YLR121C / YPS3

Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR121C / YPS3

Click on Significant Values for Screen Details ID:SGTC_115|Compound:0527-0192|FD-Score:4.90|P-value:4.58E-7 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.10|P-value:9.86E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.46|P-value:2.74E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.66|P-value:1.26E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.30|P-value:4.30E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.35|P-value:3.60E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.61|P-value:1.51E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.53|P-value:2.11E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.11|P-value:9.58E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.29|P-value:5.10E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.34|P-value:4.18E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.33|P-value:4.32E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.35|P-value:4.08E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.56|P-value:1.85E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.12|P-value:9.15E-4 ID:SGTC_1763|Compound:st044482|FD-Score:7.46|P-value:3.69E-14 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.33|P-value:3.80E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-4.51|P-value:2.73E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.69|P-value:1.12E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.17|P-value:7.79E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.44|P-value:2.96E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.42|P-value:2.77E-4 ID:SGTC_1932|Compound:st074806|FD-Score:5.28|P-value:6.12E-8 ID:SGTC_2066|Compound:5222451|FD-Score:-3.16|P-value:7.09E-4 ID:SGTC_2104|Compound:5389443|FD-Score:-3.77|P-value:7.24E-5 ID:SGTC_2377|Compound:9073351|FD-Score:3.16|P-value:7.97E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.37|P-value:3.84E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.78|P-value:8.76E-7 ID:SGTC_2446|Compound:5162541|FD-Score:3.62|P-value:1.49E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-3.98|P-value:2.96E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:3.84|P-value:6.15E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.17|P-value:7.71E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.31|P-value:4.68E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.53|P-value:2.12E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.70|P-value:1.07E-4 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:4.36|P-value:6.41E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:4.57|P-value:2.34E-6 ID:SGTC_2894|Compound:9048625|FD-Score:-3.44|P-value:2.61E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-3.42|P-value:2.77E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.12|P-value:9.02E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.10|P-value:8.77E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.18|P-value:7.48E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.67|P-value:1.21E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.90|P-value:4.58E-7 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.10|P-value:9.86E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.46|P-value:2.74E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.66|P-value:1.26E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.30|P-value:4.30E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.35|P-value:3.60E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.61|P-value:1.51E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.53|P-value:2.11E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.11|P-value:9.58E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.29|P-value:5.10E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.34|P-value:4.18E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.33|P-value:4.32E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.35|P-value:4.08E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.56|P-value:1.85E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.12|P-value:9.15E-4 ID:SGTC_1763|Compound:st044482|FD-Score:7.46|P-value:3.69E-14 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.33|P-value:3.80E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-4.51|P-value:2.73E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.69|P-value:1.12E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.17|P-value:7.79E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.44|P-value:2.96E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.42|P-value:2.77E-4 ID:SGTC_1932|Compound:st074806|FD-Score:5.28|P-value:6.12E-8 ID:SGTC_2066|Compound:5222451|FD-Score:-3.16|P-value:7.09E-4 ID:SGTC_2104|Compound:5389443|FD-Score:-3.77|P-value:7.24E-5 ID:SGTC_2377|Compound:9073351|FD-Score:3.16|P-value:7.97E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.37|P-value:3.84E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.78|P-value:8.76E-7 ID:SGTC_2446|Compound:5162541|FD-Score:3.62|P-value:1.49E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-3.98|P-value:2.96E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:3.84|P-value:6.15E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.17|P-value:7.71E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.31|P-value:4.68E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.53|P-value:2.12E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.70|P-value:1.07E-4 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:4.36|P-value:6.41E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:4.57|P-value:2.34E-6 ID:SGTC_2894|Compound:9048625|FD-Score:-3.44|P-value:2.61E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-3.42|P-value:2.77E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.12|P-value:9.02E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.10|P-value:8.77E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.18|P-value:7.48E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.67|P-value:1.21E-4

Top fitness defect scores for YLR121C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1763 st044482 7.46 94.5 µM 3.69E-14 copper-dependent oxidative stress 3 4.21E-14
2 SGTC_1932 st074806 5.28 40.9 µM 6.12E-8 4 6.36E-8
3 SGTC_115 0527-0192 4.90 112.0 µM 4.58E-7 36 4.71E-7
4 SGTC_2438 5259590 4.78 200.0 µM 8.76E-7 9 8.97E-7
5 SGTC_2760 etidronate 4.57 98.0 µM 2.34E-6 14 2.38E-6
6 SGTC_2728 chlorpromazine 4.36 9.2 µM 6.41E-6 1 6.50E-6
7 SGTC_2686 alizarin 3.84 95.4 µM 6.15E-5 RPP1 & pyrimidine depletion 35 6.16E-5
8 SGTC_2706 st078239 3.70 82.5 µM 1.07E-4 16 1.07E-4
9 SGTC_1875 nocodazole 3.69 6.0 µM 1.12E-4 tubulin folding & SWR complex 56 1.12E-4
10 SGTC_3131 9127911 3.67 49.5 µM 1.21E-4 38 1.21E-4
11 SGTC_331 k048-0133 3.66 24.5 µM 1.26E-4 RSC & ERG11 16 1.25E-4
12 SGTC_2446 5162541 3.62 200.0 µM 1.49E-4 16 1.48E-4
13 SGTC_768 0384-0033 3.61 77.3 µM 1.51E-4 fatty acid desaturase (OLE1) 97 1.50E-4
14 SGTC_1601 4'-hydroxyflavanone 3.56 55.5 µM 1.85E-4 RPP1 & pyrimidine depletion 45 1.84E-4
15 SGTC_824 1304-0008 3.53 100.0 µM 2.11E-4 DNA damage response 51 2.11E-4
16 SGTC_2700 st077718 3.53 96.8 µM 2.12E-4 22 2.11E-4
17 SGTC_228 caffeine 3.46 993.1 µM 2.74E-4 18 2.73E-4
18 SGTC_1893 st059353 3.44 36.1 µM 2.96E-4 44 2.95E-4
19 SGTC_2429 5902844 3.37 64.4 µM 3.84E-4 53 3.82E-4
20 SGTC_1477 0139-0234 3.35 16.0 µM 4.08E-4 22 4.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.16E-13 YOL014W_p YOL014W_p hom Putative protein of unknown function
0.118 8.08E-12 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.110 1.46E-10 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.095 3.14E-8 YNR055C HOL1 hom Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake
0.095 3.86E-8 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.091 1.38E-7 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.083 1.52E-6 YMR148W OSW5 hom Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
0.083 1.64E-6 YDL168W SFA1 hom Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress
0.081 2.41E-6 YMR073C IRC21 hom Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
0.080 3.90E-6 YGL115W SNF4 hom Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress
0.079 4.20E-6 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.079 5.19E-6 YLR433C CNA1 hom Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.078 5.85E-6 YCR005C CIT2 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication
0.078 5.82E-6 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.076 9.98E-6 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo