YLR109W / AHP1

Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR109W / AHP1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-4.44|P-value:1.94E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.04|P-value:7.70E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.09|P-value:7.07E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.23|P-value:4.19E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.35|P-value:2.43E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.02|P-value:8.97E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.86|P-value:2.94E-5 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.95|P-value:2.17E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.18|P-value:5.07E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.17|P-value:5.32E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.26|P-value:3.71E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.42|P-value:2.02E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.48|P-value:1.62E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.61|P-value:8.54E-5 ID:SGTC_699|Compound:0375-0592|FD-Score:4.79|P-value:3.55E-7 ID:SGTC_964|Compound:1287-0107|FD-Score:3.43|P-value:1.99E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.37|P-value:2.24E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.67|P-value:6.55E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.50|P-value:1.51E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.40|P-value:2.20E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.10|P-value:6.89E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.86|P-value:3.27E-5 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.02|P-value:8.89E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.76|P-value:5.07E-5 ID:SGTC_1677|Compound:st019204|FD-Score:-3.13|P-value:5.57E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.10|P-value:6.84E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.85|P-value:3.38E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-3.50|P-value:1.34E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-2.98|P-value:9.33E-4 ID:SGTC_1764|Compound:st044502|FD-Score:4.53|P-value:1.41E-6 ID:SGTC_1770|Compound:st043884|FD-Score:3.10|P-value:6.88E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.51|P-value:1.43E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:3.21|P-value:4.50E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.23|P-value:4.30E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.13|P-value:5.51E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.67|P-value:7.50E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-3.72|P-value:5.41E-5 ID:SGTC_2835|Compound:9006588|FD-Score:5.54|P-value:4.86E-9 ID:SGTC_2842|Compound:9000675|FD-Score:-7.83|P-value:1.99E-16 ID:SGTC_3039|Compound:9090270|FD-Score:3.20|P-value:4.79E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.08|P-value:1.24E-5 ID:SGTC_3104|Compound:9120930|FD-Score:-4.06|P-value:1.20E-5 ID:SGTC_3106|Compound:9121286|FD-Score:3.59|P-value:1.03E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.62|P-value:8.59E-7 ID:SGTC_3142|Compound:9086498|FD-Score:3.91|P-value:2.63E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.05|P-value:8.26E-4 ID:SGTC_3186|Compound:9110464|FD-Score:4.22|P-value:6.34E-6 ID:SGTC_3202|Compound:9113761|FD-Score:3.32|P-value:2.96E-4 ID:SGTC_3257|Compound:9139206|FD-Score:-3.03|P-value:8.05E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-3.60|P-value:8.72E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.44|P-value:1.94E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.04|P-value:7.70E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.09|P-value:7.07E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.23|P-value:4.19E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.35|P-value:2.43E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.02|P-value:8.97E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.86|P-value:2.94E-5 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.95|P-value:2.17E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.18|P-value:5.07E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.17|P-value:5.32E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.26|P-value:3.71E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.42|P-value:2.02E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.48|P-value:1.62E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.61|P-value:8.54E-5 ID:SGTC_699|Compound:0375-0592|FD-Score:4.79|P-value:3.55E-7 ID:SGTC_964|Compound:1287-0107|FD-Score:3.43|P-value:1.99E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.37|P-value:2.24E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.67|P-value:6.55E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.50|P-value:1.51E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.40|P-value:2.20E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.10|P-value:6.89E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.86|P-value:3.27E-5 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.02|P-value:8.89E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.76|P-value:5.07E-5 ID:SGTC_1677|Compound:st019204|FD-Score:-3.13|P-value:5.57E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.10|P-value:6.84E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.85|P-value:3.38E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-3.50|P-value:1.34E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-2.98|P-value:9.33E-4 ID:SGTC_1764|Compound:st044502|FD-Score:4.53|P-value:1.41E-6 ID:SGTC_1770|Compound:st043884|FD-Score:3.10|P-value:6.88E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.51|P-value:1.43E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:3.21|P-value:4.50E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.23|P-value:4.30E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.13|P-value:5.51E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.67|P-value:7.50E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-3.72|P-value:5.41E-5 ID:SGTC_2835|Compound:9006588|FD-Score:5.54|P-value:4.86E-9 ID:SGTC_2842|Compound:9000675|FD-Score:-7.83|P-value:1.99E-16 ID:SGTC_3039|Compound:9090270|FD-Score:3.20|P-value:4.79E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.08|P-value:1.24E-5 ID:SGTC_3104|Compound:9120930|FD-Score:-4.06|P-value:1.20E-5 ID:SGTC_3106|Compound:9121286|FD-Score:3.59|P-value:1.03E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.62|P-value:8.59E-7 ID:SGTC_3142|Compound:9086498|FD-Score:3.91|P-value:2.63E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.05|P-value:8.26E-4 ID:SGTC_3186|Compound:9110464|FD-Score:4.22|P-value:6.34E-6 ID:SGTC_3202|Compound:9113761|FD-Score:3.32|P-value:2.96E-4 ID:SGTC_3257|Compound:9139206|FD-Score:-3.03|P-value:8.05E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-3.60|P-value:8.72E-5

Top fitness defect scores for YLR109W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2835 9006588 5.54 71.4 µM 4.86E-9 11 1.51E-8
2 SGTC_699 0375-0592 4.79 111.0 µM 3.55E-7 iron homeostasis 10 8.27E-7
3 SGTC_3137 9097352 4.62 49.5 µM 8.59E-7 22 1.89E-6
4 SGTC_1764 st044502 4.53 93.5 µM 1.41E-6 22 3.00E-6
5 SGTC_3186 9110464 4.22 49.5 µM 6.34E-6 RPP1 & pyrimidine depletion 10 1.22E-5
6 SGTC_3101 9120531 4.08 49.5 µM 1.24E-5 28 2.28E-5
7 SGTC_247 mechlorethamine 3.95 29.7 µM 2.17E-5 DNA damage response 14 3.85E-5
8 SGTC_3142 9086498 3.91 49.5 µM 2.63E-5 iron homeostasis 38 4.61E-5
9 SGTC_1528 arabinosylhypoxanthine 3.86 74.6 µM 3.27E-5 25 5.65E-5
10 SGTC_1708 st033234 3.85 31.8 µM 3.38E-5 19 5.83E-5
11 SGTC_1610 st001799 3.76 48.1 µM 5.07E-5 13 8.52E-5
12 SGTC_2709 st078560 3.67 56.0 µM 7.50E-5 18 1.23E-4
13 SGTC_3106 9121286 3.59 49.5 µM 1.03E-4 22 1.65E-4
14 SGTC_2044 5102272 3.51 200.0 µM 1.43E-4 21 2.25E-4
15 SGTC_1088 bifonazole 3.50 369.0 nM 1.51E-4 27 2.37E-4
16 SGTC_458 nppb 3.48 133.0 µM 1.62E-4 24 2.52E-4
17 SGTC_964 1287-0107 3.43 19.4 µM 1.99E-4 cell wall 70 3.07E-4
18 SGTC_457 grayanotoxin iii 3.42 135.0 µM 2.02E-4 100 3.10E-4
19 SGTC_1149 3909-7961 3.40 23.3 µM 2.20E-4 42 3.37E-4
20 SGTC_3202 9113761 3.32 49.5 µM 2.96E-4 76 4.45E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.47E-17 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.100 6.44E-9 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.100 6.94E-9 YOR045W TOM6 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.094 4.95E-8 YKL144C RPC25 het RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p
0.090 1.57E-7 YDR223W CRF1 hom Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain
0.089 2.29E-7 YPL155C KIP2 hom Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle
0.089 2.50E-7 YKR016W FCJ1 hom Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane
0.087 4.64E-7 YIL113W SDP1 hom Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
0.079 4.48E-6 YDL124W YDL124W hom NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress
0.078 5.79E-6 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.076 1.03E-5 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.076 1.05E-5 YJL125C GCD14 het Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.076 1.19E-5 YDR033W MRH1 hom Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication
0.075 1.33E-5 YDR406W PDR15 hom Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
0.075 1.47E-5 YER185W PUG1 hom Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins