YLR131C / ACE2

Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR131C / ACE2

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:4.12|P-value:5.30E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:6.22|P-value:1.75E-7 ID:SGTC_82|Compound:0054-0107|FD-Score:4.06|P-value:6.28E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:6.14|P-value:2.58E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:7.44|P-value:3.92E-10 ID:SGTC_160|Compound:3453-0671|FD-Score:25.20|P-value:3.12E-103 ID:SGTC_182|Compound:3448-4371|FD-Score:6.13|P-value:2.67E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:6.45|P-value:5.99E-8 ID:SGTC_250|Compound:brefeldin a|FD-Score:5.43|P-value:5.31E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:5.35|P-value:7.27E-6 ID:SGTC_316|Compound:k060-0003|FD-Score:7.10|P-value:2.47E-9 ID:SGTC_317|Compound:4495-0002|FD-Score:7.71|P-value:8.84E-11 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.32|P-value:7.77E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:5.28|P-value:9.23E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:3.95|P-value:8.79E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.01|P-value:7.43E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.63|P-value:9.95E-5 ID:SGTC_456|Compound:gingerol|FD-Score:-3.25|P-value:9.64E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.57|P-value:1.25E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.53|P-value:1.40E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:5.41|P-value:5.73E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:4.62|P-value:1.06E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:6.41|P-value:7.29E-8 ID:SGTC_659|Compound:k018-0002|FD-Score:5.47|P-value:4.38E-6 ID:SGTC_662|Compound:k832-1615|FD-Score:4.30|P-value:3.00E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:7.98|P-value:1.89E-11 ID:SGTC_691|Compound:1548-0686|FD-Score:4.05|P-value:6.54E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:5.98|P-value:5.26E-7 ID:SGTC_752|Compound:1896-0090|FD-Score:6.12|P-value:2.81E-7 ID:SGTC_764|Compound:1951-2361|FD-Score:6.96|P-value:4.91E-9 ID:SGTC_959|Compound:1222-0044|FD-Score:4.24|P-value:3.65E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:16.90|P-value:6.30E-47 ID:SGTC_983|Compound:1491-0821|FD-Score:4.39|P-value:2.29E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:4.81|P-value:5.34E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.37|P-value:2.38E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:5.97|P-value:5.54E-7 ID:SGTC_1073|Compound:triclabendazole|FD-Score:6.66|P-value:2.17E-8 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.53|P-value:4.13E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.35|P-value:7.10E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.34|P-value:2.66E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.19|P-value:4.21E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.96|P-value:8.46E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.80|P-value:5.67E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:5.03|P-value:2.41E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.39|P-value:2.28E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.25|P-value:3.50E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.46|P-value:1.79E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:5.38|P-value:6.28E-6 ID:SGTC_1403|Compound:3909-7815|FD-Score:6.33|P-value:1.07E-7 ID:SGTC_1436|Compound:4092-1007|FD-Score:5.22|P-value:1.18E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.17|P-value:4.55E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.19|P-value:1.35E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.58|P-value:2.80E-6 ID:SGTC_1504|Compound:k297-0033|FD-Score:5.48|P-value:4.19E-6 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.23|P-value:3.70E-4 ID:SGTC_1607|Compound:st000305|FD-Score:4.42|P-value:2.04E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.00|P-value:7.59E-4 ID:SGTC_1662|Compound:st014054|FD-Score:4.73|P-value:7.14E-5 ID:SGTC_1666|Compound:st014829|FD-Score:4.42|P-value:2.02E-4 ID:SGTC_1682|Compound:st012968|FD-Score:4.33|P-value:2.70E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.27|P-value:3.27E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.36|P-value:2.51E-4 ID:SGTC_1749|Compound:st037932|FD-Score:6.21|P-value:1.86E-7 ID:SGTC_1755|Compound:st041960|FD-Score:5.98|P-value:5.24E-7 ID:SGTC_1757|Compound:st041620|FD-Score:5.86|P-value:8.94E-7 ID:SGTC_1802|Compound:st050112|FD-Score:4.28|P-value:3.17E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.91|P-value:9.99E-4 ID:SGTC_1852|Compound:st056254|FD-Score:4.67|P-value:8.69E-5 ID:SGTC_1870|Compound:st057514|FD-Score:4.36|P-value:2.47E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:5.97|P-value:5.41E-7 ID:SGTC_1908|Compound:st060353|FD-Score:7.88|P-value:3.39E-11 ID:SGTC_1931|Compound:st074438|FD-Score:5.68|P-value:1.87E-6 ID:SGTC_1945|Compound:st075991|FD-Score:4.37|P-value:2.37E-4 ID:SGTC_2067|Compound:5224629|FD-Score:4.95|P-value:3.21E-5 ID:SGTC_2084|Compound:5306078|FD-Score:4.14|P-value:4.93E-4 ID:SGTC_2095|Compound:5432005|FD-Score:5.21|P-value:1.23E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.33|P-value:2.70E-4 ID:SGTC_2128|Compound:5255449|FD-Score:5.20|P-value:1.28E-5 ID:SGTC_2136|Compound:5328288|FD-Score:4.74|P-value:6.85E-5 ID:SGTC_2148|Compound:5546263|FD-Score:6.46|P-value:5.84E-8 ID:SGTC_2150|Compound:5556613|FD-Score:4.98|P-value:2.88E-5 ID:SGTC_2172|Compound:5754775|FD-Score:6.57|P-value:3.45E-8 ID:SGTC_2184|Compound:6075246|FD-Score:7.65|P-value:1.22E-10 ID:SGTC_2238|Compound:6671620|FD-Score:4.05|P-value:6.59E-4 ID:SGTC_2266|Compound:7929956|FD-Score:4.12|P-value:5.27E-4 ID:SGTC_2302|Compound:7771753|FD-Score:5.58|P-value:2.84E-6 ID:SGTC_2303|Compound:7774051|FD-Score:5.42|P-value:5.46E-6 ID:SGTC_2325|Compound:6158266|FD-Score:5.43|P-value:5.15E-6 ID:SGTC_2339|Compound:9000433|FD-Score:5.50|P-value:3.86E-6 ID:SGTC_2341|Compound:7987486|FD-Score:4.23|P-value:3.73E-4 ID:SGTC_2357|Compound:9067248|FD-Score:6.24|P-value:1.59E-7 ID:SGTC_2370|Compound:9071495|FD-Score:4.38|P-value:2.35E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:5.36|P-value:6.83E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:8.61|P-value:4.19E-13 ID:SGTC_2430|Compound:5571206|FD-Score:4.54|P-value:1.39E-4 ID:SGTC_2462|Compound:5162487|FD-Score:6.51|P-value:4.49E-8 ID:SGTC_2479|Compound:5617353|FD-Score:4.40|P-value:2.16E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:4.40|P-value:2.20E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:6.68|P-value:1.97E-8 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:5.08|P-value:2.03E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.17|P-value:4.48E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:12.90|P-value:1.28E-27 ID:SGTC_2630|Compound:antimycin a|FD-Score:7.69|P-value:9.82E-11 ID:SGTC_2657|Compound:nystatin|FD-Score:4.77|P-value:6.28E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:5.30|P-value:8.71E-6 ID:SGTC_2674|Compound:ligustilide|FD-Score:6.20|P-value:1.97E-7 ID:SGTC_2676|Compound:harmalol|FD-Score:4.12|P-value:5.20E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:6.86|P-value:8.05E-9 ID:SGTC_2699|Compound:st077704|FD-Score:4.68|P-value:8.37E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:6.02|P-value:4.30E-7 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.42|P-value:5.42E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.37|P-value:2.40E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.07|P-value:6.11E-4 ID:SGTC_2787|Compound:5284540|FD-Score:4.55|P-value:1.31E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.62|P-value:3.09E-4 ID:SGTC_2819|Compound:7996655|FD-Score:6.08|P-value:3.30E-7 ID:SGTC_2831|Compound:7999036|FD-Score:4.39|P-value:2.29E-4 ID:SGTC_2874|Compound:9043904|FD-Score:4.03|P-value:6.94E-4 ID:SGTC_2884|Compound:9058502|FD-Score:6.13|P-value:2.71E-7 ID:SGTC_2903|Compound:5923464|FD-Score:4.20|P-value:4.17E-4 ID:SGTC_2966|Compound:9084041|FD-Score:9.62|P-value:4.89E-16 ID:SGTC_2969|Compound:9091408|FD-Score:-3.40|P-value:6.29E-4 ID:SGTC_2978|Compound:9011784|FD-Score:8.01|P-value:1.59E-11 ID:SGTC_3001|Compound:9076041|FD-Score:6.19|P-value:2.03E-7 ID:SGTC_3006|Compound:9075424|FD-Score:7.06|P-value:3.00E-9 ID:SGTC_3068|Compound:9116768|FD-Score:6.48|P-value:5.17E-8 ID:SGTC_3080|Compound:9117754|FD-Score:4.14|P-value:4.90E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.99|P-value:7.89E-4 ID:SGTC_3131|Compound:9127911|FD-Score:5.43|P-value:5.31E-6 ID:SGTC_3138|Compound:9097216|FD-Score:5.35|P-value:7.29E-6 ID:SGTC_3173|Compound:9105693|FD-Score:9.29|P-value:4.79E-15 ID:SGTC_3190|Compound:9110366|FD-Score:-4.33|P-value:2.74E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-3.96|P-value:1.04E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.81|P-value:1.68E-4 ID:SGTC_3202|Compound:9113761|FD-Score:5.69|P-value:1.79E-6 ID:SGTC_3208|Compound:9114115|FD-Score:5.97|P-value:5.44E-7 ID:SGTC_3216|Compound:9129716|FD-Score:4.96|P-value:3.19E-5 ID:SGTC_3259|Compound:9138485|FD-Score:5.74|P-value:1.44E-6 ID:SGTC_3314|Compound:9135860|FD-Score:5.08|P-value:2.01E-5 ID:SGTC_3316|Compound:9136639|FD-Score:11.00|P-value:1.09E-20 ID:SGTC_3327|Compound:9140648|FD-Score:6.22|P-value:1.77E-7 ID:SGTC_3345|Compound:9148410|FD-Score:5.09|P-value:1.91E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.12|P-value:5.30E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:6.22|P-value:1.75E-7 ID:SGTC_82|Compound:0054-0107|FD-Score:4.06|P-value:6.28E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:6.14|P-value:2.58E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:7.44|P-value:3.92E-10 ID:SGTC_160|Compound:3453-0671|FD-Score:25.20|P-value:3.12E-103 ID:SGTC_182|Compound:3448-4371|FD-Score:6.13|P-value:2.67E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:6.45|P-value:5.99E-8 ID:SGTC_250|Compound:brefeldin a|FD-Score:5.43|P-value:5.31E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:5.35|P-value:7.27E-6 ID:SGTC_316|Compound:k060-0003|FD-Score:7.10|P-value:2.47E-9 ID:SGTC_317|Compound:4495-0002|FD-Score:7.71|P-value:8.84E-11 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.32|P-value:7.77E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:5.28|P-value:9.23E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:3.95|P-value:8.79E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.01|P-value:7.43E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.63|P-value:9.95E-5 ID:SGTC_456|Compound:gingerol|FD-Score:-3.25|P-value:9.64E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.57|P-value:1.25E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.53|P-value:1.40E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:5.41|P-value:5.73E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:4.62|P-value:1.06E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:6.41|P-value:7.29E-8 ID:SGTC_659|Compound:k018-0002|FD-Score:5.47|P-value:4.38E-6 ID:SGTC_662|Compound:k832-1615|FD-Score:4.30|P-value:3.00E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:7.98|P-value:1.89E-11 ID:SGTC_691|Compound:1548-0686|FD-Score:4.05|P-value:6.54E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:5.98|P-value:5.26E-7 ID:SGTC_752|Compound:1896-0090|FD-Score:6.12|P-value:2.81E-7 ID:SGTC_764|Compound:1951-2361|FD-Score:6.96|P-value:4.91E-9 ID:SGTC_959|Compound:1222-0044|FD-Score:4.24|P-value:3.65E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:16.90|P-value:6.30E-47 ID:SGTC_983|Compound:1491-0821|FD-Score:4.39|P-value:2.29E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:4.81|P-value:5.34E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.37|P-value:2.38E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:5.97|P-value:5.54E-7 ID:SGTC_1073|Compound:triclabendazole|FD-Score:6.66|P-value:2.17E-8 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.53|P-value:4.13E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.35|P-value:7.10E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.34|P-value:2.66E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.19|P-value:4.21E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.96|P-value:8.46E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.80|P-value:5.67E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:5.03|P-value:2.41E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.39|P-value:2.28E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.25|P-value:3.50E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.46|P-value:1.79E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:5.38|P-value:6.28E-6 ID:SGTC_1403|Compound:3909-7815|FD-Score:6.33|P-value:1.07E-7 ID:SGTC_1436|Compound:4092-1007|FD-Score:5.22|P-value:1.18E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.17|P-value:4.55E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.19|P-value:1.35E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.58|P-value:2.80E-6 ID:SGTC_1504|Compound:k297-0033|FD-Score:5.48|P-value:4.19E-6 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.23|P-value:3.70E-4 ID:SGTC_1607|Compound:st000305|FD-Score:4.42|P-value:2.04E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.00|P-value:7.59E-4 ID:SGTC_1662|Compound:st014054|FD-Score:4.73|P-value:7.14E-5 ID:SGTC_1666|Compound:st014829|FD-Score:4.42|P-value:2.02E-4 ID:SGTC_1682|Compound:st012968|FD-Score:4.33|P-value:2.70E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.27|P-value:3.27E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.36|P-value:2.51E-4 ID:SGTC_1749|Compound:st037932|FD-Score:6.21|P-value:1.86E-7 ID:SGTC_1755|Compound:st041960|FD-Score:5.98|P-value:5.24E-7 ID:SGTC_1757|Compound:st041620|FD-Score:5.86|P-value:8.94E-7 ID:SGTC_1802|Compound:st050112|FD-Score:4.28|P-value:3.17E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.91|P-value:9.99E-4 ID:SGTC_1852|Compound:st056254|FD-Score:4.67|P-value:8.69E-5 ID:SGTC_1870|Compound:st057514|FD-Score:4.36|P-value:2.47E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:5.97|P-value:5.41E-7 ID:SGTC_1908|Compound:st060353|FD-Score:7.88|P-value:3.39E-11 ID:SGTC_1931|Compound:st074438|FD-Score:5.68|P-value:1.87E-6 ID:SGTC_1945|Compound:st075991|FD-Score:4.37|P-value:2.37E-4 ID:SGTC_2067|Compound:5224629|FD-Score:4.95|P-value:3.21E-5 ID:SGTC_2084|Compound:5306078|FD-Score:4.14|P-value:4.93E-4 ID:SGTC_2095|Compound:5432005|FD-Score:5.21|P-value:1.23E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.33|P-value:2.70E-4 ID:SGTC_2128|Compound:5255449|FD-Score:5.20|P-value:1.28E-5 ID:SGTC_2136|Compound:5328288|FD-Score:4.74|P-value:6.85E-5 ID:SGTC_2148|Compound:5546263|FD-Score:6.46|P-value:5.84E-8 ID:SGTC_2150|Compound:5556613|FD-Score:4.98|P-value:2.88E-5 ID:SGTC_2172|Compound:5754775|FD-Score:6.57|P-value:3.45E-8 ID:SGTC_2184|Compound:6075246|FD-Score:7.65|P-value:1.22E-10 ID:SGTC_2238|Compound:6671620|FD-Score:4.05|P-value:6.59E-4 ID:SGTC_2266|Compound:7929956|FD-Score:4.12|P-value:5.27E-4 ID:SGTC_2302|Compound:7771753|FD-Score:5.58|P-value:2.84E-6 ID:SGTC_2303|Compound:7774051|FD-Score:5.42|P-value:5.46E-6 ID:SGTC_2325|Compound:6158266|FD-Score:5.43|P-value:5.15E-6 ID:SGTC_2339|Compound:9000433|FD-Score:5.50|P-value:3.86E-6 ID:SGTC_2341|Compound:7987486|FD-Score:4.23|P-value:3.73E-4 ID:SGTC_2357|Compound:9067248|FD-Score:6.24|P-value:1.59E-7 ID:SGTC_2370|Compound:9071495|FD-Score:4.38|P-value:2.35E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:5.36|P-value:6.83E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:8.61|P-value:4.19E-13 ID:SGTC_2430|Compound:5571206|FD-Score:4.54|P-value:1.39E-4 ID:SGTC_2462|Compound:5162487|FD-Score:6.51|P-value:4.49E-8 ID:SGTC_2479|Compound:5617353|FD-Score:4.40|P-value:2.16E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:4.40|P-value:2.20E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:6.68|P-value:1.97E-8 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:5.08|P-value:2.03E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.17|P-value:4.48E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:12.90|P-value:1.28E-27 ID:SGTC_2630|Compound:antimycin a|FD-Score:7.69|P-value:9.82E-11 ID:SGTC_2657|Compound:nystatin|FD-Score:4.77|P-value:6.28E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:5.30|P-value:8.71E-6 ID:SGTC_2674|Compound:ligustilide|FD-Score:6.20|P-value:1.97E-7 ID:SGTC_2676|Compound:harmalol|FD-Score:4.12|P-value:5.20E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:6.86|P-value:8.05E-9 ID:SGTC_2699|Compound:st077704|FD-Score:4.68|P-value:8.37E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:6.02|P-value:4.30E-7 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.42|P-value:5.42E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.37|P-value:2.40E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.07|P-value:6.11E-4 ID:SGTC_2787|Compound:5284540|FD-Score:4.55|P-value:1.31E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.62|P-value:3.09E-4 ID:SGTC_2819|Compound:7996655|FD-Score:6.08|P-value:3.30E-7 ID:SGTC_2831|Compound:7999036|FD-Score:4.39|P-value:2.29E-4 ID:SGTC_2874|Compound:9043904|FD-Score:4.03|P-value:6.94E-4 ID:SGTC_2884|Compound:9058502|FD-Score:6.13|P-value:2.71E-7 ID:SGTC_2903|Compound:5923464|FD-Score:4.20|P-value:4.17E-4 ID:SGTC_2966|Compound:9084041|FD-Score:9.62|P-value:4.89E-16 ID:SGTC_2969|Compound:9091408|FD-Score:-3.40|P-value:6.29E-4 ID:SGTC_2978|Compound:9011784|FD-Score:8.01|P-value:1.59E-11 ID:SGTC_3001|Compound:9076041|FD-Score:6.19|P-value:2.03E-7 ID:SGTC_3006|Compound:9075424|FD-Score:7.06|P-value:3.00E-9 ID:SGTC_3068|Compound:9116768|FD-Score:6.48|P-value:5.17E-8 ID:SGTC_3080|Compound:9117754|FD-Score:4.14|P-value:4.90E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.99|P-value:7.89E-4 ID:SGTC_3131|Compound:9127911|FD-Score:5.43|P-value:5.31E-6 ID:SGTC_3138|Compound:9097216|FD-Score:5.35|P-value:7.29E-6 ID:SGTC_3173|Compound:9105693|FD-Score:9.29|P-value:4.79E-15 ID:SGTC_3190|Compound:9110366|FD-Score:-4.33|P-value:2.74E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-3.96|P-value:1.04E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.81|P-value:1.68E-4 ID:SGTC_3202|Compound:9113761|FD-Score:5.69|P-value:1.79E-6 ID:SGTC_3208|Compound:9114115|FD-Score:5.97|P-value:5.44E-7 ID:SGTC_3216|Compound:9129716|FD-Score:4.96|P-value:3.19E-5 ID:SGTC_3259|Compound:9138485|FD-Score:5.74|P-value:1.44E-6 ID:SGTC_3314|Compound:9135860|FD-Score:5.08|P-value:2.01E-5 ID:SGTC_3316|Compound:9136639|FD-Score:11.00|P-value:1.09E-20 ID:SGTC_3327|Compound:9140648|FD-Score:6.22|P-value:1.77E-7 ID:SGTC_3345|Compound:9148410|FD-Score:5.09|P-value:1.91E-5

Top fitness defect scores for YLR131C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_160 3453-0671 25.20 289.7 µM 3.12E-103 1 7.59E-141
2 SGTC_972 1319-0219 16.90 195.0 µM 6.30E-47 1 1.90E-64
3 SGTC_2629 bisabolol 12.90 100.0 µM 1.28E-27 1 4.24E-38
4 SGTC_3316 9136639 11.00 10.6 µM 1.09E-20 1 1.35E-28
5 SGTC_2966 9084041 9.62 48.0 µM 4.89E-16 1 3.40E-22
6 SGTC_3173 9105693 9.29 49.5 µM 4.79E-15 1 7.93E-21
7 SGTC_2419 paclitaxel 8.61 166.5 µM 4.19E-13 2 3.81E-18
8 SGTC_2978 9011784 8.01 43.0 µM 1.59E-11 1 5.84E-16
9 SGTC_664 1222-0054 7.98 14.9 µM 1.89E-11 sphingolipid biosynthesis & PDR1 8 7.44E-16
10 SGTC_1908 st060353 7.88 56.5 µM 3.39E-11 RPP1 & pyrimidine depletion 2 1.67E-15
11 SGTC_317 4495-0002 7.71 170.0 µM 8.84E-11 1 6.30E-15
12 SGTC_2630 antimycin a 7.69 100.0 µM 9.82E-11 mitochondrial processes 6 7.29E-15
13 SGTC_2184 6075246 7.65 200.0 µM 1.22E-10 1 9.88E-15
14 SGTC_86 0417-1630 7.44 471.9 µM 3.92E-10 ubiquinone biosynthesis & proteasome 65 4.98E-14
15 SGTC_316 k060-0003 7.10 58.6 µM 2.47E-9 1 6.43E-13
16 SGTC_3006 9075424 7.06 71.4 µM 3.00E-9 2 8.41E-13
17 SGTC_764 1951-2361 6.96 146.0 µM 4.91E-9 3 1.67E-12
18 SGTC_2687 chenodiol 6.86 100.0 µM 8.05E-9 1 3.33E-12
19 SGTC_2506 ethyl hematommate 6.68 54.2 µM 1.97E-8 RPP1 & pyrimidine depletion 1 1.16E-11
20 SGTC_1073 triclabendazole 6.66 3.1 µM 2.17E-8 3 1.32E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.170 4.93E-23 YKL048C ELM1 hom Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring
0.116 1.58E-11 YKR047W_d YKR047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1
0.111 1.09E-10 YER137C_p YER137C_p hom Putative protein of unknown function
0.108 4.04E-10 YNR055C HOL1 hom Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake
0.100 6.30E-9 YDR336W_p YDR336W_p hom Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene
0.100 6.44E-9 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.098 1.37E-8 YKR048C NAP1 hom Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress
0.091 1.17E-7 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.091 1.51E-7 YLR458W_d YLR458W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis
0.088 3.15E-7 YKL096W CWP1 hom Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance
0.084 1.09E-6 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.080 3.67E-6 YPR194C OPT2 hom Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles
0.077 9.30E-6 YBR293W VBA2 hom Permease of basic amino acids in the vacuolar membrane
0.076 9.89E-6 YJL108C PRM10 hom Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.076 1.19E-5 YER087C-A_d YER087C-A_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase