YLR095C / IOC2

Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR095C / IOC2

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.86|P-value:4.30E-7 ID:SGTC_7|Compound:0192-1582|FD-Score:5.31|P-value:3.79E-8 ID:SGTC_18|Compound:0111-0177|FD-Score:4.13|P-value:1.47E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.83|P-value:5.33E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.88|P-value:4.37E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.69|P-value:9.61E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.00|P-value:2.59E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.50|P-value:1.33E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:3.69|P-value:9.61E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.33|P-value:3.73E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.51|P-value:1.94E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.30|P-value:4.21E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.94|P-value:3.28E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.22|P-value:9.89E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.52|P-value:1.84E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-4.00|P-value:2.64E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:3.25|P-value:4.98E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:4.43|P-value:3.67E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:3.29|P-value:4.35E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.71|P-value:8.62E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.30|P-value:4.20E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.35|P-value:3.44E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.95|P-value:2.78E-7 ID:SGTC_1800|Compound:st050079|FD-Score:4.43|P-value:3.70E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.04|P-value:2.20E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.93|P-value:3.50E-5 ID:SGTC_1895|Compound:st058434|FD-Score:3.29|P-value:4.39E-4 ID:SGTC_1958|Compound:st076513|FD-Score:5.91|P-value:1.14E-9 ID:SGTC_1966|Compound:st070145|FD-Score:4.65|P-value:1.25E-6 ID:SGTC_2082|Compound:5219693|FD-Score:-3.29|P-value:4.43E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-3.51|P-value:1.93E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.16|P-value:7.02E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.54|P-value:1.71E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.36|P-value:5.21E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.83|P-value:5.25E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.32|P-value:3.87E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.70|P-value:6.24E-12 ID:SGTC_3099|Compound:9120367|FD-Score:3.23|P-value:5.45E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-3.94|P-value:3.30E-5 ID:SGTC_3259|Compound:9138485|FD-Score:3.32|P-value:3.97E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.53|P-value:1.76E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.27|P-value:4.78E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.53|P-value:1.76E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.66|P-value:1.08E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-4.55|P-value:2.13E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:4.86|P-value:4.30E-7 ID:SGTC_7|Compound:0192-1582|FD-Score:5.31|P-value:3.79E-8 ID:SGTC_18|Compound:0111-0177|FD-Score:4.13|P-value:1.47E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.83|P-value:5.33E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.88|P-value:4.37E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.69|P-value:9.61E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.00|P-value:2.59E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.50|P-value:1.33E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:3.69|P-value:9.61E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.33|P-value:3.73E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.51|P-value:1.94E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.30|P-value:4.21E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.94|P-value:3.28E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.22|P-value:9.89E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.52|P-value:1.84E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-4.00|P-value:2.64E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:3.25|P-value:4.98E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:4.43|P-value:3.67E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:3.29|P-value:4.35E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.71|P-value:8.62E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.30|P-value:4.20E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.35|P-value:3.44E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.95|P-value:2.78E-7 ID:SGTC_1800|Compound:st050079|FD-Score:4.43|P-value:3.70E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.04|P-value:2.20E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.93|P-value:3.50E-5 ID:SGTC_1895|Compound:st058434|FD-Score:3.29|P-value:4.39E-4 ID:SGTC_1958|Compound:st076513|FD-Score:5.91|P-value:1.14E-9 ID:SGTC_1966|Compound:st070145|FD-Score:4.65|P-value:1.25E-6 ID:SGTC_2082|Compound:5219693|FD-Score:-3.29|P-value:4.43E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-3.51|P-value:1.93E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.16|P-value:7.02E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.54|P-value:1.71E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.36|P-value:5.21E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.83|P-value:5.25E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.32|P-value:3.87E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.70|P-value:6.24E-12 ID:SGTC_3099|Compound:9120367|FD-Score:3.23|P-value:5.45E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-3.94|P-value:3.30E-5 ID:SGTC_3259|Compound:9138485|FD-Score:3.32|P-value:3.97E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.53|P-value:1.76E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.27|P-value:4.78E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.53|P-value:1.76E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.66|P-value:1.08E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-4.55|P-value:2.13E-6

Top fitness defect scores for YLR095C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3037 9091026 6.70 49.5 µM 6.24E-12 NEO1-PIK1 34 1.07E-11
2 SGTC_1958 st076513 5.91 41.9 µM 1.14E-9 60S ribosome export 11 1.74E-9
3 SGTC_221 trifluoperazine 5.50 10.3 µM 1.33E-8 NEO1-PIK1 143 1.92E-8
4 SGTC_7 0192-1582 5.31 4.2 µM 3.79E-8 31 5.36E-8
5 SGTC_1754 st042065 4.95 16.1 µM 2.78E-7 NEO1-PIK1 128 3.76E-7
6 SGTC_6 0844-0013 4.86 19.8 µM 4.30E-7 41 5.76E-7
7 SGTC_1966 st070145 4.65 16.1 µM 1.25E-6 14 1.64E-6
8 SGTC_873 0591-4978 4.43 488.0 µM 3.67E-6 10 4.69E-6
9 SGTC_1800 st050079 4.43 29.1 µM 3.70E-6 NEO1-PIK1 100 4.73E-6
10 SGTC_2582 agaric acid 4.36 100.0 µM 5.21E-6 redox potentiating 274 6.60E-6
11 SGTC_445 e6 berbamine 4.22 66.0 µM 9.89E-6 NEO1-PIK1 94 1.24E-5
12 SGTC_18 0111-0177 4.13 500.0 nM 1.47E-5 65 1.82E-5
13 SGTC_1803 st050068 4.04 52.4 µM 2.20E-5 NEO1-PIK1 173 2.70E-5
14 SGTC_158 k038-0087 4.00 26.4 µM 2.59E-5 ubiquinone biosynthesis & proteasome 132 3.17E-5
15 SGTC_439 amiodarone 3.94 34.4 µM 3.28E-5 NEO1-PIK1 98 3.99E-5
16 SGTC_1818 st052136 3.93 56.3 µM 3.50E-5 NEO1-PIK1 53 4.25E-5
17 SGTC_137 0438-0332 3.88 85.4 µM 4.37E-5 ubiquinone biosynthesis & proteasome 129 5.29E-5
18 SGTC_2635 hydroquinidine 3.83 100.0 µM 5.25E-5 26 6.32E-5
19 SGTC_67 0335-0847 3.83 266.0 µM 5.33E-5 ubiquinone biosynthesis & proteasome 125 6.41E-5
20 SGTC_142 0335-0849 3.69 62.7 µM 9.61E-5 ubiquinone biosynthesis & proteasome 143 1.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.281 8.13E-62 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.277 3.63E-60 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.275 1.88E-59 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.263 4.74E-54 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.259 1.71E-52 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.242 4.27E-46 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.236 8.42E-44 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.233 1.54E-42 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.229 2.92E-41 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.225 1.42E-39 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.224 2.21E-39 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.219 9.68E-38 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.214 4.63E-36 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.213 6.50E-36 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.210 9.19E-35 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A