YLR098C / CHA4

DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR098C / CHA4

Click on Significant Values for Screen Details ID:SGTC_355|Compound:1311-2252|FD-Score:4.60|P-value:2.19E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.27|P-value:4.54E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.53|P-value:2.22E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.60|P-value:1.70E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.76|P-value:8.90E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:3.60|P-value:1.71E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.77|P-value:7.12E-7 ID:SGTC_667|Compound:1498-1044|FD-Score:3.34|P-value:4.45E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.93|P-value:4.41E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:-3.30|P-value:4.18E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.75|P-value:7.45E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.05|P-value:2.68E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.28|P-value:5.55E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.40|P-value:5.60E-6 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.75|P-value:9.16E-5 ID:SGTC_1591|Compound:genipin|FD-Score:4.22|P-value:1.30E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-3.38|P-value:3.11E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.68|P-value:9.78E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.36|P-value:3.30E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.53|P-value:2.18E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-3.22|P-value:5.44E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.91|P-value:3.83E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:5.28|P-value:6.77E-8 ID:SGTC_2241|Compound:6772625|FD-Score:-3.62|P-value:1.23E-4 ID:SGTC_2344|Compound:7990960|FD-Score:5.77|P-value:4.12E-9 ID:SGTC_2456|Compound:5770359|FD-Score:4.67|P-value:1.55E-6 ID:SGTC_2465|Compound:5809242|FD-Score:3.53|P-value:2.17E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.61|P-value:1.60E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.60|P-value:1.33E-4 ID:SGTC_2833|Compound:9001315|FD-Score:7.49|P-value:3.38E-14 ID:SGTC_3079|Compound:9117512|FD-Score:3.17|P-value:8.00E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.18|P-value:1.53E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.20|P-value:7.34E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.15|P-value:8.66E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.26|P-value:4.71E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:4.60|P-value:2.19E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.27|P-value:4.54E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.53|P-value:2.22E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.60|P-value:1.70E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.76|P-value:8.90E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:3.60|P-value:1.71E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.77|P-value:7.12E-7 ID:SGTC_667|Compound:1498-1044|FD-Score:3.34|P-value:4.45E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.93|P-value:4.41E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:-3.30|P-value:4.18E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.75|P-value:7.45E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.05|P-value:2.68E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.28|P-value:5.55E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.40|P-value:5.60E-6 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.75|P-value:9.16E-5 ID:SGTC_1591|Compound:genipin|FD-Score:4.22|P-value:1.30E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-3.38|P-value:3.11E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.68|P-value:9.78E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.36|P-value:3.30E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.53|P-value:2.18E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-3.22|P-value:5.44E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.91|P-value:3.83E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:5.28|P-value:6.77E-8 ID:SGTC_2241|Compound:6772625|FD-Score:-3.62|P-value:1.23E-4 ID:SGTC_2344|Compound:7990960|FD-Score:5.77|P-value:4.12E-9 ID:SGTC_2456|Compound:5770359|FD-Score:4.67|P-value:1.55E-6 ID:SGTC_2465|Compound:5809242|FD-Score:3.53|P-value:2.17E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.61|P-value:1.60E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.60|P-value:1.33E-4 ID:SGTC_2833|Compound:9001315|FD-Score:7.49|P-value:3.38E-14 ID:SGTC_3079|Compound:9117512|FD-Score:3.17|P-value:8.00E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.18|P-value:1.53E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.20|P-value:7.34E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.15|P-value:8.66E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.26|P-value:4.71E-4

Top fitness defect scores for YLR098C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2833 9001315 7.49 45.5 µM 3.38E-14 amide catabolism 7 3.46E-14
2 SGTC_2344 7990960 5.77 77.0 µM 4.12E-9 7 4.01E-9
3 SGTC_2131 toluylene red 5.28 5.3 µM 6.77E-8 60S ribosome export 3 6.54E-8
4 SGTC_2456 5770359 4.67 74.5 µM 1.55E-6 9 1.48E-6
5 SGTC_355 1311-2252 4.60 105.0 µM 2.19E-6 9 2.10E-6
6 SGTC_1221 2958-7315 4.40 257.0 µM 5.60E-6 14 5.34E-6
7 SGTC_1591 genipin 4.22 88.4 µM 1.30E-5 mitochondrial processes 7 1.24E-5
8 SGTC_3091 9116372 4.18 49.5 µM 1.53E-5 11 1.46E-5
9 SGTC_1131 3454-3128 4.05 32.3 µM 2.68E-5 42 2.54E-5
10 SGTC_705 1124-0212 3.93 310.0 µM 4.41E-5 13 4.19E-5
11 SGTC_471 1-acyl-paf 3.76 4.0 µM 8.90E-5 DNA intercalators 38 8.45E-5
12 SGTC_1579 chlormadinone acetate 3.75 49.4 µM 9.16E-5 11 8.69E-5
13 SGTC_2611 pyromycin 3.61 23.9 µM 1.60E-4 43 1.51E-4
14 SGTC_429 1112-0049 3.60 25.5 µM 1.70E-4 DNA damage response 48 1.61E-4
15 SGTC_514 4466-0038 3.60 2.6 nM 1.71E-4 cell wall 175 1.62E-4
16 SGTC_2465 5809242 3.53 33.2 µM 2.17E-4 8 2.05E-4
17 SGTC_1922 5578187 3.53 25.0 µM 2.18E-4 TRP & mitochondrial translation 48 2.07E-4
18 SGTC_418 lividomycin a 3.53 100.0 µM 2.22E-4 19 2.11E-4
19 SGTC_667 1498-1044 3.34 59.0 µM 4.45E-4 RPP1 & pyrimidine depletion 41 4.22E-4
20 SGTC_1214 0358-0031 3.28 63.7 µM 5.55E-4 38 5.26E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 9.15E-17 YMR106C YKU80 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.134 6.92E-15 YKL018C-A_p YKL018C-A_p hom Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.125 3.13E-13 YPL150W_p YPL150W_p hom Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study
0.112 8.04E-11 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.109 2.60E-10 YLR089C ALT1 hom Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive
0.106 7.14E-10 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.103 2.43E-9 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.097 2.06E-8 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.095 3.12E-8 YMR122C_d YMR122C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 7.94E-8 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.092 9.49E-8 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.091 1.18E-7 YDL212W SHR3 het Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
0.091 1.30E-7 YMR306C-A_d YMR306C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.74E-7 YGR029W ERV1 het Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)
0.087 4.24E-7 YKL129C MYO3 hom One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization