Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR118C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.126 | 2.13E-13 | YEL004W | YEA4 | hom | Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER |
0.119 | 4.78E-12 | YKL151C | YKL151C | hom | NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress |
0.109 | 2.41E-10 | YBL068W | PRS4 | hom | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication |
0.108 | 3.41E-10 | YHL003C | LAG1 | hom | Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress |
0.107 | 6.12E-10 | YOR291W | YPK9 | hom | Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome |
0.104 | 1.38E-9 | YKL072W | STB6 | hom | Protein that binds Sin3p in a two-hybrid assay |
0.103 | 2.49E-9 | YLR049C_p | YLR049C_p | hom | Putative protein of unknown function |
0.091 | 1.35E-7 | YPL167C | REV3 | hom | Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair |
0.089 | 2.26E-7 | YIL139C | REV7 | hom | Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair |
0.088 | 3.26E-7 | YPR017C | DSS4 | hom | Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol |
0.087 | 4.33E-7 | YOL019W-A_p | YOL019W-A_p | hom | Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
0.086 | 5.37E-7 | YBR144C_d | YBR144C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene |
0.086 | 6.42E-7 | YDR102C_d | YDR102C_d | hom | Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index |
0.084 | 1.05E-6 | YDR453C | TSA2 | hom | Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress |
0.084 | 1.16E-6 | YPR004C | AIM45 | hom | Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response |