YLR088W / GAA1

Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR088W / GAA1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.14|P-value:7.68E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.70|P-value:9.34E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:3.38|P-value:3.19E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.38|P-value:3.15E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.20|P-value:1.12E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.31|P-value:4.19E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:-3.71|P-value:8.46E-5 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.26|P-value:5.01E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.89|P-value:3.93E-7 ID:SGTC_606|Compound:k015-0008|FD-Score:3.08|P-value:9.32E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.11|P-value:8.52E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.25|P-value:5.18E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.90|P-value:4.09E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:4.38|P-value:4.81E-6 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.29|P-value:4.31E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:6.63|P-value:1.02E-11 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.12|P-value:7.73E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.27|P-value:4.74E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.48|P-value:3.06E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.46|P-value:2.34E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:-4.37|P-value:4.71E-6 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.35|P-value:3.60E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.46|P-value:3.28E-6 ID:SGTC_1713|Compound:st033146|FD-Score:3.82|P-value:5.65E-5 ID:SGTC_1714|Compound:st033236|FD-Score:3.22|P-value:5.70E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-3.71|P-value:8.70E-5 ID:SGTC_1765|Compound:st044815|FD-Score:3.29|P-value:4.37E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.09|P-value:9.03E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.77|P-value:6.98E-5 ID:SGTC_1968|Compound:st069590|FD-Score:4.19|P-value:1.15E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.28|P-value:7.46E-6 ID:SGTC_2028|Compound:5153890|FD-Score:3.39|P-value:3.09E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.45|P-value:2.37E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.48|P-value:2.19E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.78|P-value:6.62E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:4.00|P-value:2.60E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.09|P-value:1.68E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.37|P-value:2.79E-8 ID:SGTC_2816|Compound:7982706|FD-Score:3.62|P-value:1.28E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.98|P-value:2.84E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.07|P-value:9.67E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.10|P-value:8.76E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.67|P-value:1.02E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.51|P-value:2.62E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:3.14|P-value:7.68E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.70|P-value:9.34E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:3.38|P-value:3.19E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.38|P-value:3.15E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.20|P-value:1.12E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.31|P-value:4.19E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:-3.71|P-value:8.46E-5 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.26|P-value:5.01E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.89|P-value:3.93E-7 ID:SGTC_606|Compound:k015-0008|FD-Score:3.08|P-value:9.32E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.11|P-value:8.52E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.25|P-value:5.18E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.90|P-value:4.09E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:4.38|P-value:4.81E-6 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.29|P-value:4.31E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:6.63|P-value:1.02E-11 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.12|P-value:7.73E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.27|P-value:4.74E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.48|P-value:3.06E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.46|P-value:2.34E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:-4.37|P-value:4.71E-6 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.35|P-value:3.60E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.46|P-value:3.28E-6 ID:SGTC_1713|Compound:st033146|FD-Score:3.82|P-value:5.65E-5 ID:SGTC_1714|Compound:st033236|FD-Score:3.22|P-value:5.70E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-3.71|P-value:8.70E-5 ID:SGTC_1765|Compound:st044815|FD-Score:3.29|P-value:4.37E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.09|P-value:9.03E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.77|P-value:6.98E-5 ID:SGTC_1968|Compound:st069590|FD-Score:4.19|P-value:1.15E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.28|P-value:7.46E-6 ID:SGTC_2028|Compound:5153890|FD-Score:3.39|P-value:3.09E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.45|P-value:2.37E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.48|P-value:2.19E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.78|P-value:6.62E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:4.00|P-value:2.60E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.09|P-value:1.68E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.37|P-value:2.79E-8 ID:SGTC_2816|Compound:7982706|FD-Score:3.62|P-value:1.28E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.98|P-value:2.84E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.07|P-value:9.67E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.10|P-value:8.76E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.67|P-value:1.02E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.51|P-value:2.62E-6

Top fitness defect scores for YLR088W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1113 artemisinin 6.63 1.2 µM 1.02E-11 heme biosynthesis & mitochondrial translocase 11 1.67E-11 0.04
2 SGTC_2682 pyrogallin 5.37 40.0 µM 2.79E-8 copper-dependent oxidative stress 1 3.84E-8 0.95
3 SGTC_513 4245-1575 4.89 41.7 µM 3.93E-7 unfolded protein response 18 5.12E-7 0.07
4 SGTC_3299 9121982 4.51 43.1 µM 2.62E-6 4 3.28E-6 0.05
5 SGTC_1297 1068-0111 4.48 14.1 µM 3.06E-6 2 3.82E-6 0.39
6 SGTC_1464 k208-0027 4.46 110.0 µM 3.28E-6 4 4.10E-6 0.41
7 SGTC_887 0885-0007 4.38 9.6 µM 4.81E-6 endomembrane recycling 10 5.95E-6 0.01
8 SGTC_2008 4012253 4.28 172.0 µM 7.46E-6 8 9.15E-6 0.12
9 SGTC_151 3013-0144 4.20 2.3 µM 1.12E-5 iron homeostasis 6 1.36E-5 0.02
10 SGTC_1968 st069590 4.19 43.6 µM 1.15E-5 13 1.39E-5 0.40
11 SGTC_2657 nystatin 4.00 74.4 µM 2.60E-5 3 3.10E-5 0.19
12 SGTC_2825 7998094 3.98 58.4 µM 2.84E-5 fatty acid desaturase (OLE1) 12 3.38E-5 0.16
13 SGTC_869 0564-0080 3.90 44.1 µM 4.09E-5 1 4.84E-5 0.35
14 SGTC_1713 st033146 3.82 12.8 µM 5.65E-5 11 6.64E-5 0.23
15 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.78 100.0 µM 6.62E-5 8 7.76E-5 0.17
16 SGTC_1967 st070177 3.77 51.4 µM 6.98E-5 8 8.17E-5 0.11
17 SGTC_64 000l-0018 3.70 272.1 µM 9.34E-5 ubiquinone biosynthesis & proteasome 52 1.09E-4 0.04
18 SGTC_3249 9135183 3.67 49.5 µM 1.02E-4 60S ribosome export 7 1.19E-4 0.21
19 SGTC_2816 7982706 3.62 58.4 µM 1.28E-4 azole & statin 16 1.48E-4 0.08
20 SGTC_2627 acetyl isogambogic acid 3.48 100.0 µM 2.19E-4 TSC3-RPN4 10 2.50E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 8.69E-23 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.163 1.60E-21 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.163 1.88E-21 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.157 7.71E-20 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.155 1.95E-19 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.153 4.57E-19 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.149 3.44E-18 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.138 1.26E-15 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.137 1.70E-15 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.137 1.78E-15 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.135 3.58E-15 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.134 6.28E-15 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.133 8.64E-15 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.133 1.30E-14 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.132 1.94E-14 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP