Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR087C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.452 | 4.45E-168 | YBL079W | NUP170 | hom | Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication |
0.409 | 3.30E-135 | YGR164W_d | YGR164W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.339 | 5.07E-91 | YLR055C | SPT8 | hom | Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters |
0.336 | 1.58E-89 | YPR153W | YPR153W | hom | Putative protein of unknown function |
0.330 | 4.57E-86 | YDR120C | TRM1 | hom | tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments |
0.329 | 3.19E-85 | YLR204W | QRI5 | hom | Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA |
0.324 | 7.45E-83 | YMR031W-A_d | YMR031W-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C |
0.320 | 1.15E-80 | YMR126C_p | DLT1_p | hom | Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA) |
0.287 | 1.97E-64 | YNL237W | YTP1 | hom | Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins |
0.279 | 5.10E-61 | YDR392W | SPT3 | hom | Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters |
0.276 | 1.71E-59 | YPL077C_p | YPL077C_p | hom | Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication |
0.269 | 7.73E-57 | YMR015C | ERG5 | hom | C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs |
0.264 | 2.19E-54 | YNL229C | URE2 | hom | Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion |
0.262 | 1.19E-53 | YKL098W | MTC2 | hom | Protein of unknown function; mtc2 is synthetically sick with cdc13-1 |
0.260 | 7.90E-53 | YOL050C_d | YOL050C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) |