YLR076C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR076C / YLR076C

Click on Significant Values for Screen Details ID:SGTC_105|Compound:0111-0055|FD-Score:4.77|P-value:7.82E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:-4.79|P-value:6.89E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:5.37|P-value:1.04E-5 ID:SGTC_264|Compound:promethazine|FD-Score:5.31|P-value:1.30E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-4.54|P-value:1.50E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.49|P-value:1.90E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:4.37|P-value:2.73E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:5.32|P-value:1.24E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:5.88|P-value:1.61E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:4.91|P-value:4.97E-5 ID:SGTC_394|Compound:menadione|FD-Score:-4.75|P-value:7.84E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-5.85|P-value:1.64E-6 ID:SGTC_501|Compound:nsc-95397|FD-Score:6.18|P-value:4.90E-7 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-5.08|P-value:2.67E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:4.19|P-value:4.57E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-4.00|P-value:7.20E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.67|P-value:1.01E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.14|P-value:5.28E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.96|P-value:4.25E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.56|P-value:1.50E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.95|P-value:8.86E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.07|P-value:6.03E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-4.26|P-value:3.47E-4 ID:SGTC_1812|Compound:st052057|FD-Score:6.45|P-value:1.58E-7 ID:SGTC_1930|Compound:st074634|FD-Score:-5.15|P-value:2.09E-5 ID:SGTC_1956|Compound:st077085|FD-Score:4.88|P-value:5.64E-5 ID:SGTC_1960|Compound:st011366|FD-Score:5.73|P-value:2.85E-6 ID:SGTC_1992|Compound:st073643|FD-Score:4.22|P-value:4.16E-4 ID:SGTC_2309|Compound:7664088|FD-Score:6.18|P-value:4.95E-7 ID:SGTC_2337|Compound:9009472|FD-Score:4.20|P-value:4.43E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.83|P-value:6.09E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-4.75|P-value:7.99E-5 ID:SGTC_2701|Compound:st077767|FD-Score:-4.53|P-value:1.55E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:5.66|P-value:3.60E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.93|P-value:4.43E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.51|P-value:1.64E-4 ID:SGTC_2838|Compound:9002687|FD-Score:7.84|P-value:2.53E-10 ID:SGTC_2887|Compound:9044784|FD-Score:4.35|P-value:2.88E-4 ID:SGTC_2923|Compound:7992654|FD-Score:5.01|P-value:3.68E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-5.88|P-value:1.48E-6 ID:SGTC_2927|Compound:9011802|FD-Score:6.56|P-value:9.91E-8 ID:SGTC_3032|Compound:9089427|FD-Score:-4.29|P-value:3.24E-4 ID:SGTC_3033|Compound:9090887|FD-Score:5.38|P-value:9.99E-6 ID:SGTC_3081|Compound:9117243|FD-Score:4.11|P-value:5.73E-4 ID:SGTC_3093|Compound:9117344|FD-Score:4.13|P-value:5.38E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-4.59|P-value:1.29E-4 ID:SGTC_3129|Compound:9127257|FD-Score:5.10|P-value:2.70E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-5.88|P-value:1.48E-6 ID:SGTC_3139|Compound:9095020|FD-Score:-5.24|P-value:1.53E-5 ID:SGTC_3170|Compound:9103054|FD-Score:-4.80|P-value:6.81E-5 ID:SGTC_3181|Compound:9108277|FD-Score:-4.20|P-value:4.11E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.93|P-value:8.72E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-4.57|P-value:1.37E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:4.77|P-value:7.82E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:-4.79|P-value:6.89E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:5.37|P-value:1.04E-5 ID:SGTC_264|Compound:promethazine|FD-Score:5.31|P-value:1.30E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-4.54|P-value:1.50E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.49|P-value:1.90E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:4.37|P-value:2.73E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:5.32|P-value:1.24E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:5.88|P-value:1.61E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:4.91|P-value:4.97E-5 ID:SGTC_394|Compound:menadione|FD-Score:-4.75|P-value:7.84E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-5.85|P-value:1.64E-6 ID:SGTC_501|Compound:nsc-95397|FD-Score:6.18|P-value:4.90E-7 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-5.08|P-value:2.67E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:4.19|P-value:4.57E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-4.00|P-value:7.20E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.67|P-value:1.01E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.14|P-value:5.28E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.96|P-value:4.25E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.56|P-value:1.50E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.95|P-value:8.86E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.07|P-value:6.03E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-4.26|P-value:3.47E-4 ID:SGTC_1812|Compound:st052057|FD-Score:6.45|P-value:1.58E-7 ID:SGTC_1930|Compound:st074634|FD-Score:-5.15|P-value:2.09E-5 ID:SGTC_1956|Compound:st077085|FD-Score:4.88|P-value:5.64E-5 ID:SGTC_1960|Compound:st011366|FD-Score:5.73|P-value:2.85E-6 ID:SGTC_1992|Compound:st073643|FD-Score:4.22|P-value:4.16E-4 ID:SGTC_2309|Compound:7664088|FD-Score:6.18|P-value:4.95E-7 ID:SGTC_2337|Compound:9009472|FD-Score:4.20|P-value:4.43E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.83|P-value:6.09E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-4.75|P-value:7.99E-5 ID:SGTC_2701|Compound:st077767|FD-Score:-4.53|P-value:1.55E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:5.66|P-value:3.60E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.93|P-value:4.43E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.51|P-value:1.64E-4 ID:SGTC_2838|Compound:9002687|FD-Score:7.84|P-value:2.53E-10 ID:SGTC_2887|Compound:9044784|FD-Score:4.35|P-value:2.88E-4 ID:SGTC_2923|Compound:7992654|FD-Score:5.01|P-value:3.68E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-5.88|P-value:1.48E-6 ID:SGTC_2927|Compound:9011802|FD-Score:6.56|P-value:9.91E-8 ID:SGTC_3032|Compound:9089427|FD-Score:-4.29|P-value:3.24E-4 ID:SGTC_3033|Compound:9090887|FD-Score:5.38|P-value:9.99E-6 ID:SGTC_3081|Compound:9117243|FD-Score:4.11|P-value:5.73E-4 ID:SGTC_3093|Compound:9117344|FD-Score:4.13|P-value:5.38E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-4.59|P-value:1.29E-4 ID:SGTC_3129|Compound:9127257|FD-Score:5.10|P-value:2.70E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-5.88|P-value:1.48E-6 ID:SGTC_3139|Compound:9095020|FD-Score:-5.24|P-value:1.53E-5 ID:SGTC_3170|Compound:9103054|FD-Score:-4.80|P-value:6.81E-5 ID:SGTC_3181|Compound:9108277|FD-Score:-4.20|P-value:4.11E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.93|P-value:8.72E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-4.57|P-value:1.37E-4

Top fitness defect scores for YLR076C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2838 9002687 7.84 71.4 µM 2.53E-10 fatty acid desaturase (OLE1) 1 2.19E-15 1.05
2 SGTC_2927 9011802 6.56 47.9 µM 9.91E-8 1 2.63E-11 0.64
3 SGTC_1812 st052057 6.45 4.3 µM 1.58E-7 calcium & mitochondrial duress 3 5.45E-11 1.68
4 SGTC_501 nsc-95397 6.18 161.0 µM 4.90E-7 1 3.22E-10 0.95
5 SGTC_2309 7664088 6.18 163.9 µM 4.95E-7 4 3.27E-10 1.36
6 SGTC_349 k015-0014 5.88 24.0 µM 1.61E-6 3 2.09E-9 1.78
7 SGTC_1960 st011366 5.73 51.8 µM 2.85E-6 2 5.09E-9 1.64
8 SGTC_2725 haloperidol 5.66 53.2 µM 3.60E-6 plasma membrane duress 8 7.36E-9 0.20
9 SGTC_3033 9090887 5.38 49.5 µM 9.99E-6 fatty acid desaturase (OLE1) 3 3.63E-8 0.10
10 SGTC_258 haloperidol 5.37 50.8 µM 1.04E-5 fatty acid desaturase (OLE1) 7 3.89E-8 0.06
11 SGTC_347 4534-1311 5.32 26.2 µM 1.24E-5 RPP1 & pyrimidine depletion 1 5.10E-8 1.23
12 SGTC_264 promethazine 5.31 12.5 mM 1.30E-5 DNA intercalators 13 5.51E-8 0.38
13 SGTC_3129 9127257 5.10 49.5 µM 2.70E-5 1 1.72E-7 0.48
14 SGTC_2923 7992654 5.01 58.1 µM 3.68E-5 Golgi 3 2.79E-7 0.63
15 SGTC_1363 1636-0063 4.96 10.4 µM 4.25E-5 Golgi 4 3.49E-7 0.64
16 SGTC_355 1311-2252 4.91 105.0 µM 4.97E-5 1 4.46E-7 0.95
17 SGTC_1956 st077085 4.88 54.0 µM 5.64E-5 1 5.42E-7 1.07
18 SGTC_105 0111-0055 4.77 734.8 µM 7.82E-5 1 9.02E-7 0.76
19 SGTC_1466 k213-0079 4.56 57.5 µM 1.50E-4 5 2.50E-6 0.05
20 SGTC_343 4130-2827 4.49 29.8 µM 1.90E-4 4 3.58E-6 0.92

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.234 1.88E-42 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.229 6.03E-41 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.179 2.02E-25 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.177 9.06E-25 YPL142C_d YPL142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
0.175 2.32E-24 YLR075W RPL10 het Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects
0.163 3.61E-21 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.158 6.29E-20 YPL143W RPL33A het Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication
0.156 1.51E-19 YGL030W RPL30 het Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
0.149 4.21E-18 YPL235W RVB2 het ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly
0.143 8.26E-17 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.141 2.91E-16 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.134 8.16E-15 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.134 8.89E-15 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.127 1.58E-13 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.122 1.90E-12 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles