YLR105C / SEN2

Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR105C / SEN2

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-2.93|P-value:6.94E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.38|P-value:1.15E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.01|P-value:6.31E-6 ID:SGTC_321|Compound:4534-3890|FD-Score:2.94|P-value:7.02E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.79|P-value:1.86E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:2.92|P-value:7.57E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.39|P-value:1.08E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.60|P-value:4.55E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:3.05|P-value:4.52E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-2.88|P-value:8.45E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.68|P-value:3.22E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.28|P-value:1.81E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.99|P-value:5.54E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.19|P-value:2.55E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.33|P-value:1.51E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.43|P-value:9.37E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-3.46|P-value:8.07E-5 ID:SGTC_2098|Compound:5376439|FD-Score:5.24|P-value:6.00E-9 ID:SGTC_2100|Compound:5377183|FD-Score:4.17|P-value:2.84E-6 ID:SGTC_2124|Compound:5246320|FD-Score:3.08|P-value:4.17E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.05|P-value:4.58E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.16|P-value:2.99E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.31|P-value:1.58E-4 ID:SGTC_2894|Compound:9048625|FD-Score:2.99|P-value:5.73E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.43|P-value:9.13E-5 ID:SGTC_3273|Compound:9137859|FD-Score:3.48|P-value:7.88E-5 ID:SGTC_3288|Compound:9119690|FD-Score:3.41|P-value:1.07E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-2.93|P-value:6.94E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.38|P-value:1.15E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.01|P-value:6.31E-6 ID:SGTC_321|Compound:4534-3890|FD-Score:2.94|P-value:7.02E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.79|P-value:1.86E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:2.92|P-value:7.57E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.39|P-value:1.08E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.60|P-value:4.55E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:3.05|P-value:4.52E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-2.88|P-value:8.45E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.68|P-value:3.22E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.28|P-value:1.81E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.99|P-value:5.54E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.19|P-value:2.55E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.33|P-value:1.51E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.43|P-value:9.37E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-3.46|P-value:8.07E-5 ID:SGTC_2098|Compound:5376439|FD-Score:5.24|P-value:6.00E-9 ID:SGTC_2100|Compound:5377183|FD-Score:4.17|P-value:2.84E-6 ID:SGTC_2124|Compound:5246320|FD-Score:3.08|P-value:4.17E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.05|P-value:4.58E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.16|P-value:2.99E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.31|P-value:1.58E-4 ID:SGTC_2894|Compound:9048625|FD-Score:2.99|P-value:5.73E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.43|P-value:9.13E-5 ID:SGTC_3273|Compound:9137859|FD-Score:3.48|P-value:7.88E-5 ID:SGTC_3288|Compound:9119690|FD-Score:3.41|P-value:1.07E-4

Top fitness defect scores for YLR105C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2098 5376439 5.24 882.5 nM 6.00E-9 2 7.94E-8 0.56
2 SGTC_2100 5377183 4.17 190.0 µM 2.84E-6 60S ribosome export 7 1.49E-5 0.37
3 SGTC_781 4335-2806 3.79 94.4 µM 1.86E-5 5 7.39E-5 0.01
4 SGTC_1233 0325-0408 3.68 14.2 µM 3.22E-5 9 1.18E-4 0.06
5 SGTC_812 4251-0442 3.60 148.0 µM 4.55E-5 6 1.59E-4 0.11
6 SGTC_3273 9137859 3.48 49.5 µM 7.88E-5 5 2.53E-4 0.03
7 SGTC_3288 9119690 3.41 36.2 µM 1.07E-4 23 3.30E-4 0.16
8 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 3.33 54.9 µM 1.51E-4 redox potentiating 10 4.41E-4 0.01
9 SGTC_2704 st078022 3.31 71.1 µM 1.58E-4 6 4.58E-4 0.04
10 SGTC_1528 arabinosylhypoxanthine 3.28 74.6 µM 1.81E-4 13 5.15E-4 0.03
11 SGTC_2492 derrusnin 3.16 100.0 µM 2.99E-4 12 7.91E-4 0.11
12 SGTC_2124 5246320 3.08 200.0 µM 4.17E-4 heme biosynthesis & mitochondrial translocase 44 0.00105 0.06
13 SGTC_995 3931-2021 3.05 34.6 µM 4.52E-4 RPP1 & pyrimidine depletion 13 0.00113 0.02
14 SGTC_2490 carminic acid 3.05 95.4 µM 4.58E-4 12 0.00114 0.02
15 SGTC_2894 9048625 2.99 32.5 µM 5.73E-4 21 0.00138 0.02
16 SGTC_321 4534-3890 2.94 65.3 µM 7.02E-4 RPP1 & pyrimidine depletion 16 0.00164 0.03
17 SGTC_789 1309-1135 2.92 70.6 µM 7.57E-4 ERG2 8 0.00175 0.09
18 SGTC_2119 5528445 2.80 120.6 µM 0.00116 18 0.00252 9.94E-4
19 SGTC_3276 9139060 2.79 49.5 µM 0.00121 60S ribosome export 23 0.00262 0.01
20 SGTC_600 1495-0418 2.75 41.6 µM 0.00141 RPP1 & pyrimidine depletion 22 0.00298 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 3.22E-19 YGL142C GPI10 het Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog
0.142 1.62E-16 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.141 2.11E-16 YIR010W DSN1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
0.140 3.94E-16 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.136 2.83E-15 YLR230W_d YLR230W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
0.119 3.91E-12 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.119 4.95E-12 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.117 9.02E-12 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.112 8.60E-11 YKR033C_d YKR033C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80
0.111 1.09E-10 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.110 1.92E-10 YKL042W SPC42 het Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
0.109 2.79E-10 YMR251W GTO3 hom Omega class glutathione transferase; putative cytosolic localization
0.107 4.72E-10 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.106 7.85E-10 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.104 1.35E-9 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress