YLR090W / XDJ1

Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR090W / XDJ1

Click on Significant Values for Screen Details ID:SGTC_166|Compound:k072-0058|FD-Score:3.30|P-value:6.05E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.09|P-value:8.50E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:-3.45|P-value:2.42E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.60|P-value:1.34E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:4.02|P-value:3.85E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.43|P-value:2.57E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.23|P-value:5.40E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.99|P-value:4.29E-7 ID:SGTC_537|Compound:1334-0398|FD-Score:3.16|P-value:9.66E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.35|P-value:5.05E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.79|P-value:9.59E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.64|P-value:1.74E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:-3.06|P-value:9.69E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.89|P-value:6.42E-5 ID:SGTC_1523|Compound:st012844|FD-Score:-3.50|P-value:2.00E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.31|P-value:1.08E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.75|P-value:1.12E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.04|P-value:3.55E-5 ID:SGTC_1731|Compound:st035964|FD-Score:4.54|P-value:3.75E-6 ID:SGTC_1749|Compound:st037932|FD-Score:5.87|P-value:3.17E-9 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.18|P-value:9.01E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.83|P-value:8.36E-5 ID:SGTC_1809|Compound:st050081|FD-Score:4.29|P-value:1.20E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-3.20|P-value:5.95E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.13|P-value:7.51E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.18|P-value:9.10E-4 ID:SGTC_2404|Compound:5161160|FD-Score:4.08|P-value:2.88E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.95|P-value:3.24E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.50|P-value:4.55E-6 ID:SGTC_2805|Compound:7950783|FD-Score:3.42|P-value:3.88E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.43|P-value:3.72E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-3.37|P-value:3.18E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.30|P-value:6.05E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.09|P-value:8.50E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:-3.45|P-value:2.42E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.60|P-value:1.34E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:4.02|P-value:3.85E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.43|P-value:2.57E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.23|P-value:5.40E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.99|P-value:4.29E-7 ID:SGTC_537|Compound:1334-0398|FD-Score:3.16|P-value:9.66E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.35|P-value:5.05E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.79|P-value:9.59E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.64|P-value:1.74E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:-3.06|P-value:9.69E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.89|P-value:6.42E-5 ID:SGTC_1523|Compound:st012844|FD-Score:-3.50|P-value:2.00E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.31|P-value:1.08E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.75|P-value:1.12E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.04|P-value:3.55E-5 ID:SGTC_1731|Compound:st035964|FD-Score:4.54|P-value:3.75E-6 ID:SGTC_1749|Compound:st037932|FD-Score:5.87|P-value:3.17E-9 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.18|P-value:9.01E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.83|P-value:8.36E-5 ID:SGTC_1809|Compound:st050081|FD-Score:4.29|P-value:1.20E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-3.20|P-value:5.95E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.13|P-value:7.51E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.18|P-value:9.10E-4 ID:SGTC_2404|Compound:5161160|FD-Score:4.08|P-value:2.88E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.95|P-value:3.24E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.50|P-value:4.55E-6 ID:SGTC_2805|Compound:7950783|FD-Score:3.42|P-value:3.88E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.43|P-value:3.72E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-3.37|P-value:3.18E-4

Top fitness defect scores for YLR090W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1749 st037932 5.87 54.2 µM 3.17E-9 9 2.12E-9
2 SGTC_533 1222-0222 4.99 6.7 µM 4.29E-7 PDR1 11 3.08E-7
3 SGTC_1731 st035964 4.54 63.0 µM 3.75E-6 13 2.78E-6
4 SGTC_2597 laccaic acid a 4.50 100.0 µM 4.55E-6 23 3.38E-6
5 SGTC_1525 8-methoxypsoralen 4.31 92.5 µM 1.08E-5 DNA damage response 19 8.10E-6
6 SGTC_1809 st050081 4.29 57.6 µM 1.20E-5 14 9.05E-6
7 SGTC_2404 5161160 4.08 200.0 µM 2.88E-5 16 2.21E-5
8 SGTC_1728 st035614 4.04 33.8 µM 3.55E-5 43 2.73E-5
9 SGTC_345 1362-0200 4.02 395.0 µM 3.85E-5 15 2.96E-5
10 SGTC_1437 4092-1038 3.89 11.6 µM 6.42E-5 17 4.98E-5
11 SGTC_1807 st050092 3.83 58.9 µM 8.36E-5 60S ribosome export 14 6.52E-5
12 SGTC_1198 1612-1005 3.79 86.7 µM 9.59E-5 16 7.49E-5
13 SGTC_1680 diphenhydramine 3.75 100.0 µM 1.12E-4 NEO1 35 8.76E-5
14 SGTC_1331 1472-0049 3.64 76.2 µM 1.74E-4 27 1.37E-4
15 SGTC_2971 9092186 3.43 9.9 µM 3.72E-4 ergosterol biosynthesis 47 2.98E-4
16 SGTC_2805 7950783 3.42 58.4 µM 3.88E-4 49 3.11E-4
17 SGTC_982 1491-0518 3.35 27.5 µM 5.05E-4 32 4.07E-4
18 SGTC_166 k072-0058 3.30 166.4 µM 6.05E-4 DNA intercalators 65 4.89E-4
19 SGTC_1787 fluconazole 3.18 80.0 µM 9.01E-4 iron homeostasis 72 7.34E-4
20 SGTC_2145 5634607 3.18 200.0 µM 9.10E-4 26 7.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 8.48E-11 YGR030C POP6 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.107 5.59E-10 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.107 5.73E-10 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.100 6.49E-9 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.100 7.05E-9 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.094 4.55E-8 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.093 7.69E-8 YJR072C NPA3 het Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
0.092 8.25E-8 YDR481C PHO8 hom Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
0.091 1.18E-7 YAL018C_p YAL018C_p hom Putative protein of unknown function
0.086 5.69E-7 YKR094C RPL40B hom Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication
0.086 6.63E-7 YMR254C_d YMR254C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.083 1.69E-6 YFR012W DCV1 hom Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication
0.082 2.23E-6 YDR480W DIG2 hom MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p
0.081 2.62E-6 YPL228W CET1 het Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.078 5.65E-6 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity