YLR099C / ICT1

Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR099C / ICT1

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.30|P-value:1.01E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:4.22|P-value:1.44E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:3.57|P-value:2.03E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.00|P-value:3.79E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.39|P-value:3.88E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-5.49|P-value:2.52E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:4.54|P-value:3.45E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.19|P-value:1.56E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:7.58|P-value:2.87E-14 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.16|P-value:8.94E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.88|P-value:6.00E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:5.05|P-value:2.79E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:3.54|P-value:2.26E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.94|P-value:4.86E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:-4.24|P-value:1.28E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:3.55|P-value:2.20E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.24|P-value:1.36E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:5.17|P-value:1.52E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:3.79|P-value:8.58E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:3.13|P-value:9.67E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.23|P-value:6.83E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.51|P-value:2.41E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.68|P-value:1.35E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.16|P-value:8.84E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.78|P-value:9.23E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:5.49|P-value:2.66E-8 ID:SGTC_1377|Compound:2944-0135|FD-Score:12.00|P-value:5.44E-33 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.18|P-value:1.71E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.85|P-value:6.78E-5 ID:SGTC_1490|Compound:4089-0339|FD-Score:4.13|P-value:2.13E-5 ID:SGTC_1494|Compound:4358-1428|FD-Score:-3.50|P-value:2.56E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.76|P-value:9.72E-5 ID:SGTC_1645|Compound:Cervolide|FD-Score:4.21|P-value:1.55E-5 ID:SGTC_1847|Compound:st056231|FD-Score:3.40|P-value:3.82E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-4.05|P-value:2.88E-5 ID:SGTC_2018|Compound:5133068|FD-Score:3.42|P-value:3.59E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.11|P-value:2.36E-5 ID:SGTC_2243|Compound:6634756|FD-Score:-5.21|P-value:1.14E-7 ID:SGTC_2263|Compound:7948595|FD-Score:3.17|P-value:8.48E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.83|P-value:7.31E-5 ID:SGTC_2450|Compound:5739737|FD-Score:3.42|P-value:3.58E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.07|P-value:2.73E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.37|P-value:5.28E-8 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.35|P-value:4.55E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.93|P-value:5.21E-7 ID:SGTC_2787|Compound:5284540|FD-Score:6.34|P-value:1.66E-10 ID:SGTC_2791|Compound:5663188|FD-Score:-4.99|P-value:3.61E-7 ID:SGTC_2965|Compound:9082772|FD-Score:4.45|P-value:5.18E-6 ID:SGTC_3051|Compound:9093778|FD-Score:3.52|P-value:2.48E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.40|P-value:3.86E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.69|P-value:1.27E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.45|P-value:2.98E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.30|P-value:1.01E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:4.22|P-value:1.44E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:3.57|P-value:2.03E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.00|P-value:3.79E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.39|P-value:3.88E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-5.49|P-value:2.52E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:4.54|P-value:3.45E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.19|P-value:1.56E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:7.58|P-value:2.87E-14 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.16|P-value:8.94E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.88|P-value:6.00E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:5.05|P-value:2.79E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:3.54|P-value:2.26E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.94|P-value:4.86E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:-4.24|P-value:1.28E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:3.55|P-value:2.20E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.24|P-value:1.36E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:5.17|P-value:1.52E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:3.79|P-value:8.58E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:3.13|P-value:9.67E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.23|P-value:6.83E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.51|P-value:2.41E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.68|P-value:1.35E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.16|P-value:8.84E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.78|P-value:9.23E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:5.49|P-value:2.66E-8 ID:SGTC_1377|Compound:2944-0135|FD-Score:12.00|P-value:5.44E-33 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.18|P-value:1.71E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.85|P-value:6.78E-5 ID:SGTC_1490|Compound:4089-0339|FD-Score:4.13|P-value:2.13E-5 ID:SGTC_1494|Compound:4358-1428|FD-Score:-3.50|P-value:2.56E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.76|P-value:9.72E-5 ID:SGTC_1645|Compound:Cervolide|FD-Score:4.21|P-value:1.55E-5 ID:SGTC_1847|Compound:st056231|FD-Score:3.40|P-value:3.82E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-4.05|P-value:2.88E-5 ID:SGTC_2018|Compound:5133068|FD-Score:3.42|P-value:3.59E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.11|P-value:2.36E-5 ID:SGTC_2243|Compound:6634756|FD-Score:-5.21|P-value:1.14E-7 ID:SGTC_2263|Compound:7948595|FD-Score:3.17|P-value:8.48E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.83|P-value:7.31E-5 ID:SGTC_2450|Compound:5739737|FD-Score:3.42|P-value:3.58E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.07|P-value:2.73E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.37|P-value:5.28E-8 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.35|P-value:4.55E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.93|P-value:5.21E-7 ID:SGTC_2787|Compound:5284540|FD-Score:6.34|P-value:1.66E-10 ID:SGTC_2791|Compound:5663188|FD-Score:-4.99|P-value:3.61E-7 ID:SGTC_2965|Compound:9082772|FD-Score:4.45|P-value:5.18E-6 ID:SGTC_3051|Compound:9093778|FD-Score:3.52|P-value:2.48E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.40|P-value:3.86E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.69|P-value:1.27E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.45|P-value:2.98E-4

Top fitness defect scores for YLR099C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1377 2944-0135 12.00 198.0 µM 5.44E-33 calcium & mitochondrial duress 3 1.58E-33
2 SGTC_141 0443-0274 7.58 32.3 µM 2.87E-14 mitochondrial response to ROS 12 1.71E-14
3 SGTC_2787 5284540 6.34 71.4 µM 1.66E-10 4 1.15E-10
4 SGTC_1370 2001-0092 5.49 44.6 µM 2.66E-8 9 2.00E-8
5 SGTC_2541 muurolladie-3-one 5.37 83.1 µM 5.28E-8 excess fatty acid 8 4.02E-8
6 SGTC_717 1532-0246 5.17 73.2 µM 1.52E-7 Golgi 10 1.17E-7
7 SGTC_261 5-fluorouridine 5.05 15.4 µM 2.79E-7 exosome 4 2.18E-7
8 SGTC_2691 st077356 4.93 60.2 µM 5.21E-7 13 4.12E-7
9 SGTC_137 0438-0332 4.54 85.4 µM 3.45E-6 ubiquinone biosynthesis & proteasome 93 2.81E-6
10 SGTC_2965 9082772 4.45 38.6 µM 5.18E-6 mitochondrial response to ROS 28 4.26E-6
11 SGTC_45 0kpi-0036 4.30 14.9 µM 1.01E-5 excess fatty acid 15 8.41E-6
12 SGTC_674 0498-0004 4.24 451.0 µM 1.36E-5 heme requiring 19 1.14E-5
13 SGTC_73 0327-0325 4.22 16.2 µM 1.44E-5 DNA damage response 40 1.20E-5
14 SGTC_1645 Cervolide 4.21 78.0 µM 1.55E-5 4 1.30E-5
15 SGTC_1429 4049-0205 4.18 9.5 µM 1.71E-5 8 1.43E-5
16 SGTC_1490 4089-0339 4.13 670.0 nM 2.13E-5 7 1.80E-5
17 SGTC_2238 6671620 4.11 73.2 µM 2.36E-5 24 1.99E-5
18 SGTC_2519 cryptotanshinone 4.07 88.0 µM 2.73E-5 heme biosynthesis & mitochondrial translocase 10 2.31E-5
19 SGTC_100 0086-0128 4.00 49.6 µM 3.79E-5 copper-dependent oxidative stress 49 3.22E-5
20 SGTC_570 0987-0065 3.94 62.6 µM 4.86E-5 60S ribosome export 6 4.15E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.15E-13 YCL042W_p YCL042W_p hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
0.116 1.52E-11 YIL092W_p YIL092W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
0.111 1.17E-10 YMR303C ADH2 hom Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
0.104 1.74E-9 YFR012W-A_p YFR012W-A_p hom Putative protein of unknown function; identified by homology
0.102 3.59E-9 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.095 3.67E-8 YBR032W_d YBR032W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.094 4.46E-8 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.094 5.23E-8 YLR324W PEX30 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.090 1.93E-7 YDL188C PPH22 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.087 4.84E-7 YPR048W TAH18 het Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance
0.086 5.42E-7 YBR158W AMN1 hom Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
0.086 5.85E-7 YGR181W TIM13 hom Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
0.084 1.02E-6 YOR029W_d YOR029W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 1.81E-6 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.082 1.89E-6 YCR060W TAH1 hom Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II