YLR091W / GEP5

Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR091W / GEP5

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.55|P-value:1.61E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.87|P-value:1.92E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:9.51|P-value:8.82E-19 ID:SGTC_236|Compound:1509-0011|FD-Score:13.80|P-value:3.30E-37 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.38|P-value:8.07E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.10|P-value:5.84E-25 ID:SGTC_310|Compound:1273-0058|FD-Score:9.09|P-value:2.70E-17 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.39|P-value:9.29E-4 ID:SGTC_500|Compound:h-89|FD-Score:-3.38|P-value:8.02E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.82|P-value:2.24E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:4.34|P-value:3.33E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:3.68|P-value:3.65E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.99|P-value:1.00E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.44|P-value:2.27E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:5.13|P-value:1.17E-6 ID:SGTC_700|Compound:3453-2283|FD-Score:3.77|P-value:2.68E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:-3.62|P-value:3.78E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.44|P-value:2.30E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:4.28|P-value:4.25E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.38|P-value:3.78E-7 ID:SGTC_963|Compound:1269-2853|FD-Score:5.73|P-value:6.83E-8 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.26|P-value:4.48E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.74|P-value:6.72E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.55|P-value:5.56E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:7.07|P-value:3.77E-11 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.88|P-value:3.59E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.45|P-value:2.13E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.67|P-value:3.09E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.39|P-value:2.71E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.47|P-value:1.57E-5 ID:SGTC_1731|Compound:st035964|FD-Score:-3.63|P-value:3.59E-4 ID:SGTC_1736|Compound:st036774|FD-Score:-3.57|P-value:4.38E-4 ID:SGTC_1742|Compound:st038235|FD-Score:10.30|P-value:8.86E-22 ID:SGTC_1754|Compound:st042065|FD-Score:-4.85|P-value:3.20E-6 ID:SGTC_1758|Compound:st042942|FD-Score:4.27|P-value:4.46E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.12|P-value:9.77E-7 ID:SGTC_1884|Compound:5633444|FD-Score:-3.41|P-value:7.30E-4 ID:SGTC_2006|Compound:4011487|FD-Score:4.51|P-value:1.69E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-4.15|P-value:5.53E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.60|P-value:4.85E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-4.34|P-value:2.70E-5 ID:SGTC_2183|Compound:6420625|FD-Score:5.82|P-value:4.29E-8 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.19|P-value:8.89E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.17|P-value:9.91E-7 ID:SGTC_2351|Compound:9026858|FD-Score:-4.78|P-value:4.40E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.05|P-value:9.95E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.55|P-value:5.56E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.40|P-value:2.60E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.50|P-value:6.59E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-6.52|P-value:7.04E-10 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.92|P-value:3.03E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.74|P-value:2.67E-10 ID:SGTC_2692|Compound:st077426|FD-Score:-4.19|P-value:4.73E-5 ID:SGTC_2872|Compound:9044037|FD-Score:3.77|P-value:2.73E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.17|P-value:6.41E-5 ID:SGTC_3134|Compound:9127454|FD-Score:3.63|P-value:4.39E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.59|P-value:4.14E-4 ID:SGTC_3184|Compound:9108758|FD-Score:3.63|P-value:4.37E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-3.57|P-value:4.33E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.55|P-value:1.61E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.87|P-value:1.92E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:9.51|P-value:8.82E-19 ID:SGTC_236|Compound:1509-0011|FD-Score:13.80|P-value:3.30E-37 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.38|P-value:8.07E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.10|P-value:5.84E-25 ID:SGTC_310|Compound:1273-0058|FD-Score:9.09|P-value:2.70E-17 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.39|P-value:9.29E-4 ID:SGTC_500|Compound:h-89|FD-Score:-3.38|P-value:8.02E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.82|P-value:2.24E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:4.34|P-value:3.33E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:3.68|P-value:3.65E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.99|P-value:1.00E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.44|P-value:2.27E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:5.13|P-value:1.17E-6 ID:SGTC_700|Compound:3453-2283|FD-Score:3.77|P-value:2.68E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:-3.62|P-value:3.78E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.44|P-value:2.30E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:4.28|P-value:4.25E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.38|P-value:3.78E-7 ID:SGTC_963|Compound:1269-2853|FD-Score:5.73|P-value:6.83E-8 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.26|P-value:4.48E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.74|P-value:6.72E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.55|P-value:5.56E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:7.07|P-value:3.77E-11 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.88|P-value:3.59E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.45|P-value:2.13E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.67|P-value:3.09E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.39|P-value:2.71E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.47|P-value:1.57E-5 ID:SGTC_1731|Compound:st035964|FD-Score:-3.63|P-value:3.59E-4 ID:SGTC_1736|Compound:st036774|FD-Score:-3.57|P-value:4.38E-4 ID:SGTC_1742|Compound:st038235|FD-Score:10.30|P-value:8.86E-22 ID:SGTC_1754|Compound:st042065|FD-Score:-4.85|P-value:3.20E-6 ID:SGTC_1758|Compound:st042942|FD-Score:4.27|P-value:4.46E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.12|P-value:9.77E-7 ID:SGTC_1884|Compound:5633444|FD-Score:-3.41|P-value:7.30E-4 ID:SGTC_2006|Compound:4011487|FD-Score:4.51|P-value:1.69E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-4.15|P-value:5.53E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.60|P-value:4.85E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-4.34|P-value:2.70E-5 ID:SGTC_2183|Compound:6420625|FD-Score:5.82|P-value:4.29E-8 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.19|P-value:8.89E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.17|P-value:9.91E-7 ID:SGTC_2351|Compound:9026858|FD-Score:-4.78|P-value:4.40E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.05|P-value:9.95E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.55|P-value:5.56E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.40|P-value:2.60E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.50|P-value:6.59E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-6.52|P-value:7.04E-10 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.92|P-value:3.03E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.74|P-value:2.67E-10 ID:SGTC_2692|Compound:st077426|FD-Score:-4.19|P-value:4.73E-5 ID:SGTC_2872|Compound:9044037|FD-Score:3.77|P-value:2.73E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.17|P-value:6.41E-5 ID:SGTC_3134|Compound:9127454|FD-Score:3.63|P-value:4.39E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.59|P-value:4.14E-4 ID:SGTC_3184|Compound:9108758|FD-Score:3.63|P-value:4.37E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-3.57|P-value:4.33E-4

Top fitness defect scores for YLR091W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 13.80 5.3 µM 3.30E-37 123 2.39E-43
2 SGTC_275 trichlorophene 11.10 5.7 µM 5.84E-25 mitochondrial stress 33 5.28E-29
3 SGTC_1742 st038235 10.30 28.9 µM 8.86E-22 mitochondrial stress 10 2.80E-25
4 SGTC_173 1273-0061 9.51 2.7 µM 8.82E-19 mitochondrial stress 45 9.09E-22
5 SGTC_310 1273-0058 9.09 1.1 µM 2.70E-17 mitochondrial stress 63 5.00E-20
6 SGTC_1274 0865-0114 7.07 173.0 µM 3.77E-11 1 7.83E-13
7 SGTC_2688 kanamycin b 6.74 96.7 µM 2.67E-10 calcium & mitochondrial duress 116 7.76E-12
8 SGTC_2183 6420625 5.82 130.5 µM 4.29E-8 mitochondrial processes 14 2.95E-9
9 SGTC_963 1269-2853 5.73 151.0 µM 6.83E-8 5 5.10E-9
10 SGTC_10 0279-0212 5.55 42.6 µM 1.61E-7 TRP & mitochondrial translation 38 1.39E-8
11 SGTC_908 3448-7491 5.38 47.7 µM 3.78E-7 mitochondrial stress 65 3.77E-8
12 SGTC_2232 chlorophetanol 5.19 41.5 µM 8.89E-7 TRP & mitochondrial translation 70 1.02E-7
13 SGTC_2250 alverine citrate 5.17 130.0 µM 9.91E-7 87 1.16E-7
14 SGTC_691 1548-0686 5.13 185.0 µM 1.17E-6 12 1.41E-7
15 SGTC_2626 ethyl orsellinate 4.92 100.0 µM 3.03E-6 15 4.30E-7
16 SGTC_1298 1079-1278 4.88 263.0 µM 3.59E-6 DNA damage response 5 5.23E-7
17 SGTC_1057 3448-5381 4.74 134.0 µM 6.72E-6 calcium & mitochondrial duress 15 1.09E-6
18 SGTC_2006 4011487 4.51 200.0 µM 1.69E-5 endomembrane recycling 67 3.21E-6
19 SGTC_1468 k284-1086 4.45 134.0 µM 2.13E-5 DNA intercalators 21 4.20E-6
20 SGTC_581 0958-0271 4.44 211.0 µM 2.27E-5 38 4.51E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.451 5.89E-168 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.449 5.93E-166 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.447 7.01E-165 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.445 6.28E-163 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.439 1.26E-157 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.433 1.05E-153 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.431 9.55E-152 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.429 3.47E-150 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.428 2.71E-149 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.426 7.50E-148 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.425 2.95E-147 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.423 5.23E-146 YLR067C PET309 hom Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)
0.420 1.42E-143 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.417 1.73E-141 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.414 2.70E-139 YIL093C RSM25 hom Mitochondrial ribosomal protein of the small subunit