YLR096W / KIN2

Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR096W / KIN2

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:3.16|P-value:9.61E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.34|P-value:5.21E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.36|P-value:4.89E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.79|P-value:1.01E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.60|P-value:2.09E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.93|P-value:5.73E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.47|P-value:3.37E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.79|P-value:1.02E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.73|P-value:1.25E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.86|P-value:7.78E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.44|P-value:3.67E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.29|P-value:6.34E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.37|P-value:4.69E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-4.21|P-value:1.83E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.83|P-value:8.80E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.63|P-value:2.79E-6 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.55|P-value:2.51E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.68|P-value:1.53E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:5.36|P-value:7.30E-8 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.38|P-value:4.53E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.17|P-value:9.52E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:-3.33|P-value:5.41E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.26|P-value:6.93E-4 ID:SGTC_1628|Compound:st004252|FD-Score:5.00|P-value:4.65E-7 ID:SGTC_1899|Compound:st063254|FD-Score:3.46|P-value:3.44E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.28|P-value:6.57E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.20|P-value:8.56E-4 ID:SGTC_2006|Compound:4011487|FD-Score:4.21|P-value:1.83E-5 ID:SGTC_2237|Compound:6667747|FD-Score:-3.82|P-value:8.87E-5 ID:SGTC_2294|Compound:7971431|FD-Score:3.86|P-value:7.77E-5 ID:SGTC_2377|Compound:9073351|FD-Score:3.35|P-value:5.01E-4 ID:SGTC_2462|Compound:5162487|FD-Score:5.67|P-value:1.35E-8 ID:SGTC_2471|Compound:5466956|FD-Score:4.74|P-value:1.68E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.10|P-value:2.82E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.61|P-value:2.04E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.01|P-value:4.20E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-3.87|P-value:7.29E-5 ID:SGTC_2816|Compound:7982706|FD-Score:4.08|P-value:3.09E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.45|P-value:3.56E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.11|P-value:2.77E-5 ID:SGTC_2862|Compound:9027634|FD-Score:-3.30|P-value:6.04E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-4.16|P-value:2.22E-5 ID:SGTC_2924|Compound:9010168|FD-Score:3.64|P-value:1.81E-4 ID:SGTC_3033|Compound:9090887|FD-Score:-3.51|P-value:2.88E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-3.42|P-value:3.90E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.43|P-value:3.86E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:3.16|P-value:9.61E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.34|P-value:5.21E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.36|P-value:4.89E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.79|P-value:1.01E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.60|P-value:2.09E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.93|P-value:5.73E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.47|P-value:3.37E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.79|P-value:1.02E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.73|P-value:1.25E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.86|P-value:7.78E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.44|P-value:3.67E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.29|P-value:6.34E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.37|P-value:4.69E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-4.21|P-value:1.83E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.83|P-value:8.80E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.63|P-value:2.79E-6 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.55|P-value:2.51E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.68|P-value:1.53E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:5.36|P-value:7.30E-8 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.38|P-value:4.53E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.17|P-value:9.52E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:-3.33|P-value:5.41E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.26|P-value:6.93E-4 ID:SGTC_1628|Compound:st004252|FD-Score:5.00|P-value:4.65E-7 ID:SGTC_1899|Compound:st063254|FD-Score:3.46|P-value:3.44E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.28|P-value:6.57E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.20|P-value:8.56E-4 ID:SGTC_2006|Compound:4011487|FD-Score:4.21|P-value:1.83E-5 ID:SGTC_2237|Compound:6667747|FD-Score:-3.82|P-value:8.87E-5 ID:SGTC_2294|Compound:7971431|FD-Score:3.86|P-value:7.77E-5 ID:SGTC_2377|Compound:9073351|FD-Score:3.35|P-value:5.01E-4 ID:SGTC_2462|Compound:5162487|FD-Score:5.67|P-value:1.35E-8 ID:SGTC_2471|Compound:5466956|FD-Score:4.74|P-value:1.68E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.10|P-value:2.82E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.61|P-value:2.04E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.01|P-value:4.20E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-3.87|P-value:7.29E-5 ID:SGTC_2816|Compound:7982706|FD-Score:4.08|P-value:3.09E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.45|P-value:3.56E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.11|P-value:2.77E-5 ID:SGTC_2862|Compound:9027634|FD-Score:-3.30|P-value:6.04E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-4.16|P-value:2.22E-5 ID:SGTC_2924|Compound:9010168|FD-Score:3.64|P-value:1.81E-4 ID:SGTC_3033|Compound:9090887|FD-Score:-3.51|P-value:2.88E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-3.42|P-value:3.90E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.43|P-value:3.86E-4

Top fitness defect scores for YLR096W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2462 5162487 5.67 171.8 µM 1.35E-8 8 7.22E-9
2 SGTC_1233 0325-0408 5.36 14.2 µM 7.30E-8 6 4.15E-8
3 SGTC_1628 st004252 5.00 77.7 µM 4.65E-7 8 2.84E-7
4 SGTC_2471 5466956 4.74 24.8 µM 1.68E-6 mitochondrial processes 3 1.08E-6
5 SGTC_1216 1165-0504 4.63 9.7 µM 2.79E-6 6 1.82E-6
6 SGTC_2006 4011487 4.21 200.0 µM 1.83E-5 endomembrane recycling 74 1.29E-5
7 SGTC_2850 9015429 4.11 58.4 µM 2.77E-5 9 1.97E-5
8 SGTC_2816 7982706 4.08 58.4 µM 3.09E-5 azole & statin 48 2.21E-5
9 SGTC_2794 7785382 4.01 27.3 µM 4.20E-5 34 3.03E-5
10 SGTC_431 k089-0097 3.93 107.0 µM 5.73E-5 iron homeostasis 44 4.19E-5
11 SGTC_2294 7971431 3.86 200.0 µM 7.77E-5 14 5.74E-5
12 SGTC_697 0508-1955 3.86 564.0 µM 7.78E-5 38 5.76E-5
13 SGTC_1144 3486-0183 3.83 12.5 µM 8.80E-5 29 6.54E-5
14 SGTC_261 5-fluorouridine 3.79 15.4 µM 1.01E-4 exosome 15 7.53E-5
15 SGTC_471 1-acyl-paf 3.79 4.0 µM 1.02E-4 DNA intercalators 36 7.64E-5
16 SGTC_1224 0823-0416 3.68 294.0 µM 1.53E-4 15 1.16E-4
17 SGTC_2924 9010168 3.64 62.8 µM 1.81E-4 cell wall signaling 49 1.38E-4
18 SGTC_2594 a-mangostin 3.61 100.0 µM 2.04E-4 40 1.56E-4
19 SGTC_423 5-fluorouracil 3.60 457.0 µM 2.09E-4 exosome 32 1.61E-4
20 SGTC_436 n,n-dimethylsphingosine 3.47 3.3 µM 3.37E-4 43 2.63E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.95E-15 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.104 1.55E-9 YDR258C HSP78 hom Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
0.091 1.29E-7 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.088 2.97E-7 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.086 5.29E-7 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.085 7.79E-7 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.080 3.11E-6 YHR122W CIA2 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B
0.080 3.82E-6 YGR182C_d YGR182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
0.078 5.37E-6 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.075 1.36E-5 YOR016C ERP4 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.075 1.41E-5 YDL233W_p MFG1_p hom Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.074 1.72E-5 YPR008W HAA1 hom Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress
0.074 1.80E-5 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.074 1.94E-5 YOL015W IRC10 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
0.073 2.34E-5 YHR022C-A_p YHR022C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching