YLR085C / ARP6

Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR085C / ARP6

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:4.28|P-value:1.36E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:8.48|P-value:2.05E-13 ID:SGTC_64|Compound:000l-0018|FD-Score:6.47|P-value:1.64E-8 ID:SGTC_67|Compound:0335-0847|FD-Score:9.26|P-value:1.21E-15 ID:SGTC_86|Compound:0417-1630|FD-Score:9.71|P-value:4.90E-17 ID:SGTC_93|Compound:0109-0045|FD-Score:4.13|P-value:2.23E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:6.96|P-value:1.42E-9 ID:SGTC_138|Compound:0850-0259|FD-Score:4.17|P-value:1.93E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:6.05|P-value:1.22E-7 ID:SGTC_149|Compound:3970-0822|FD-Score:5.10|P-value:6.93E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:11.70|P-value:8.10E-24 ID:SGTC_165|Compound:k038-0023|FD-Score:5.44|P-value:1.78E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:5.44|P-value:1.77E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:8.64|P-value:7.69E-14 ID:SGTC_212|Compound:3807-4682|FD-Score:6.78|P-value:3.52E-9 ID:SGTC_216|Compound:k038-0035|FD-Score:5.90|P-value:2.47E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:12.30|P-value:2.78E-26 ID:SGTC_227|Compound:fluconazole|FD-Score:4.12|P-value:2.29E-4 ID:SGTC_229|Compound:benomyl|FD-Score:16.00|P-value:7.32E-43 ID:SGTC_284|Compound:0988-0104|FD-Score:-4.03|P-value:2.30E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:12.20|P-value:5.33E-26 ID:SGTC_294|Compound:k038-0071|FD-Score:9.38|P-value:5.05E-16 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.95|P-value:2.98E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:4.61|P-value:4.35E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.47|P-value:7.08E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:7.80|P-value:1.35E-11 ID:SGTC_375|Compound:3970-0961|FD-Score:4.20|P-value:1.77E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:5.38|P-value:2.24E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.58|P-value:4.85E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.89|P-value:4.80E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.15|P-value:2.12E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.08|P-value:2.65E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.41|P-value:8.89E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:7.13|P-value:5.67E-10 ID:SGTC_594|Compound:1487-1584|FD-Score:4.54|P-value:5.64E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:4.09|P-value:2.53E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.88|P-value:4.96E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.76|P-value:7.07E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:15.60|P-value:6.03E-41 ID:SGTC_788|Compound:1182-0090|FD-Score:3.72|P-value:7.96E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:10.70|P-value:2.93E-20 ID:SGTC_825|Compound:1988-2224|FD-Score:7.01|P-value:1.10E-9 ID:SGTC_871|Compound:0574-0004|FD-Score:4.74|P-value:2.73E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:5.80|P-value:3.86E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:4.94|P-value:1.30E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.07|P-value:2.73E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.45|P-value:7.55E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.98|P-value:3.57E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:5.78|P-value:4.08E-7 ID:SGTC_1326|Compound:1431-2094|FD-Score:17.30|P-value:7.64E-50 ID:SGTC_1339|Compound:1486-1321|FD-Score:5.22|P-value:4.40E-6 ID:SGTC_1370|Compound:2001-0092|FD-Score:-5.45|P-value:1.17E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.22|P-value:1.22E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:6.44|P-value:1.93E-8 ID:SGTC_1433|Compound:4060-0023|FD-Score:7.46|P-value:9.13E-11 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.80|P-value:6.24E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.34|P-value:1.10E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.68|P-value:8.82E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.27|P-value:1.41E-4 ID:SGTC_1643|Compound:st009866|FD-Score:6.15|P-value:7.66E-8 ID:SGTC_1712|Compound:st032288|FD-Score:6.35|P-value:2.94E-8 ID:SGTC_1754|Compound:st042065|FD-Score:7.51|P-value:7.09E-11 ID:SGTC_1760|Compound:st045453|FD-Score:5.95|P-value:1.97E-7 ID:SGTC_1773|Compound:st048542|FD-Score:3.84|P-value:5.61E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.13|P-value:2.25E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.99|P-value:3.46E-4 ID:SGTC_1803|Compound:st050068|FD-Score:6.54|P-value:1.16E-8 ID:SGTC_1846|Compound:st056244|FD-Score:5.49|P-value:1.41E-6 ID:SGTC_1852|Compound:st056254|FD-Score:-3.61|P-value:8.32E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.90|P-value:4.62E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:11.00|P-value:2.10E-21 ID:SGTC_1906|Compound:st060206|FD-Score:-4.44|P-value:5.74E-5 ID:SGTC_1915|Compound:st067105|FD-Score:3.69|P-value:8.57E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.95|P-value:3.94E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.52|P-value:6.05E-5 ID:SGTC_2061|Compound:5245884|FD-Score:11.60|P-value:2.00E-23 ID:SGTC_2066|Compound:5222451|FD-Score:4.47|P-value:7.22E-5 ID:SGTC_2067|Compound:5224629|FD-Score:4.19|P-value:1.84E-4 ID:SGTC_2077|Compound:5212015|FD-Score:4.43|P-value:8.26E-5 ID:SGTC_2090|Compound:5301565|FD-Score:4.71|P-value:3.05E-5 ID:SGTC_2125|Compound:5246583|FD-Score:8.37|P-value:4.16E-13 ID:SGTC_2140|Compound:5586273|FD-Score:3.95|P-value:3.96E-4 ID:SGTC_2141|Compound:5621638|FD-Score:14.50|P-value:7.32E-36 ID:SGTC_2158|Compound:5657123|FD-Score:4.14|P-value:2.13E-4 ID:SGTC_2161|Compound:5662504|FD-Score:5.67|P-value:6.75E-7 ID:SGTC_2166|Compound:5933061|FD-Score:15.10|P-value:2.29E-38 ID:SGTC_2173|Compound:5763948|FD-Score:3.78|P-value:6.72E-4 ID:SGTC_2174|Compound:5790901|FD-Score:12.90|P-value:9.78E-29 ID:SGTC_2176|Compound:5809774|FD-Score:3.77|P-value:6.91E-4 ID:SGTC_2186|Compound:6124449|FD-Score:5.60|P-value:9.06E-7 ID:SGTC_2200|Compound:6600604|FD-Score:9.66|P-value:6.84E-17 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.12|P-value:2.33E-4 ID:SGTC_2254|Compound:7938975|FD-Score:5.45|P-value:1.71E-6 ID:SGTC_2269|Compound:7935389|FD-Score:11.50|P-value:5.39E-23 ID:SGTC_2277|Compound:7947813|FD-Score:6.36|P-value:2.84E-8 ID:SGTC_2319|Compound:6033012|FD-Score:10.60|P-value:7.83E-20 ID:SGTC_2352|Compound:9027995|FD-Score:13.10|P-value:1.26E-29 ID:SGTC_2461|Compound:5755302|FD-Score:5.15|P-value:5.69E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.70|P-value:8.33E-4 ID:SGTC_2534|Compound:helenine|FD-Score:6.16|P-value:7.45E-8 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.83|P-value:5.68E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.55|P-value:1.13E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:3.97|P-value:3.72E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.73|P-value:5.91E-4 ID:SGTC_2845|Compound:9003024|FD-Score:5.47|P-value:1.57E-6 ID:SGTC_2873|Compound:9040596|FD-Score:4.06|P-value:2.79E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.93|P-value:4.23E-4 ID:SGTC_2912|Compound:7964298|FD-Score:6.34|P-value:3.10E-8 ID:SGTC_2936|Compound:9038235|FD-Score:3.79|P-value:6.50E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.89|P-value:4.74E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-3.70|P-value:6.54E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.68|P-value:8.89E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.75|P-value:7.16E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.61|P-value:4.32E-5 ID:SGTC_3294|Compound:9122953|FD-Score:8.08|P-value:2.55E-12 ID:SGTC_12|Compound:0849-0099|FD-Score:4.28|P-value:1.36E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:8.48|P-value:2.05E-13 ID:SGTC_64|Compound:000l-0018|FD-Score:6.47|P-value:1.64E-8 ID:SGTC_67|Compound:0335-0847|FD-Score:9.26|P-value:1.21E-15 ID:SGTC_86|Compound:0417-1630|FD-Score:9.71|P-value:4.90E-17 ID:SGTC_93|Compound:0109-0045|FD-Score:4.13|P-value:2.23E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:6.96|P-value:1.42E-9 ID:SGTC_138|Compound:0850-0259|FD-Score:4.17|P-value:1.93E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:6.05|P-value:1.22E-7 ID:SGTC_149|Compound:3970-0822|FD-Score:5.10|P-value:6.93E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:11.70|P-value:8.10E-24 ID:SGTC_165|Compound:k038-0023|FD-Score:5.44|P-value:1.78E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:5.44|P-value:1.77E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:8.64|P-value:7.69E-14 ID:SGTC_212|Compound:3807-4682|FD-Score:6.78|P-value:3.52E-9 ID:SGTC_216|Compound:k038-0035|FD-Score:5.90|P-value:2.47E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:12.30|P-value:2.78E-26 ID:SGTC_227|Compound:fluconazole|FD-Score:4.12|P-value:2.29E-4 ID:SGTC_229|Compound:benomyl|FD-Score:16.00|P-value:7.32E-43 ID:SGTC_284|Compound:0988-0104|FD-Score:-4.03|P-value:2.30E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:12.20|P-value:5.33E-26 ID:SGTC_294|Compound:k038-0071|FD-Score:9.38|P-value:5.05E-16 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.95|P-value:2.98E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:4.61|P-value:4.35E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.47|P-value:7.08E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:7.80|P-value:1.35E-11 ID:SGTC_375|Compound:3970-0961|FD-Score:4.20|P-value:1.77E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:5.38|P-value:2.24E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.58|P-value:4.85E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.89|P-value:4.80E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.15|P-value:2.12E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.08|P-value:2.65E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.41|P-value:8.89E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:7.13|P-value:5.67E-10 ID:SGTC_594|Compound:1487-1584|FD-Score:4.54|P-value:5.64E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:4.09|P-value:2.53E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.88|P-value:4.96E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.76|P-value:7.07E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:15.60|P-value:6.03E-41 ID:SGTC_788|Compound:1182-0090|FD-Score:3.72|P-value:7.96E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:10.70|P-value:2.93E-20 ID:SGTC_825|Compound:1988-2224|FD-Score:7.01|P-value:1.10E-9 ID:SGTC_871|Compound:0574-0004|FD-Score:4.74|P-value:2.73E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:5.80|P-value:3.86E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:4.94|P-value:1.30E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.07|P-value:2.73E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.45|P-value:7.55E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.98|P-value:3.57E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:5.78|P-value:4.08E-7 ID:SGTC_1326|Compound:1431-2094|FD-Score:17.30|P-value:7.64E-50 ID:SGTC_1339|Compound:1486-1321|FD-Score:5.22|P-value:4.40E-6 ID:SGTC_1370|Compound:2001-0092|FD-Score:-5.45|P-value:1.17E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.22|P-value:1.22E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:6.44|P-value:1.93E-8 ID:SGTC_1433|Compound:4060-0023|FD-Score:7.46|P-value:9.13E-11 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.80|P-value:6.24E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.34|P-value:1.10E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.68|P-value:8.82E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.27|P-value:1.41E-4 ID:SGTC_1643|Compound:st009866|FD-Score:6.15|P-value:7.66E-8 ID:SGTC_1712|Compound:st032288|FD-Score:6.35|P-value:2.94E-8 ID:SGTC_1754|Compound:st042065|FD-Score:7.51|P-value:7.09E-11 ID:SGTC_1760|Compound:st045453|FD-Score:5.95|P-value:1.97E-7 ID:SGTC_1773|Compound:st048542|FD-Score:3.84|P-value:5.61E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.13|P-value:2.25E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.99|P-value:3.46E-4 ID:SGTC_1803|Compound:st050068|FD-Score:6.54|P-value:1.16E-8 ID:SGTC_1846|Compound:st056244|FD-Score:5.49|P-value:1.41E-6 ID:SGTC_1852|Compound:st056254|FD-Score:-3.61|P-value:8.32E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.90|P-value:4.62E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:11.00|P-value:2.10E-21 ID:SGTC_1906|Compound:st060206|FD-Score:-4.44|P-value:5.74E-5 ID:SGTC_1915|Compound:st067105|FD-Score:3.69|P-value:8.57E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.95|P-value:3.94E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.52|P-value:6.05E-5 ID:SGTC_2061|Compound:5245884|FD-Score:11.60|P-value:2.00E-23 ID:SGTC_2066|Compound:5222451|FD-Score:4.47|P-value:7.22E-5 ID:SGTC_2067|Compound:5224629|FD-Score:4.19|P-value:1.84E-4 ID:SGTC_2077|Compound:5212015|FD-Score:4.43|P-value:8.26E-5 ID:SGTC_2090|Compound:5301565|FD-Score:4.71|P-value:3.05E-5 ID:SGTC_2125|Compound:5246583|FD-Score:8.37|P-value:4.16E-13 ID:SGTC_2140|Compound:5586273|FD-Score:3.95|P-value:3.96E-4 ID:SGTC_2141|Compound:5621638|FD-Score:14.50|P-value:7.32E-36 ID:SGTC_2158|Compound:5657123|FD-Score:4.14|P-value:2.13E-4 ID:SGTC_2161|Compound:5662504|FD-Score:5.67|P-value:6.75E-7 ID:SGTC_2166|Compound:5933061|FD-Score:15.10|P-value:2.29E-38 ID:SGTC_2173|Compound:5763948|FD-Score:3.78|P-value:6.72E-4 ID:SGTC_2174|Compound:5790901|FD-Score:12.90|P-value:9.78E-29 ID:SGTC_2176|Compound:5809774|FD-Score:3.77|P-value:6.91E-4 ID:SGTC_2186|Compound:6124449|FD-Score:5.60|P-value:9.06E-7 ID:SGTC_2200|Compound:6600604|FD-Score:9.66|P-value:6.84E-17 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.12|P-value:2.33E-4 ID:SGTC_2254|Compound:7938975|FD-Score:5.45|P-value:1.71E-6 ID:SGTC_2269|Compound:7935389|FD-Score:11.50|P-value:5.39E-23 ID:SGTC_2277|Compound:7947813|FD-Score:6.36|P-value:2.84E-8 ID:SGTC_2319|Compound:6033012|FD-Score:10.60|P-value:7.83E-20 ID:SGTC_2352|Compound:9027995|FD-Score:13.10|P-value:1.26E-29 ID:SGTC_2461|Compound:5755302|FD-Score:5.15|P-value:5.69E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.70|P-value:8.33E-4 ID:SGTC_2534|Compound:helenine|FD-Score:6.16|P-value:7.45E-8 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.83|P-value:5.68E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.55|P-value:1.13E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:3.97|P-value:3.72E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.73|P-value:5.91E-4 ID:SGTC_2845|Compound:9003024|FD-Score:5.47|P-value:1.57E-6 ID:SGTC_2873|Compound:9040596|FD-Score:4.06|P-value:2.79E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.93|P-value:4.23E-4 ID:SGTC_2912|Compound:7964298|FD-Score:6.34|P-value:3.10E-8 ID:SGTC_2936|Compound:9038235|FD-Score:3.79|P-value:6.50E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.89|P-value:4.74E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-3.70|P-value:6.54E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.68|P-value:8.89E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.75|P-value:7.16E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.61|P-value:4.32E-5 ID:SGTC_3294|Compound:9122953|FD-Score:8.08|P-value:2.55E-12

Top fitness defect scores for YLR085C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1326 1431-2094 17.30 10.8 µM 7.64E-50 tubulin folding & SWR complex 2 4.54E-67
2 SGTC_229 benomyl 16.00 22.9 µM 7.32E-43 tubulin folding & SWR complex 5 1.33E-57
3 SGTC_673 1082-0474 15.60 110.0 µM 6.03E-41 RSC complex & mRNA processing 2 5.25E-55
4 SGTC_2166 5933061 15.10 31.5 µM 2.29E-38 tubulin folding & SWR complex 1 1.65E-51
5 SGTC_2141 5621638 14.50 7.7 µM 7.32E-36 tubulin folding & SWR complex 2 4.10E-48
6 SGTC_2352 9027995 13.10 87.8 µM 1.26E-29 tubulin folding & SWR complex 3 1.17E-39
7 SGTC_2174 5790901 12.90 200.0 µM 9.78E-29 tubulin folding & SWR complex 6 1.88E-38
8 SGTC_221 trifluoperazine 12.30 10.3 µM 2.78E-26 NEO1-PIK1 36 3.98E-35
9 SGTC_286 k060-0067 12.20 22.9 µM 5.33E-26 tubulin folding & SWR complex 3 9.63E-35
10 SGTC_158 k038-0087 11.70 26.4 µM 8.10E-24 ubiquinone biosynthesis & proteasome 25 8.73E-32
11 SGTC_2061 5245884 11.60 81.0 µM 2.00E-23 tubulin folding & SWR complex 1 2.97E-31
12 SGTC_2269 7935389 11.50 174.4 µM 5.39E-23 tubulin folding & SWR complex 1 1.14E-30
13 SGTC_1875 nocodazole 11.00 6.0 µM 2.10E-21 tubulin folding & SWR complex 12 1.64E-28
14 SGTC_794 k038-0031 10.70 316.0 µM 2.93E-20 ubiquinone biosynthesis & proteasome 12 5.80E-27
15 SGTC_2319 6033012 10.60 152.6 µM 7.83E-20 tubulin folding & SWR complex 8 2.20E-26
16 SGTC_86 0417-1630 9.71 471.9 µM 4.90E-17 ubiquinone biosynthesis & proteasome 40 1.36E-22
17 SGTC_2200 6600604 9.66 21.9 µM 6.84E-17 tubulin folding & SWR complex 12 2.13E-22
18 SGTC_294 k038-0071 9.38 157.0 µM 5.05E-16 ubiquinone biosynthesis & proteasome 3 3.20E-21
19 SGTC_67 0335-0847 9.26 266.0 µM 1.21E-15 ubiquinone biosynthesis & proteasome 27 1.05E-20
20 SGTC_210 3551-0445 8.64 56.8 µM 7.69E-14 16 2.91E-18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.717 0 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.686 0 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.672 0 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.671 0 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.559 2.35E-275 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.524 3.22E-236 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.505 1.08E-216 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.471 4.74E-185 YOL012C HTZ1 hom Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
0.421 1.59E-144 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.374 1.32E-111 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.349 1.27E-96 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.318 9.39E-80 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.306 9.07E-74 YNL107W YAF9 hom Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
0.292 6.76E-67 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.285 6.51E-64 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2