HIPHOP chemogenomics database
YLR131C / ACE2 
Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR131C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.170 | 4.93E-23 | YKL048C | ELM1 | hom | Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring |
| 0.116 | 1.58E-11 | YKR047W_d | YKR047W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 |
| 0.111 | 1.09E-10 | YER137C_p | YER137C_p | hom | Putative protein of unknown function |
| 0.108 | 4.04E-10 | YNR055C | HOL1 | hom | Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake |
| 0.100 | 6.30E-9 | YDR336W_p | YDR336W_p | hom | Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene |
| 0.100 | 6.44E-9 | YJL149W | DAS1 | hom | Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C |
| 0.098 | 1.37E-8 | YKR048C | NAP1 | hom | Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress |
| 0.091 | 1.17E-7 | YNL181W_p | YNL181W_p | het | Putative oxidoreductase; required for cell viability |
| 0.091 | 1.51E-7 | YLR458W_d | YLR458W_d | het | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis |
| 0.088 | 3.15E-7 | YKL096W | CWP1 | hom | Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance |
| 0.084 | 1.09E-6 | YLR021W | IRC25 | hom | Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions |
| 0.080 | 3.67E-6 | YPR194C | OPT2 | hom | Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles |
| 0.077 | 9.30E-6 | YBR293W | VBA2 | hom | Permease of basic amino acids in the vacuolar membrane |
| 0.076 | 9.89E-6 | YJL108C | PRM10 | hom | Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation |
| 0.076 | 1.19E-5 | YER087C-A_d | YER087C-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase |