YLR108C

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR108C / YLR108C

Click on Significant Values for Screen Details

Top fitness defect scores for YLR108C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_117 lucigenin 6.67 22.1 µM 6.21E-11 redox potentiating 33 1.32E-11
2 SGTC_1054 3429-0080 5.38 167.0 µM 1.05E-7 11 3.67E-8
3 SGTC_1058 3448-5425 5.29 97.3 µM 1.66E-7 20 5.98E-8
4 SGTC_1128 3448-9350 4.89 235.0 µM 1.19E-6 12 4.92E-7
5 SGTC_2426 5582046 4.43 32.2 µM 9.81E-6 15 4.66E-6
6 SGTC_1370 2001-0092 4.18 44.6 µM 2.84E-5 23 1.45E-5
7 SGTC_817 1391-0715 4.09 46.0 µM 4.11E-5 15 2.15E-5
8 SGTC_387 norethindrone acetate 3.98 66.7 µM 6.45E-5 16 3.48E-5
9 SGTC_732 3970-1727 3.93 52.7 µM 7.67E-5 8 4.18E-5
10 SGTC_972 1319-0219 3.82 195.0 µM 1.20E-4 32 6.72E-5
11 SGTC_2100 5377183 3.71 190.0 µM 1.80E-4 60S ribosome export 14 1.04E-4
12 SGTC_1055 3448-0672 3.69 86.0 µM 1.95E-4 37 1.13E-4
13 SGTC_2454 5-benzylidenerhodanine 3.53 10.4 µM 3.44E-4 TRP & mitochondrial translation 56 2.08E-4
14 SGTC_655 k060-0012 3.41 42.0 µM 5.31E-4 28 3.30E-4
15 SGTC_3294 9122953 3.36 26.3 µM 6.23E-4 tubulin folding & SWR complex 52 3.92E-4
16 SGTC_375 3970-0961 3.32 9.3 µM 7.05E-4 tubulin folding & SWR complex 42 4.47E-4
17 SGTC_1173 0443-0020 3.30 122.0 µM 7.60E-4 TSC3-RPN4 73 4.84E-4
18 SGTC_2684 capsaicin 3.28 100.0 µM 8.20E-4 37 5.25E-4
19 SGTC_1195 1502-0147 3.21 41.1 µM 0.00102 57 6.63E-4
20 SGTC_2282 7944268 3.15 200.0 µM 0.00123 RPP1 & pyrimidine depletion 76 8.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.81E-11 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.114 3.80E-11 YMR155W_p YMR155W_p hom Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen
0.098 1.24E-8 YJR130C STR2 hom Cystathionine gamma-synthase, converts cysteine into cystathionine
0.094 5.06E-8 YOL147C PEX11 hom Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p
0.092 9.31E-8 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.089 2.41E-7 YOR197W MCA1 hom Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization
0.081 3.02E-6 YDL095W PMT1 hom Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen
0.079 4.68E-6 YOR384W FRE5 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.078 6.73E-6 YIL156W UBP7 hom Ubiquitin-specific protease that cleaves ubiquitin-protein fusions
0.077 7.57E-6 YBR147W RTC2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter
0.077 8.84E-6 YOR318C_d YOR318C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
0.076 1.10E-5 YBL014C RRN6 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.076 1.12E-5 YBR238C YBR238C hom Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
0.075 1.41E-5 YPR035W GLN1 het Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.074 1.68E-5 YDL170W UGA3 hom Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus