YLR092W / SUL2

High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR092W / SUL2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.58|P-value:9.64E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.72|P-value:5.40E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:3.11|P-value:6.16E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.64|P-value:7.68E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.11|P-value:7.84E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.61|P-value:7.36E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.42|P-value:1.64E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.90|P-value:1.69E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:6.80|P-value:6.43E-13 ID:SGTC_430|Compound:0958-0115|FD-Score:6.84|P-value:4.97E-13 ID:SGTC_446|Compound:go6976|FD-Score:3.16|P-value:5.09E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.88|P-value:2.71E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:-3.53|P-value:1.05E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.00|P-value:9.04E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:4.17|P-value:7.00E-6 ID:SGTC_537|Compound:1334-0398|FD-Score:4.33|P-value:3.33E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:2.98|P-value:9.86E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:4.00|P-value:1.59E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:3.08|P-value:6.78E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:-4.51|P-value:1.08E-6 ID:SGTC_668|Compound:1682-0499|FD-Score:3.48|P-value:1.50E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:3.67|P-value:6.75E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:3.71|P-value:5.60E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.95|P-value:1.97E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.83|P-value:3.29E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.36|P-value:2.08E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.36|P-value:2.38E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.10|P-value:6.33E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:4.45|P-value:1.79E-6 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.15|P-value:5.22E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.42|P-value:1.90E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.45|P-value:1.68E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.23|P-value:3.42E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.61|P-value:8.67E-5 ID:SGTC_1990|Compound:st072050|FD-Score:-2.99|P-value:8.19E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.58|P-value:9.92E-5 ID:SGTC_2004|Compound:4023728|FD-Score:5.33|P-value:1.38E-8 ID:SGTC_2020|Compound:4017018|FD-Score:3.52|P-value:1.25E-4 ID:SGTC_2113|Compound:5491891|FD-Score:5.53|P-value:4.01E-9 ID:SGTC_2180|Compound:6301957|FD-Score:-3.12|P-value:5.12E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-3.11|P-value:5.42E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.17|P-value:4.93E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.56|P-value:1.07E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.14|P-value:4.74E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.10|P-value:6.29E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.38|P-value:1.89E-4 ID:SGTC_2694|Compound:st077685|FD-Score:4.31|P-value:3.52E-6 ID:SGTC_2716|Compound:st080858|FD-Score:3.45|P-value:1.68E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.38|P-value:2.23E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-3.33|P-value:2.32E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.47|P-value:1.53E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.81|P-value:3.64E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:4.08|P-value:1.10E-5 ID:SGTC_3073|Compound:9114972|FD-Score:3.07|P-value:7.02E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.58|P-value:9.64E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.72|P-value:5.40E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:3.11|P-value:6.16E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.64|P-value:7.68E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.11|P-value:7.84E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.61|P-value:7.36E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.42|P-value:1.64E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.90|P-value:1.69E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:6.80|P-value:6.43E-13 ID:SGTC_430|Compound:0958-0115|FD-Score:6.84|P-value:4.97E-13 ID:SGTC_446|Compound:go6976|FD-Score:3.16|P-value:5.09E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.88|P-value:2.71E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:-3.53|P-value:1.05E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.00|P-value:9.04E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:4.17|P-value:7.00E-6 ID:SGTC_537|Compound:1334-0398|FD-Score:4.33|P-value:3.33E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:2.98|P-value:9.86E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:4.00|P-value:1.59E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:3.08|P-value:6.78E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:-4.51|P-value:1.08E-6 ID:SGTC_668|Compound:1682-0499|FD-Score:3.48|P-value:1.50E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:3.67|P-value:6.75E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:3.71|P-value:5.60E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.95|P-value:1.97E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.83|P-value:3.29E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.36|P-value:2.08E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.36|P-value:2.38E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.10|P-value:6.33E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:4.45|P-value:1.79E-6 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.15|P-value:5.22E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.42|P-value:1.90E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.45|P-value:1.68E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.23|P-value:3.42E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.61|P-value:8.67E-5 ID:SGTC_1990|Compound:st072050|FD-Score:-2.99|P-value:8.19E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.58|P-value:9.92E-5 ID:SGTC_2004|Compound:4023728|FD-Score:5.33|P-value:1.38E-8 ID:SGTC_2020|Compound:4017018|FD-Score:3.52|P-value:1.25E-4 ID:SGTC_2113|Compound:5491891|FD-Score:5.53|P-value:4.01E-9 ID:SGTC_2180|Compound:6301957|FD-Score:-3.12|P-value:5.12E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-3.11|P-value:5.42E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.17|P-value:4.93E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.56|P-value:1.07E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.14|P-value:4.74E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.10|P-value:6.29E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.38|P-value:1.89E-4 ID:SGTC_2694|Compound:st077685|FD-Score:4.31|P-value:3.52E-6 ID:SGTC_2716|Compound:st080858|FD-Score:3.45|P-value:1.68E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.38|P-value:2.23E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-3.33|P-value:2.32E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.47|P-value:1.53E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.81|P-value:3.64E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:4.08|P-value:1.10E-5 ID:SGTC_3073|Compound:9114972|FD-Score:3.07|P-value:7.02E-4

Top fitness defect scores for YLR092W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_430 0958-0115 6.84 16.4 µM 4.97E-13 4 4.04E-12
2 SGTC_425 3825-7017 6.80 13.1 µM 6.43E-13 5 5.11E-12
3 SGTC_2113 5491891 5.53 107.0 µM 4.01E-9 TSC3-RPN4 5 1.57E-8
4 SGTC_2004 4023728 5.33 41.9 µM 1.38E-8 11 4.87E-8
5 SGTC_421 streptovitacin 4.90 30.0 mM 1.69E-7 8 4.89E-7
6 SGTC_1492 4158-0558 4.45 28.5 µM 1.79E-6 60S ribosome export 8 4.31E-6
7 SGTC_537 1334-0398 4.33 209.0 µM 3.33E-6 17 7.62E-6
8 SGTC_2694 st077685 4.31 81.9 µM 3.52E-6 endomembrane recycling 21 8.02E-6
9 SGTC_525 k781-2675 4.17 26.7 µM 7.00E-6 redox potentiating 48 1.51E-5
10 SGTC_3061 glucosamine 4.08 200.0 µM 1.10E-5 8 2.29E-5
11 SGTC_652 0437-0092 4.00 114.0 µM 1.59E-5 15 3.23E-5
12 SGTC_1020 4335-0961 3.95 93.3 µM 1.97E-5 16 3.92E-5
13 SGTC_468 gf-109203x 3.88 121.0 µM 2.71E-5 amide catabolism 6 5.26E-5
14 SGTC_1047 2043-3044 3.83 82.0 µM 3.29E-5 40 6.30E-5
15 SGTC_2968 9090663 3.81 33.4 µM 3.64E-5 31 6.91E-5
16 SGTC_115 0527-0192 3.72 112.0 µM 5.40E-5 86 9.94E-5
17 SGTC_729 4092-0585 3.71 94.1 µM 5.60E-5 29 1.03E-4
18 SGTC_723 4182-0001 3.67 115.0 µM 6.75E-5 32 1.22E-4
19 SGTC_344 k064-0035 3.64 6.4 µM 7.68E-5 60S ribosome export 30 1.38E-4
20 SGTC_1983 st071813 3.61 46.9 µM 8.67E-5 RPP1 & pyrimidine depletion 29 1.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 7.20E-21 YOR287C RRP36 het Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit
0.105 1.27E-9 YPL236C ENV7 hom Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)
0.102 3.43E-9 YKL078W DHR2 het Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
0.102 3.56E-9 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.098 1.15E-8 YMR254C_d YMR254C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.085 7.92E-7 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.079 4.15E-6 YDR041W RSM10 het Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
0.079 4.24E-6 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.079 4.36E-6 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.079 5.14E-6 YKL091C YKL091C hom Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study
0.078 5.40E-6 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.077 8.33E-6 YOR380W RDR1 hom Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins
0.076 9.89E-6 YPL110C GDE1 hom Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
0.075 1.35E-5 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.074 1.56E-5 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein