YLR119W / SRN2

Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR119W / SRN2

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.45|P-value:4.32E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.97|P-value:7.54E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:3.26|P-value:8.18E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.51|P-value:6.46E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:6.00|P-value:3.38E-9 ID:SGTC_168|Compound:3970-0862|FD-Score:5.59|P-value:3.20E-8 ID:SGTC_199|Compound:4063-0024|FD-Score:3.35|P-value:6.08E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:3.51|P-value:3.43E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.28|P-value:7.69E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.54|P-value:3.13E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:5.36|P-value:1.11E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.55|P-value:1.22E-10 ID:SGTC_227|Compound:fluconazole|FD-Score:7.27|P-value:1.08E-12 ID:SGTC_298|Compound:1391-0729|FD-Score:-3.68|P-value:1.83E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.20|P-value:9.97E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.92|P-value:7.50E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:3.63|P-value:2.23E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:6.49|P-value:1.72E-10 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.53|P-value:3.20E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.64|P-value:2.14E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.99|P-value:6.84E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-4.45|P-value:8.43E-6 ID:SGTC_470|Compound:aa-861|FD-Score:4.14|P-value:3.21E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:3.24|P-value:8.75E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.93|P-value:7.36E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.71|P-value:2.62E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:3.53|P-value:3.21E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:4.43|P-value:9.25E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.81|P-value:1.12E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:4.54|P-value:5.78E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:3.45|P-value:4.35E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.50|P-value:3.56E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.38|P-value:5.42E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:5.93|P-value:4.88E-9 ID:SGTC_918|Compound:glabranin|FD-Score:6.13|P-value:1.52E-9 ID:SGTC_919|Compound:tnp00227|FD-Score:3.60|P-value:2.51E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.71|P-value:1.68E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:8.89|P-value:4.25E-18 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.29|P-value:7.29E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.81|P-value:1.17E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.50|P-value:3.62E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.33|P-value:6.44E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.41|P-value:4.94E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.10|P-value:4.06E-7 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.12|P-value:3.35E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.95|P-value:6.61E-5 ID:SGTC_1518|Compound:st038567|FD-Score:5.52|P-value:4.70E-8 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.27|P-value:7.83E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:6.15|P-value:1.35E-9 ID:SGTC_1605|Compound:st000082|FD-Score:3.24|P-value:8.61E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.41|P-value:4.94E-4 ID:SGTC_1687|Compound:st020778|FD-Score:7.99|P-value:5.48E-15 ID:SGTC_1745|Compound:st081495|FD-Score:-3.44|P-value:4.39E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.41|P-value:4.99E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.27|P-value:8.01E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.22|P-value:9.20E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.76|P-value:2.12E-6 ID:SGTC_1803|Compound:st050068|FD-Score:3.88|P-value:8.77E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.53|P-value:1.34E-10 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.10|P-value:3.69E-5 ID:SGTC_1884|Compound:5633444|FD-Score:3.70|P-value:1.74E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.72|P-value:1.62E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.55|P-value:2.98E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.83|P-value:1.08E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-5.18|P-value:2.78E-7 ID:SGTC_2333|Compound:9017922|FD-Score:-3.68|P-value:1.89E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.27|P-value:7.79E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.81|P-value:1.14E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.53|P-value:3.18E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:12.30|P-value:5.19E-33 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.56|P-value:2.91E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.01|P-value:6.21E-12 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.78|P-value:1.91E-6 ID:SGTC_2802|Compound:7925815|FD-Score:7.50|P-value:2.08E-13 ID:SGTC_2803|Compound:7707263|FD-Score:5.46|P-value:6.44E-8 ID:SGTC_2987|Compound:9018338|FD-Score:3.73|P-value:1.58E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.66|P-value:2.05E-4 ID:SGTC_3133|Compound:9127736|FD-Score:4.58|P-value:4.80E-6 ID:SGTC_3143|Compound:9086658|FD-Score:-3.22|P-value:9.21E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.45|P-value:4.32E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.97|P-value:7.54E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:3.26|P-value:8.18E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.51|P-value:6.46E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:6.00|P-value:3.38E-9 ID:SGTC_168|Compound:3970-0862|FD-Score:5.59|P-value:3.20E-8 ID:SGTC_199|Compound:4063-0024|FD-Score:3.35|P-value:6.08E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:3.51|P-value:3.43E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.28|P-value:7.69E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.54|P-value:3.13E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:5.36|P-value:1.11E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.55|P-value:1.22E-10 ID:SGTC_227|Compound:fluconazole|FD-Score:7.27|P-value:1.08E-12 ID:SGTC_298|Compound:1391-0729|FD-Score:-3.68|P-value:1.83E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.20|P-value:9.97E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.92|P-value:7.50E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:3.63|P-value:2.23E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:6.49|P-value:1.72E-10 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.53|P-value:3.20E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.64|P-value:2.14E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.99|P-value:6.84E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-4.45|P-value:8.43E-6 ID:SGTC_470|Compound:aa-861|FD-Score:4.14|P-value:3.21E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:3.24|P-value:8.75E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.93|P-value:7.36E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.71|P-value:2.62E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:3.53|P-value:3.21E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:4.43|P-value:9.25E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.81|P-value:1.12E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:4.54|P-value:5.78E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:3.45|P-value:4.35E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.50|P-value:3.56E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.38|P-value:5.42E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:5.93|P-value:4.88E-9 ID:SGTC_918|Compound:glabranin|FD-Score:6.13|P-value:1.52E-9 ID:SGTC_919|Compound:tnp00227|FD-Score:3.60|P-value:2.51E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.71|P-value:1.68E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:8.89|P-value:4.25E-18 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.29|P-value:7.29E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.81|P-value:1.17E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.50|P-value:3.62E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.33|P-value:6.44E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.41|P-value:4.94E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.10|P-value:4.06E-7 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.12|P-value:3.35E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.95|P-value:6.61E-5 ID:SGTC_1518|Compound:st038567|FD-Score:5.52|P-value:4.70E-8 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.27|P-value:7.83E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:6.15|P-value:1.35E-9 ID:SGTC_1605|Compound:st000082|FD-Score:3.24|P-value:8.61E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.41|P-value:4.94E-4 ID:SGTC_1687|Compound:st020778|FD-Score:7.99|P-value:5.48E-15 ID:SGTC_1745|Compound:st081495|FD-Score:-3.44|P-value:4.39E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.41|P-value:4.99E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.27|P-value:8.01E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.22|P-value:9.20E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.76|P-value:2.12E-6 ID:SGTC_1803|Compound:st050068|FD-Score:3.88|P-value:8.77E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.53|P-value:1.34E-10 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.10|P-value:3.69E-5 ID:SGTC_1884|Compound:5633444|FD-Score:3.70|P-value:1.74E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.72|P-value:1.62E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.55|P-value:2.98E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.83|P-value:1.08E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-5.18|P-value:2.78E-7 ID:SGTC_2333|Compound:9017922|FD-Score:-3.68|P-value:1.89E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.27|P-value:7.79E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.81|P-value:1.14E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.53|P-value:3.18E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:12.30|P-value:5.19E-33 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.56|P-value:2.91E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.01|P-value:6.21E-12 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.78|P-value:1.91E-6 ID:SGTC_2802|Compound:7925815|FD-Score:7.50|P-value:2.08E-13 ID:SGTC_2803|Compound:7707263|FD-Score:5.46|P-value:6.44E-8 ID:SGTC_2987|Compound:9018338|FD-Score:3.73|P-value:1.58E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.66|P-value:2.05E-4 ID:SGTC_3133|Compound:9127736|FD-Score:4.58|P-value:4.80E-6 ID:SGTC_3143|Compound:9086658|FD-Score:-3.22|P-value:9.21E-4

Top fitness defect scores for YLR119W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2619 obliquin 12.30 87.9 µM 5.19E-33 cell wall 12 3.53E-35
2 SGTC_1174 0739-0097 8.89 51.1 µM 4.25E-18 redox potentiating 1 3.11E-19
3 SGTC_1687 st020778 7.99 55.4 µM 5.48E-15 70 6.56E-16
4 SGTC_2802 7925815 7.50 54.5 µM 2.08E-13 2 3.19E-14
5 SGTC_227 fluconazole 7.27 33.5 µM 1.08E-12 azole & statin 29 1.85E-13
6 SGTC_2679 rapamycin 7.01 1.0 nM 6.21E-12 59 1.20E-12
7 SGTC_221 trifluoperazine 6.55 10.3 µM 1.22E-10 NEO1-PIK1 106 2.90E-11
8 SGTC_1844 rapamycin 6.53 4.0 nM 1.34E-10 80 3.21E-11
9 SGTC_377 3970-0964 6.49 33.1 µM 1.72E-10 14 4.19E-11
10 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 6.15 54.9 µM 1.35E-9 redox potentiating 31 3.78E-10
11 SGTC_918 glabranin 6.13 770.7 nM 1.52E-9 4 4.28E-10
12 SGTC_159 3970-0959 6.00 50.0 µM 3.38E-9 25 1.01E-9
13 SGTC_916 4466-0038 5.93 42.0 nM 4.88E-9 cell wall 27 1.49E-9
14 SGTC_168 3970-0862 5.59 530.5 µM 3.20E-8 55 1.11E-8
15 SGTC_1518 st038567 5.52 90.8 µM 4.70E-8 6 1.67E-8
16 SGTC_2803 7707263 5.46 71.4 µM 6.44E-8 9 2.35E-8
17 SGTC_214 4373-3496 5.36 70.0 µM 1.11E-7 19 4.19E-8
18 SGTC_1495 4469-0029 5.10 237.0 µM 4.06E-7 67 1.67E-7
19 SGTC_2688 kanamycin b 4.78 96.7 µM 1.91E-6 calcium & mitochondrial duress 269 8.73E-7
20 SGTC_1800 st050079 4.76 29.1 µM 2.12E-6 NEO1-PIK1 87 9.74E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.353 7.88E-99 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.349 9.41E-97 YNR006W VPS27 hom Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
0.347 1.97E-95 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.335 1.55E-88 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.328 9.68E-85 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.326 4.64E-84 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.323 3.57E-82 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.312 2.02E-76 YKR035C_d OPI8_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A
0.309 6.00E-75 YPL084W BRO1 hom Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
0.291 1.66E-66 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.286 3.68E-64 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.280 1.28E-61 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.276 1.02E-59 YPL120W VPS30 hom Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1
0.275 4.30E-59 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.272 8.20E-58 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication