YLR094C / GIS3

Protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR094C / GIS3

Click on Significant Values for Screen Details ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.53|P-value:6.70E-4 ID:SGTC_229|Compound:benomyl|FD-Score:4.26|P-value:5.49E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:3.42|P-value:9.39E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.72|P-value:3.64E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:4.01|P-value:1.34E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.82|P-value:2.65E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.65|P-value:4.61E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.42|P-value:9.39E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.80|P-value:2.83E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.91|P-value:1.90E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:6.70|P-value:5.96E-10 ID:SGTC_1078|Compound:idebenone|FD-Score:7.92|P-value:3.25E-13 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.94|P-value:1.75E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-4.70|P-value:9.95E-6 ID:SGTC_1816|Compound:st051957|FD-Score:4.11|P-value:9.34E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.68|P-value:4.16E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.50|P-value:7.57E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-4.20|P-value:6.91E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-4.49|P-value:2.30E-5 ID:SGTC_2313|Compound:7726885|FD-Score:3.88|P-value:2.09E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.67|P-value:4.32E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.89|P-value:2.11E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.39|P-value:4.97E-7 ID:SGTC_2802|Compound:7925815|FD-Score:3.56|P-value:6.05E-4 ID:SGTC_2817|Compound:7995342|FD-Score:6.62|P-value:9.12E-10 ID:SGTC_2856|Compound:9022925|FD-Score:-3.97|P-value:1.59E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.47|P-value:8.06E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.51|P-value:7.23E-4 ID:SGTC_3193|Compound:9111931|FD-Score:5.13|P-value:1.56E-6 ID:SGTC_3197|Compound:9113331|FD-Score:-3.56|P-value:6.30E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-3.93|P-value:1.83E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.53|P-value:6.70E-4 ID:SGTC_229|Compound:benomyl|FD-Score:4.26|P-value:5.49E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:3.42|P-value:9.39E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.72|P-value:3.64E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:4.01|P-value:1.34E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.82|P-value:2.65E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.65|P-value:4.61E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.42|P-value:9.39E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.80|P-value:2.83E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.91|P-value:1.90E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:6.70|P-value:5.96E-10 ID:SGTC_1078|Compound:idebenone|FD-Score:7.92|P-value:3.25E-13 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.94|P-value:1.75E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-4.70|P-value:9.95E-6 ID:SGTC_1816|Compound:st051957|FD-Score:4.11|P-value:9.34E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.68|P-value:4.16E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.50|P-value:7.57E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-4.20|P-value:6.91E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-4.49|P-value:2.30E-5 ID:SGTC_2313|Compound:7726885|FD-Score:3.88|P-value:2.09E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.67|P-value:4.32E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.89|P-value:2.11E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.39|P-value:4.97E-7 ID:SGTC_2802|Compound:7925815|FD-Score:3.56|P-value:6.05E-4 ID:SGTC_2817|Compound:7995342|FD-Score:6.62|P-value:9.12E-10 ID:SGTC_2856|Compound:9022925|FD-Score:-3.97|P-value:1.59E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.47|P-value:8.06E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.51|P-value:7.23E-4 ID:SGTC_3193|Compound:9111931|FD-Score:5.13|P-value:1.56E-6 ID:SGTC_3197|Compound:9113331|FD-Score:-3.56|P-value:6.30E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-3.93|P-value:1.83E-4

Top fitness defect scores for YLR094C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1078 idebenone 7.92 36.1 µM 3.25E-13 Golgi 9 1.22E-15
2 SGTC_1058 3448-5425 6.70 97.3 µM 5.96E-10 11 1.07E-11
3 SGTC_2817 7995342 6.62 71.4 µM 9.12E-10 2 1.79E-11
4 SGTC_2765 myclobutanil 5.39 7.7 µM 4.97E-7 azole & statin 18 3.58E-8
5 SGTC_3193 9111931 5.13 49.5 µM 1.56E-6 7 1.42E-7
6 SGTC_229 benomyl 4.26 22.9 µM 5.49E-5 tubulin folding & SWR complex 26 1.03E-5
7 SGTC_1816 st051957 4.11 91.6 µM 9.34E-5 8 1.96E-5
8 SGTC_396 dithiazanine 4.01 1.2 µM 1.34E-4 6 3.01E-5
9 SGTC_1461 k072-0203 3.94 53.8 µM 1.75E-4 11 4.16E-5
10 SGTC_979 1426-2828 3.91 121.0 µM 1.90E-4 18 4.57E-5
11 SGTC_2313 7726885 3.88 200.0 µM 2.09E-4 RPP1 & pyrimidine depletion 36 5.14E-5
12 SGTC_2012 4023501 3.68 200.0 µM 4.16E-4 36 1.17E-4
13 SGTC_2329 6138490 3.67 200.0 µM 4.32E-4 41 1.23E-4
14 SGTC_542 3381-0244 3.65 89.3 µM 4.61E-4 51 1.33E-4
15 SGTC_2802 7925815 3.56 54.5 µM 6.05E-4 55 1.84E-4
16 SGTC_221 trifluoperazine 3.53 10.3 µM 6.70E-4 NEO1-PIK1 235 2.08E-4
17 SGTC_2998 9066762 3.51 71.4 µM 7.23E-4 RPP1 & pyrimidine depletion 36 2.28E-4
18 SGTC_2936 9038235 3.47 15.6 µM 8.06E-4 39 2.59E-4
19 SGTC_773 4358-1457 3.42 44.6 µM 9.39E-4 58 3.11E-4
20 SGTC_279 1273-0055 3.42 2.9 µM 9.39E-4 azole & statin 55 3.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.51E-9 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.092 8.96E-8 YGL009C LEU1 hom Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
0.089 2.54E-7 YJL147C_p YJL147C_p hom Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
0.087 4.55E-7 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.087 5.12E-7 YNL196C_p SLZ1_p hom Sporulation-specific protein with a leucine zipper motif
0.087 5.19E-7 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.086 6.62E-7 YLR064W PER33 hom Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress
0.084 1.08E-6 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.082 2.17E-6 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.080 3.03E-6 YDR031W MIC14 hom Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.080 3.51E-6 YBL102W SFT2 hom Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5
0.080 3.62E-6 YER177W BMH1 hom 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.079 4.85E-6 YER139C RTR1 hom CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication
0.079 4.89E-6 YKL040C NFU1 hom Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
0.077 7.34E-6 YJL133W MRS3 hom Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication