YLR130C / ZRT2

Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR130C / ZRT2

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:-3.42|P-value:1.49E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.28|P-value:3.63E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:4.78|P-value:2.69E-7 ID:SGTC_737|Compound:1950-0117|FD-Score:3.23|P-value:3.58E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.91|P-value:2.09E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.02|P-value:7.82E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-2.97|P-value:8.47E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.41|P-value:1.78E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.60|P-value:8.23E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:3.42|P-value:1.74E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.49|P-value:1.30E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.01|P-value:8.27E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-2.96|P-value:8.82E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:3.37|P-value:2.10E-4 ID:SGTC_1629|Compound:st005085|FD-Score:2.96|P-value:9.88E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.65|P-value:6.56E-5 ID:SGTC_1757|Compound:st041620|FD-Score:-2.92|P-value:9.96E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.75|P-value:3.68E-5 ID:SGTC_1793|Compound:st048256|FD-Score:3.20|P-value:4.16E-4 ID:SGTC_1931|Compound:st074438|FD-Score:-3.60|P-value:7.14E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.13|P-value:5.41E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.01|P-value:1.36E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.70|P-value:5.45E-5 ID:SGTC_1999|Compound:st074831|FD-Score:-3.06|P-value:5.98E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.11|P-value:8.29E-6 ID:SGTC_2184|Compound:6075246|FD-Score:3.85|P-value:2.76E-5 ID:SGTC_2185|Compound:6113692|FD-Score:3.07|P-value:6.64E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.77|P-value:3.88E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.63|P-value:7.30E-5 ID:SGTC_3304|Compound:9125678|FD-Score:-3.13|P-value:4.70E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.97|P-value:1.58E-5 ID:SGTC_31|Compound:0508-1974|FD-Score:-3.42|P-value:1.49E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.28|P-value:3.63E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:4.78|P-value:2.69E-7 ID:SGTC_737|Compound:1950-0117|FD-Score:3.23|P-value:3.58E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.91|P-value:2.09E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.02|P-value:7.82E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-2.97|P-value:8.47E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.41|P-value:1.78E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.60|P-value:8.23E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:3.42|P-value:1.74E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.49|P-value:1.30E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.01|P-value:8.27E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-2.96|P-value:8.82E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:3.37|P-value:2.10E-4 ID:SGTC_1629|Compound:st005085|FD-Score:2.96|P-value:9.88E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.65|P-value:6.56E-5 ID:SGTC_1757|Compound:st041620|FD-Score:-2.92|P-value:9.96E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.75|P-value:3.68E-5 ID:SGTC_1793|Compound:st048256|FD-Score:3.20|P-value:4.16E-4 ID:SGTC_1931|Compound:st074438|FD-Score:-3.60|P-value:7.14E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.13|P-value:5.41E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.01|P-value:1.36E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.70|P-value:5.45E-5 ID:SGTC_1999|Compound:st074831|FD-Score:-3.06|P-value:5.98E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.11|P-value:8.29E-6 ID:SGTC_2184|Compound:6075246|FD-Score:3.85|P-value:2.76E-5 ID:SGTC_2185|Compound:6113692|FD-Score:3.07|P-value:6.64E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.77|P-value:3.88E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.63|P-value:7.30E-5 ID:SGTC_3304|Compound:9125678|FD-Score:-3.13|P-value:4.70E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.97|P-value:1.58E-5

Top fitness defect scores for YLR130C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_165 k038-0023 4.78 64.4 µM 2.69E-7 ubiquinone biosynthesis & proteasome 49 8.62E-7
2 SGTC_67 0335-0847 4.28 266.0 µM 3.63E-6 ubiquinone biosynthesis & proteasome 99 9.23E-6
3 SGTC_2102 5377816 4.11 72.8 µM 8.29E-6 23 1.96E-5
4 SGTC_1982 st072467 4.01 71.9 µM 1.36E-5 34 3.09E-5
5 SGTC_3305 9127027 3.97 53.8 µM 1.58E-5 15 3.53E-5
6 SGTC_744 1594-0068 3.91 283.0 µM 2.09E-5 amide catabolism 28 4.55E-5
7 SGTC_2184 6075246 3.85 200.0 µM 2.76E-5 28 5.87E-5
8 SGTC_2403 6032726 3.77 181.2 µM 3.88E-5 42 8.02E-5
9 SGTC_1988 st071872 3.70 53.4 µM 5.45E-5 13 1.09E-4
10 SGTC_1755 st041960 3.65 45.2 µM 6.56E-5 32 1.29E-4
11 SGTC_2755 lomerizine 3.63 42.7 µM 7.30E-5 31 1.43E-4
12 SGTC_1295 1013-0063 3.60 9.8 µM 8.23E-5 21 1.59E-4
13 SGTC_1514 1189-1591 3.49 158.0 µM 1.30E-4 56 2.42E-4
14 SGTC_1462 k081-0014 3.42 26.5 µM 1.74E-4 16 3.16E-4
15 SGTC_1029 k015-0030 3.41 64.7 µM 1.78E-4 51 3.22E-4
16 SGTC_1540 guanosine 3.37 70.6 µM 2.10E-4 18 3.75E-4
17 SGTC_737 1950-0117 3.23 57.9 µM 3.58E-4 47 6.10E-4
18 SGTC_1793 st048256 3.20 72.2 µM 4.16E-4 15 6.99E-4
19 SGTC_1941 st076221 3.13 61.8 µM 5.41E-4 sphingolipid biosynthesis & PDR1 128 8.89E-4
20 SGTC_2185 6113692 3.07 200.0 µM 6.64E-4 ergosterol biosynthesis 43 0.00107

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 8.86E-22 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.148 7.42E-18 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.146 1.63E-17 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.126 2.76E-13 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.117 1.28E-11 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.111 1.14E-10 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.105 8.86E-10 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.102 3.49E-9 YCR023C YCR023C hom Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene
0.093 6.25E-8 YLR247C IRC20 hom Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
0.093 6.27E-8 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.089 2.39E-7 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.089 2.54E-7 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.088 2.83E-7 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.087 4.55E-7 YKL147C_d YKL147C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
0.086 6.11E-7 YER087C-A_d YER087C-A_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase