HIPHOP chemogenomics database

YLR087C / CSF1

Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR087C / CSF1

Click on Significant Values for Screen Details

Top fitness defect scores for YLR087C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1750	st081859	22.90	2.4 µM	2.03E-64	endomembrane recycling	9	1.98E-116
2	SGTC_1687	st020778	15.90	55.4 µM	5.72E-32		16	5.25E-57
3	SGTC_2858	9025781	15.20	9.0 µM	1.80E-29	sphingolipid biosynthesis & PDR1	12	1.95E-52
4	SGTC_1941	st076221	13.10	61.8 µM	2.99E-22	sphingolipid biosynthesis & PDR1	5	3.08E-39
5	SGTC_1877	wortmannin	12.50	25.0 µM	1.94E-20		4	6.28E-36
6	SGTC_87	0100-0052	12.20	35.5 µM	8.25E-20		2	8.86E-35
7	SGTC_682	0kpi-0099	11.90	17.0 µM	6.57E-19		4	3.92E-33
8	SGTC_59	0330-0160	10.60	1.3 µM	2.85E-15		7	1.69E-26
9	SGTC_1875	nocodazole	10.30	6.0 µM	1.68E-14	tubulin folding & SWR complex	14	4.28E-25
10	SGTC_2322	7413319	10.10	38.2 µM	4.02E-14	ERAD & cell cycle	19	2.11E-24
11	SGTC_513	4245-1575	9.40	41.7 µM	2.08E-12	unfolded protein response	19	2.78E-21
12	SGTC_2077	5212015	8.36	200.0 µM	3.50E-10		10	3.11E-17
13	SGTC_528	3492-0019	7.97	172.0 µM	2.08E-9	calcium & mitochondrial duress	72	7.92E-16
14	SGTC_129	0088-0017	7.96	176.6 µM	2.20E-9		16	8.78E-16
15	SGTC_3025	9087895	7.64	49.5 µM	8.64E-9	PDR1	5	1.05E-14
16	SGTC_1119	parthenolide	7.41	318.5 nM	2.36E-8	TSC3-RPN4	4	6.48E-14
17	SGTC_2752	diclazuril	7.39	33.1 µM	2.57E-8		42	7.55E-14
18	SGTC_2312	7706453	6.93	155.7 µM	1.62E-7		8	2.10E-12
19	SGTC_488	nitrendipine	6.87	139.0 µM	2.07E-7		10	3.29E-12
20	SGTC_1970	st070122	6.78	35.8 µM	2.83E-7	TSC3-RPN4	5	5.81E-12

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.452	4.45E-168	YBL079W	NUP170	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.409	3.30E-135	YGR164W_d	YGR164W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.339	5.07E-91	YLR055C	SPT8	hom	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.336	1.58E-89	YPR153W	YPR153W	hom	Putative protein of unknown function
0.330	4.57E-86	YDR120C	TRM1	hom	tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.329	3.19E-85	YLR204W	QRI5	hom	Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.324	7.45E-83	YMR031W-A_d	YMR031W-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.320	1.15E-80	YMR126C_p	DLT1_p	hom	Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.287	1.97E-64	YNL237W	YTP1	hom	Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.279	5.10E-61	YDR392W	SPT3	hom	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.276	1.71E-59	YPL077C_p	YPL077C_p	hom	Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.269	7.73E-57	YMR015C	ERG5	hom	C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.264	2.19E-54	YNL229C	URE2	hom	Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.262	1.19E-53	YKL098W	MTC2	hom	Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.260	7.90E-53	YOL050C_d	YOL050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)