HIPHOP chemogenomics database

YLR111W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR111W / YLR111W

Click on Significant Values for Screen Details

Top fitness defect scores for YLR111W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_206	4546-0025	15.40	72.0 µM	3.37E-46	NEO1	6	1.47E-53
2	SGTC_3125	9127534	11.10	49.5 µM	5.79E-25		2	7.91E-29
3	SGTC_161	4065-0411	8.19	162.2 µM	1.81E-14		12	1.31E-16
4	SGTC_455	paf C-16	8.17	10.0 µM	2.04E-14		2	1.51E-16
5	SGTC_179	1273-0063	8.09	6.8 µM	3.77E-14		3	3.08E-16
6	SGTC_453	enantio-paf c16	7.94	10.0 µM	1.04E-13		15	1.01E-15
7	SGTC_1026	k007-1105	7.53	30.6 µM	1.66E-12	ERAD & cell cycle	23	2.52E-14
8	SGTC_2376	9072922	7.39	81.3 µM	4.04E-12		4	7.10E-14
9	SGTC_310	1273-0058	7.24	1.1 µM	1.12E-11	mitochondrial stress	113	2.33E-13
10	SGTC_3296	9122258	7.00	64.0 µM	4.98E-11	redox potentiating	5	1.32E-12
11	SGTC_2332	7982454	6.79	138.9 µM	1.71E-10		9	5.53E-12
12	SGTC_1055	3448-0672	6.73	86.0 µM	2.40E-10		7	8.21E-12
13	SGTC_43	0570-0105	6.46	72.5 µM	1.21E-9	ERG2	26	5.41E-11
14	SGTC_2633	5,7-dihydroxyisoflavone	6.39	100.0 µM	1.73E-9		5	8.18E-11
15	SGTC_581	0958-0271	6.14	211.0 µM	7.05E-9		16	4.20E-10
16	SGTC_885	0865-0106	6.11	16.8 µM	8.17E-9	TSC3-RPN4	7	4.98E-10
17	SGTC_1673	st016611	5.95	27.3 µM	1.96E-8		14	1.38E-9
18	SGTC_274	sirtinol	5.82	40.1 µM	3.70E-8		5	2.89E-9
19	SGTC_569	4130-2812	5.82	160.0 µM	3.74E-8	amide catabolism	2	2.92E-9
20	SGTC_1389	3405-0187	5.77	19.0 µM	4.92E-8		3	4.01E-9

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.395	1.54E-125	YLR110C	CCW12	hom	Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication
0.123	9.25E-13	YIL030C	SSM4	hom	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.120	2.85E-12	YDR456W	NHX1	hom	Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.116	1.42E-11	YOL002C	IZH2	hom	Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.116	1.97E-11	YGL025C	PGD1	hom	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.115	2.75E-11	YJL159W	HSP150	hom	O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.114	3.05E-11	YBR036C	CSG2	hom	Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress
0.113	6.59E-11	YDR372C	VPS74	hom	Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.111	1.18E-10	YER084W_p	YER084W_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.107	5.76E-10	YAL012W	CYS3	hom	Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress
0.101	4.47E-9	YJR073C	OPI3	hom	Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
0.101	5.24E-9	YPL120W	VPS30	hom	Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1
0.100	5.90E-9	YMR077C	VPS20	hom	Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
0.098	1.20E-8	YNL140C_p	YNL140C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.098	1.41E-8	YNL199C	GCR2	hom	Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p