Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR099C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.126 | 2.15E-13 | YCL042W_p | YCL042W_p | hom | Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm |
0.116 | 1.52E-11 | YIL092W_p | YIL092W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus |
0.111 | 1.17E-10 | YMR303C | ADH2 | hom | Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 |
0.104 | 1.74E-9 | YFR012W-A_p | YFR012W-A_p | hom | Putative protein of unknown function; identified by homology |
0.102 | 3.59E-9 | YNR008W | LRO1 | hom | Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase |
0.095 | 3.67E-8 | YBR032W_d | YBR032W_d | hom | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data |
0.094 | 4.46E-8 | YLL001W | DNM1 | hom | Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance |
0.094 | 5.23E-8 | YLR324W | PEX30 | hom | Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p |
0.090 | 1.93E-7 | YDL188C | PPH22 | hom | Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication |
0.087 | 4.84E-7 | YPR048W | TAH18 | het | Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance |
0.086 | 5.42E-7 | YBR158W | AMN1 | hom | Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) |
0.086 | 5.85E-7 | YGR181W | TIM13 | hom | Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane |
0.084 | 1.02E-6 | YOR029W_d | YOR029W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.082 | 1.81E-6 | YER068W | MOT2 | hom | Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications |
0.082 | 1.89E-6 | YCR060W | TAH1 | hom | Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II |