YLR111W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR111W / YLR111W

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:6.46|P-value:1.21E-9 ID:SGTC_55|Compound:0767-0285|FD-Score:4.96|P-value:2.34E-6 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.89|P-value:1.68E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.89|P-value:3.08E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:4.42|P-value:2.27E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:8.19|P-value:1.81E-14 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.48|P-value:5.90E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:8.09|P-value:3.77E-14 ID:SGTC_180|Compound:1486-1293|FD-Score:-4.47|P-value:1.61E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.64|P-value:3.50E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:15.40|P-value:3.37E-46 ID:SGTC_209|Compound:4077-0173|FD-Score:3.36|P-value:9.70E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.73|P-value:6.30E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:5.82|P-value:3.70E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:7.24|P-value:1.12E-11 ID:SGTC_317|Compound:4495-0002|FD-Score:3.66|P-value:3.68E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:5.04|P-value:1.63E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.35|P-value:9.93E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.94|P-value:1.04E-13 ID:SGTC_455|Compound:paf C-16|FD-Score:8.17|P-value:2.04E-14 ID:SGTC_513|Compound:4245-1575|FD-Score:4.28|P-value:3.95E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:4.35|P-value:2.91E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.85|P-value:1.92E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.89|P-value:1.67E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.74|P-value:2.81E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:5.82|P-value:3.74E-8 ID:SGTC_581|Compound:0958-0271|FD-Score:6.14|P-value:7.05E-9 ID:SGTC_595|Compound:3909-8003|FD-Score:4.02|P-value:1.03E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.42|P-value:8.01E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:5.34|P-value:4.07E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:3.36|P-value:9.74E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:4.24|P-value:4.59E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:3.99|P-value:1.16E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.11|P-value:7.42E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.67|P-value:3.59E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:4.26|P-value:4.27E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:3.57|P-value:5.00E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:6.11|P-value:8.17E-9 ID:SGTC_926|Compound:2268-1401|FD-Score:3.90|P-value:1.59E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:5.11|P-value:1.20E-6 ID:SGTC_993|Compound:3909-8757|FD-Score:4.08|P-value:8.32E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.53|P-value:1.66E-12 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.80|P-value:4.57E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.16|P-value:6.21E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:6.73|P-value:2.40E-10 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.30|P-value:4.98E-7 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.24|P-value:6.47E-7 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.25|P-value:4.34E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.00|P-value:1.10E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.54|P-value:5.52E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.77|P-value:5.35E-6 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.37|P-value:2.77E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:5.77|P-value:4.92E-8 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.64|P-value:9.03E-6 ID:SGTC_1588|Compound:farnesol|FD-Score:3.56|P-value:5.20E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.51|P-value:1.57E-5 ID:SGTC_1673|Compound:st016611|FD-Score:5.95|P-value:1.96E-8 ID:SGTC_1773|Compound:st048542|FD-Score:5.51|P-value:1.75E-7 ID:SGTC_1847|Compound:st056231|FD-Score:-3.92|P-value:1.31E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.71|P-value:3.14E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.47|P-value:6.77E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.75|P-value:2.66E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.74|P-value:2.82E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.37|P-value:9.48E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.60|P-value:4.06E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.36|P-value:9.72E-4 ID:SGTC_2189|Compound:6047310|FD-Score:4.56|P-value:1.29E-5 ID:SGTC_2276|Compound:7947513|FD-Score:4.16|P-value:6.17E-5 ID:SGTC_2318|Compound:6029776|FD-Score:4.08|P-value:8.38E-5 ID:SGTC_2332|Compound:7982454|FD-Score:6.79|P-value:1.71E-10 ID:SGTC_2340|Compound:7987427|FD-Score:3.65|P-value:3.83E-4 ID:SGTC_2376|Compound:9072922|FD-Score:7.39|P-value:4.04E-12 ID:SGTC_2437|Compound:5741531|FD-Score:4.03|P-value:1.01E-4 ID:SGTC_2462|Compound:5162487|FD-Score:4.03|P-value:1.02E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.51|P-value:5.96E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.74|P-value:2.77E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.35|P-value:9.12E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.55|P-value:4.70E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.35|P-value:8.95E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.49|P-value:1.71E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.62|P-value:4.26E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:6.39|P-value:1.73E-9 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.08|P-value:8.40E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-4.11|P-value:6.66E-5 ID:SGTC_2852|Compound:9023854|FD-Score:4.18|P-value:5.68E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.67|P-value:3.20E-4 ID:SGTC_2913|Compound:7966556|FD-Score:4.05|P-value:9.23E-5 ID:SGTC_2924|Compound:9010168|FD-Score:4.85|P-value:3.77E-6 ID:SGTC_2958|Compound:9077254|FD-Score:4.70|P-value:7.11E-6 ID:SGTC_2962|Compound:9082311|FD-Score:3.83|P-value:2.02E-4 ID:SGTC_2988|Compound:9073640|FD-Score:4.34|P-value:3.12E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.47|P-value:6.88E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.68|P-value:3.49E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.83|P-value:2.01E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.09|P-value:8.13E-5 ID:SGTC_3123|Compound:9126162|FD-Score:3.66|P-value:3.73E-4 ID:SGTC_3125|Compound:9127534|FD-Score:11.10|P-value:5.79E-25 ID:SGTC_3137|Compound:9097352|FD-Score:4.00|P-value:1.14E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.39|P-value:8.79E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-5.59|P-value:1.02E-7 ID:SGTC_3234|Compound:9132280|FD-Score:4.98|P-value:2.12E-6 ID:SGTC_3243|Compound:9134147|FD-Score:4.11|P-value:7.41E-5 ID:SGTC_3284|Compound:9108171|FD-Score:4.26|P-value:4.23E-5 ID:SGTC_3296|Compound:9122258|FD-Score:7.00|P-value:4.98E-11 ID:SGTC_43|Compound:0570-0105|FD-Score:6.46|P-value:1.21E-9 ID:SGTC_55|Compound:0767-0285|FD-Score:4.96|P-value:2.34E-6 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.89|P-value:1.68E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.89|P-value:3.08E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:4.42|P-value:2.27E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:8.19|P-value:1.81E-14 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.48|P-value:5.90E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:8.09|P-value:3.77E-14 ID:SGTC_180|Compound:1486-1293|FD-Score:-4.47|P-value:1.61E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.64|P-value:3.50E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:15.40|P-value:3.37E-46 ID:SGTC_209|Compound:4077-0173|FD-Score:3.36|P-value:9.70E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.73|P-value:6.30E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:5.82|P-value:3.70E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:7.24|P-value:1.12E-11 ID:SGTC_317|Compound:4495-0002|FD-Score:3.66|P-value:3.68E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:5.04|P-value:1.63E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.35|P-value:9.93E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.94|P-value:1.04E-13 ID:SGTC_455|Compound:paf C-16|FD-Score:8.17|P-value:2.04E-14 ID:SGTC_513|Compound:4245-1575|FD-Score:4.28|P-value:3.95E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:4.35|P-value:2.91E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.85|P-value:1.92E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.89|P-value:1.67E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.74|P-value:2.81E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:5.82|P-value:3.74E-8 ID:SGTC_581|Compound:0958-0271|FD-Score:6.14|P-value:7.05E-9 ID:SGTC_595|Compound:3909-8003|FD-Score:4.02|P-value:1.03E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.42|P-value:8.01E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:5.34|P-value:4.07E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:3.36|P-value:9.74E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:4.24|P-value:4.59E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:3.99|P-value:1.16E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.11|P-value:7.42E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.67|P-value:3.59E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:4.26|P-value:4.27E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:3.57|P-value:5.00E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:6.11|P-value:8.17E-9 ID:SGTC_926|Compound:2268-1401|FD-Score:3.90|P-value:1.59E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:5.11|P-value:1.20E-6 ID:SGTC_993|Compound:3909-8757|FD-Score:4.08|P-value:8.32E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.53|P-value:1.66E-12 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.80|P-value:4.57E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.16|P-value:6.21E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:6.73|P-value:2.40E-10 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.30|P-value:4.98E-7 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.24|P-value:6.47E-7 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.25|P-value:4.34E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.00|P-value:1.10E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.54|P-value:5.52E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.77|P-value:5.35E-6 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.37|P-value:2.77E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:5.77|P-value:4.92E-8 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.64|P-value:9.03E-6 ID:SGTC_1588|Compound:farnesol|FD-Score:3.56|P-value:5.20E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.51|P-value:1.57E-5 ID:SGTC_1673|Compound:st016611|FD-Score:5.95|P-value:1.96E-8 ID:SGTC_1773|Compound:st048542|FD-Score:5.51|P-value:1.75E-7 ID:SGTC_1847|Compound:st056231|FD-Score:-3.92|P-value:1.31E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.71|P-value:3.14E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.47|P-value:6.77E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.75|P-value:2.66E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.74|P-value:2.82E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.37|P-value:9.48E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.60|P-value:4.06E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.36|P-value:9.72E-4 ID:SGTC_2189|Compound:6047310|FD-Score:4.56|P-value:1.29E-5 ID:SGTC_2276|Compound:7947513|FD-Score:4.16|P-value:6.17E-5 ID:SGTC_2318|Compound:6029776|FD-Score:4.08|P-value:8.38E-5 ID:SGTC_2332|Compound:7982454|FD-Score:6.79|P-value:1.71E-10 ID:SGTC_2340|Compound:7987427|FD-Score:3.65|P-value:3.83E-4 ID:SGTC_2376|Compound:9072922|FD-Score:7.39|P-value:4.04E-12 ID:SGTC_2437|Compound:5741531|FD-Score:4.03|P-value:1.01E-4 ID:SGTC_2462|Compound:5162487|FD-Score:4.03|P-value:1.02E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.51|P-value:5.96E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.74|P-value:2.77E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.35|P-value:9.12E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.55|P-value:4.70E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.35|P-value:8.95E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.49|P-value:1.71E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.62|P-value:4.26E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:6.39|P-value:1.73E-9 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.08|P-value:8.40E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-4.11|P-value:6.66E-5 ID:SGTC_2852|Compound:9023854|FD-Score:4.18|P-value:5.68E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.67|P-value:3.20E-4 ID:SGTC_2913|Compound:7966556|FD-Score:4.05|P-value:9.23E-5 ID:SGTC_2924|Compound:9010168|FD-Score:4.85|P-value:3.77E-6 ID:SGTC_2958|Compound:9077254|FD-Score:4.70|P-value:7.11E-6 ID:SGTC_2962|Compound:9082311|FD-Score:3.83|P-value:2.02E-4 ID:SGTC_2988|Compound:9073640|FD-Score:4.34|P-value:3.12E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.47|P-value:6.88E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.68|P-value:3.49E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.83|P-value:2.01E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.09|P-value:8.13E-5 ID:SGTC_3123|Compound:9126162|FD-Score:3.66|P-value:3.73E-4 ID:SGTC_3125|Compound:9127534|FD-Score:11.10|P-value:5.79E-25 ID:SGTC_3137|Compound:9097352|FD-Score:4.00|P-value:1.14E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.39|P-value:8.79E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-5.59|P-value:1.02E-7 ID:SGTC_3234|Compound:9132280|FD-Score:4.98|P-value:2.12E-6 ID:SGTC_3243|Compound:9134147|FD-Score:4.11|P-value:7.41E-5 ID:SGTC_3284|Compound:9108171|FD-Score:4.26|P-value:4.23E-5 ID:SGTC_3296|Compound:9122258|FD-Score:7.00|P-value:4.98E-11

Top fitness defect scores for YLR111W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_206 4546-0025 15.40 72.0 µM 3.37E-46 NEO1 6 1.47E-53
2 SGTC_3125 9127534 11.10 49.5 µM 5.79E-25 2 7.91E-29
3 SGTC_161 4065-0411 8.19 162.2 µM 1.81E-14 12 1.31E-16
4 SGTC_455 paf C-16 8.17 10.0 µM 2.04E-14 2 1.51E-16
5 SGTC_179 1273-0063 8.09 6.8 µM 3.77E-14 3 3.08E-16
6 SGTC_453 enantio-paf c16 7.94 10.0 µM 1.04E-13 15 1.01E-15
7 SGTC_1026 k007-1105 7.53 30.6 µM 1.66E-12 ERAD & cell cycle 23 2.52E-14
8 SGTC_2376 9072922 7.39 81.3 µM 4.04E-12 4 7.10E-14
9 SGTC_310 1273-0058 7.24 1.1 µM 1.12E-11 mitochondrial stress 113 2.33E-13
10 SGTC_3296 9122258 7.00 64.0 µM 4.98E-11 redox potentiating 5 1.32E-12
11 SGTC_2332 7982454 6.79 138.9 µM 1.71E-10 9 5.53E-12
12 SGTC_1055 3448-0672 6.73 86.0 µM 2.40E-10 7 8.21E-12
13 SGTC_43 0570-0105 6.46 72.5 µM 1.21E-9 ERG2 26 5.41E-11
14 SGTC_2633 5,7-dihydroxyisoflavone 6.39 100.0 µM 1.73E-9 5 8.18E-11
15 SGTC_581 0958-0271 6.14 211.0 µM 7.05E-9 16 4.20E-10
16 SGTC_885 0865-0106 6.11 16.8 µM 8.17E-9 TSC3-RPN4 7 4.98E-10
17 SGTC_1673 st016611 5.95 27.3 µM 1.96E-8 14 1.38E-9
18 SGTC_274 sirtinol 5.82 40.1 µM 3.70E-8 5 2.89E-9
19 SGTC_569 4130-2812 5.82 160.0 µM 3.74E-8 amide catabolism 2 2.92E-9
20 SGTC_1389 3405-0187 5.77 19.0 µM 4.92E-8 3 4.01E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.395 1.54E-125 YLR110C CCW12 hom Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication
0.123 9.25E-13 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.120 2.85E-12 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.116 1.42E-11 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.116 1.97E-11 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.115 2.75E-11 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.114 3.05E-11 YBR036C CSG2 hom Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress
0.113 6.59E-11 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.111 1.18E-10 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.107 5.76E-10 YAL012W CYS3 hom Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress
0.101 4.47E-9 YJR073C OPI3 hom Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
0.101 5.24E-9 YPL120W VPS30 hom Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1
0.100 5.90E-9 YMR077C VPS20 hom Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
0.098 1.20E-8 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.098 1.41E-8 YNL199C GCR2 hom Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p