YLR118C

Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR118C / YLR118C

Click on Significant Values for Screen Details ID:SGTC_172|Compound:1112-0046|FD-Score:-4.48|P-value:3.59E-7 ID:SGTC_174|Compound:3553-0389|FD-Score:-5.14|P-value:6.56E-9 ID:SGTC_177|Compound:1327-0068|FD-Score:-4.18|P-value:1.92E-6 ID:SGTC_279|Compound:1273-0055|FD-Score:4.01|P-value:4.87E-6 ID:SGTC_284|Compound:0988-0104|FD-Score:3.12|P-value:2.93E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.89|P-value:8.28E-6 ID:SGTC_347|Compound:4534-1311|FD-Score:-2.79|P-value:9.88E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:2.90|P-value:7.11E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.13|P-value:2.85E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:2.92|P-value:6.57E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-4.33|P-value:8.50E-7 ID:SGTC_719|Compound:2810-4230|FD-Score:-2.81|P-value:9.20E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.44|P-value:7.66E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:3.63|P-value:3.16E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:-4.05|P-value:3.74E-6 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.26|P-value:1.54E-4 ID:SGTC_1115|Compound:galangin|FD-Score:2.88|P-value:7.58E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.87|P-value:1.00E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.22|P-value:1.98E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.34|P-value:1.17E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.03|P-value:4.46E-6 ID:SGTC_1523|Compound:st012844|FD-Score:3.87|P-value:9.96E-6 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-3.42|P-value:7.54E-5 ID:SGTC_2395|Compound:5646831|FD-Score:2.86|P-value:8.14E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:2.82|P-value:9.57E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-2.93|P-value:5.91E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.35|P-value:1.06E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.39|P-value:9.59E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-3.76|P-value:1.62E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.56|P-value:4.43E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.54|P-value:4.72E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:-4.48|P-value:3.59E-7 ID:SGTC_174|Compound:3553-0389|FD-Score:-5.14|P-value:6.56E-9 ID:SGTC_177|Compound:1327-0068|FD-Score:-4.18|P-value:1.92E-6 ID:SGTC_279|Compound:1273-0055|FD-Score:4.01|P-value:4.87E-6 ID:SGTC_284|Compound:0988-0104|FD-Score:3.12|P-value:2.93E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.89|P-value:8.28E-6 ID:SGTC_347|Compound:4534-1311|FD-Score:-2.79|P-value:9.88E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:2.90|P-value:7.11E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.13|P-value:2.85E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:2.92|P-value:6.57E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-4.33|P-value:8.50E-7 ID:SGTC_719|Compound:2810-4230|FD-Score:-2.81|P-value:9.20E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.44|P-value:7.66E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:3.63|P-value:3.16E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:-4.05|P-value:3.74E-6 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.26|P-value:1.54E-4 ID:SGTC_1115|Compound:galangin|FD-Score:2.88|P-value:7.58E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.87|P-value:1.00E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.22|P-value:1.98E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.34|P-value:1.17E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.03|P-value:4.46E-6 ID:SGTC_1523|Compound:st012844|FD-Score:3.87|P-value:9.96E-6 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-3.42|P-value:7.54E-5 ID:SGTC_2395|Compound:5646831|FD-Score:2.86|P-value:8.14E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:2.82|P-value:9.57E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-2.93|P-value:5.91E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.35|P-value:1.06E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.39|P-value:9.59E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-3.76|P-value:1.62E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.56|P-value:4.43E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.54|P-value:4.72E-5

Top fitness defect scores for YLR118C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1284 0929-0043 4.03 16.0 µM 4.46E-6 22 2.78E-5
2 SGTC_279 1273-0055 4.01 2.9 µM 4.87E-6 azole & statin 39 2.99E-5
3 SGTC_1523 st012844 3.87 44.7 µM 9.96E-6 60S ribosome export 23 5.42E-5
4 SGTC_1169 aniline yellow 3.87 25.8 µM 1.00E-5 10 5.45E-5
5 SGTC_986 1493-0483 3.63 84.0 µM 3.16E-5 19 1.41E-4
6 SGTC_3202 9113761 3.56 49.5 µM 4.43E-5 61 1.87E-4
7 SGTC_3212 9128307 3.54 49.5 µM 4.72E-5 65 1.97E-4
8 SGTC_935 2996-0153 3.44 430.0 µM 7.66E-5 PDR1 35 2.95E-4
9 SGTC_3128 9127691 3.39 49.5 µM 9.59E-5 32 3.55E-4
10 SGTC_1281 0884-0031 3.34 11.8 µM 1.17E-4 fatty acid desaturase (OLE1) 46 4.19E-4
11 SGTC_1171 0368-0077 3.22 21.4 µM 1.98E-4 37 6.50E-4
12 SGTC_503 tyrphostin 8 3.13 294.0 µM 2.85E-4 TSC3-RPN4 65 8.80E-4
13 SGTC_284 0988-0104 3.12 32.6 µM 2.93E-4 heme requiring 31 9.01E-4
14 SGTC_559 1550-0661 2.92 158.0 µM 6.57E-4 50 0.00176
15 SGTC_415 dibenzyl ketone 2.90 100.0 µM 7.11E-4 46 0.00189
16 SGTC_1115 galangin 2.88 695.7 nM 7.58E-4 RPP1 & pyrimidine depletion 68 0.00199
17 SGTC_2395 5646831 2.86 180.2 µM 8.14E-4 79 0.00211
18 SGTC_2612 dictamnine 2.82 15.5 µM 9.57E-4 RNA pol III & RNase P/MRP 111 0.00241
19 SGTC_2504 purpurogallin 2.79 52.3 µM 0.00108 RPP1 & pyrimidine depletion 74 0.00266
20 SGTC_3133 9127736 2.75 49.5 µM 0.00125 87 0.00302

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.13E-13 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.119 4.78E-12 YKL151C YKL151C hom NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.109 2.41E-10 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.108 3.41E-10 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.107 6.12E-10 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.104 1.38E-9 YKL072W STB6 hom Protein that binds Sin3p in a two-hybrid assay
0.103 2.49E-9 YLR049C_p YLR049C_p hom Putative protein of unknown function
0.091 1.35E-7 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.089 2.26E-7 YIL139C REV7 hom Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.088 3.26E-7 YPR017C DSS4 hom Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol
0.087 4.33E-7 YOL019W-A_p YOL019W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.086 5.37E-7 YBR144C_d YBR144C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
0.086 6.42E-7 YDR102C_d YDR102C_d hom Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
0.084 1.05E-6 YDR453C TSA2 hom Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress
0.084 1.16E-6 YPR004C AIM45 hom Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response