YLR075W / RPL10

Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR075W / RPL10

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:4.02|P-value:8.10E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:5.55|P-value:6.72E-6 ID:SGTC_88|Compound:0180-0332|FD-Score:4.85|P-value:7.10E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:4.50|P-value:2.06E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:7.35|P-value:4.25E-9 ID:SGTC_375|Compound:3970-0961|FD-Score:4.31|P-value:3.61E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:4.00|P-value:8.54E-4 ID:SGTC_394|Compound:menadione|FD-Score:-4.68|P-value:1.35E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:5.44|P-value:9.91E-6 ID:SGTC_612|Compound:0302-0167|FD-Score:4.95|P-value:5.19E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:4.46|P-value:2.36E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:6.57|P-value:1.35E-7 ID:SGTC_889|Compound:0919-1524|FD-Score:4.16|P-value:5.48E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-4.10|P-value:7.17E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-4.20|P-value:5.48E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.98|P-value:8.93E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.09|P-value:6.65E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.23|P-value:4.48E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.59|P-value:1.58E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.94|P-value:9.84E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:5.94|P-value:1.65E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:7.57|P-value:1.53E-9 ID:SGTC_1522|Compound:st012842|FD-Score:-5.76|P-value:3.66E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.02|P-value:8.10E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-5.88|P-value:2.39E-6 ID:SGTC_1702|Compound:st027038|FD-Score:4.87|P-value:6.65E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-4.36|P-value:3.46E-4 ID:SGTC_1803|Compound:st050068|FD-Score:-4.17|P-value:5.96E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.40|P-value:2.81E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.16|P-value:5.53E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.80|P-value:9.35E-5 ID:SGTC_1963|Compound:st076565|FD-Score:4.18|P-value:5.24E-4 ID:SGTC_1978|Compound:st071761|FD-Score:-5.10|P-value:3.58E-5 ID:SGTC_1993|Compound:st073995|FD-Score:6.17|P-value:6.63E-7 ID:SGTC_2016|Compound:5121758|FD-Score:4.34|P-value:3.35E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.00|P-value:9.26E-4 ID:SGTC_2050|Compound:5263056|FD-Score:8.34|P-value:3.23E-11 ID:SGTC_2052|Compound:5265182|FD-Score:-4.42|P-value:2.95E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.44|P-value:2.51E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-4.90|P-value:6.85E-5 ID:SGTC_2290|Compound:7904846|FD-Score:5.11|P-value:3.04E-5 ID:SGTC_2309|Compound:7664088|FD-Score:7.83|P-value:4.49E-10 ID:SGTC_2344|Compound:7990960|FD-Score:6.31|P-value:3.87E-7 ID:SGTC_2350|Compound:9023895|FD-Score:-5.55|P-value:7.79E-6 ID:SGTC_2367|Compound:9070478|FD-Score:-3.98|P-value:9.98E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.31|P-value:4.05E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.72|P-value:1.07E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-4.71|P-value:1.26E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.78|P-value:9.97E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.30|P-value:4.19E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.69|P-value:1.17E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.40|P-value:3.09E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.96|P-value:9.40E-4 ID:SGTC_2920|Compound:7982904|FD-Score:5.00|P-value:4.36E-5 ID:SGTC_2927|Compound:9011802|FD-Score:5.92|P-value:1.75E-6 ID:SGTC_2970|Compound:9090938|FD-Score:4.80|P-value:8.29E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-4.35|P-value:3.61E-4 ID:SGTC_3050|Compound:9093513|FD-Score:5.71|P-value:3.89E-6 ID:SGTC_3130|Compound:9127414|FD-Score:5.25|P-value:1.96E-5 ID:SGTC_3346|Compound:9158254|FD-Score:4.06|P-value:7.12E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:4.02|P-value:8.10E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:5.55|P-value:6.72E-6 ID:SGTC_88|Compound:0180-0332|FD-Score:4.85|P-value:7.10E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:4.50|P-value:2.06E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:7.35|P-value:4.25E-9 ID:SGTC_375|Compound:3970-0961|FD-Score:4.31|P-value:3.61E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:4.00|P-value:8.54E-4 ID:SGTC_394|Compound:menadione|FD-Score:-4.68|P-value:1.35E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:5.44|P-value:9.91E-6 ID:SGTC_612|Compound:0302-0167|FD-Score:4.95|P-value:5.19E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:4.46|P-value:2.36E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:6.57|P-value:1.35E-7 ID:SGTC_889|Compound:0919-1524|FD-Score:4.16|P-value:5.48E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-4.10|P-value:7.17E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-4.20|P-value:5.48E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.98|P-value:8.93E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.09|P-value:6.65E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.23|P-value:4.48E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.59|P-value:1.58E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.94|P-value:9.84E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:5.94|P-value:1.65E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:7.57|P-value:1.53E-9 ID:SGTC_1522|Compound:st012842|FD-Score:-5.76|P-value:3.66E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.02|P-value:8.10E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-5.88|P-value:2.39E-6 ID:SGTC_1702|Compound:st027038|FD-Score:4.87|P-value:6.65E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-4.36|P-value:3.46E-4 ID:SGTC_1803|Compound:st050068|FD-Score:-4.17|P-value:5.96E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.40|P-value:2.81E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.16|P-value:5.53E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.80|P-value:9.35E-5 ID:SGTC_1963|Compound:st076565|FD-Score:4.18|P-value:5.24E-4 ID:SGTC_1978|Compound:st071761|FD-Score:-5.10|P-value:3.58E-5 ID:SGTC_1993|Compound:st073995|FD-Score:6.17|P-value:6.63E-7 ID:SGTC_2016|Compound:5121758|FD-Score:4.34|P-value:3.35E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.00|P-value:9.26E-4 ID:SGTC_2050|Compound:5263056|FD-Score:8.34|P-value:3.23E-11 ID:SGTC_2052|Compound:5265182|FD-Score:-4.42|P-value:2.95E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.44|P-value:2.51E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-4.90|P-value:6.85E-5 ID:SGTC_2290|Compound:7904846|FD-Score:5.11|P-value:3.04E-5 ID:SGTC_2309|Compound:7664088|FD-Score:7.83|P-value:4.49E-10 ID:SGTC_2344|Compound:7990960|FD-Score:6.31|P-value:3.87E-7 ID:SGTC_2350|Compound:9023895|FD-Score:-5.55|P-value:7.79E-6 ID:SGTC_2367|Compound:9070478|FD-Score:-3.98|P-value:9.98E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.31|P-value:4.05E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.72|P-value:1.07E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-4.71|P-value:1.26E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.78|P-value:9.97E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.30|P-value:4.19E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.69|P-value:1.17E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.40|P-value:3.09E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.96|P-value:9.40E-4 ID:SGTC_2920|Compound:7982904|FD-Score:5.00|P-value:4.36E-5 ID:SGTC_2927|Compound:9011802|FD-Score:5.92|P-value:1.75E-6 ID:SGTC_2970|Compound:9090938|FD-Score:4.80|P-value:8.29E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-4.35|P-value:3.61E-4 ID:SGTC_3050|Compound:9093513|FD-Score:5.71|P-value:3.89E-6 ID:SGTC_3130|Compound:9127414|FD-Score:5.25|P-value:1.96E-5 ID:SGTC_3346|Compound:9158254|FD-Score:4.06|P-value:7.12E-4

