HIPHOP chemogenomics database

YLR099C / ICT1

Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR099C / ICT1

Click on Significant Values for Screen Details

Top fitness defect scores for YLR099C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1377	2944-0135	12.00	198.0 µM	5.44E-33	calcium & mitochondrial duress	3	1.58E-33
2	SGTC_141	0443-0274	7.58	32.3 µM	2.87E-14	mitochondrial response to ROS	12	1.71E-14
3	SGTC_2787	5284540	6.34	71.4 µM	1.66E-10		4	1.15E-10
4	SGTC_1370	2001-0092	5.49	44.6 µM	2.66E-8		9	2.00E-8
5	SGTC_2541	muurolladie-3-one	5.37	83.1 µM	5.28E-8	excess fatty acid	8	4.02E-8
6	SGTC_717	1532-0246	5.17	73.2 µM	1.52E-7	Golgi	10	1.17E-7
7	SGTC_261	5-fluorouridine	5.05	15.4 µM	2.79E-7	exosome	4	2.18E-7
8	SGTC_2691	st077356	4.93	60.2 µM	5.21E-7		13	4.12E-7
9	SGTC_137	0438-0332	4.54	85.4 µM	3.45E-6	ubiquinone biosynthesis & proteasome	93	2.81E-6
10	SGTC_2965	9082772	4.45	38.6 µM	5.18E-6	mitochondrial response to ROS	28	4.26E-6
11	SGTC_45	0kpi-0036	4.30	14.9 µM	1.01E-5	excess fatty acid	15	8.41E-6
12	SGTC_674	0498-0004	4.24	451.0 µM	1.36E-5	heme requiring	19	1.14E-5
13	SGTC_73	0327-0325	4.22	16.2 µM	1.44E-5	DNA damage response	40	1.20E-5
14	SGTC_1645	Cervolide	4.21	78.0 µM	1.55E-5		4	1.30E-5
15	SGTC_1429	4049-0205	4.18	9.5 µM	1.71E-5		8	1.43E-5
16	SGTC_1490	4089-0339	4.13	670.0 nM	2.13E-5		7	1.80E-5
17	SGTC_2238	6671620	4.11	73.2 µM	2.36E-5		24	1.99E-5
18	SGTC_2519	cryptotanshinone	4.07	88.0 µM	2.73E-5	heme biosynthesis & mitochondrial translocase	10	2.31E-5
19	SGTC_100	0086-0128	4.00	49.6 µM	3.79E-5	copper-dependent oxidative stress	49	3.22E-5
20	SGTC_570	0987-0065	3.94	62.6 µM	4.86E-5	60S ribosome export	6	4.15E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.126	2.15E-13	YCL042W_p	YCL042W_p	hom	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
0.116	1.52E-11	YIL092W_p	YIL092W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
0.111	1.17E-10	YMR303C	ADH2	hom	Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
0.104	1.74E-9	YFR012W-A_p	YFR012W-A_p	hom	Putative protein of unknown function; identified by homology
0.102	3.59E-9	YNR008W	LRO1	hom	Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.095	3.67E-8	YBR032W_d	YBR032W_d	hom	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.094	4.46E-8	YLL001W	DNM1	hom	Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.094	5.23E-8	YLR324W	PEX30	hom	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.090	1.93E-7	YDL188C	PPH22	hom	Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.087	4.84E-7	YPR048W	TAH18	het	Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance
0.086	5.42E-7	YBR158W	AMN1	hom	Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
0.086	5.85E-7	YGR181W	TIM13	hom	Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
0.084	1.02E-6	YOR029W_d	YOR029W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082	1.81E-6	YER068W	MOT2	hom	Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.082	1.89E-6	YCR060W	TAH1	hom	Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II