YLR081W / GAL2

Galactose permease, required for utilization of galactose; also able to transport glucose

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR081W / GAL2

Click on Significant Values for Screen Details ID:SGTC_134|Compound:0269-0018|FD-Score:-3.55|P-value:1.50E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.46|P-value:1.85E-6 ID:SGTC_548|Compound:1436-0017|FD-Score:5.29|P-value:2.13E-8 ID:SGTC_552|Compound:k242-0005|FD-Score:3.39|P-value:2.07E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.39|P-value:2.10E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.32|P-value:2.75E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:2.99|P-value:9.28E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.35|P-value:2.44E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.10|P-value:6.13E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.61|P-value:8.52E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:3.08|P-value:6.55E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.93|P-value:2.25E-5 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.54|P-value:1.14E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.70|P-value:5.84E-5 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.06|P-value:9.45E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-4.36|P-value:4.43E-6 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.51|P-value:1.79E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.17|P-value:4.74E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.04|P-value:7.56E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.03|P-value:7.87E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.59|P-value:9.46E-7 ID:SGTC_1652|Compound:st011932|FD-Score:3.71|P-value:5.62E-5 ID:SGTC_1661|Compound:st013063|FD-Score:5.22|P-value:3.19E-8 ID:SGTC_1705|Compound:st027868|FD-Score:3.12|P-value:5.68E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.04|P-value:7.65E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.12|P-value:5.82E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.15|P-value:5.10E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:4.64|P-value:7.25E-7 ID:SGTC_1967|Compound:st070177|FD-Score:3.05|P-value:7.34E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.91|P-value:2.42E-5 ID:SGTC_2452|Compound:5863136|FD-Score:2.99|P-value:9.24E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.57|P-value:1.04E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.80|P-value:3.83E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.27|P-value:3.26E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.36|P-value:2.38E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.59|P-value:9.39E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.32|P-value:2.71E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.29|P-value:4.19E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-8.21|P-value:2.05E-17 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.22|P-value:4.04E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.15|P-value:6.95E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.02|P-value:8.08E-4 ID:SGTC_2790|Compound:5423970|FD-Score:5.21|P-value:3.21E-8 ID:SGTC_2873|Compound:9040596|FD-Score:3.56|P-value:1.06E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.02|P-value:8.21E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.59|P-value:9.58E-5 ID:SGTC_2998|Compound:9066762|FD-Score:3.47|P-value:1.55E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.03|P-value:7.81E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.55|P-value:1.50E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.46|P-value:1.85E-6 ID:SGTC_548|Compound:1436-0017|FD-Score:5.29|P-value:2.13E-8 ID:SGTC_552|Compound:k242-0005|FD-Score:3.39|P-value:2.07E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.39|P-value:2.10E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.32|P-value:2.75E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:2.99|P-value:9.28E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.35|P-value:2.44E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.10|P-value:6.13E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.61|P-value:8.52E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:3.08|P-value:6.55E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.93|P-value:2.25E-5 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.54|P-value:1.14E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.70|P-value:5.84E-5 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.06|P-value:9.45E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-4.36|P-value:4.43E-6 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.51|P-value:1.79E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.17|P-value:4.74E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.04|P-value:7.56E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.03|P-value:7.87E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.59|P-value:9.46E-7 ID:SGTC_1652|Compound:st011932|FD-Score:3.71|P-value:5.62E-5 ID:SGTC_1661|Compound:st013063|FD-Score:5.22|P-value:3.19E-8 ID:SGTC_1705|Compound:st027868|FD-Score:3.12|P-value:5.68E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.04|P-value:7.65E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.12|P-value:5.82E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.15|P-value:5.10E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:4.64|P-value:7.25E-7 ID:SGTC_1967|Compound:st070177|FD-Score:3.05|P-value:7.34E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.91|P-value:2.42E-5 ID:SGTC_2452|Compound:5863136|FD-Score:2.99|P-value:9.24E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.57|P-value:1.04E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.80|P-value:3.83E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.27|P-value:3.26E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.36|P-value:2.38E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.59|P-value:9.39E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.32|P-value:2.71E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.29|P-value:4.19E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-8.21|P-value:2.05E-17 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.22|P-value:4.04E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.15|P-value:6.95E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.02|P-value:8.08E-4 ID:SGTC_2790|Compound:5423970|FD-Score:5.21|P-value:3.21E-8 ID:SGTC_2873|Compound:9040596|FD-Score:3.56|P-value:1.06E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.02|P-value:8.21E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.59|P-value:9.58E-5 ID:SGTC_2998|Compound:9066762|FD-Score:3.47|P-value:1.55E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.03|P-value:7.81E-4

Top fitness defect scores for YLR081W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_548 1436-0017 5.29 110.0 µM 2.13E-8 TSC3-RPN4 17 6.26E-8
2 SGTC_1661 st013063 5.22 9.7 µM 3.19E-8 11 9.14E-8
3 SGTC_2790 5423970 5.21 71.4 µM 3.21E-8 endomembrane recycling 36 9.20E-8
4 SGTC_1965 Pectolinarigenin 4.64 58.4 µM 7.25E-7 RPP1 & pyrimidine depletion 8 1.72E-6
5 SGTC_1562 morin hydrate 4.59 59.1 µM 9.46E-7 7 2.21E-6
6 SGTC_546 peri-Naphthalide 4.46 147.0 µM 1.85E-6 DNA damage response 11 4.15E-6
7 SGTC_2583 asiatic acid 4.29 100.0 µM 4.19E-6 28 8.94E-6
8 SGTC_1170 0310-0127 3.93 64.8 µM 2.25E-5 29 4.32E-5
9 SGTC_2109 5483026 3.91 200.0 µM 2.42E-5 RSC complex & mRNA processing 27 4.63E-5
10 SGTC_2544 sphondin 3.80 68.5 µM 3.83E-5 RNA pol III & RNase P/MRP 29 7.13E-5
11 SGTC_1652 st011932 3.71 78.0 µM 5.62E-5 RSC complex & mRNA processing 13 1.02E-4
12 SGTC_1279 0874-0590 3.70 65.2 µM 5.84E-5 40 1.06E-4
13 SGTC_925 2064-1272 3.61 59.6 µM 8.52E-5 32 1.51E-4
14 SGTC_2573 2',4'-dihydroxychalcone 3.59 15.0 µM 9.39E-5 72 1.65E-4
15 SGTC_2893 9048488 3.59 26.0 µM 9.58E-5 fatty acid desaturase (OLE1) 29 1.68E-4
16 SGTC_2541 muurolladie-3-one 3.57 83.1 µM 1.04E-4 excess fatty acid 46 1.81E-4
17 SGTC_2873 9040596 3.56 71.4 µM 1.06E-4 66 1.86E-4
18 SGTC_1273 0849-0096 3.54 14.1 µM 1.14E-4 RPP1 & pyrimidine depletion 35 1.99E-4
19 SGTC_2998 9066762 3.47 71.4 µM 1.55E-4 RPP1 & pyrimidine depletion 39 2.64E-4
20 SGTC_552 k242-0005 3.39 476.0 µM 2.07E-4 35 3.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 7.54E-16 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.134 7.93E-15 YCL023C_d YCL023C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
0.121 1.90E-12 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.110 1.89E-10 YIL059C_d YIL059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
0.100 6.18E-9 YFR014C CMK1 hom Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication
0.100 6.09E-9 YBR241C_p YBR241C_p hom Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
0.099 8.37E-9 YOL005C RPB11 het RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
0.092 8.34E-8 YBL092W RPL32 het Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.092 1.00E-7 YOR140W SFL1 hom Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
0.090 1.69E-7 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.090 2.02E-7 YHR123W EPT1 hom sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication
0.087 4.38E-7 YNL285W_d YNL285W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.78E-7 YNL078W NIS1 hom Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
0.086 6.63E-7 YOL054W PSH1 hom E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p
0.085 8.62E-7 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p