Top fitness defect scores for YLR075W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2050 5263056 8.34 171.0 µM 3.23E-11 fatty acid desaturase (OLE1) 6 3.56E-17 0.02
2 SGTC_2309 7664088 7.83 163.9 µM 4.49E-10 1 2.54E-15 1.36
3 SGTC_1513 0337-0559 7.57 19.0 µM 1.53E-9 1 1.84E-14 1.48
4 SGTC_288 1315-0019 7.35 35.1 µM 4.25E-9 RSC & ERG11 7 9.68E-14 1.67
5 SGTC_887 0885-0007 6.57 9.6 µM 1.35E-7 endomembrane recycling 6 2.59E-11 0.31
6 SGTC_2344 7990960 6.31 77.0 µM 3.87E-7 17 1.42E-10 0.29
7 SGTC_1993 st073995 6.17 70.8 µM 6.63E-7 1 3.36E-10 0.85
8 SGTC_1449 4112-4002 5.94 201.0 µM 1.65E-6 RPP1 & pyrimidine depletion 1 1.46E-9 0.85
9 SGTC_2927 9011802 5.92 47.9 µM 1.75E-6 2 1.60E-9 0.56
10 SGTC_3050 9093513 5.71 49.5 µM 3.89E-6 2 5.80E-9 0.68
11 SGTC_16 erodoxin 5.55 22.8 µM 6.72E-6 unfolded protein response 13 1.40E-8 0.10
12 SGTC_562 3772-2733 5.44 112.0 µM 9.91E-6 ERG2 6 2.61E-8 0.27
13 SGTC_3130 9127414 5.25 49.5 µM 1.96E-5 1 7.80E-8 0.84
14 SGTC_2290 7904846 5.11 200.0 µM 3.04E-5 6 1.57E-7 0.01
15 SGTC_2920 7982904 5.00 15.8 µM 4.36E-5 6 2.80E-7 0.15
16 SGTC_612 0302-0167 4.95 22.4 µM 5.19E-5 copper-dependent oxidative stress 4 3.70E-7 0.69
17 SGTC_1702 st027038 4.87 51.0 µM 6.65E-5 1 5.50E-7 1.21
18 SGTC_88 0180-0332 4.85 8.7 µM 7.10E-5 5 6.11E-7 0.72
19 SGTC_2970 9090938 4.80 41.9 µM 8.29E-5 RNA processing & uracil transport 5 7.82E-7 0.21
20 SGTC_2538 3',7'-epoxycaryophyllan-6-one 4.72 100.0 µM 1.07E-4 4 1.17E-6 0.14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 2.32E-24 YLR076C_d YLR076C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
0.172 1.27E-23 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.154 2.39E-19 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.151 1.36E-18 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.147 1.42E-17 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.145 3.91E-17 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.143 9.17E-17 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.137 1.70E-15 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.133 1.33E-14 YPL142C_d YPL142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
0.122 1.13E-12 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.119 3.98E-12 YDR449C UTP6 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.111 1.14E-10 YHR069C RRP4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.108 4.14E-10 YGL030W RPL30 het Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
0.106 7.53E-10 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.106 7.56E-10 YBR140C IRA1 het GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication