YLR110C / CCW12

Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR110C / CCW12

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.43|P-value:2.77E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:5.93|P-value:1.77E-6 ID:SGTC_55|Compound:0767-0285|FD-Score:7.53|P-value:1.82E-9 ID:SGTC_86|Compound:0417-1630|FD-Score:5.45|P-value:1.04E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:9.25|P-value:2.00E-13 ID:SGTC_146|Compound:3448-8650|FD-Score:6.38|P-value:2.97E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:3.98|P-value:9.71E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:7.76|P-value:5.99E-10 ID:SGTC_263|Compound:alizarin|FD-Score:8.66|P-value:5.72E-12 ID:SGTC_274|Compound:sirtinol|FD-Score:4.03|P-value:8.57E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.09|P-value:7.29E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:8.01|P-value:1.79E-10 ID:SGTC_373|Compound:0844-0104|FD-Score:4.49|P-value:2.32E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:7.55|P-value:1.72E-9 ID:SGTC_426|Compound:0988-0037|FD-Score:6.76|P-value:6.10E-8 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.68|P-value:1.33E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:5.92|P-value:1.87E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.27|P-value:4.40E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.32|P-value:3.80E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:5.68|P-value:4.56E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:5.81|P-value:2.86E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:4.80|P-value:8.95E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:5.70|P-value:4.25E-6 ID:SGTC_608|Compound:k048-0125|FD-Score:5.02|P-value:4.51E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:5.38|P-value:1.35E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:4.99|P-value:4.92E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:4.37|P-value:3.28E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:7.34|P-value:4.47E-9 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.41|P-value:2.17E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:4.36|P-value:3.44E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:5.73|P-value:3.72E-6 ID:SGTC_811|Compound:0416-0114|FD-Score:4.96|P-value:5.42E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:5.09|P-value:3.60E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:4.80|P-value:9.13E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:4.23|P-value:4.88E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:6.28|P-value:4.53E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.70|P-value:7.87E-8 ID:SGTC_1055|Compound:3448-0672|FD-Score:5.76|P-value:3.41E-6 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.99|P-value:9.47E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:5.17|P-value:2.74E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.53|P-value:2.08E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.55|P-value:1.97E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.61|P-value:1.62E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.35|P-value:1.45E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.95|P-value:5.58E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.05|P-value:8.13E-4 ID:SGTC_1602|Compound:st001878|FD-Score:4.32|P-value:3.80E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.03|P-value:8.48E-4 ID:SGTC_1773|Compound:st048542|FD-Score:17.50|P-value:3.71E-43 ID:SGTC_1775|Compound:st081588|FD-Score:-3.93|P-value:8.43E-4 ID:SGTC_1781|Compound:st038725|FD-Score:5.47|P-value:9.74E-6 ID:SGTC_1854|Compound:st056233|FD-Score:-4.77|P-value:7.18E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-5.31|P-value:1.17E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-4.95|P-value:3.96E-5 ID:SGTC_1949|Compound:st076024|FD-Score:7.39|P-value:3.68E-9 ID:SGTC_1991|Compound:st073000|FD-Score:5.28|P-value:1.90E-5 ID:SGTC_2058|Compound:5236698|FD-Score:4.03|P-value:8.48E-4 ID:SGTC_2067|Compound:5224629|FD-Score:6.52|P-value:1.68E-7 ID:SGTC_2118|Compound:5526350|FD-Score:4.36|P-value:3.46E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.19|P-value:5.51E-4 ID:SGTC_2189|Compound:6047310|FD-Score:7.15|P-value:1.09E-8 ID:SGTC_2268|Compound:7933382|FD-Score:7.13|P-value:1.20E-8 ID:SGTC_2283|Compound:7944793|FD-Score:5.58|P-value:6.66E-6 ID:SGTC_2289|Compound:7946404|FD-Score:6.70|P-value:8.01E-8 ID:SGTC_2318|Compound:6029776|FD-Score:4.21|P-value:5.29E-4 ID:SGTC_2332|Compound:7982454|FD-Score:5.69|P-value:4.44E-6 ID:SGTC_2358|Compound:9037157|FD-Score:4.60|P-value:1.66E-4 ID:SGTC_2366|Compound:9070441|FD-Score:4.59|P-value:1.75E-4 ID:SGTC_2376|Compound:9072922|FD-Score:4.11|P-value:6.98E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.34|P-value:3.66E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.19|P-value:5.52E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-5.14|P-value:2.13E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:6.21|P-value:5.89E-7 ID:SGTC_2593|Compound:nobiletin|FD-Score:-4.12|P-value:4.94E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:7.00|P-value:2.15E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.28|P-value:1.91E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:4.72|P-value:1.17E-4 ID:SGTC_2683|Compound:piperine|FD-Score:4.19|P-value:5.59E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.11|P-value:6.94E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.72|P-value:1.15E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:5.44|P-value:1.07E-5 ID:SGTC_2844|Compound:9010103|FD-Score:4.15|P-value:6.11E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.10|P-value:7.01E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.48|P-value:2.37E-4 ID:SGTC_2981|Compound:9013952|FD-Score:5.81|P-value:2.85E-6 ID:SGTC_2982|Compound:9019404|FD-Score:6.75|P-value:6.50E-8 ID:SGTC_3000|Compound:9075062|FD-Score:-4.24|P-value:3.54E-4 ID:SGTC_3002|Compound:9075603|FD-Score:5.25|P-value:2.05E-5 ID:SGTC_3003|Compound:9075612|FD-Score:-4.51|P-value:1.60E-4 ID:SGTC_3009|Compound:9080819|FD-Score:4.75|P-value:1.06E-4 ID:SGTC_3078|Compound:9116413|FD-Score:5.09|P-value:3.52E-5 ID:SGTC_3125|Compound:9127534|FD-Score:15.70|P-value:2.24E-35 ID:SGTC_3135|Compound:9127742|FD-Score:3.98|P-value:9.90E-4 ID:SGTC_3137|Compound:9097352|FD-Score:6.54|P-value:1.56E-7 ID:SGTC_3140|Compound:9094243|FD-Score:5.82|P-value:2.72E-6 ID:SGTC_3143|Compound:9086658|FD-Score:6.37|P-value:3.17E-7 ID:SGTC_3155|Compound:9099265|FD-Score:6.06|P-value:1.06E-6 ID:SGTC_3166|Compound:9102297|FD-Score:6.35|P-value:3.42E-7 ID:SGTC_3182|Compound:9108849|FD-Score:5.37|P-value:1.38E-5 ID:SGTC_3185|Compound:9108267|FD-Score:4.51|P-value:2.21E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.62|P-value:1.13E-4 ID:SGTC_3333|Compound:9141820|FD-Score:5.56|P-value:6.97E-6 ID:SGTC_7|Compound:0192-1582|FD-Score:4.43|P-value:2.77E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:5.93|P-value:1.77E-6 ID:SGTC_55|Compound:0767-0285|FD-Score:7.53|P-value:1.82E-9 ID:SGTC_86|Compound:0417-1630|FD-Score:5.45|P-value:1.04E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:9.25|P-value:2.00E-13 ID:SGTC_146|Compound:3448-8650|FD-Score:6.38|P-value:2.97E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:3.98|P-value:9.71E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:7.76|P-value:5.99E-10 ID:SGTC_263|Compound:alizarin|FD-Score:8.66|P-value:5.72E-12 ID:SGTC_274|Compound:sirtinol|FD-Score:4.03|P-value:8.57E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.09|P-value:7.29E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:8.01|P-value:1.79E-10 ID:SGTC_373|Compound:0844-0104|FD-Score:4.49|P-value:2.32E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:7.55|P-value:1.72E-9 ID:SGTC_426|Compound:0988-0037|FD-Score:6.76|P-value:6.10E-8 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.68|P-value:1.33E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:5.92|P-value:1.87E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.27|P-value:4.40E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.32|P-value:3.80E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:5.68|P-value:4.56E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:5.81|P-value:2.86E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:4.80|P-value:8.95E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:5.70|P-value:4.25E-6 ID:SGTC_608|Compound:k048-0125|FD-Score:5.02|P-value:4.51E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:5.38|P-value:1.35E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:4.99|P-value:4.92E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:4.37|P-value:3.28E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:7.34|P-value:4.47E-9 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.41|P-value:2.17E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:4.36|P-value:3.44E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:5.73|P-value:3.72E-6 ID:SGTC_811|Compound:0416-0114|FD-Score:4.96|P-value:5.42E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:5.09|P-value:3.60E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:4.80|P-value:9.13E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:4.23|P-value:4.88E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:6.28|P-value:4.53E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.70|P-value:7.87E-8 ID:SGTC_1055|Compound:3448-0672|FD-Score:5.76|P-value:3.41E-6 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.99|P-value:9.47E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:5.17|P-value:2.74E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.53|P-value:2.08E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.55|P-value:1.97E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.61|P-value:1.62E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.35|P-value:1.45E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.95|P-value:5.58E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.05|P-value:8.13E-4 ID:SGTC_1602|Compound:st001878|FD-Score:4.32|P-value:3.80E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.03|P-value:8.48E-4 ID:SGTC_1773|Compound:st048542|FD-Score:17.50|P-value:3.71E-43 ID:SGTC_1775|Compound:st081588|FD-Score:-3.93|P-value:8.43E-4 ID:SGTC_1781|Compound:st038725|FD-Score:5.47|P-value:9.74E-6 ID:SGTC_1854|Compound:st056233|FD-Score:-4.77|P-value:7.18E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-5.31|P-value:1.17E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-4.95|P-value:3.96E-5 ID:SGTC_1949|Compound:st076024|FD-Score:7.39|P-value:3.68E-9 ID:SGTC_1991|Compound:st073000|FD-Score:5.28|P-value:1.90E-5 ID:SGTC_2058|Compound:5236698|FD-Score:4.03|P-value:8.48E-4 ID:SGTC_2067|Compound:5224629|FD-Score:6.52|P-value:1.68E-7 ID:SGTC_2118|Compound:5526350|FD-Score:4.36|P-value:3.46E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.19|P-value:5.51E-4 ID:SGTC_2189|Compound:6047310|FD-Score:7.15|P-value:1.09E-8 ID:SGTC_2268|Compound:7933382|FD-Score:7.13|P-value:1.20E-8 ID:SGTC_2283|Compound:7944793|FD-Score:5.58|P-value:6.66E-6 ID:SGTC_2289|Compound:7946404|FD-Score:6.70|P-value:8.01E-8 ID:SGTC_2318|Compound:6029776|FD-Score:4.21|P-value:5.29E-4 ID:SGTC_2332|Compound:7982454|FD-Score:5.69|P-value:4.44E-6 ID:SGTC_2358|Compound:9037157|FD-Score:4.60|P-value:1.66E-4 ID:SGTC_2366|Compound:9070441|FD-Score:4.59|P-value:1.75E-4 ID:SGTC_2376|Compound:9072922|FD-Score:4.11|P-value:6.98E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.34|P-value:3.66E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.19|P-value:5.52E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-5.14|P-value:2.13E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:6.21|P-value:5.89E-7 ID:SGTC_2593|Compound:nobiletin|FD-Score:-4.12|P-value:4.94E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:7.00|P-value:2.15E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.28|P-value:1.91E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:4.72|P-value:1.17E-4 ID:SGTC_2683|Compound:piperine|FD-Score:4.19|P-value:5.59E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.11|P-value:6.94E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.72|P-value:1.15E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:5.44|P-value:1.07E-5 ID:SGTC_2844|Compound:9010103|FD-Score:4.15|P-value:6.11E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.10|P-value:7.01E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.48|P-value:2.37E-4 ID:SGTC_2981|Compound:9013952|FD-Score:5.81|P-value:2.85E-6 ID:SGTC_2982|Compound:9019404|FD-Score:6.75|P-value:6.50E-8 ID:SGTC_3000|Compound:9075062|FD-Score:-4.24|P-value:3.54E-4 ID:SGTC_3002|Compound:9075603|FD-Score:5.25|P-value:2.05E-5 ID:SGTC_3003|Compound:9075612|FD-Score:-4.51|P-value:1.60E-4 ID:SGTC_3009|Compound:9080819|FD-Score:4.75|P-value:1.06E-4 ID:SGTC_3078|Compound:9116413|FD-Score:5.09|P-value:3.52E-5 ID:SGTC_3125|Compound:9127534|FD-Score:15.70|P-value:2.24E-35 ID:SGTC_3135|Compound:9127742|FD-Score:3.98|P-value:9.90E-4 ID:SGTC_3137|Compound:9097352|FD-Score:6.54|P-value:1.56E-7 ID:SGTC_3140|Compound:9094243|FD-Score:5.82|P-value:2.72E-6 ID:SGTC_3143|Compound:9086658|FD-Score:6.37|P-value:3.17E-7 ID:SGTC_3155|Compound:9099265|FD-Score:6.06|P-value:1.06E-6 ID:SGTC_3166|Compound:9102297|FD-Score:6.35|P-value:3.42E-7 ID:SGTC_3182|Compound:9108849|FD-Score:5.37|P-value:1.38E-5 ID:SGTC_3185|Compound:9108267|FD-Score:4.51|P-value:2.21E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.62|P-value:1.13E-4 ID:SGTC_3333|Compound:9141820|FD-Score:5.56|P-value:6.97E-6

Top fitness defect scores for YLR110C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1773 st048542 17.50 73.6 µM 3.71E-43 2 1.64E-68
2 SGTC_3125 9127534 15.70 49.5 µM 2.24E-35 1 5.45E-56
3 SGTC_103 0844-0104 9.25 51.8 µM 2.00E-13 ERAD & cell cycle 35 1.09E-20
4 SGTC_263 alizarin 8.66 107.9 µM 5.72E-12 iron homeostasis 8 2.38E-18
5 SGTC_310 1273-0058 8.01 1.1 µM 1.79E-10 mitochondrial stress 88 5.95E-16
6 SGTC_206 4546-0025 7.76 72.0 µM 5.99E-10 NEO1 22 4.14E-15
7 SGTC_384 k007-0144 7.55 5.2 µM 1.72E-9 ERAD & cell cycle 15 2.26E-14
8 SGTC_55 0767-0285 7.53 6.6 µM 1.82E-9 9 2.47E-14
9 SGTC_1949 st076024 7.39 69.1 µM 3.68E-9 2 7.62E-14
10 SGTC_676 falcarinol 7.34 140.0 µM 4.47E-9 8 1.04E-13
11 SGTC_2189 6047310 7.15 154.4 µM 1.09E-8 RPP1 & pyrimidine depletion 1 4.36E-13
12 SGTC_2268 7933382 7.13 153.8 µM 1.20E-8 5 5.03E-13
13 SGTC_2594 a-mangostin 7.00 100.0 µM 2.15E-8 5 1.29E-12
14 SGTC_426 0988-0037 6.76 14.6 µM 6.10E-8 ERAD & cell cycle 8 6.83E-12
15 SGTC_2982 9019404 6.75 26.0 µM 6.50E-8 3 7.57E-12
16 SGTC_1026 k007-1105 6.70 30.6 µM 7.87E-8 ERAD & cell cycle 31 1.03E-11
17 SGTC_2289 7946404 6.70 165.1 µM 8.01E-8 29 1.06E-11
18 SGTC_3137 9097352 6.54 49.5 µM 1.56E-7 4 3.06E-11
19 SGTC_2067 5224629 6.52 34.1 µM 1.68E-7 2 3.44E-11
20 SGTC_146 3448-8650 6.38 53.1 µM 2.97E-7 NEO1-PIK1 48 8.58E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.395 1.54E-125 YLR111W_d YLR111W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.157 5.68E-20 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.155 1.53E-19 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.155 1.95E-19 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.146 1.79E-17 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.138 9.49E-16 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.131 2.65E-14 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.123 7.59E-13 YDR207C UME6 hom Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
0.120 3.67E-12 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.119 4.17E-12 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.117 8.72E-12 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.115 2.54E-11 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.114 3.79E-11 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.113 5.84E-11 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.112 8.20E-11 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc