YLR079W / SIC1

Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR079W / SIC1

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:-4.00|P-value:3.89E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.56|P-value:2.52E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.93|P-value:6.14E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.19|P-value:2.12E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:3.58|P-value:2.35E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.32|P-value:5.91E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.30|P-value:6.40E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.45|P-value:3.75E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.55|P-value:2.58E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.52|P-value:4.86E-6 ID:SGTC_848|Compound:0368-0089|FD-Score:3.65|P-value:1.82E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.76|P-value:1.19E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.76|P-value:1.17E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.70|P-value:1.52E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.82|P-value:9.28E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:7.06|P-value:2.32E-12 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.31|P-value:6.20E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.21|P-value:8.66E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.22|P-value:1.86E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.00|P-value:4.66E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.32|P-value:5.88E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.21|P-value:8.69E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:4.00|P-value:4.62E-5 ID:SGTC_1655|Compound:st012546|FD-Score:3.43|P-value:4.02E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.37|P-value:4.92E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.90|P-value:6.97E-5 ID:SGTC_1942|Compound:st076330|FD-Score:4.02|P-value:4.22E-5 ID:SGTC_1971|Compound:st069429|FD-Score:4.13|P-value:2.65E-5 ID:SGTC_2380|Compound:9035439|FD-Score:3.54|P-value:2.73E-4 ID:SGTC_2428|Compound:5615643|FD-Score:4.07|P-value:3.41E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.73|P-value:1.49E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.17|P-value:8.54E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-4.19|P-value:1.72E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.40|P-value:8.35E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:3.41|P-value:4.38E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.84|P-value:1.08E-6 ID:SGTC_2921|Compound:7974240|FD-Score:4.18|P-value:2.16E-5 ID:SGTC_3038|Compound:9091290|FD-Score:-3.87|P-value:6.38E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.50|P-value:3.11E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-5.98|P-value:1.84E-9 ID:SGTC_3147|Compound:9097027|FD-Score:-4.58|P-value:2.94E-6 ID:SGTC_3151|Compound:9099821|FD-Score:3.43|P-value:4.05E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.69|P-value:1.58E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.93|P-value:6.20E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.00|P-value:3.89E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.56|P-value:2.52E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.93|P-value:6.14E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.19|P-value:2.12E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:3.58|P-value:2.35E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.32|P-value:5.91E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.30|P-value:6.40E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.45|P-value:3.75E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.55|P-value:2.58E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.52|P-value:4.86E-6 ID:SGTC_848|Compound:0368-0089|FD-Score:3.65|P-value:1.82E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.76|P-value:1.19E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.76|P-value:1.17E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.70|P-value:1.52E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.82|P-value:9.28E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:7.06|P-value:2.32E-12 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.31|P-value:6.20E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.21|P-value:8.66E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.22|P-value:1.86E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.00|P-value:4.66E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.32|P-value:5.88E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.21|P-value:8.69E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:4.00|P-value:4.62E-5 ID:SGTC_1655|Compound:st012546|FD-Score:3.43|P-value:4.02E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.37|P-value:4.92E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.90|P-value:6.97E-5 ID:SGTC_1942|Compound:st076330|FD-Score:4.02|P-value:4.22E-5 ID:SGTC_1971|Compound:st069429|FD-Score:4.13|P-value:2.65E-5 ID:SGTC_2380|Compound:9035439|FD-Score:3.54|P-value:2.73E-4 ID:SGTC_2428|Compound:5615643|FD-Score:4.07|P-value:3.41E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.73|P-value:1.49E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.17|P-value:8.54E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-4.19|P-value:1.72E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.40|P-value:8.35E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:3.41|P-value:4.38E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.84|P-value:1.08E-6 ID:SGTC_2921|Compound:7974240|FD-Score:4.18|P-value:2.16E-5 ID:SGTC_3038|Compound:9091290|FD-Score:-3.87|P-value:6.38E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.50|P-value:3.11E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-5.98|P-value:1.84E-9 ID:SGTC_3147|Compound:9097027|FD-Score:-4.58|P-value:2.94E-6 ID:SGTC_3151|Compound:9099821|FD-Score:3.43|P-value:4.05E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.69|P-value:1.58E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.93|P-value:6.20E-5

Top fitness defect scores for YLR079W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1121 fusaric acid 7.06 630.5 nM 2.32E-12 8 8.57E-13
2 SGTC_2771 fluoxetine 4.84 41.0 µM 1.08E-6 9 6.45E-7
3 SGTC_580 1123-0028 4.52 41.0 µM 4.86E-6 DNA damage response 19 3.08E-6
4 SGTC_2768 sulfasalazine 4.40 50.2 µM 8.35E-6 11 5.40E-6
5 SGTC_1183 1254-0324 4.22 198.0 µM 1.86E-5 15 1.24E-5
6 SGTC_138 0850-0259 4.19 40.9 µM 2.12E-5 cell wall 184 1.42E-5
7 SGTC_2921 7974240 4.18 10.7 µM 2.16E-5 42 1.45E-5
8 SGTC_1971 st069429 4.13 63.5 µM 2.65E-5 60S ribosome export 11 1.79E-5
9 SGTC_2428 5615643 4.07 7.8 µM 3.41E-5 30 2.33E-5
10 SGTC_1942 st076330 4.02 65.2 µM 4.22E-5 28 2.90E-5
11 SGTC_1541 2',3',6-trimethoxyflavone 4.00 64.0 µM 4.62E-5 11 3.19E-5
12 SGTC_1319 1306-0155 4.00 43.7 µM 4.66E-5 22 3.21E-5
13 SGTC_119 0121-0043 3.93 24.8 µM 6.14E-5 mitochondrial stress 114 4.28E-5
14 SGTC_3233 9132340 3.93 49.5 µM 6.20E-5 18 4.32E-5
15 SGTC_1916 st067606 3.90 49.2 µM 6.97E-5 39 4.88E-5
16 SGTC_1098 clofazimine 3.82 15.1 µM 9.28E-5 heme biosynthesis & mitochondrial translocase 26 6.57E-5
17 SGTC_960 1222-0186 3.76 7.7 µM 1.17E-4 37 8.37E-5
18 SGTC_942 3253-1115 3.76 227.0 µM 1.19E-4 34 8.48E-5
19 SGTC_1075 aripiprazole 3.70 15.2 µM 1.52E-4 39 1.10E-4
20 SGTC_3212 9128307 3.69 49.5 µM 1.58E-4 57 1.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.02E-20 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.153 4.29E-19 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.132 1.32E-14 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.128 8.25E-14 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.127 1.43E-13 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.126 2.93E-13 YMR316W DIA1 hom Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.124 5.64E-13 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.117 1.08E-11 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.116 1.34E-11 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.112 7.54E-11 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.111 1.19E-10 YJL039C NUP192 het Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205
0.111 1.37E-10 YOR046C DBP5 het Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p
0.110 1.57E-10 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.110 1.78E-10 YNL094W APP1 hom Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway
0.108 3.45E-10 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth