YLR086W / SMC4

Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR086W / SMC4

Click on Significant Values for Screen Details ID:SGTC_279|Compound:1273-0055|FD-Score:-4.02|P-value:9.30E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:3.64|P-value:3.53E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:4.14|P-value:5.86E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.61|P-value:3.99E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.39|P-value:8.07E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.43|P-value:7.22E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:-3.76|P-value:2.33E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.95|P-value:1.18E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:4.24|P-value:4.10E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:6.23|P-value:3.54E-9 ID:SGTC_1128|Compound:3448-9350|FD-Score:6.96|P-value:4.76E-11 ID:SGTC_1530|Compound:rhein|FD-Score:3.70|P-value:2.87E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.79|P-value:2.15E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.55|P-value:4.88E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-4.07|P-value:7.69E-5 ID:SGTC_2013|Compound:4024628|FD-Score:9.57|P-value:2.87E-19 ID:SGTC_2021|Compound:4019055|FD-Score:7.35|P-value:4.15E-12 ID:SGTC_2106|Compound:5357045|FD-Score:6.55|P-value:5.68E-10 ID:SGTC_2173|Compound:5763948|FD-Score:3.40|P-value:7.93E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.98|P-value:1.06E-4 ID:SGTC_2345|Compound:9052315|FD-Score:4.76|P-value:4.74E-6 ID:SGTC_2438|Compound:5259590|FD-Score:-3.88|P-value:1.53E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.56|P-value:4.67E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-3.69|P-value:2.98E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.12|P-value:6.44E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.75|P-value:2.44E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.48|P-value:6.15E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-3.55|P-value:4.86E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.50|P-value:5.69E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-3.67|P-value:3.26E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.83|P-value:1.86E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.59|P-value:4.27E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.38|P-value:8.48E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.69|P-value:3.01E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.10|P-value:6.99E-5 ID:SGTC_2881|Compound:9058953|FD-Score:3.54|P-value:5.01E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.95|P-value:1.20E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.37|P-value:8.71E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.67|P-value:3.17E-4 ID:SGTC_2982|Compound:9019404|FD-Score:4.49|P-value:1.46E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.67|P-value:3.20E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-3.61|P-value:4.01E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.39|P-value:8.12E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.79|P-value:4.28E-6 ID:SGTC_3242|Compound:9133940|FD-Score:4.22|P-value:4.36E-5 ID:SGTC_3264|Compound:9137442|FD-Score:4.05|P-value:8.33E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:-4.02|P-value:9.30E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:3.64|P-value:3.53E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:4.14|P-value:5.86E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.61|P-value:3.99E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.39|P-value:8.07E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.43|P-value:7.22E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:-3.76|P-value:2.33E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.95|P-value:1.18E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:4.24|P-value:4.10E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:6.23|P-value:3.54E-9 ID:SGTC_1128|Compound:3448-9350|FD-Score:6.96|P-value:4.76E-11 ID:SGTC_1530|Compound:rhein|FD-Score:3.70|P-value:2.87E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.79|P-value:2.15E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.55|P-value:4.88E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-4.07|P-value:7.69E-5 ID:SGTC_2013|Compound:4024628|FD-Score:9.57|P-value:2.87E-19 ID:SGTC_2021|Compound:4019055|FD-Score:7.35|P-value:4.15E-12 ID:SGTC_2106|Compound:5357045|FD-Score:6.55|P-value:5.68E-10 ID:SGTC_2173|Compound:5763948|FD-Score:3.40|P-value:7.93E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.98|P-value:1.06E-4 ID:SGTC_2345|Compound:9052315|FD-Score:4.76|P-value:4.74E-6 ID:SGTC_2438|Compound:5259590|FD-Score:-3.88|P-value:1.53E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.56|P-value:4.67E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-3.69|P-value:2.98E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.12|P-value:6.44E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.75|P-value:2.44E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.48|P-value:6.15E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-3.55|P-value:4.86E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.50|P-value:5.69E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-3.67|P-value:3.26E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.83|P-value:1.86E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.59|P-value:4.27E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.38|P-value:8.48E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.69|P-value:3.01E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.10|P-value:6.99E-5 ID:SGTC_2881|Compound:9058953|FD-Score:3.54|P-value:5.01E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.95|P-value:1.20E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.37|P-value:8.71E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.67|P-value:3.17E-4 ID:SGTC_2982|Compound:9019404|FD-Score:4.49|P-value:1.46E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.67|P-value:3.20E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-3.61|P-value:4.01E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.39|P-value:8.12E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.79|P-value:4.28E-6 ID:SGTC_3242|Compound:9133940|FD-Score:4.22|P-value:4.36E-5 ID:SGTC_3264|Compound:9137442|FD-Score:4.05|P-value:8.33E-5

Top fitness defect scores for YLR086W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2013 4024628 9.57 200.0 µM 2.87E-19 2 5.43E-22 4.67
2 SGTC_2021 4019055 7.35 173.0 µM 4.15E-12 endomembrane recycling 12 1.00E-13 0.13
3 SGTC_1128 3448-9350 6.96 235.0 µM 4.76E-11 2 1.67E-12 1.91
4 SGTC_2106 5357045 6.55 167.3 µM 5.68E-10 1 2.91E-11 1.04
5 SGTC_1015 4130-4525 6.23 82.0 µM 3.54E-9 60S ribosome export 4 2.40E-10 0.41
6 SGTC_3189 9110682 4.79 49.5 µM 4.28E-6 4 8.49E-7 0.26
7 SGTC_2345 9052315 4.76 157.4 µM 4.74E-6 3 9.54E-7 0.22
8 SGTC_2982 9019404 4.49 26.0 µM 1.46E-5 3 3.49E-6 0.26
9 SGTC_924 2046-0044 4.24 21.3 µM 4.10E-5 6 1.14E-5 0.21
10 SGTC_3242 9133940 4.22 49.5 µM 4.36E-5 2 1.22E-5 0.19
11 SGTC_416 estradiol valerate 4.14 100.0 µM 5.86E-5 2 1.72E-5 0.01
12 SGTC_2689 tacrolimus 4.12 100.0 µM 6.44E-5 12 1.91E-5 0.12
13 SGTC_3264 9137442 4.05 49.5 µM 8.33E-5 6 2.57E-5 0.45
14 SGTC_2292 7671323 3.98 168.1 µM 1.06E-4 RNA processing & uracil transport 12 3.38E-5 0.17
15 SGTC_920 mycophenolic acid 3.95 780.4 nM 1.18E-4 3 3.85E-5 0.09
16 SGTC_2890 9046729 3.95 58.4 µM 1.20E-4 Golgi 21 3.90E-5 0.15
17 SGTC_1592 4',5'-dihydroxyflavone 3.79 8.8 µM 2.15E-4 60S ribosome export 8 7.64E-5 0.17
18 SGTC_2713 st079149 3.75 53.4 µM 2.44E-4 4 8.85E-5 0.00
19 SGTC_1530 rhein 3.70 70.4 µM 2.87E-4 3 1.06E-4 0.38
20 SGTC_2991 9074669 3.67 71.4 µM 3.20E-4 azole & statin 24 1.21E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.75E-18 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.112 7.28E-11 YJL030W MAD2 hom Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I
0.108 3.03E-10 YLL014W EMC6 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93
0.105 1.08E-9 YLR413W_p YLR413W_p hom Putative protein of unknown function; YLR413W is not an essential gene
0.098 1.37E-8 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.094 4.34E-8 YMR013C SEC59 het Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
0.093 5.81E-8 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
0.089 2.11E-7 YKL079W SMY1 hom Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
0.089 2.48E-7 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.088 3.09E-7 YIL163C_p YIL163C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.088 3.40E-7 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.33E-6 YPL247C_p YPL247C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest
0.083 1.63E-6 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.082 2.09E-6 YDR310C SUM1 hom Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint
0.081 2.96E-6 YDR160W SSY1 het Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes