YLR087C / CSF1

Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR087C / CSF1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:5.56|P-value:2.08E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:4.52|P-value:4.30E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.57|P-value:3.64E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.39|P-value:2.35E-8 ID:SGTC_59|Compound:0330-0160|FD-Score:10.60|P-value:2.85E-15 ID:SGTC_79|Compound:0052-0007|FD-Score:4.66|P-value:2.98E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:12.20|P-value:8.25E-20 ID:SGTC_129|Compound:0088-0017|FD-Score:7.96|P-value:2.20E-9 ID:SGTC_146|Compound:3448-8650|FD-Score:4.93|P-value:1.39E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.50|P-value:4.57E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.02|P-value:1.02E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.73|P-value:2.34E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:5.43|P-value:3.16E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:4.72|P-value:2.56E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-4.45|P-value:4.93E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:6.87|P-value:2.07E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:9.40|P-value:2.08E-12 ID:SGTC_528|Compound:3492-0019|FD-Score:7.97|P-value:2.08E-9 ID:SGTC_542|Compound:3381-0244|FD-Score:4.48|P-value:4.80E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.56|P-value:3.94E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:6.08|P-value:3.68E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:4.91|P-value:1.49E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:11.90|P-value:6.57E-19 ID:SGTC_690|Compound:glyoxal|FD-Score:4.22|P-value:9.32E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.56|P-value:3.92E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:4.63|P-value:3.27E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:6.06|P-value:3.94E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:4.99|P-value:1.16E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:4.50|P-value:4.63E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:5.05|P-value:9.78E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:6.63|P-value:5.03E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:5.82|P-value:8.90E-6 ID:SGTC_1001|Compound:4048-4355|FD-Score:4.37|P-value:6.43E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.77|P-value:2.22E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.44|P-value:5.42E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:7.41|P-value:2.36E-8 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.93|P-value:1.40E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.76|P-value:1.11E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:-4.52|P-value:4.12E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.62|P-value:3.36E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.62|P-value:1.73E-5 ID:SGTC_1571|Compound:st070080|FD-Score:5.15|P-value:7.39E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.62|P-value:1.75E-5 ID:SGTC_1616|Compound:st002734|FD-Score:-4.36|P-value:6.24E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.63|P-value:3.26E-4 ID:SGTC_1687|Compound:st020778|FD-Score:15.90|P-value:5.72E-32 ID:SGTC_1750|Compound:st081859|FD-Score:22.90|P-value:2.03E-64 ID:SGTC_1768|Compound:st044301|FD-Score:-4.36|P-value:6.31E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.20|P-value:9.89E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.58|P-value:3.48E-4 ID:SGTC_1791|Compound:st048313|FD-Score:4.93|P-value:1.41E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.35|P-value:4.03E-5 ID:SGTC_1826|Compound:st055655|FD-Score:5.74|P-value:1.16E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:10.30|P-value:1.68E-14 ID:SGTC_1877|Compound:wortmannin|FD-Score:12.50|P-value:1.94E-20 ID:SGTC_1941|Compound:st076221|FD-Score:13.10|P-value:2.99E-22 ID:SGTC_1970|Compound:st070122|FD-Score:6.78|P-value:2.83E-7 ID:SGTC_2007|Compound:4011539|FD-Score:6.76|P-value:3.15E-7 ID:SGTC_2077|Compound:5212015|FD-Score:8.36|P-value:3.50E-10 ID:SGTC_2081|Compound:5214970|FD-Score:4.66|P-value:2.99E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.57|P-value:3.80E-4 ID:SGTC_2181|Compound:6316240|FD-Score:6.34|P-value:1.48E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.83|P-value:8.62E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.52|P-value:4.07E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-7.76|P-value:4.82E-9 ID:SGTC_2312|Compound:7706453|FD-Score:6.93|P-value:1.62E-7 ID:SGTC_2314|Compound:7727897|FD-Score:-4.71|P-value:2.46E-4 ID:SGTC_2322|Compound:7413319|FD-Score:10.10|P-value:4.02E-14 ID:SGTC_2442|Compound:5158906|FD-Score:-5.54|P-value:2.06E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-4.32|P-value:6.97E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.45|P-value:5.21E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.31|P-value:7.08E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.25|P-value:2.04E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.39|P-value:2.57E-8 ID:SGTC_2858|Compound:9025781|FD-Score:15.20|P-value:1.80E-29 ID:SGTC_2949|Compound:9072542|FD-Score:4.92|P-value:1.45E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.63|P-value:3.20E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.72|P-value:2.53E-4 ID:SGTC_3025|Compound:9087895|FD-Score:7.64|P-value:8.64E-9 ID:SGTC_3174|Compound:9107204|FD-Score:4.61|P-value:3.37E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-4.58|P-value:3.48E-4 ID:SGTC_3223|Compound:9129970|FD-Score:5.52|P-value:2.38E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-4.72|P-value:2.37E-4 ID:SGTC_3288|Compound:9119690|FD-Score:-4.18|P-value:9.93E-4 ID:SGTC_3303|Compound:9125618|FD-Score:5.51|P-value:2.46E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:5.56|P-value:2.08E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:4.52|P-value:4.30E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.57|P-value:3.64E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.39|P-value:2.35E-8 ID:SGTC_59|Compound:0330-0160|FD-Score:10.60|P-value:2.85E-15 ID:SGTC_79|Compound:0052-0007|FD-Score:4.66|P-value:2.98E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:12.20|P-value:8.25E-20 ID:SGTC_129|Compound:0088-0017|FD-Score:7.96|P-value:2.20E-9 ID:SGTC_146|Compound:3448-8650|FD-Score:4.93|P-value:1.39E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.50|P-value:4.57E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.02|P-value:1.02E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.73|P-value:2.34E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:5.43|P-value:3.16E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:4.72|P-value:2.56E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-4.45|P-value:4.93E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:6.87|P-value:2.07E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:9.40|P-value:2.08E-12 ID:SGTC_528|Compound:3492-0019|FD-Score:7.97|P-value:2.08E-9 ID:SGTC_542|Compound:3381-0244|FD-Score:4.48|P-value:4.80E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.56|P-value:3.94E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:6.08|P-value:3.68E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:4.91|P-value:1.49E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:11.90|P-value:6.57E-19 ID:SGTC_690|Compound:glyoxal|FD-Score:4.22|P-value:9.32E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.56|P-value:3.92E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:4.63|P-value:3.27E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:6.06|P-value:3.94E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:4.99|P-value:1.16E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:4.50|P-value:4.63E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:5.05|P-value:9.78E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:6.63|P-value:5.03E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:5.82|P-value:8.90E-6 ID:SGTC_1001|Compound:4048-4355|FD-Score:4.37|P-value:6.43E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.77|P-value:2.22E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.44|P-value:5.42E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:7.41|P-value:2.36E-8 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.93|P-value:1.40E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.76|P-value:1.11E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:-4.52|P-value:4.12E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.62|P-value:3.36E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.62|P-value:1.73E-5 ID:SGTC_1571|Compound:st070080|FD-Score:5.15|P-value:7.39E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.62|P-value:1.75E-5 ID:SGTC_1616|Compound:st002734|FD-Score:-4.36|P-value:6.24E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.63|P-value:3.26E-4 ID:SGTC_1687|Compound:st020778|FD-Score:15.90|P-value:5.72E-32 ID:SGTC_1750|Compound:st081859|FD-Score:22.90|P-value:2.03E-64 ID:SGTC_1768|Compound:st044301|FD-Score:-4.36|P-value:6.31E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.20|P-value:9.89E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.58|P-value:3.48E-4 ID:SGTC_1791|Compound:st048313|FD-Score:4.93|P-value:1.41E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.35|P-value:4.03E-5 ID:SGTC_1826|Compound:st055655|FD-Score:5.74|P-value:1.16E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:10.30|P-value:1.68E-14 ID:SGTC_1877|Compound:wortmannin|FD-Score:12.50|P-value:1.94E-20 ID:SGTC_1941|Compound:st076221|FD-Score:13.10|P-value:2.99E-22 ID:SGTC_1970|Compound:st070122|FD-Score:6.78|P-value:2.83E-7 ID:SGTC_2007|Compound:4011539|FD-Score:6.76|P-value:3.15E-7 ID:SGTC_2077|Compound:5212015|FD-Score:8.36|P-value:3.50E-10 ID:SGTC_2081|Compound:5214970|FD-Score:4.66|P-value:2.99E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.57|P-value:3.80E-4 ID:SGTC_2181|Compound:6316240|FD-Score:6.34|P-value:1.48E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.83|P-value:8.62E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.52|P-value:4.07E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-7.76|P-value:4.82E-9 ID:SGTC_2312|Compound:7706453|FD-Score:6.93|P-value:1.62E-7 ID:SGTC_2314|Compound:7727897|FD-Score:-4.71|P-value:2.46E-4 ID:SGTC_2322|Compound:7413319|FD-Score:10.10|P-value:4.02E-14 ID:SGTC_2442|Compound:5158906|FD-Score:-5.54|P-value:2.06E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-4.32|P-value:6.97E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.45|P-value:5.21E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.31|P-value:7.08E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.25|P-value:2.04E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.39|P-value:2.57E-8 ID:SGTC_2858|Compound:9025781|FD-Score:15.20|P-value:1.80E-29 ID:SGTC_2949|Compound:9072542|FD-Score:4.92|P-value:1.45E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.63|P-value:3.20E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.72|P-value:2.53E-4 ID:SGTC_3025|Compound:9087895|FD-Score:7.64|P-value:8.64E-9 ID:SGTC_3174|Compound:9107204|FD-Score:4.61|P-value:3.37E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-4.58|P-value:3.48E-4 ID:SGTC_3223|Compound:9129970|FD-Score:5.52|P-value:2.38E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-4.72|P-value:2.37E-4 ID:SGTC_3288|Compound:9119690|FD-Score:-4.18|P-value:9.93E-4 ID:SGTC_3303|Compound:9125618|FD-Score:5.51|P-value:2.46E-5

Top fitness defect scores for YLR087C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 22.90 2.4 µM 2.03E-64 endomembrane recycling 9 1.98E-116
2 SGTC_1687 st020778 15.90 55.4 µM 5.72E-32 16 5.25E-57
3 SGTC_2858 9025781 15.20 9.0 µM 1.80E-29 sphingolipid biosynthesis & PDR1 12 1.95E-52
4 SGTC_1941 st076221 13.10 61.8 µM 2.99E-22 sphingolipid biosynthesis & PDR1 5 3.08E-39
5 SGTC_1877 wortmannin 12.50 25.0 µM 1.94E-20 4 6.28E-36
6 SGTC_87 0100-0052 12.20 35.5 µM 8.25E-20 2 8.86E-35
7 SGTC_682 0kpi-0099 11.90 17.0 µM 6.57E-19 4 3.92E-33
8 SGTC_59 0330-0160 10.60 1.3 µM 2.85E-15 7 1.69E-26
9 SGTC_1875 nocodazole 10.30 6.0 µM 1.68E-14 tubulin folding & SWR complex 14 4.28E-25
10 SGTC_2322 7413319 10.10 38.2 µM 4.02E-14 ERAD & cell cycle 19 2.11E-24
11 SGTC_513 4245-1575 9.40 41.7 µM 2.08E-12 unfolded protein response 19 2.78E-21
12 SGTC_2077 5212015 8.36 200.0 µM 3.50E-10 10 3.11E-17
13 SGTC_528 3492-0019 7.97 172.0 µM 2.08E-9 calcium & mitochondrial duress 72 7.92E-16
14 SGTC_129 0088-0017 7.96 176.6 µM 2.20E-9 16 8.78E-16
15 SGTC_3025 9087895 7.64 49.5 µM 8.64E-9 PDR1 5 1.05E-14
16 SGTC_1119 parthenolide 7.41 318.5 nM 2.36E-8 TSC3-RPN4 4 6.48E-14
17 SGTC_2752 diclazuril 7.39 33.1 µM 2.57E-8 42 7.55E-14
18 SGTC_2312 7706453 6.93 155.7 µM 1.62E-7 8 2.10E-12
19 SGTC_488 nitrendipine 6.87 139.0 µM 2.07E-7 10 3.29E-12
20 SGTC_1970 st070122 6.78 35.8 µM 2.83E-7 TSC3-RPN4 5 5.81E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.452 4.45E-168 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.409 3.30E-135 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.339 5.07E-91 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.336 1.58E-89 YPR153W YPR153W hom Putative protein of unknown function
0.330 4.57E-86 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.329 3.19E-85 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.324 7.45E-83 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.320 1.15E-80 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.287 1.97E-64 YNL237W YTP1 hom Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.279 5.10E-61 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.276 1.71E-59 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.269 7.73E-57 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.264 2.19E-54 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.262 1.19E-53 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.260 7.90E-53 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)