YLR101C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR101C / YLR101C

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:4.33|P-value:3.09E-7 ID:SGTC_360|Compound:0957-0399|FD-Score:-3.07|P-value:1.80E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.13|P-value:1.59E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:11.00|P-value:3.95E-37 ID:SGTC_675|Compound:1309-0189|FD-Score:-2.93|P-value:3.32E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:-2.85|P-value:4.68E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.59|P-value:1.55E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:2.89|P-value:4.48E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:2.89|P-value:4.60E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.84|P-value:4.79E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.63|P-value:1.24E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.12|P-value:1.09E-6 ID:SGTC_1711|Compound:st032263|FD-Score:-3.21|P-value:9.57E-5 ID:SGTC_1725|Compound:st036284|FD-Score:-3.01|P-value:2.37E-4 ID:SGTC_1737|Compound:st035557|FD-Score:4.53|P-value:9.16E-8 ID:SGTC_1759|Compound:st043059|FD-Score:2.74|P-value:8.44E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.10|P-value:1.84E-4 ID:SGTC_1766|Compound:st045414|FD-Score:2.70|P-value:9.54E-4 ID:SGTC_1828|Compound:st055811|FD-Score:3.06|P-value:2.22E-4 ID:SGTC_1830|Compound:st055982|FD-Score:2.72|P-value:8.83E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.42|P-value:4.26E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.48|P-value:3.12E-5 ID:SGTC_2094|Compound:5332512|FD-Score:2.75|P-value:8.08E-4 ID:SGTC_2141|Compound:5621638|FD-Score:2.92|P-value:3.93E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.26|P-value:8.95E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.14|P-value:1.36E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.02|P-value:2.28E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:2.98|P-value:3.13E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:4.40|P-value:2.05E-7 ID:SGTC_2505|Compound:galangin|FD-Score:8.38|P-value:2.29E-22 ID:SGTC_2507|Compound:purpurin|FD-Score:-4.48|P-value:1.02E-7 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.71|P-value:9.36E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-2.91|P-value:3.64E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.59|P-value:6.49E-8 ID:SGTC_3227|Compound:9130768|FD-Score:-2.89|P-value:3.96E-4 ID:SGTC_3240|Compound:9133527|FD-Score:2.82|P-value:6.07E-4 ID:SGTC_3322|Compound:9139058|FD-Score:2.84|P-value:5.57E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.33|P-value:3.09E-7 ID:SGTC_360|Compound:0957-0399|FD-Score:-3.07|P-value:1.80E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.13|P-value:1.59E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:11.00|P-value:3.95E-37 ID:SGTC_675|Compound:1309-0189|FD-Score:-2.93|P-value:3.32E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:-2.85|P-value:4.68E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.59|P-value:1.55E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:2.89|P-value:4.48E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:2.89|P-value:4.60E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.84|P-value:4.79E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.63|P-value:1.24E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.12|P-value:1.09E-6 ID:SGTC_1711|Compound:st032263|FD-Score:-3.21|P-value:9.57E-5 ID:SGTC_1725|Compound:st036284|FD-Score:-3.01|P-value:2.37E-4 ID:SGTC_1737|Compound:st035557|FD-Score:4.53|P-value:9.16E-8 ID:SGTC_1759|Compound:st043059|FD-Score:2.74|P-value:8.44E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.10|P-value:1.84E-4 ID:SGTC_1766|Compound:st045414|FD-Score:2.70|P-value:9.54E-4 ID:SGTC_1828|Compound:st055811|FD-Score:3.06|P-value:2.22E-4 ID:SGTC_1830|Compound:st055982|FD-Score:2.72|P-value:8.83E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.42|P-value:4.26E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.48|P-value:3.12E-5 ID:SGTC_2094|Compound:5332512|FD-Score:2.75|P-value:8.08E-4 ID:SGTC_2141|Compound:5621638|FD-Score:2.92|P-value:3.93E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.26|P-value:8.95E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.14|P-value:1.36E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.02|P-value:2.28E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:2.98|P-value:3.13E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:4.40|P-value:2.05E-7 ID:SGTC_2505|Compound:galangin|FD-Score:8.38|P-value:2.29E-22 ID:SGTC_2507|Compound:purpurin|FD-Score:-4.48|P-value:1.02E-7 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.71|P-value:9.36E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-2.91|P-value:3.64E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.59|P-value:6.49E-8 ID:SGTC_3227|Compound:9130768|FD-Score:-2.89|P-value:3.96E-4 ID:SGTC_3240|Compound:9133527|FD-Score:2.82|P-value:6.07E-4 ID:SGTC_3322|Compound:9139058|FD-Score:2.84|P-value:5.57E-4

Top fitness defect scores for YLR101C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_664 1222-0054 11.00 14.9 µM 3.95E-37 sphingolipid biosynthesis & PDR1 2 2.10E-28 4.66
2 SGTC_2505 galangin 8.38 7.9 µM 2.29E-22 RPP1 & pyrimidine depletion 1 2.72E-17 3.04
3 SGTC_2973 9094665 4.59 18.0 µM 6.49E-8 NEO1 12 2.25E-6 0.09
4 SGTC_1737 st035557 4.53 69.7 µM 9.16E-8 3 2.92E-6 0.39
5 SGTC_2492 derrusnin 4.40 100.0 µM 2.05E-7 3 5.40E-6 0.27
6 SGTC_64 000l-0018 4.33 272.1 µM 3.09E-7 ubiquinone biosynthesis & proteasome 43 7.37E-6 0.28
7 SGTC_1203 3992-3522 4.12 103.0 µM 1.09E-6 10 1.92E-5 0.04
8 SGTC_1876 myriocin 3.48 605.0 nM 3.12E-5 8 2.48E-4 0.06
9 SGTC_1841 st054148 3.42 70.0 µM 4.26E-5 6 3.15E-4 0.01
10 SGTC_2401 5128683 3.26 200.0 µM 8.95E-5 19 5.56E-4 0.02
11 SGTC_474 dl-dihydrosphingosine 3.13 5.0 µM 1.59E-4 17 8.63E-4 0.02
12 SGTC_1764 st044502 3.10 93.5 µM 1.84E-4 12 9.66E-4 0.01
13 SGTC_1828 st055811 3.06 49.0 µM 2.22E-4 4 0.00112 0.29
14 SGTC_2454 5-benzylidenerhodanine 2.98 10.4 µM 3.13E-4 TRP & mitochondrial translation 16 0.00145 0.10
15 SGTC_2141 5621638 2.92 7.7 µM 3.93E-4 tubulin folding & SWR complex 11 0.00173 0.07
16 SGTC_875 0709-0210 2.89 25.7 µM 4.48E-4 fatty acid desaturase (OLE1) 24 0.00192 0.03
17 SGTC_883 0850-0245 2.89 24.6 µM 4.60E-4 cell wall 26 0.00195 0.01
18 SGTC_3322 9139058 2.84 2.1 µM 5.57E-4 cell wall 24 0.00226 0.03
19 SGTC_3240 9133527 2.82 49.5 µM 6.07E-4 10 0.00242 0.01
20 SGTC_2094 5332512 2.75 191.7 µM 8.08E-4 22 0.00302 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.223 3.24E-39 YLR100W ERG27 het 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs
0.176 7.44E-25 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.163 2.08E-21 YER051W JHD1 hom JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
0.161 7.50E-21 YJL028W YJL028W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments
0.157 5.76E-20 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.155 1.71E-19 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.143 9.22E-17 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.130 4.83E-14 YKR096W ESL2 hom Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain
0.127 1.47E-13 YHR059W FYV4 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.123 8.63E-13 YHR112C YHR112C hom Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway
0.116 1.87E-11 YCL032W STE50 hom Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction
0.115 2.73E-11 YDR468C TLG1 het Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p
0.112 7.63E-11 YNR054C ESF2 het Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
0.105 1.03E-9 YJL160C_p YJL160C_p hom Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication
0.104 1.29E-9 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine