YLR070C / XYL2

Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR070C / XYL2

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.25|P-value:6.19E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.70|P-value:1.03E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.27|P-value:5.91E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.29|P-value:4.76E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.29|P-value:4.83E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.23|P-value:6.79E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.55|P-value:2.14E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.18|P-value:7.87E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.79|P-value:8.14E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.51|P-value:2.45E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.51|P-value:2.43E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.60|P-value:1.74E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.32|P-value:8.57E-6 ID:SGTC_1505|Compound:k297-0037|FD-Score:6.64|P-value:1.86E-11 ID:SGTC_1522|Compound:st012842|FD-Score:-3.09|P-value:9.46E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.15|P-value:8.86E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.61|P-value:1.45E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.34|P-value:4.56E-4 ID:SGTC_1900|Compound:st060200|FD-Score:5.02|P-value:2.93E-7 ID:SGTC_1907|Compound:st060210|FD-Score:3.17|P-value:8.24E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.24|P-value:5.69E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.45|P-value:3.07E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.28|P-value:5.53E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.56|P-value:2.01E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.87|P-value:5.24E-5 ID:SGTC_2340|Compound:7987427|FD-Score:-3.46|P-value:2.56E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.13|P-value:9.48E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.91|P-value:4.98E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.49|P-value:2.65E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.37|P-value:3.62E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.29|P-value:5.40E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.34|P-value:4.56E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.27|P-value:9.20E-6 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.57|P-value:1.94E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.46|P-value:2.54E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.82|P-value:6.23E-5 ID:SGTC_2923|Compound:7992654|FD-Score:4.46|P-value:4.64E-6 ID:SGTC_3082|Compound:9117008|FD-Score:3.56|P-value:2.02E-4 ID:SGTC_3147|Compound:9097027|FD-Score:6.00|P-value:1.16E-9 ID:SGTC_3151|Compound:9099821|FD-Score:-3.96|P-value:3.49E-5 ID:SGTC_3206|Compound:9114350|FD-Score:5.02|P-value:2.91E-7 ID:SGTC_3265|Compound:9137266|FD-Score:-3.91|P-value:4.46E-5 ID:SGTC_3277|Compound:9138724|FD-Score:-3.32|P-value:4.28E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.25|P-value:6.19E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.70|P-value:1.03E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.27|P-value:5.91E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.29|P-value:4.76E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.29|P-value:4.83E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.23|P-value:6.79E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.55|P-value:2.14E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.18|P-value:7.87E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.79|P-value:8.14E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.51|P-value:2.45E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.51|P-value:2.43E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.60|P-value:1.74E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.32|P-value:8.57E-6 ID:SGTC_1505|Compound:k297-0037|FD-Score:6.64|P-value:1.86E-11 ID:SGTC_1522|Compound:st012842|FD-Score:-3.09|P-value:9.46E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.15|P-value:8.86E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.61|P-value:1.45E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.34|P-value:4.56E-4 ID:SGTC_1900|Compound:st060200|FD-Score:5.02|P-value:2.93E-7 ID:SGTC_1907|Compound:st060210|FD-Score:3.17|P-value:8.24E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.24|P-value:5.69E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.45|P-value:3.07E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.28|P-value:5.53E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.56|P-value:2.01E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.87|P-value:5.24E-5 ID:SGTC_2340|Compound:7987427|FD-Score:-3.46|P-value:2.56E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.13|P-value:9.48E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.91|P-value:4.98E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.49|P-value:2.65E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.37|P-value:3.62E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.29|P-value:5.40E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.34|P-value:4.56E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.27|P-value:9.20E-6 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.57|P-value:1.94E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.46|P-value:2.54E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.82|P-value:6.23E-5 ID:SGTC_2923|Compound:7992654|FD-Score:4.46|P-value:4.64E-6 ID:SGTC_3082|Compound:9117008|FD-Score:3.56|P-value:2.02E-4 ID:SGTC_3147|Compound:9097027|FD-Score:6.00|P-value:1.16E-9 ID:SGTC_3151|Compound:9099821|FD-Score:-3.96|P-value:3.49E-5 ID:SGTC_3206|Compound:9114350|FD-Score:5.02|P-value:2.91E-7 ID:SGTC_3265|Compound:9137266|FD-Score:-3.91|P-value:4.46E-5 ID:SGTC_3277|Compound:9138724|FD-Score:-3.32|P-value:4.28E-4

Top fitness defect scores for YLR070C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1505 k297-0037 6.64 20.6 µM 1.86E-11 4 1.56E-11
2 SGTC_3147 9097027 6.00 49.5 µM 1.16E-9 4 9.92E-10
3 SGTC_3206 9114350 5.02 49.5 µM 2.91E-7 5 2.56E-7
4 SGTC_1900 st060200 5.02 72.8 µM 2.93E-7 8 2.58E-7
5 SGTC_2923 7992654 4.46 58.1 µM 4.64E-6 Golgi 16 4.15E-6
6 SGTC_1503 4585-0012 4.32 61.3 µM 8.57E-6 8 7.71E-6
7 SGTC_2441 5730946 3.91 39.1 µM 4.98E-5 16 4.53E-5
8 SGTC_919 tnp00227 3.79 403.6 nM 8.14E-5 RNA pol III & RNase P/MRP 40 7.43E-5
9 SGTC_1418 3966-3099 3.60 2.4 µM 1.74E-4 32 1.60E-4
10 SGTC_2541 muurolladie-3-one 3.57 83.1 µM 1.94E-4 excess fatty acid 45 1.78E-4
11 SGTC_2074 5212007 3.56 75.4 µM 2.01E-4 20 1.84E-4
12 SGTC_3082 9117008 3.56 49.5 µM 2.02E-4 26 1.85E-4
13 SGTC_690 glyoxal 3.55 20.3 µM 2.14E-4 102 1.96E-4
14 SGTC_1389 3405-0187 3.51 19.0 µM 2.43E-4 27 2.23E-4
15 SGTC_1061 3448-9325 3.51 110.0 µM 2.45E-4 34 2.25E-4
16 SGTC_2472 5377652 3.49 49.4 µM 2.65E-4 TRP & mitochondrial translation 79 2.44E-4
17 SGTC_1958 st076513 3.45 41.9 µM 3.07E-4 60S ribosome export 52 2.83E-4
18 SGTC_1888 azatryptophan 3.34 97.5 µM 4.56E-4 35 4.21E-4
19 SGTC_2517 totarol 3.34 10.0 µM 4.56E-4 39 4.22E-4
20 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.29 3.7 µM 5.40E-4 152 4.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 2.28E-22 YNR031C SSK2 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
0.118 6.13E-12 YJR006W POL31 het Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair
0.112 7.78E-11 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.112 8.39E-11 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.102 3.09E-9 YJL110C GZF3 hom GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication
0.102 3.52E-9 YOR220W RCN2 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress
0.098 1.17E-8 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.098 1.21E-8 YGL001C ERG26 het C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
0.097 1.57E-8 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.092 9.63E-8 YLR113W HOG1 hom Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress
0.089 2.51E-7 YPL227C ALG5 hom UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
0.087 4.08E-7 YPL082C MOT1 het Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA
0.085 8.41E-7 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.085 9.26E-7 YGR026W_p YGR026W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.082 1.81E-6 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7