.50|P-value:1.18E-22 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.03|P-value:3.41E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:13.70|P-value:2.77E-37 ID:SGTC_314|Compound:1671-0008|FD-Score:4.93|P-value:2.24E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.86|P-value:4.20E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.23|P-value:8.29E-7 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.81|P-value:1.87E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:4.42|P-value:1.94E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:4.22|P-value:4.20E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:3.68|P-value:2.99E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.58|P-value:4.22E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.69|P-value:2.88E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.33|P-value:9.36E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.58|P-value:4.09E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.77|P-value:2.90E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.79|P-value:2.06E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.96|P-value:1.46E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.37|P-value:8.33E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.57|P-value:4.24E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.09|P-value:6.86E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.59|P-value:3.99E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.47|P-value:5.94E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:6.11|P-value:6.77E-9 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.86|P-value:1.61E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.95|P-value:1.14E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.49|P-value:1.46E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.85|P-value:1.66E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.73|P-value:2.47E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.92|P-value:2.35E-6 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.85|P-value:2.14E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.67|P-value:3.02E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.48|P-value:1.49E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.50|P-value:5.36E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.71|P-value:2.68E-4 ID:SGTC_1627|Compound:st003713|FD-Score:7.37|P-value:3.92E-12 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.11|P-value:6.45E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-3.66|P-value:4.20E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.18|P-value:6.56E-5 ID:SGTC_1742|Compound:st038235|FD-Score:13.60|P-value:9.36E-37 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.31|P-value:5.70E-7 ID:SGTC_1882|Compound:5615643|FD-Score:4.07|P-value:7.30E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.89|P-value:2.66E-6 ID:SGTC_2010|Compound:4012422|FD-Score:3.35|P-value:8.67E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.06|P-value:7.67E-5 ID:SGTC_2077|Compound:5212015|FD-Score:4.59|P-value:9.56E-6 ID:SGTC_2136|Compound:5328288|FD-Score:-5.51|P-value:2.23E-7 ID:SGTC_2157|Compound:5649910|FD-Score:-3.46|P-value:7.83E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.61|P-value:4.89E-4 ID:SGTC_2167|Compound:5876490|FD-Score:4.04|P-value:8.20E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.62|P-value:3.61E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-5.11|P-value:1.41E-6 ID:SGTC_2242|Compound:6630449|FD-Score:-5.12|P-value:1.38E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.31|P-value:5.90E-12 ID:SGTC_2254|Compound:7938975|FD-Score:3.95|P-value:1.15E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.23|P-value:4.11E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-7.09|P-value:3.83E-11 ID:SGTC_2301|Compound:7769476|FD-Score:-3.75|P-value:3.07E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.50|P-value:1.39E-5 ID:SGTC_2367|Compound:9070478|FD-Score:-3.60|P-value:5.03E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.42|P-value:7.07E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-4.57|P-value:1.43E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.30|P-value:3.10E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.09|P-value:1.09E-6 ID:SGTC_2698|Compound:st077697|FD-Score:-4.01|P-value:1.24E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-7.34|P-value:7.92E-12 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.58|P-value:1.39E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.94|P-value:1.20E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.14|P-value:7.56E-5 ID:SGTC_2926|Compound:9010726|FD-Score:3.40|P-value:7.42E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.68|P-value:2.97E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-7.01|P-value:5.98E-11 ID:SGTC_2947|Compound:9072639|FD-Score:-7.06|P-value:4.57E-11 ID:SGTC_2954|Compound:9074818|FD-Score:7.32|P-value:5.36E-12 ID:SGTC_2960|Compound:9079389|FD-Score:4.26|P-value:3.63E-5 ID:SGTC_3194|Compound:9111903|FD-Score:4.19|P-value:4.63E-5

Top fitness defect scores for YLR069C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 13.70 1.1 µM 2.77E-37 mitochondrial stress 12 3.95E-43
2 SGTC_1742 st038235 13.60 28.9 µM 9.36E-37 mitochondrial stress 1 1.64E-42
3 SGTC_173 1273-0061 11.90 2.7 µM 2.01E-28 mitochondrial stress 27 8.80E-33
4 SGTC_236 1509-0011 10.50 5.3 µM 1.18E-22 188 4.76E-26
5 SGTC_1627 st003713 7.37 25.6 µM 3.92E-12 calcium & mitochondrial duress 18 8.60E-14
6 SGTC_2954 9074818 7.32 52.7 µM 5.36E-12 6 1.24E-13
7 SGTC_2250 alverine citrate 7.31 130.0 µM 5.90E-12 30 1.38E-13
8 SGTC_275 trichlorophene 7.03 5.7 µM 3.41E-11 mitochondrial stress 93 1.06E-12
9 SGTC_1368 1852-0141 6.11 284.0 µM 6.77E-9 ERG2 8 4.97E-10
10 SGTC_63 0099-0242 5.82 26.7 µM 3.16E-8 mitochondrial stress 29 2.97E-9
11 SGTC_70 0141-0289 5.25 43.3 µM 5.07E-7 mitochondrial stress 106 7.41E-8
12 SGTC_2682 pyrogallin 5.09 40.0 µM 1.09E-6 copper-dependent oxidative stress 10 1.80E-7
13 SGTC_314 1671-0008 4.93 2.7 µM 2.24E-6 24 4.14E-7
14 SGTC_1544 7-methoxy-4-methylcoumarin 4.92 105.0 µM 2.35E-6 7 4.39E-7
15 SGTC_1883 5-benzylidenerhodanine 4.89 20.0 µM 2.66E-6 TRP & mitochondrial translation 34 5.04E-7
16 SGTC_2077 5212015 4.59 200.0 µM 9.56E-6 44 2.22E-6
17 SGTC_2361 9034121 4.50 116.0 µM 1.39E-5 RSC complex & mRNA processing 12 3.42E-6
18 SGTC_1373 2887-0003 4.49 58.5 µM 1.46E-5 Golgi 13 3.62E-6
19 SGTC_1623 st003709 4.48 20.3 µM 1.49E-5 calcium & mitochondrial duress 50 3.69E-6
20 SGTC_629 3448-6466 4.42 76.7 µM 1.94E-5 10 5.02E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.502 4.39E-214 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.499 7.68E-211 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.484 2.18E-196 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.481 1.35E-193 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.475 2.15E-188 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.471 5.61E-185 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.459 2.05E-174 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.456 4.28E-172 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.454 9.35E-170 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.450 3.39E-167 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.448 1.74E-165 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.445 2.96E-163 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.443 1.58E-161 YIL060W_p YIL060W_p hom Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene
0.439 1.19E-157 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.438 3.57E-157 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene