YLR078C / BOS1

v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR078C / BOS1

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:-3.46|P-value:2.18E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.22|P-value:5.27E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.54|P-value:1.59E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:3.47|P-value:2.08E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.65|P-value:1.02E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.66|P-value:9.81E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.23|P-value:5.16E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.67|P-value:9.62E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.54|P-value:1.62E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.22|P-value:8.83E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:3.81|P-value:5.30E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.08|P-value:8.70E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.60|P-value:1.26E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.30|P-value:4.00E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:4.41|P-value:3.66E-6 ID:SGTC_1588|Compound:farnesol|FD-Score:3.72|P-value:7.74E-5 ID:SGTC_1782|Compound:st039423|FD-Score:3.94|P-value:3.08E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.22|P-value:5.35E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.07|P-value:9.04E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.22|P-value:5.21E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.40|P-value:2.73E-4 ID:SGTC_2411|Compound:st077133|FD-Score:4.20|P-value:9.51E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.18|P-value:6.06E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.70|P-value:8.81E-7 ID:SGTC_2816|Compound:7982706|FD-Score:3.88|P-value:3.97E-5 ID:SGTC_2905|Compound:7799065|FD-Score:4.30|P-value:6.10E-6 ID:SGTC_2909|Compound:7941780|FD-Score:-5.28|P-value:4.05E-8 ID:SGTC_2910|Compound:7948405|FD-Score:-3.15|P-value:6.73E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.17|P-value:6.39E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.86|P-value:4.34E-5 ID:SGTC_3161|Compound:9100388|FD-Score:3.43|P-value:2.41E-4 ID:SGTC_3167|Compound:9103034|FD-Score:3.49|P-value:1.94E-4 ID:SGTC_3169|Compound:9102970|FD-Score:3.19|P-value:5.87E-4 ID:SGTC_3172|Compound:9105863|FD-Score:3.26|P-value:4.57E-4 ID:SGTC_3184|Compound:9108758|FD-Score:3.12|P-value:7.62E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.46|P-value:2.18E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.22|P-value:5.27E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.54|P-value:1.59E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:3.47|P-value:2.08E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.65|P-value:1.02E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.66|P-value:9.81E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.23|P-value:5.16E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.67|P-value:9.62E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.54|P-value:1.62E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.22|P-value:8.83E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:3.81|P-value:5.30E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.08|P-value:8.70E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.60|P-value:1.26E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.30|P-value:4.00E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:4.41|P-value:3.66E-6 ID:SGTC_1588|Compound:farnesol|FD-Score:3.72|P-value:7.74E-5 ID:SGTC_1782|Compound:st039423|FD-Score:3.94|P-value:3.08E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.22|P-value:5.35E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.07|P-value:9.04E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.22|P-value:5.21E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.40|P-value:2.73E-4 ID:SGTC_2411|Compound:st077133|FD-Score:4.20|P-value:9.51E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.18|P-value:6.06E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.70|P-value:8.81E-7 ID:SGTC_2816|Compound:7982706|FD-Score:3.88|P-value:3.97E-5 ID:SGTC_2905|Compound:7799065|FD-Score:4.30|P-value:6.10E-6 ID:SGTC_2909|Compound:7941780|FD-Score:-5.28|P-value:4.05E-8 ID:SGTC_2910|Compound:7948405|FD-Score:-3.15|P-value:6.73E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.17|P-value:6.39E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.86|P-value:4.34E-5 ID:SGTC_3161|Compound:9100388|FD-Score:3.43|P-value:2.41E-4 ID:SGTC_3167|Compound:9103034|FD-Score:3.49|P-value:1.94E-4 ID:SGTC_3169|Compound:9102970|FD-Score:3.19|P-value:5.87E-4 ID:SGTC_3172|Compound:9105863|FD-Score:3.26|P-value:4.57E-4 ID:SGTC_3184|Compound:9108758|FD-Score:3.12|P-value:7.62E-4

Top fitness defect scores for YLR078C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 4.70 100.0 µM 8.81E-7 3 1.31E-6 1.08
2 SGTC_1501 4491-0275 4.41 38.4 µM 3.66E-6 1 5.21E-6 0.51
3 SGTC_2905 7799065 4.30 20.1 µM 6.10E-6 6 8.54E-6 0.41
4 SGTC_918 glabranin 4.22 770.7 nM 8.83E-6 3 1.22E-5 0.16
5 SGTC_2411 st077133 4.20 39.9 µM 9.51E-6 RNA pol III & RNase P/MRP 17 1.31E-5 0.17
6 SGTC_1782 st039423 3.94 80.6 µM 3.08E-5 3 4.09E-5 0.42
7 SGTC_2816 7982706 3.88 58.4 µM 3.97E-5 azole & statin 13 5.23E-5 0.01
8 SGTC_3057 9095946 3.86 49.5 µM 4.34E-5 Golgi 5 5.71E-5 0.33
9 SGTC_927 2425-1185 3.81 123.0 µM 5.30E-5 3 6.92E-5 0.05
10 SGTC_1588 farnesol 3.72 29.9 µM 7.74E-5 8 9.99E-5 0.10
11 SGTC_738 1315-0003 3.67 72.4 µM 9.62E-5 7 1.23E-4 0.04
12 SGTC_622 1348-1566 3.66 26.3 µM 9.81E-5 5 1.26E-4 0.20
13 SGTC_216 k038-0035 3.65 28.4 µM 1.02E-4 ubiquinone biosynthesis & proteasome 16 1.31E-4 0.02
14 SGTC_1259 0671-0132 3.60 43.0 µM 1.26E-4 10 1.60E-4 0.02
15 SGTC_169 k015-0017 3.54 16.0 µM 1.59E-4 4 2.01E-4 0.10
16 SGTC_3167 9103034 3.49 49.5 µM 1.94E-4 RPP1 & pyrimidine depletion 6 2.44E-4 0.19
17 SGTC_207 4185-0010 3.47 4.5 µM 2.08E-4 endomembrane recycling 22 2.60E-4 0.07
18 SGTC_3161 9100388 3.43 49.5 µM 2.41E-4 iron homeostasis 9 3.01E-4 0.03
19 SGTC_1473 k844-0725 3.30 134.0 µM 4.00E-4 13 4.90E-4 0.08
20 SGTC_3172 9105863 3.26 49.5 µM 4.57E-4 ERG2 1 5.58E-4 0.31

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.36E-10 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.107 5.60E-10 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.096 2.20E-8 YBR044C TCM62 hom Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
0.094 5.14E-8 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.091 1.25E-7 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.091 1.35E-7 YGR121C MEP1 hom Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.090 1.75E-7 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.089 2.56E-7 YFR012W-A_p YFR012W-A_p hom Putative protein of unknown function; identified by homology
0.089 2.56E-7 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.088 3.18E-7 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.087 4.76E-7 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.087 4.82E-7 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.084 9.97E-7 YKR002W PAP1 het Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.083 1.40E-6 YOR135C_d IRC14_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci
0.083 1.68E-6 YHL042W_p YHL042W_p hom Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins